Vue transversale de la maladie
Lupus
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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719 résultats correspondants
· 46 visibles sur cette page
dans le périmètre Lupus
Niveau clinique
Études et traitements 248
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Obinutuzumab NCT06084936 · GLOBRYTE — A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's C… | Cancer | À vérifier | Phase 3 | RECRUITING | This phase II, randomized, double-blind, placebo-controlled study is desig… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:24 | Détail |
| Blood sample NCT05746845 · RESEPTOR 5-HT7 — Implication of 5-HT7 Receptor in Inflammatory Mechanisms in Mul… | Sclérose en plaques | Immunomodulation | À vérifier | COMPLETED | This study evaluates the variation of expression of the neonatal Fc recept… À vérifier | ClinicalTrials.gov 2026-09-03 16:30:52 | Détail |
| Acetaminophen/Paracetamol Étude non communiquée | Lupus · Migraine | À vérifier | Phase 2 | Actif | The purpose of this study is to evaluate the safety and efficacy of telcag… À vérifier | ClinicalTrials.gov 2026-09-02 | Détail |
| Diphenhydramine hydrochloride (HCl) Étude non communiquée | Lupus | À vérifier | Phase 2 | Actif | This phase II, randomized, double-blind, placebo-controlled study is desig… À vérifier | ClinicalTrials.gov 2026-09-02 | Détail |
| Prednisone Étude non communiquée | Cancer · Lupus · Myasthénie · Myopathies · Sclérose en plaques | À vérifier | Phase 3 | Terminé | The purpose of this study is to evaluate the efficacy and tolerability of… À vérifier | ClinicalTrials.gov 2026-09-02 | Détail |
| Tocilizumab Étude non communiquée | Cancer · Épilepsie · Lupus | À vérifier | Phase 1 | Actif | The purpose of this study is to investigate the safety, tolerability, phar… À vérifier | ClinicalTrials.gov 2026-09-02 | Détail |
| CABA-201 NCT06121297 · RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of C… | Lupus | À vérifier | Phase 1/2 | RECRUITING | RESET-MG: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| Emapalumab NCT05001737 · EMERALD — Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in… | Lupus | À vérifier | Phase 3 | COMPLETED | The purpose of this study is to assess the safety, tolerability and effica… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| HOP-STEPsIRB — The HOP-STEP Intervention: Improving Maternal Health i… NCT05818254 · NCT05818254 | Lupus | Thérapie génique | Non applicable | COMPLETED | While the HOP-STEP (Healthy Outcomes in Pregnancy with SLE Through Educati… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| Ianalumab NCT06711887 · Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without St… | Lupus | À vérifier | Phase 3 | RECRUITING | The purpose of this study is to evaluate long-term safety and tolerability… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| LBL-047 for Injection NCT07323173 · A Study to Assess the Safety and PK/PD of LBL-047 in Healthy Adults and Patients… | Lupus | À vérifier | Phase 1 | RECRUITING | A Double-blind, Randomized, Placebo-controlled, Dose-escalation Phase I St… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| Low Dose Mesenchymal Stem Cells (MSCs) NCT02633163 · Phase 2 Trial of Mesenchymal Stem Cells in Systemic Lupus Erythematosus (MiSLE) | Lupus | Thérapie cellulaire | Phase 2 | COMPLETED | The purpose of this study is to evaluate the safety of mesenchymal stromal… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| Nipocalimab NCT07438496 · GARDENIA-SLE — A Study of Nipocalimab in Adults With Moderate to Severe Systemic… | Lupus | À vérifier | Phase 3 | RECRUITING | The purpose of this study is to evaluate how well nipocalimab works as com… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| Obecabtagene autoleucel NCT07053800 · LUMINA — Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With A… | Lupus | À vérifier | Phase 2 | RECRUITING | The purpose of this trial is to evaluate the efficacy and safety of obecab… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| obinutuzumab (RO5072759) NCT07767188 · A Trial to Explore the Efficacy and Safety of O-triple as Initial Therapy in the… | Lupus | À vérifier | Phase 3 | NOT_YET_RECRUITING | This is a prospective single-arm multi-center trial to evaluate the effica… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| Predictors of ICU Admission and In-Hospital Mortality in Hospitalized… NCT07783711 · Predictors of ICU Admission and In-Hospital Mortality in Hospitalized Patients W… | Lupus | À vérifier | À vérifier | NOT_YET_RECRUITING | To identify clinical and laboratory predictors of ICU admission and in-hos… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:26 | Détail |
| IM19 CAR-T cells NCT06513429 · IM19 CAR-T Cell Therapy in Refractory Systemic Lupus Erythematosus (SLE) | Lupus | Thérapie cellulaire | Non applicable | RECRUITING | The study is a single-arm, open-label clinical trial intended to recruit 6… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:25 | Détail |
| IMVT-1402 NCT06980805 · A Study to Assess the Safety, Tolerability, and Efficacy of IMVT-1402 in Partici… | Lupus | À vérifier | Phase 2 | ACTIVE_NOT_RECRUITING | The purpose of the study is to assess the efficacy, safety and tolerabilit… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:25 | Détail |
| KYV-101 anti-CD19 CAR-T cell therapy NCT05938725 · KYSA-1: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Thera… | Lupus | Thérapie cellulaire | Phase 1/2 | TERMINATED | A Study of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy for Subjects… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:25 | Détail |
| KYV-101 anti-CD19 CAR-T cell therapy NCT06342960 · KYSA-3: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Thera… | Lupus | Thérapie cellulaire | Phase 1/2 | TERMINATED | A Study of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy for Subjects… À vérifier | ClinicalTrials.gov 2026-09-01 09:22:25 | Détail |
Découverte scientifique
Recherches et trouvailles 0
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune trouvaille ne correspond aux filtres. | |||||||
Bibliographie
Publications 465
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Sympathetic ophthalmia induced by vitrectomy for endogenous fungal en… Prednisone · PMID 42482889 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Sympathetic ophthalmia (SO) is a rare but serious inflammatory ocular disorder. We report a case of endogenous fungal e… | Frontiers in medicine 2026-07-22 21:23:10 | Source |
| Accelerated recovery and alleviated pain by oral whey protein in herp… standard therapy · PMID 42482061 | Lupus | Neuroprotection · Traitement symptomatique | Publication | PubMed | Voir la publication source Herpes zoster is usually caused by varicella-zoster virus reactivation, particularly in the aged. It imposes postherpet… | Nutrition journal 2026-07-22 21:22:26 | Source |
| Successful Trifarotene Treatment of a Typical Kyrle's Disease With Ov… standard therapy · PMID 42480558 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Kyrle's disease is a rare skin disorder involving transepidermal keratin elimination, usually linked to systemic illnes… | Skin research and technology : official journal of Int… 2026-07-22 21:22:26 | Source |
| Atorvastatin-associated neurological adverse events: a disproportiona… Atorvastatin · PMID 42482918 | Lupus | Neuroprotection | Publication | PubMed | Voir la publication source Atorvastatin, a widely prescribed HMG-CoA reductase inhibitor, is associated with neurological adverse events (NAEs) be… | Frontiers in medicine 2026-07-22 21:22:20 | Source |
| Derived inflammatory indicators for identifying preeclampsia in pregn… Assessment of Blood Indices in Systemic Lupus Erythematosus · PMID 42481938 | Lupus | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Pregnant women with systemic lupus erythematosus (SLE) are at high risk of preeclampsia (PE). However, overlapping clin… | BMC pregnancy and childbirth 2026-07-22 21:22:19 | Source |
| A WO@Bi-BiVO based Z-scheme heterojunction for photoelectrochemical s… Anti-CD19-CD3E-CAR-T cells · PMID 42485065 | Lupus | Remyélinisation indirecte / réparation · Neuroprotection · Thérapie cellulaire | Publication | PubMed | Voir la publication source Batatasin (a natural antioxidant ingredient) is expected to have an effect on the release of reactive oxygen species fr… | Chemical communications (Cambridge, England) 2026-07-22 21:22:17 | Source |
| Exosome-Loaded Zinc Sulfide Nanoparticles Therapy for Psoriasis: Immu… Anti-CD19-CD3E-CAR-T cells · PMID 42485082 | Lupus | Immunomodulation · Traitement symptomatique · Thérapie cellulaire | Publication | PubMed | Voir la publication source This study investigates the therapeutic efficacy of zinc sulfide nanoparticles (ZnS NPs) encapsulated within adipose-de… | Journal of drug targeting 2026-07-22 21:22:17 | Source |
| From Molecular Pathophysiology to Clinical Trial Design in Sjögren's… Ianalumab · PMID 42449965 | Lupus | Traitement symptomatique | Publication | PubMed | Voir la publication source Sjögren's disease (SjD) remains one of the few major systemic autoimmune diseases without an approved disease-modifying… | International journal of molecular sciences 2026-07-22 21:22:16 | Source |
| Case Report: Severe ANCA-positive eosinophilic granulomatosis with po… Rituximab · PMID 42483201 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated syste… | Frontiers in immunology 2026-07-22 21:22:10 | Source |
| Post-transplant lymphoproliferative disorder after solid organ transp… Rituximab · PMID 42483433 | Lupus | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Post-transplant lymphoproliferative disorder (PTLD) is a serious and heterogeneous neoplastic complication of solid org… | Frontiers in transplantation 2026-07-22 21:22:10 | Source |
| Efficacy and safety of immunotherapy-based combination therapy as fir… Cabozantinib · PMID 42484760 | Lupus | Ralentissement de la progression | Publication | PubMed | Voir la publication source To update a network meta-analysis of first-line immunotherapy combinations in advanced renal cell carcinoma (RCC) using… | Medical oncology (Northwood, London, England) 2026-07-22 21:21:48 | Source |
| The HGF/c-Met Signaling Axis: A Master Regulator of Invasion and Meta… Cabozantinib · PMID 42480911 | Lupus | Ralentissement de la progression | Publication | PubMed | Voir la publication source Oral squamous cell carcinoma (OSCC) is a major global health concern because local invasion and regional lymph node met… | Journal of stomatology, oral and maxillofacial surgery 2026-07-22 21:21:48 | Source |
| Systemic lupus erythematosus complicated by thrombotic microangiopath… eculizumab · PMID 42470044 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Systemic lupus erythematosus (SLE)-associated thrombotic microangiopathy with features of atypical hemolytic uremic syn… | Medicine 2026-07-18 15:48:16 | Source |
| In situ engineering of a self-healing drug-scaffold hydrogel to block… Artesunate · PMID 42468382 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Surgical resection inadvertently promotes metastasis via platelet activation and tumor cell-platelet aggregation. Conve… | Biomaterials 2026-07-18 15:47:39 | Source |
| Two Cases of Malaria-Associated Acute Respiratory Distress Syndrome a… Artesunate · PMID 42464474 | Lupus | À vérifier | Publication | PubMed | Voir la publication source BACKGROUND Malaria remains a major cause of morbidity and mortality in tropical regions. Severe Plasmodium falciparum m… | The American journal of case reports 2026-07-18 15:47:39 | Source |
| Draft genome for the horse hair fungus, , isolated from cacao in Ghan… MRA 003 US · PMID 39898667 | Lupus | À vérifier | Publication | PubMed | Voir la publication source , known as the horse hair fungus, is a litter-decomposing fungus that is opportunistically pathogenic on various plants… | Microbiology resource announcements 2026-07-18 15:47:38 | Source |
| Whole genome sequence analysis of eight isolates from sugar beet fact… MRA 003 US · PMID 41870269 | Lupus | Neuroprotection | Publication | PubMed | Voir la publication source species, prevalent in sugar beet factories, consume sucrose and produce potentially problematic exopolysaccharides duri… | Microbiology resource announcements 2026-07-18 15:47:38 | Source |
| High-Intensity Statin Treatment Is Associated With Reduced Growth Dif… Atorvastatin · PMID 42460854 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Growth differentiation factor-15 (GDF-15) is upregulated in coronary artery disease (CAD). The relationship of intensiv… | European journal of clinical investigation 2026-07-18 15:47:36 | Source |
| Statin Therapy and Outcomes in Heart Failure with Mildly Reduced Ejec… Atorvastatin · PMID 42468779 | Lupus | À vérifier | Publication | PubMed | Voir la publication source This study investigates the association of statin therapy and prognosis in heart failure with mildly reduced ejection f… | Hellenic journal of cardiology : HJC = Hellenike kardi… 2026-07-18 15:47:36 | Source |
| Integrated immune profiling identifies a coordinated T-cell activatio… Assessment of Blood Indices in Systemic Lupus Erythematosus · PMID 42457337 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Patients with SLE have an increased risk of infections and infection-related mortality, which may be associated with di… | Lupus science & medicine 2026-07-18 15:47:35 | Source |
Exploration — prudence
Pistes exploratoires 6
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Lupus | Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation immunométabolique de la microglie 4-octyl itaconate et dérivés est étudié dans Sclérose latérale amyotrophique et documente plusieurs axes biologiques po… | Rapprochement Biomedical Watch · Sclérose latérale amy… | Détail |
| Bavisant BRAVEinMS — Bavisant | Lupus | Remyélinisation · Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Antagonisme du récepteur H3 de l’histamine Bavisant est étudié dans Sclérose en plaques et documente plusieurs axes biologiques pouvant être pertinents pour Lupus… | Rapprochement Biomedical Watch · Sclérose en plaques | Détail |
| Vecteur Ple389 (ADORA2A) MiniPromoter Ple389 — ciblage striatal | Lupus | Thérapie génique | Hypothèse exploratoire | Rapprochement automatique non validé | Expression génique ciblée dans les neurones striataux Vecteur Ple389 (ADORA2A) est étudié dans Maladie de Huntington et documente plusieurs axes biologiques pouvant être per… | Rapprochement Biomedical Watch · Maladie de Huntington | Détail |
| Tol-MP Tol-MP — tolérance immunitaire spécifique de la myéline | Lupus | Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Microparticules biodégradables chargées en rapamycine et fonctionnalisées… Tol-MP est étudié dans Sclérose en plaques et documente plusieurs axes biologiques pouvant être pertinents pour Lupus :… | Rapprochement Biomedical Watch · Sclérose en plaques | Détail |
| SetPoint System SetPoint System — SetPoint Medical | Lupus | Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | re ApplicationsPublicationsCompanyCareersNewsGet startedGet startedNewsThe… SetPoint System est étudié dans Sclérose en plaques et documente plusieurs axes biologiques pouvant être pertinents pou… | Rapprochement Biomedical Watch · Sclérose en plaques | Détail |
| Thonningianin A Thonningianin A — neuroprotection anti-amyloïde | Lupus | Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation du stress oxydatif et des protéines associées à Alzheimer Thonningianin A est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pou… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |