Vue transversale de la maladie
Lupus
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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719 résultats correspondants
· 46 visibles sur cette page
dans le périmètre Lupus
Niveau clinique
Études et traitements 248
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| SAR441344 IV NCT05039840 · APATURA — Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Syst… | Lupus | À vérifier | Phase 2 | ACTIVE_NOT_RECRUITING | This is a multinational, randomized, placebo-controlled, parallel treatmen… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:31 | Détail |
| ABBV-319 NCT06977724 · A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effect… | Lupus | Immunomodulation · Traitement symptomatique | Phase 1 | RECRUITING | Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disea… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| Anifrolumab NCT06795893 · The Anifrolumab PRIM Program | Lupus | À vérifier | À vérifier | RECRUITING | This is an observational study, in which the main research question is to… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| Cevostamab NCT07629583 · To Evaluate the Effects of Cevostamab in Participants With Systemic Lupus Erythe… | Lupus | À vérifier | Phase 1 | RECRUITING | The study will evaluate the safety, tolerability, pharmacokinetics, and ph… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| Creating Health Course Study for People With Rheumatological Conditio… NCT07180537 · NCT07180537 | Lupus | Traitement symptomatique | Non applicable | RECRUITING | The goal of this project is to critically evaluate the effectiveness of an… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| DZP NCT06617325 · PHOENYCS FLY — A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pego… | Lupus | À vérifier | Phase 3 | RECRUITING | The purpose of this study is to evaluate the ability of dapirolizumab pego… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| ESG206 NCT07760155 · A Phase 2 Study on the Safety and Efficacy of the Anti-BAFF-R Monoclonal Antibod… | Lupus | À vérifier | Phase 2 | NOT_YET_RECRUITING | This is a multicenter, randomized, double-blind, placebo-controlled Phase… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| HEAL-SLE: Holistic Energy for Alleviating Lupus Symptoms NCT07203157 · NCT07203157 | Lupus | Traitement symptomatique | Non applicable | ACTIVE_NOT_RECRUITING | The purpose of this study is to assess the efficacy, feasibility, and acce… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| HN2301 injection NCT06801119 · SLE，SSc，RA — Efficacy and Safety of HN2301 in Autoimmune Diseases（AIDs） | Lupus | À vérifier | Phase 1 | RECRUITING | This is an open lable and single arm study, is designed to evaluate the sa… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| HN2302 Injection NCT07523282 · AID — Safety and Preliminary Efficacy of HN2302 in Patients With Autoimmune Dise… | Lupus | À vérifier | Phase 1 | NOT_YET_RECRUITING | This is an open-label, single-arm study designed to evaluate the safety an… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| Ia:QLS2404 very low dose NCT07751315 · A Study of QLS2404 Injection in Healthy Participants and Participants With Rheum… | Lupus | À vérifier | Phase 1 | NOT_YET_RECRUITING | This study consists of a randomized, double-blind, placebo-controlled Phas… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| IASO-782 injection NCT07483346 · IASO-782 in Systemic Lupus Erythematosus | Lupus | À vérifier | Phase 1 | RECRUITING | his study is a randomized, double-blinded, and placebo-controlled phase Ia… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| Inebilizumab NCT06570798 · A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune… | Lupus | À vérifier | Phase 2 | RECRUITING | The main objective is to assess the safety and tolerability of inebilizuma… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| Kidney Biopsy NCT07760480 · MAPLE — Assessing Residual Inflammation and Macrophage Presence in Lupus Nephrit… | Lupus | Immunomodulation · Thérapie génique | Phase 4 | RECRUITING | The goal of this clinical trial is to learn how different treatments affec… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| MK-6194 NCT06161116 · Efficacy and Safety of MK-6194 in Adult Participants With Systemic Lupus Erythem… | Lupus | À vérifier | Phase 2 | TERMINATED | The purpose of this study is to evaluate the efficacy and safety of MK-619… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| PF-06823859 NCT05879718 · A Study to Learn About the Study Medicine (PF-06823859) in Adults With Active CL… | Lupus | Traitement symptomatique · Thérapie génique | Phase 2 | TERMINATED | The purpose of this study is to learn about the effects, safety and how PF… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| PREPCOV — Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine… NCT04481633 · NCT04481633 | Lupus | À vérifier | Non applicable | COMPLETED | There is a pandemic in the world by COVID-19. Currently, the pharmacologic… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| Quinacrine Hydrochloride NCT07694336 · A Study of Quinacrine in Participants With Cutaneous Lupus Erythematosus | Lupus | Immunomodulation · Traitement symptomatique · Thérapie génique | Phase 2 | RECRUITING | The research study is being conducted to learn more about how patients wit… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| SG301 SC Injection NCT06144710 · SG301-SC Injection Safety Study in Subjects With Systemic Lupus Erythematosus | Lupus | À vérifier | Phase 1 | COMPLETED | This is a randomized, double-blind, placebo-controlled phase I clinical st… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
| Vonsetamig NCT06975787 · Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupu… | Lupus | À vérifier | Phase 1 | RECRUITING | This study is researching a particular group of experimental drugs adminis… À vérifier | ClinicalTrials.gov 2026-08-13 14:17:30 | Détail |
Découverte scientifique
Recherches et trouvailles 0
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune trouvaille ne correspond aux filtres. | |||||||
Bibliographie
Publications 465
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Biomarkers of nivolumab benefit in resectable non-small cell lung can… Nivolumab · PMID 42587156 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Perioperative nivolumab significantly improved event-free survival (EFS) compared with placebo in patients with resecta… | Nature 2026-08-13 15:00:11 | Source |
| Genetic basis of immune-mediated necrotizing myopathy: A genomic stru… Deciphering the Genetic Architecture of Autoimmune Diseases · PMID 41775122 | Lupus | Ralentissement de la progression | Publication | PubMed | Voir la publication source Immune-mediated necrotizing myopathy (IMNM) constitutes an autoimmune myopathy precipitated by autoantibodies, marked b… | Computational biology and chemistry 2026-08-13 15:00:11 | Source |
| Metabolic-epigenetic rewiring in rheumatoid arthritis: from pathogeni… Deciphering the Genetic Architecture of Autoimmune Diseases · PMID 42131326 | Lupus | Remyélinisation indirecte / réparation · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Rheumatoid arthritis (RA) is a systemic autoimmune disorder wherein sustained, drug-free remission remains an elusive c… | Frontiers in immunology 2026-08-13 15:00:11 | Source |
| Clinical relevance of loneliness in the treatment of depression: stud… Biospecimen Collection · PMID 42568550 | Lupus | Traitement symptomatique | Publication | PubMed | Voir la publication source Loneliness and depression are widespread and severely debilitating health conditions. Notably, loneliness and depressio… | Frontiers in psychiatry 2026-08-13 15:00:09 | Source |
| National Coordinated Care and Translational Research Program for Uvea… Biospecimen Collection · PMID 42583538 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Uveal melanoma (UM) is a rare malignancy in Latin America (LA), where coordinated clinical and translational research i… | Ocular oncology and pathology 2026-08-13 15:00:09 | Source |
| Long-Term Survival of Borna Disease Virus 1 (BoDV-1)-Encephalitis: An… Mycophenolate Mofetil · PMID 42587244 | Lupus | Immunomodulation · Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Borna disease virus 1 (BoDV-1) encephalitis has a (sub)acute and mostly fatal course. Initial flu-like symptoms are typ… | Infectious diseases and therapy 2026-08-13 15:00:08 | Source |
| Bendamustine-based lymphodepletion prior to CAR T-cell therapy: a sys… Cyclophosphamide LD · PMID 42332219 | Lupus | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire · Thé… | Publication | PubMed | Voir la publication source Lymphodepletion (LD) is a critical prerequisite for successful chimeric antigen receptor T-cell (CAR-T) therapy. While… | Bone marrow transplantation 2026-08-13 15:00:06 | Source |
| Comparison of Fludarabine Versus Bendamustine as a Lymphodepleting Ch… Cyclophosphamide LD · PMID 42341926 | Lupus | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire · Thé… | Publication | PubMed | Voir la publication source Lymphodepleting chemotherapy (LD) enhances chimeric antigen receptor T cell (CAR-T) expansion, persistence, and clinica… | Transplantation and cellular therapy 2026-08-13 15:00:06 | Source |
| Integrated Physics-Informed Machine Learning Framework for Structural… Study of Families With Twins or Siblings Discordant for Rheumatic Disorders · PMID 42590751 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Structural health monitoring (SHM) plays a critical role in the early identification and assessment of structural damag… | Sensors (Basel, Switzerland) 2026-08-13 15:00:06 | Source |
| Reactor-Grade Non-Additive Polypropylene Architecture Defines the Phy… Study of Families With Twins or Siblings Discordant for Rheumatic Disorders · PMID 42589809 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Rapid estimation of the melt flow index (MFI) is essential for the timely control of industrial polypropylene polymeriz… | Polymers 2026-08-13 15:00:06 | Source |
| Fetal developmental venous anomaly with varix mimicking an intracrani… Sirolimus · PMID 42580651 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | American journal of obstetrics and gynecology 2026-08-13 15:00:04 | Source |
| Survival and Homeostasis of Alveolar Macrophages in Vivo Depend on mT… Sirolimus · PMID 42578718 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Alveolar homeostasis depends on tissue-resident professional phagocytes known as alveolar macrophages (AMs) that catabo… | American journal of respiratory cell and molecular bio… 2026-08-13 15:00:04 | Source |
| Clinicopathological Correlations, Treatment Response, and Predictors… GSK1550188 IV · PMID 42470259 | Lupus | À vérifier | Publication | PubMed | Voir la publication source To investigate clinicopathological correlations, treatment responses, and predictors of outcomes in childhood lupus nep… | International journal of rheumatic diseases 2026-08-13 15:00:03 | Source |
| Efficacy and safety of emerging immunomodulatory agents versus standa… GSK1550188 SC · PMID 42522483 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Refractory cutaneous lupus (RCL) remains challenging to treat, with limited response to standard therapies. Emerging im… | Dermatology online journal 2026-08-13 15:00:03 | Source |
| Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacok… GSK1550188 IV · PMID 42570058 | Lupus | À vérifier | Publication | PubMed | Voir la publication source This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with syst… | Rheumatology and therapy 2026-08-13 15:00:03 | Source |
| Deep profiling of lupus nephritis kidneys reveals dynamic changes in… Urinary T Cell Biomarker for Prediction in Lupus Nephritis · PMID 42055919 | Lupus | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Lupus nephritis (LN) is a common, potentially fatal manifestation of systemic lupus erythematosus. We aimed to gain new… | Annals of the rheumatic diseases 2026-08-13 15:00:01 | Source |
| Serum sPD-1 and sTIM-3 as T-cell exhaustion biomarkers in systemic lu… Urinary T Cell Biomarker for Prediction in Lupus Nephritis · PMID 42551186 | Lupus | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source T-cell exhaustion marked by soluble PD-1 (sPD-1) and soluble TIM-3 (sTIM-3) has been implicated in systemic lupus eryth… | Human immunology 2026-08-13 15:00:01 | Source |
| Voclosporin for the treatment of lupus nephritis flares in patients w… Belimumab · PMID 42584031 | Lupus | Ralentissement de la progression | Publication | PubMed | Voir la publication source Lupus nephritis (LN) is a frequent and severe manifestation of systemic lupus erythematosus (SLE) associated with progr… | Journal of nephrology 2026-08-13 15:00:00 | Source |
| Effectiveness and safety of glucocorticoids bridging rituximab in neu… oral Prednisone 5mg · PMID 39923413 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Anti-CD20 monoclonal antibody rituximab have been widely used to prevent relapses in patients with neuromyelitis optica… | Multiple sclerosis and related disorders 2026-08-13 14:59:58 | Source |
| Maternal Thyroid Dysfunction During Pregnancy and Childhood Autism or… Blood sample · PMID 42590824 | Lupus | Thérapie génique | Publication | PubMed | Voir la publication source Overt maternal hypothyroidism during pregnancy has been associated with cognitive impairment in offspring, but less is… | Autism research : official journal of the Internationa… 2026-08-13 14:59:58 | Source |
Exploration — prudence
Pistes exploratoires 6
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Lupus | Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation immunométabolique de la microglie 4-octyl itaconate et dérivés est étudié dans Sclérose latérale amyotrophique et documente plusieurs axes biologiques po… | Rapprochement Biomedical Watch · Sclérose latérale amy… | Détail |
| Bavisant BRAVEinMS — Bavisant | Lupus | Remyélinisation · Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Antagonisme du récepteur H3 de l’histamine Bavisant est étudié dans Sclérose en plaques et documente plusieurs axes biologiques pouvant être pertinents pour Lupus… | Rapprochement Biomedical Watch · Sclérose en plaques | Détail |
| Vecteur Ple389 (ADORA2A) MiniPromoter Ple389 — ciblage striatal | Lupus | Thérapie génique | Hypothèse exploratoire | Rapprochement automatique non validé | Expression génique ciblée dans les neurones striataux Vecteur Ple389 (ADORA2A) est étudié dans Maladie de Huntington et documente plusieurs axes biologiques pouvant être per… | Rapprochement Biomedical Watch · Maladie de Huntington | Détail |
| Tol-MP Tol-MP — tolérance immunitaire spécifique de la myéline | Lupus | Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Microparticules biodégradables chargées en rapamycine et fonctionnalisées… Tol-MP est étudié dans Sclérose en plaques et documente plusieurs axes biologiques pouvant être pertinents pour Lupus :… | Rapprochement Biomedical Watch · Sclérose en plaques | Détail |
| SetPoint System SetPoint System — SetPoint Medical | Lupus | Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | re ApplicationsPublicationsCompanyCareersNewsGet startedGet startedNewsThe… SetPoint System est étudié dans Sclérose en plaques et documente plusieurs axes biologiques pouvant être pertinents pou… | Rapprochement Biomedical Watch · Sclérose en plaques | Détail |
| Thonningianin A Thonningianin A — neuroprotection anti-amyloïde | Lupus | Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation du stress oxydatif et des protéines associées à Alzheimer Thonningianin A est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pou… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |