Vue transversale de la maladie
Myopathies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
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1012 résultats correspondants
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dans le périmètre Myopathies
Niveau clinique
Études et traitements 421
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Semaglutide (Rybelsus®) NCT07642635 · Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individ… | Myopathies | Traitement symptomatique | Phase 1/2 | NOT_YET_RECRUITING | Duchenne Muscular Dystrophy (DMD) is a rare, genetic disease that leads to… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:44 | Détail |
| Skeletal muscle biopsy (residual specimen) NCT06101940 · Chinese Multicenter Clinical Outcome Cohort Study of Myotonic Dystrophy Type 1 (… | Myopathies | Ralentissement de la progression | À vérifier | ENROLLING_BY_INVITATION | Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystem disor… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:44 | Détail |
| TODDLER — A Remote Study Using Technology to Assess Outcomes in DMD NCT07423026 · NCT07423026 | Myopathies | À vérifier | À vérifier | RECRUITING | Every year, 100 boys are born in the UK with a rare muscle disease called… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:44 | Détail |
| Adult and Juvenile Myositis NCT00017914 · NCT00017914 | Myopathies | Ralentissement de la progression · Immunomodulation · Traitement symptomatique… | À vérifier | RECRUITING | This study will evaluate subjects with adult- and childhood-onset myositis… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Botulinum toxin type A NCT05720065 · Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A | Myopathies | Traitement symptomatique | Phase 2 | RECRUITING | The main purpose of this study is to determine which is the best dose of a… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| CovExc — Muscular Rehabilitation by Eccentric Exercise After Severe C… NCT04649086 · NCT04649086 | Myopathies | À vérifier | Non applicable | TERMINATED | With the COVID-19 pandemic, the number of patients to be treated in rehabi… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Effectiveness of Conservative Interventions in the Treatment of Trigg… NCT06296017 · NCT06296017 | Myopathies | À vérifier | Non applicable | RECRUITING | There is no study in the literature comparing the effectiveness of ESWT an… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Electrophysiological measurement of reflex nociceptive flexion thresh… NCT04624581 · FIbromyalgia anD GenetIcs Subgroups (FIDGIS) | Myopathies | Traitement symptomatique | Non applicable | COMPLETED | Fibromyalgia syndrome (FS) is characterized by widespread pain and affect… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Fascial Distortion Model NCT06627855 · Effectiveness of the Fascial Distortion Model in Temporomandibular Disorders: A… | Myopathies | Ralentissement de la progression · Traitement symptomatique | Non applicable | RECRUITING | The aim of the study was to investigate the effectiveness of Manual Therap… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Intravenously administered pooled human immunoglobulin (IVIG) NCT06599697 · The MIGHT Trial - An Exploratory Clinical Trial of IVIG in Anti-HMGCR Immune Med… | Myopathies | À vérifier | Phase 2 | RECRUITING | This is a randomized, placebo-controlled, double blinded phase 2 explorato… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| LOLA — Effectiveness of Health Education Program on Musculoskeletal P… NCT07160478 · NCT07160478 | Myopathies | Traitement symptomatique | Non applicable | COMPLETED | Musculoskeletal pain during childhood can negatively affect school attenda… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Prospective, Longitudinal, Observational Registry of Adult Patients W… NCT05596539 · NCT05596539 | Myopathies | À vérifier | À vérifier | RECRUITING | The purpose of this study is to assess medical events during follow-up of… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| Real radial extracorporeal shock wave therapy (rESWT) NCT07476690 · CP-rESWT-FREQ — Effect of rESWT Session Frequency on Spasticity and Function Ass… | Myopathies | Traitement symptomatique | Non applicable | COMPLETED | Spasticity is a major contributor to functional limitations in children wi… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| SeMAFor — Magnesium, Stress and Fibromyalgia NCT03887000 · NCT03887000 | Myopathies | Traitement symptomatique | Non applicable | COMPLETED | Fibromyalgia affects an average of 2% of the French population. Data from… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:43 | Détail |
| AZD5492 NCT06916806 · TITAN — A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharm… | Lupus | Immunomodulation | Phase 1 | RECRUITING | The purpose of this study is to measure the safety, tolerability, PK, and… À vérifier | ClinicalTrials.gov 2026-08-16 21:21:41 | Détail |
| AOC 1020 NCT05747924 · FORTITUDE — Phase 1/2 Study of AOC 1020 in Participants With Facioscapulohumeral… | Myopathies | À vérifier | Phase 1/2 | COMPLETED | A Randomized, Double-blind, Placebo-controlled, Phase 1/2 Study to Evaluat… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
| BMN 351 NCT06280209 · A Phase 1/2 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Phar… | Myopathies | À vérifier | Phase 1/2 | ACTIVE_NOT_RECRUITING | This open-label extension study aims to evaluate the long-term safety and… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
| EPI-321 NCT06907875 · FSHD — A First-in-human Study of EPI-321 in Facioscapulohumeral Muscular Dystrop… | Myopathies | Thérapie génique | Phase 1/2 | ACTIVE_NOT_RECRUITING | The goal of this clinical trial is to learn how safe and tolerable EPI-321… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
| GNR-097 NCT07673809 · A Study to Evaluate the Tolerability, Safety and Efficacy of GNR-097 Gene Therap… | Myopathies | Thérapie génique | Phase 1/2 | RECRUITING | The study will evaluate the tolerability, safety and efficacy of gene ther… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
| PBGENE-DMD (IV) NCT07429240 · PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular… | Myopathies | À vérifier | Phase 1/2 | RECRUITING | The purpose of this Phase 1/2a trial is to evaluate the safety, tolerabili… À vérifier | ClinicalTrials.gov 2026-08-16 19:04:32 | Détail |
Découverte scientifique
Recherches et trouvailles 0
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune trouvaille ne correspond aux filtres. | |||||||
Bibliographie
Publications 585
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| A custom-made sling to achieve personal goals in shoulder pain or sub… Shoulder orthosis · PMID 40845630 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source The efficacy of the different shoulder orthoses available to prevent hemiplegic shoulder complications still remains de… | Annals of physical and rehabilitation medicine 2026-09-14 15:37:09 | Source |
| Evaluating the clinical effects of a dynamic shoulder orthosis. Shoulder orthosis · PMID 37318316 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Shoulder orthoses reduce the gravitational pull on the shoulder by providing an upward force to the arm, which can decr… | Prosthetics and orthotics international 2026-09-14 15:37:09 | Source |
| Utilization of the external rotation abduction thermoplastic shoulder… Shoulder orthosis · PMID 38942656 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Journal of hand therapy : official journal of the Amer… 2026-09-14 15:37:09 | Source |
| Evaluating pitolisant as a narcolepsy treatment option. Pitolisant Oral Tablet · PMID 32941089 | Myopathies | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Narcolepsy is a chronic sleep disorder characterized by a pentad of excessive daytime sleepiness (EDS), cataplexy, slee… | Expert opinion on pharmacotherapy 2026-09-14 12:37:10 | Source |
| New pharmacologic agents for insomnia and hypersomnia. Pitolisant Oral Tablet · PMID 32890017 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Insomnia and hypersomnia are conditions with multifactorial causes that can be difficult to treat. There have been rece… | Current opinion in pulmonary medicine 2026-09-14 12:37:10 | Source |
| The digital motor output: a conceptual framework for a meaningful cli… Motor Neuroprosthesis (MNP) · PMID 37524520 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source In recent years, the majority of the population has become increasingly reliant on continuous and independent control o… | Journal of neurointerventional surgery 2026-09-11 23:42:30 | Source |
| How Do Patients with Chronic Pain Benefit from a Peer-Supported Pain… Piloting a Novel Peer Support Pain Self-Management Intervention (Project CONNECT) · PMID 28025… | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Peer support is a novel and under-studied approach to the management of chronic pain. This study's purpose was to uncov… | Pain medicine (Malden, Mass.) 2026-09-03 16:32:00 | Source |
| Decade-long persistence of CD19 CAR T cells in B cell lymphomas. anti-CD19 CAR-T cells · PMID 42575986 | Myopathies | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Chimeric antigen receptor (CAR) T cell therapy induces durable remissions in lymphoid malignancies, yet the extent and… | Nature medicine 2026-09-03 16:31:59 | Source |
| Long-term outcomes of anti-CD19 CAR T cell therapy in refractory myas… anti-CD19 CAR-T cells · PMID 42628528 | Myopathies | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Anti-CD19 CAR T cell therapy represents an emerging therapeutic approach for generalized, treatment-refractory myasthen… | Cell reports. Medicine 2026-09-03 16:31:59 | Source |
| An Overview of Acute Flaccid Myelitis. Investigational Use of Neuromuscular Ultrasound · PMID 34823462 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Acute Flaccid Myelitis is defined by the presence of Acute Flaccid Paralysis (AFP) and a spinal cord lesion on magnetic… | CNS & neurological disorders drug targets 2026-09-01 09:22:56 | Source |
| Point of Care Quantitative Assessment of Muscle Health in Older Indiv… Investigational Use of Neuromuscular Ultrasound · PMID 31011127 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Muscle health is recognized for its critical role in the functionality and well-being of older adults. Readily accessib… | Geriatrics (Basel, Switzerland) 2026-09-01 09:22:56 | Source |
