Vue transversale de la maladie
Myopathies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
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1012 résultats correspondants
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dans le périmètre Myopathies
Niveau clinique
Études et traitements 421
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Semaglutide (Rybelsus®) NCT07642635 · Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individ… | Myopathies | Traitement symptomatique | Phase 1/2 | NOT_YET_RECRUITING | Duchenne Muscular Dystrophy (DMD) is a rare, genetic disease that leads to… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:44 | Détail |
| Skeletal muscle biopsy (residual specimen) NCT06101940 · Chinese Multicenter Clinical Outcome Cohort Study of Myotonic Dystrophy Type 1 (… | Myopathies | Ralentissement de la progression | À vérifier | ENROLLING_BY_INVITATION | Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystem disor… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:44 | Détail |
| TODDLER — A Remote Study Using Technology to Assess Outcomes in DMD NCT07423026 · NCT07423026 | Myopathies | À vérifier | À vérifier | RECRUITING | Every year, 100 boys are born in the UK with a rare muscle disease called… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:44 | Détail |
| Adult and Juvenile Myositis NCT00017914 · NCT00017914 | Myopathies | Ralentissement de la progression · Immunomodulation · Traitement symptomatique… | À vérifier | RECRUITING | This study will evaluate subjects with adult- and childhood-onset myositis… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Botulinum toxin type A NCT05720065 · Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A | Myopathies | Traitement symptomatique | Phase 2 | RECRUITING | The main purpose of this study is to determine which is the best dose of a… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| CovExc — Muscular Rehabilitation by Eccentric Exercise After Severe C… NCT04649086 · NCT04649086 | Myopathies | À vérifier | Non applicable | TERMINATED | With the COVID-19 pandemic, the number of patients to be treated in rehabi… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Effectiveness of Conservative Interventions in the Treatment of Trigg… NCT06296017 · NCT06296017 | Myopathies | À vérifier | Non applicable | RECRUITING | There is no study in the literature comparing the effectiveness of ESWT an… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Electrophysiological measurement of reflex nociceptive flexion thresh… NCT04624581 · FIbromyalgia anD GenetIcs Subgroups (FIDGIS) | Myopathies | Traitement symptomatique | Non applicable | COMPLETED | Fibromyalgia syndrome (FS) is characterized by widespread pain and affect… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Fascial Distortion Model NCT06627855 · Effectiveness of the Fascial Distortion Model in Temporomandibular Disorders: A… | Myopathies | Ralentissement de la progression · Traitement symptomatique | Non applicable | RECRUITING | The aim of the study was to investigate the effectiveness of Manual Therap… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Intravenously administered pooled human immunoglobulin (IVIG) NCT06599697 · The MIGHT Trial - An Exploratory Clinical Trial of IVIG in Anti-HMGCR Immune Med… | Myopathies | À vérifier | Phase 2 | RECRUITING | This is a randomized, placebo-controlled, double blinded phase 2 explorato… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| LOLA — Effectiveness of Health Education Program on Musculoskeletal P… NCT07160478 · NCT07160478 | Myopathies | Traitement symptomatique | Non applicable | COMPLETED | Musculoskeletal pain during childhood can negatively affect school attenda… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Prospective, Longitudinal, Observational Registry of Adult Patients W… NCT05596539 · NCT05596539 | Myopathies | À vérifier | À vérifier | RECRUITING | The purpose of this study is to assess medical events during follow-up of… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Real radial extracorporeal shock wave therapy (rESWT) NCT07476690 · CP-rESWT-FREQ — Effect of rESWT Session Frequency on Spasticity and Function Ass… | Myopathies | Traitement symptomatique | Non applicable | COMPLETED | Spasticity is a major contributor to functional limitations in children wi… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| SeMAFor — Magnesium, Stress and Fibromyalgia NCT03887000 · NCT03887000 | Myopathies | Traitement symptomatique | Non applicable | COMPLETED | Fibromyalgia affects an average of 2% of the French population. Data from… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| AZD5492 NCT06916806 · TITAN — A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharm… | Lupus | Immunomodulation | Phase 1 | RECRUITING | The purpose of this study is to measure the safety, tolerability, PK, and… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:41 | Détail |
| AOC 1020 NCT05747924 · FORTITUDE — Phase 1/2 Study of AOC 1020 in Participants With Facioscapulohumeral… | Myopathies | À vérifier | Phase 1/2 | COMPLETED | A Randomized, Double-blind, Placebo-controlled, Phase 1/2 Study to Evaluat… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
| BMN 351 NCT06280209 · A Phase 1/2 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Phar… | Myopathies | À vérifier | Phase 1/2 | ACTIVE_NOT_RECRUITING | This open-label extension study aims to evaluate the long-term safety and… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
| EPI-321 NCT06907875 · FSHD — A First-in-human Study of EPI-321 in Facioscapulohumeral Muscular Dystrop… | Myopathies | Thérapie génique | Phase 1/2 | ACTIVE_NOT_RECRUITING | The goal of this clinical trial is to learn how safe and tolerable EPI-321… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
| GNR-097 NCT07673809 · A Study to Evaluate the Tolerability, Safety and Efficacy of GNR-097 Gene Therap… | Myopathies | Thérapie génique | Phase 1/2 | RECRUITING | The study will evaluate the tolerability, safety and efficacy of gene ther… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
| PBGENE-DMD (IV) NCT07429240 · PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular… | Myopathies | À vérifier | Phase 1/2 | RECRUITING | The purpose of this Phase 1/2a trial is to evaluate the safety, tolerabili… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
Découverte scientifique
Recherches et trouvailles 0
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune trouvaille ne correspond aux filtres. | |||||||
Bibliographie
Publications 585
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Nonmyeloablative and reduced-intensity conditioning for allogeneic he… Cyclophosphamide · PMID 42486917 | Myopathies | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Allogeneic hematopoietic stem cell transplantation (HSCT) is the only widely available cure for sickle cell disease (SC… | Bone marrow transplantation 2026-07-23 12:26:27 | Source |
| [Sustained complete remission achieved with tofacitinib in a refracto… Cyclophosphamide · PMID 42486736 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Treatment of large granular lymphocytic leukemia, particularly T-cell leukemia (LGL-T), remains challenging. JAK inhibi… | La Revue de medecine interne 2026-07-23 12:26:27 | Source |
| Diabetic Patients With Newly Diagnosed Chronic Myeloid Leukemia: TKI… Metformin · PMID 42486531 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Limited data are available regarding patients with newly diagnosed chronic myeloid leukemia (CML) and concomitant diabe… | European journal of haematology 2026-07-23 12:26:08 | Source |
| Metformin enhances hippocampal excitatory synaptic transmission and p… Metformin · PMID 42486330 | Myopathies | Neuroprotection | Publication | PubMed | Voir la publication source Early stages of Alzheimer's disease (AD) are characterized by synaptic dysfunction and alterations in synaptic plastici… | Neuropharmacology 2026-07-23 12:26:08 | Source |
| Pneumocystis jirovecii pneumonia and prophylaxis in patients with sol… Prednisone · PMID 42484810 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Pneumocystis jirovecii pneumonia (PJP) is an uncommon but potentially fatal opportunistic fungal infection in immunocom… | Clinical & translational oncology : official publicati… 2026-07-22 21:23:10 | Source |
| Sympathetic ophthalmia induced by vitrectomy for endogenous fungal en… Prednisone · PMID 42482889 | Myopathies | Immunomodulation | Publication | PubMed | Voir la publication source Sympathetic ophthalmia (SO) is a rare but serious inflammatory ocular disorder. We report a case of endogenous fungal e… | Frontiers in medicine 2026-07-22 21:23:10 | Source |
| Selective pulmonary vasorelaxant effects of an N,N-diaminoquinazoline… Sildenafil · PMID 42468673 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary vascular resistance… | European journal of pharmacology 2026-07-22 21:23:01 | Source |
| Sildenafil-associated severe cholestatic drug-induced liver injury pr… Sildenafil · PMID 42474650 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Sildenafil is widely used as a phosphodiesterase type 5 inhibitor for erectile dysfunction. Drug-induced liver injury (… | Clinical journal of gastroenterology 2026-07-22 21:23:01 | Source |
| Beyond awareness: evaluating the impact of a hospital-wide, multi-sta… GenPHSat injection (Safety) · PMID 42483475 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Infection prevention is fundamental to patient safety, yet conventional audits often fall short in driving sustained be… | GMS hygiene and infection control 2026-07-22 21:22:56 | Source |
| Combined anti-VEGF and intravitreal dexamethasone treatment versus an… GenPHSat injection (Safety) · PMID 42484199 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source This systematic review and meta-analysis aimed to compare the effectiveness and safety profiles of anti-vascular endoth… | Arquivos brasileiros de oftalmologia 2026-07-22 21:22:56 | Source |
| Glycosylation penetrance of N-X-S/T sequons in antibody variable doma… Glutamine · PMID 42482306 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Machine learning (ML) approaches for de novo antibody design generate thousands of candidate sequences, but most lack a… | mAbs 2026-07-22 21:22:55 | Source |
| Palometa fish (Serrasalmus maculatus) meat: Amino acids profile by ga… Glutamine · PMID 42484164 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Palometa (Serrasalmus maculatus) is a predatory freshwater fish that is abundant in South America. Palometa is rarely c… | Anais da Academia Brasileira de Ciencias 2026-07-22 21:22:55 | Source |
| From Visceral Pain to Emotional Distress: Comparative Effectiveness o… Desipramine · PMID 42470701 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Antispasmodics and antidepressants are standard therapies for managing both the gastrointestinal symptoms and psycholog… | Journal of gastrointestinal and liver diseases : JGLD 2026-07-22 21:22:52 | Source |
| Guillain-Barré syndrome with bilateral extensor plantar responses: A… IvIg · PMID 42483360 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy, typically presenting with rapidly pro… | Journal of family medicine and primary care 2026-07-22 21:22:50 | Source |
| Hormonal Contraception and Initiation of Semaglutide Therapy. Behavioral Interventions for Controlling Oral Behaviors · PMID 42485041 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Concerns regarding weight changes during hormonal contraceptive use may influence health care-seeking behavior and cont… | JAMA network open 2026-07-22 21:22:49 | Source |
| Photobiomodulation at 660 nm enhances proliferative activity while pr… Behavioral Interventions for Controlling Oral Behaviors · PMID 42484713 | Myopathies | Ralentissement de la progression | Publication | PubMed | Voir la publication source Efficient endothelialization is essential for vascular graft integration and long-term performance, yet strategies to e… | Cell and tissue banking 2026-07-22 21:22:49 | Source |
| Patient-derived cornea organoids as drug repurposing models for aniri… Ataluren · PMID 42447954 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source This study aims to investigate the efficacy of drug repurposing using a corneal organoid model developed from patient-d… | Life sciences 2026-07-22 21:22:46 | Source |
| A mobile learning environment: a preliminary study of a developmental… test of walk · PMID 42485077 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source An embodied theory of development views an infant's mobility as a causal factor in their cognitive, language and motor… | Disability and rehabilitation. Assistive technology 2026-07-22 21:22:37 | Source |
| Feasibility of Real-Time Autonomous Functional Electrical Stimulation… test of walk · PMID 42484421 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Freezing of gait is a debilitating walking disturbance that can severely worsen quality of life for people with Parkins… | The European journal of neuroscience 2026-07-22 21:22:37 | Source |
| Persistent hiccups following endobronchial ultrasound-guided transbro… baclofen · PMID 42471910 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic procedu… | Respiratory medicine case reports 2026-07-22 21:22:33 | Source |
Exploration — prudence
Pistes exploratoires 6
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| N-PPG N-PPG — modulation métabolique cérébrale | Myopathies | Remyélinisation indirecte / réparation · Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation métabolique et mitohormèse N-PPG est étudié dans Maladie de Huntington et documente plusieurs axes biologiques pouvant être pertinents pour Myopat… | Rapprochement Biomedical Watch · Maladie de Huntington | Détail |
| Vecteur Ple389 (ADORA2A) MiniPromoter Ple389 — ciblage striatal | Myopathies | Thérapie génique | Hypothèse exploratoire | Rapprochement automatique non validé | Expression génique ciblée dans les neurones striataux Vecteur Ple389 (ADORA2A) est étudié dans Maladie de Huntington et documente plusieurs axes biologiques pouvant être per… | Rapprochement Biomedical Watch · Maladie de Huntington | Détail |
| α-Amyrin α-Amyrin — protection mitochondriale | Myopathies | Remyélinisation indirecte / réparation · Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Protection mitochondriale et modulation de la pathologie Tau α-Amyrin est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pour Myopa… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Myopathies | Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation immunométabolique de la microglie 4-octyl itaconate et dérivés est étudié dans Sclérose latérale amyotrophique et documente plusieurs axes biologiques po… | Rapprochement Biomedical Watch · Sclérose latérale amy… | Détail |
| Thonningianin A Thonningianin A — neuroprotection anti-amyloïde | Myopathies | Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation du stress oxydatif et des protéines associées à Alzheimer Thonningianin A est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pou… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |
| Vutiglabridin Vutiglabridin — autophagie et PON2 | Myopathies | Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Activation de PON2 et stimulation de l’autophagie Vutiglabridin est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pour… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |