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Danish Headache Center
Traitements, essais et publications liés.
Traitements31programmes
Essais18liés
Publications27liées
SourceDBlocale
Traitements
31| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| AdrenomedullinAdrenomedullin is a neuropeptide implicated in the pathogenesis of migraine. This study investigates whether its administration, after pre-treatment with erenumab (a CGRP-receptor blocking monoclonal antibody), can trigger migraine attacks in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| AmylinPramlintide is a peptide analogue of human amylin which is a vasoactive signaling molecule involved in the pathogenesis of migraine. This study investigates whether pramlintide induces migraine attacks without aura in people with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| Calcitonin Gene-Related PeptideThe investigators aim to investigate the incidence of migraine attacks after calcitonin gene-related peptide (CGRP) infusion in patients who have tried anti-CGRP monoclonal antibody treatment for the prevention of migraine. | Migraine | NA | À vérifier | Denmark | À vérifier |
| Calcitonin-gene related peptide (CGRP)Calcitonin gene-related peptide (CGRP) is a key neuropeptide in migraine pathophysiology and treatment. This study investigates whether CGRP administration can trigger aura in individuals with a diagnosis of migraine with aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| CGRPThe investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by calcitonin gene-related peptide (CGRP) compared to patients with few genetic loci associated with migraine (low genetic load). | Migraine | Non applicable | À vérifier | À vérifier | |
| Diclofenac Potassium 50Mg/Pkt Oral PwdrIn a real-world population of adults with migraine, the investigators would like to investigate whether 50 mg diclofenac potassium is non-inferior to 75 mg rimegepant in terms of pain freedom at 2 hours after drug intake. | Migraine | Phase 4 | Traitement symptomatique | Denmark | À vérifier |
| FerahemeThe investigators aim to investigate inflammation of cranial and meningeal arteries during pharmacologically induced migraine attacks, using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles and black blood imaging (BBI) MRI. | Migraine | Non applicable | Immunomodulation | Denmark | À vérifier |
| IvabradineThis study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| LevcromakalimThis study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| MR-angiography, GTNTo examine the ability of MRA to measure the effect of GTN on the intra-cranial vascular response during the GTN-induced headache in healthy volunteers. | Migraine | NA | À vérifier | À vérifier | |
| PACAP-38To investigate whether administration of calcitonin gene-related peptide (CGRP) binding monoclonal antibodies eptinezumab prevents pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) induced migraine attacks in migraine without aura patients. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38)Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) is a key neuropeptide in migraine pathophysiology and treatment. This study investigates whether PACAP-38 administration can trigger aura in individuals with a diagnosis of migraine with aura. | Migraine | Non applicable | À vérifier | À vérifier | |
| Riociguat (BAY 63-2521)This double-blind, randomized, placebo-controlled cross-over clinical trial aims to investigate the effects of riocigaut on migraine inducing properties in people with migraine. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| Substance PSubstance P is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether its administration can trigger migraine attacks in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| SumatriptanThe study aims to explore the effects of Sumatriptan on Levcromakalim-induced migraine in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| Diclofenac Potassium 50Mg/Pkt Oral PwdrIn a real-world population of adults with migraine, the investigators would like to investigate whether 50 mg diclofenac potassium is non-inferior to 75 mg rimegepant in terms of pain freedom at 2 hours after drug intake. | Migraine | Phase 4 | Traitement symptomatique | Denmark | À vérifier |
| AmylinPramlintide is a peptide analogue of human amylin which is a vasoactive signaling molecule involved in the pathogenesis of migraine. This study investigates whether pramlintide induces migraine attacks without aura in people with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| MR-angiography, GTNTo examine the ability of MRA to measure the effect of GTN on the intra-cranial vascular response during the GTN-induced headache in healthy volunteers. | Migraine | NA | À vérifier | À vérifier | |
| Calcitonin Gene-Related PeptideThe investigators aim to investigate the incidence of migraine attacks after calcitonin gene-related peptide (CGRP) infusion in patients who have tried anti-CGRP monoclonal antibody treatment for the prevention of migraine. | Migraine | NA | À vérifier | Denmark | À vérifier |
| Calcitonin-gene related peptide (CGRP)Calcitonin gene-related peptide (CGRP) is a key neuropeptide in migraine pathophysiology and treatment. This study investigates whether CGRP administration can trigger aura in individuals with a diagnosis of migraine with aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38)Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) is a key neuropeptide in migraine pathophysiology and treatment. This study investigates whether PACAP-38 administration can trigger aura in individuals with a diagnosis of migraine with aura. | Migraine | Non applicable | À vérifier | À vérifier | |
| LevcromakalimThis study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura. | Migraine | Non applicable | Traitement symptomatique | Denmark | À vérifier |
| Substance PSubstance P is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether its administration can trigger migraine attacks in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| LevcromakalimThis study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura. | Migraine | Non applicable | Traitement symptomatique | Denmark | À vérifier |
| Riociguat (BAY 63-2521)This double-blind, randomized, placebo-controlled cross-over clinical trial aims to investigate the effects of riocigaut on migraine inducing properties in people with migraine. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| LevcromakalimThis study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| LevcromakalimThis study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura. | Migraine | Non applicable | Traitement symptomatique | Denmark | À vérifier |
| LevcromakalimThis study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
| CGRPThe investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by calcitonin gene-related peptide (CGRP) compared to patients with few genetic loci associated with migraine (low genetic load). | Migraine | Non applicable | À vérifier | À vérifier | |
| FerahemeThe investigators aim to investigate inflammation of cranial and meningeal arteries during pharmacologically induced migraine attacks, using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles and black blood imaging (BBI) MRI. | Migraine | Non applicable | Immunomodulation | Denmark | À vérifier |
| AdrenomedullinAdrenomedullin is a neuropeptide implicated in the pathogenesis of migraine. This study investigates whether its administration, after pre-treatment with erenumab (a CGRP-receptor blocking monoclonal antibody), can trigger migraine attacks in individuals with migraine without aura. | Migraine | Non applicable | À vérifier | Denmark | À vérifier |
Essais cliniques
18| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Adrenomedullin | Migraine | Non applicable | NCT07451769 | Selective Activation of the Adrenomedullin Receptors in Migraine | RECRUITING |
| Feraheme | Migraine | Non applicable | NCT02549898 | Investigation of Vascular Inflammation in Migraine Using Molecular Nano-imaging and Black Blood Imaging MRI | COMPLETED |
| CGRP | Migraine | Non applicable | NCT01924052 | CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load | COMPLETED |
| Levcromakalim | Migraine | Non applicable | NCT04905654 | Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura | COMPLETED |
| Levcromakalim | Migraine | Non applicable | NCT05565001 | The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. | UNKNOWN |
| Eptinezumab | Migraine | Non applicable | NCT05635604 | Migraine Induction Properties of PACAP-38 After Eptinezumab in Migraine Without Aura Patients. | COMPLETED |
| Sildenafil | Migraine | Non applicable | NCT05889455 | COMPETE — Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab | COMPLETED |
| Levcromakalim | Migraine | Non applicable | NCT05889442 | COLLIDE — Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab | COMPLETED |
| Riociguat (BAY 63-2521) | Migraine | Non applicable | NCT05750446 | Effect of Riocigaut on Migraine Attack Induction in People With Migraine | COMPLETED |
| Levcromakalim | Migraine | Non applicable | NCT05211050 | SLIM — Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine | COMPLETED |
| Substance P | Migraine | Non applicable | NCT06959004 | Substance P-Induced Migraine Attacks Without Aura | RECRUITING |
| Levcromakalim | Migraine | Non applicable | NCT04853797 | Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM) | COMPLETED |
| Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) | Migraine | Non applicable | NCT07342296 | Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 | NOT_YET_RECRUITING |
| Calcitonin-gene related peptide (CGRP) | Migraine | Non applicable | NCT07021859 | Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide | RECRUITING |
| Calcitonin Gene-Related Peptide | Migraine | NA | NCT03481400 | CGRP-induced Migraine Attacks in Patients Who Have Tried Anti-CGRP Monoclonal Antibody Treatment | UNKNOWN |
| MR-angiography, GTN | Migraine | NA | NCT00256802 | The Diameter of the Middle Cerebral Artery Measured With Magnetic Resonance Angiography | COMPLETED |
| Amylin | Migraine | Non applicable | NCT07340788 | Amylin-Induced Migraine Attacks Without Aura | NOT_YET_RECRUITING |
| Diclofenac Potassium 50Mg/Pkt Oral Pwdr | Migraine | Phase 4 | NCT05211154 | ATOM — Evaluation of the Efficacy of Diclofenac Potassium and Rimegepant for the Acute Treatment of Migraine | TERMINATED |
Publications
27| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Sumatriptan | Development of a transdermal sumatriptan formulation with iontophoresis. | Drug development and industrial pharmacy | ||
| Substance P | Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting. | Annals of medicine | ||
| Substance P | A mild photothermal-mediated neuroimmunomodulatory composite hydrogel reverses the inflammatory osteoclast precursor phenotype to promote osteoporotic bone defect healing. | Bioactive materials | ||
| Substance P | Da-Jian-Zhong decoction restores the gut-brain balance in diarrhea-predominant irritable bowel syndrome rats via gut microbiota-bile acid axis. | Journal of ethnopharmacology | ||
| Ivabradine | Propranolol and Ivabradine Are Equally Effective in POTS But Not Equipoise in Real Life. | JACC. Advances | ||
| Ivabradine | Retinal ON- and OFF-pathway dysfunction due to HCN channel inhibition evaluated using dark and light adapted flicker electroretinograms in rats. | Experimental eye research | ||
| Ivabradine | A novel electrochemical sensor based on Al-doped ZnO nanoparticles-modified carbon paste electrode for ivabradine sensitive monitoring in human plasma. | Analytical and bioanalytical chemistry | ||
| Levcromakalim | Molecular triggers of migraine aura: A systematic review of human pharmacological provocation studies. | Cephalalgia : an international journal of headache | ||
| Levcromakalim | Migraine induced by vascular K channel activation is independent of HCN channel activity: A randomised controlled trial with translational validation. | Cephalalgia : an international journal of headache | ||
| Levcromakalim | De novo nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: relevance to migraine and other headache disorders. | Pain | ||
| Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) | Yueju pill exerts rapid antidepressant effects via sequential activation of hippocampal GLP-1 receptor and PACAP signaling in mice. | Journal of ethnopharmacology | ||
| Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) | Herb pair of Eucommiae Folium and Gardeniae Fructus enhanced hippocampal PACAP-mediated neuroplasticity via the non-classic downstream PI3K/AKT signaling to exert antidepressant effects. | Journal of ethnopharmacology | ||
| Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) | PACAP in Parkinson's disease: A multifunctional neuropeptide at the crossroad of autophagy, inflammation, and metabolic repurposing. | Neuropharmacology | ||
| Calcitonin-gene related peptide (CGRP) | Electroacupuncture at Jiaji points regulates splenic immunity and gut microbiota to ameliorate peripheral immune dysfunction after spinal cord injury. | Journal of neuroimmunology | ||
| Calcitonin Gene-Related Peptide | Current research hotspots and difficulties of chronic prostatitis/chronic pelvic pain syndrome: neuroendocrine mechanism. | Annals of medicine | ||
| MR-angiography, GTN | A case of repetitive myocardial infarction with unobstructed coronaries due to Churg-Strauss syndrome. | European heart journal. Case reports | ||
| Amylin | Combination Pharmacotherapies for Obesity-Current Evidence and Future Directions. | Endocrinology, diabetes & metabolism | ||
| Amylin | Shared pathophysiology and therapeutic repurposing in Alzheimer's disease and type 2 diabetes: a critical review of convergent mechanisms and clinical challenges. | Bioorganic chemistry | ||
| Calcitonin Gene-Related Peptide | Papilledema is not the point: intracranial pressure dysregulation as a common pathway in migraine and idiopathic intracranial hypertension. | Brain communications | ||
| Calcitonin Gene-Related Peptide | Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation. | PNAS nexus | ||
| Amylin | Digestive Hormones and Their Impact on Bariatric and Pharmacologic Weight-Loss Therapies. | Endocrine reviews | ||
| Amylin | Beyond GLP-1: Amylin-Based Pharmacotherapy and the Search for Better-Tolerated Weight-Loss Drugs. | Pharmacological research | ||
| Calcitonin Gene-Related Peptide | Post-Craniotomy Headache: Current Concepts and Emerging Procedural Therapies. | Current pain and headache reports | ||
| MR-angiography, GTN | Intracerebral hemorrhage as initial presentation of metastatic choriocarcinoma: A case report. | Radiology case reports | ||
| MR-angiography, GTN | Interventional Diagnostic Procedure: a Practical Guide for the Assessment of Coronary Vascular Function. | Journal of visualized experiments : JoVE | ||
| Amylin | Amylin Coexisting With Peptide YY (PYY) and Amylin/PYY Cells Correspond to Subpopulations of Glucagon- and Glucagon-Like Peptide-1-Immunoreactive Cells in the Japanese Eel (Anguilla japonica) Pancreas. | Anatomia, histologia, embryologia | ||
| Amylin | Aggregation kinetics define the temporal window of IAPP proteotoxicity. | Proceedings of the National Academy of Sciences of the United States of America |