| Pregnancy and COVID-19: pharmacologic considerations. Investigational Use of Neuromuscular Ultrasound · PMID 32959455 | Myopathies | Neuroprotection · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source In this review, we summarize evidence regarding the use of routine and investigational pharmacologic interventions for… | Ultrasound in obstetrics & gynecology : the official j… 2026-09-01 09:22:56 | Source |
| Decoding GNE Myopathy: From Molecular Basis to Therapeutic Advances. International GNE Myopathy Patient Registry · PMID 41082181 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source GNE myopathy is a rare, adult-onset, autosomal recessive muscle disorder caused by biallelic pathogenic variants in the… | Annals of Indian Academy of Neurology 2026-09-01 09:22:55 | Source |
| GNE myopathy: from clinics and genetics to pathology and research str… International GNE Myopathy Patient Registry · PMID 29720219 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source GNE myopathy is an ultra-rare autosomal recessive disease, which starts as a distal muscle weakness and ultimately lead… | Orphanet journal of rare diseases 2026-09-01 09:22:55 | Source |
| Phenotypic stratification and genotype-phenotype correlation in a het… International GNE Myopathy Patient Registry · PMID 29305133 | Myopathies | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source GNE myopathy is a rare distal myopathy, caused by mutations in the GNE gene, affecting sialic acid synthesis. Clinical… | Neuromuscular disorders : NMD 2026-09-01 09:22:55 | Source |
| Biomimetic stress granules replenish lysosomal repair to reinstate ma… Antibiotics · PMID 42598102 | Myopathies | Immunomodulation | Publication | PubMed | Voir la publication source Severe intracellular bacterial infection can progressively compromise lysosomal defence in macrophages, yet the underly… | Bioactive materials 2026-08-16 21:22:11 | Source |
| Non-prescription antibiotic dispensing in community pharmacies in jor… Antibiotics · PMID 42573429 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Inappropriate antibiotic use in community settings is a major contributor to antimicrobial resistance, particularly in… | The Libyan journal of medicine 2026-08-16 21:22:11 | Source |
| Clinical associations during the year before Parkinson's disease diag… Propranolol · PMID 42261249 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Characterizing clinical associations before Parkinson's disease (PD) diagnosis may improve understanding of the diagnos… | Annals of medicine 2026-08-16 19:23:49 | Source |
| Oral propranolol treatment safety in infantile hemangiomas. Propranolol · PMID 42179355 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Infantile hemangiomas are common and can be treated with propranolol. Cardiovascular side effects are a potential risk… | The Journal of dermatological treatment 2026-08-16 19:23:49 | Source |
| Propranolol enhances the oncolytic effect of newcastle disease virus… Propranolol · PMID 41866332 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Canine mammary tumors (CMT), the most common neoplasms in intact female dogs, lack effective treatments for advanced ca… | The veterinary quarterly 2026-08-16 19:23:49 | Source |
Exploration — prudence
Pistes exploratoires 6
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| N-PPG N-PPG — modulation métabolique cérébrale | Myopathies | Remyélinisation indirecte / réparation · Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation métabolique et mitohormèse N-PPG est étudié dans Maladie de Huntington et documente plusieurs axes biologiques pouvant être pertinents pour Myopat… | Rapprochement Biomedical Watch · Maladie de Huntington | Détail |
| Vecteur Ple389 (ADORA2A) MiniPromoter Ple389 — ciblage striatal | Myopathies | Thérapie génique | Hypothèse exploratoire | Rapprochement automatique non validé | Expression génique ciblée dans les neurones striataux Vecteur Ple389 (ADORA2A) est étudié dans Maladie de Huntington et documente plusieurs axes biologiques pouvant être per… | Rapprochement Biomedical Watch · Maladie de Huntington | Détail |
| α-Amyrin α-Amyrin — protection mitochondriale | Myopathies | Remyélinisation indirecte / réparation · Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Protection mitochondriale et modulation de la pathologie Tau α-Amyrin est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pour Myopa… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Myopathies | Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation immunométabolique de la microglie 4-octyl itaconate et dérivés est étudié dans Sclérose latérale amyotrophique et documente plusieurs axes biologiques po… | Rapprochement Biomedical Watch · Sclérose latérale amy… | Détail |
| Thonningianin A Thonningianin A — neuroprotection anti-amyloïde | Myopathies | Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation du stress oxydatif et des protéines associées à Alzheimer Thonningianin A est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pou… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |
| Vutiglabridin Vutiglabridin — autophagie et PON2 | Myopathies | Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Activation de PON2 et stimulation de l’autophagie Vutiglabridin est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pour… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |