Traitements25programmes
Essais14liés
Publications27liées
SourceDBlocale

Traitements

25
MoléculeIndication / populationPhaseObjectifPaysRésultat
[ 18F]3F4APThe overall objective is to obtain an assessment of the pharmacokinetics of \[18F\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR). Alzheimer, SEP Phase 1 À vérifier United States À vérifier
[11C]PIBThe overall objective is to obtain an assessment of the pharmacokinetics of \[18F\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR). Alzheimer, SEP Phase 1 À vérifier United States À vérifier
[18F]MK6240The overall objective is to obtain an assessment of the pharmacokinetics of \[18F\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR). Alzheimer, SEP Phase 1 À vérifier United States À vérifier
AdalimumabThis is a phase 2 study to assess the ability of adalimumab as compared to placebo to reduce or prevent progression of synuclein-related neurodegeneration in persons with idiopathic REM Sleep Behavior Disorder (RBD). The Primary Endpoint will be change from baseline in expression of the Parkinson Disease Related Pattern (PDRP) will be assessed using change in 18-flurodeoxyglucose (FDG) Positron Emission Tomography (PET) imaging. Parkinson Phase 2 Ralentissement de la progression United States, Canada À vérifier
AnakinraThe goal of this clinical trial is to find out whether two existing medications-anakinra and tocilizumab-can effectively treat a rare and life-threatening brain condition called NORSE (New-Onset Refractory Status Epilepticus). NORSE causes continuous seizures in previously healthy children and adults and does not respond to standard treatments. It often leads to long-term disability or death. Doctors currently use anakinra and tocilizumab as second-line treatments when first-line therapies fail, but there is no clear evidence showing which drug works better or when it should be given. This study aims to answer those questions. The study will enroll patients across 33 hospitals in the United States, Canada, Europe, and Asia. It includes two groups: 1. Randomized Cohort Patients will be randomly assigned to receive either anakinra or tocilizumab within the first 7 days of their illness. Only patients whose doctors were already planning to use one of these medications as part of standard care will be eligible for randomization. Researchers will monitor their recovery and compare outcomes between the two treatments. 2. Observational Cohort Patients who cannot be randomized-usually because they were diagnosed too late-will still be followed to study how the timing of treatment affects recovery. Participants will: * Receive one of the two medications (depending on their group assignment). * Take part in follow-up assessments over the course of one year, including medical evaluations and surveys. Some participants may be followed annually beyond one year. * Optionally participate in a 60-minute interview to share their or their caregiver's experience with NORSE. Épilepsie Phase 3 À vérifier United States, Canada, France, Italy, South Korea, Sweden, United Kingdom À vérifier
Behavioral taskThe study consists of prospective enrollment of healthy participants and patients with epilepsy, as well as analysis of an existing data set. Healthy participants will be studied with fMRI, eye metrics and behavioral testing at Yale. Patients will be studied with intracranial thalamic and cortical recording and stimulation, eye metrics and behavioral testing. Épilepsie Non applicable À vérifier United States À vérifier
Brave-Mind — Behavioral Resources and Awareness for Veterans With Episodic Migraine: Impact on Neurological Disability and Quality of Life- PilotThe current study will evaluate effectiveness of cognitive behavioral therapy for migraine compared to migraine education (ME) to improve migraine-related quality of life in the real-world setting of the Veterans Health Administration (VHA). Migraine Non applicable À vérifier United States À vérifier
DREAM — Identifying and Characterizing Preclinical MSThe purpose of this research study is to try and identify risk factors and biologic changes that suggest that someone may go on to develop multiple sclerosis before a person has shown any symptoms of the disease. SEP À vérifier Traitement symptomatique United States À vérifier
EEGSystemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Approximately 40% of neuropsychiatric SLE (NPSLE) cases are a consequence of the disease itself; other causes of NPSLE are infections, metabolic disorders, and side effects of drugs. The American College of Rheumatology identified 19 neuropsychiatric syndromes in SLE patients that can be divided into central and peripheral nervous system manifestations. Although this classification includes syndromes with no clear pathophysiological mechanism and is not specific for neuropsychiatric events caused exclusively by SLE, it helps the physician to recognize any neurological involvement . The most common clinical manifestations of juvenile neuropsychiatric SLE (NPSLE) are headache, cognitive dysfunction, mood disturbances and seizures. The pathophysiology of juvenile NPSLE is not yet fully known, but immunological and inflammatory factors, such as autoantibodies, cytokine and prothrombotic states are widely described . The of autoantibodies in the onset of specific clinical manifestations has also been recognized. Juvenile NPSLE manifestations are often difficult to diagnose (. Nineteen neuropsychiatric syndromes have been identified associated with SLE, can be divided into central and peripheral manifestations. Alzheimer, Épilepsie, Lupus Non applicable Immunomodulation United States À vérifier
EXPLORE-MG2 — Exploring Outcomes and Characteristics of Myasthenia Gravis 2The goal of this prospective observational study is to create a network repository of clinical data and biological samples to help researchers learn more about myasthenia gravis. Myasthénie À vérifier À vérifier United States À vérifier
Eye TrackingThe study consists of prospective enrollment of healthy participants and patients with epilepsy, as well as analysis of an existing data set. Healthy participants will be studied with fMRI, eye metrics and behavioral testing at Yale. Patients will be studied with intracranial thalamic and cortical recording and stimulation, eye metrics and behavioral testing. Épilepsie Non applicable À vérifier United States À vérifier
Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their CaregiversThis study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers. Heart rate (HR), heart rate variability (HRV), and brain activity will be measured as participant-caregiver dyads listen to preferred and improvised music performed by professional musicians. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), behavioral, surveys, and physiological monitoring to study the impact of live music on anxiety in AD and inter-dyad synchrony. Alzheimer Non applicable À vérifier United States À vérifier
Serotonergic PsychedelicThis is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic psychedelic. The goal of this observational study is to learn how the brain's information processing changes during and following administration of serotonergic psychedelics (psilocybin, N,N-Dimethyltryptamine/DMT, Lystergic Acid Diethylamide/LSD, etc.) for people with and without mental illness receiving serotonergic psychedelics through any clinical trial at Yale University. The main questions it aims to answer are: 1. Do serotonergic psychedelics cause the brain to rely on new information more than previously learned information while under the influence? What about 1 day, 5-14 days, and 4-6 weeks after use? 2. Do serotonergic psychedelics cause long-lasting side-effects in how people perceive (see, hear, feel, etc.) the world and how easily people change their beliefs? 3. How does the brain's electrical activity change after using serotonergic psychedelics? How does the balance between excitation and inhibition change while under their effect? 4. Can changes in how the brain uses information predict who will benefit from a psychedelic and who will have side effects from psychedelics? Researchers will compare with people given placebos to see what changes in brain processing are unique to serotonergic psychedelics. Participants will have the opportunity to do some combination of the following: 1. Online computer assessments consisting of games and questionnaires that probe how participants think. 2. Magnetoencephalography (MEG) or electroencephalography (EEG) with eyes closed and with repeated clicks, images, or sensations delivered. 3. A magnetic resonance imaging (MRI) scan. 4. Semi-structured qualitative interviews about their experience after taking a serotonergic psychedelic recorded via Zoom. Migraine À vérifier À vérifier United States À vérifier
The EXPLORE MG Registry for Myasthenia GravisThe purpose of this study is to create a Yale University Department of Neurology Myasthenia Gravis (MG) registry that will be used for current and future research projects involving the study of Myasthenia Gravis. Myasthénie À vérifier À vérifier United States À vérifier
The EXPLORE MG Registry for Myasthenia GravisThe purpose of this study is to create a Yale University Department of Neurology Myasthenia Gravis (MG) registry that will be used for current and future research projects involving the study of Myasthenia Gravis. Myasthénie À vérifier À vérifier United States À vérifier
EEGSystemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Approximately 40% of neuropsychiatric SLE (NPSLE) cases are a consequence of the disease itself; other causes of NPSLE are infections, metabolic disorders, and side effects of drugs. The American College of Rheumatology identified 19 neuropsychiatric syndromes in SLE patients that can be divided into central and peripheral nervous system manifestations. Although this classification includes syndromes with no clear pathophysiological mechanism and is not specific for neuropsychiatric events caused exclusively by SLE, it helps the physician to recognize any neurological involvement . The most common clinical manifestations of juvenile neuropsychiatric SLE (NPSLE) are headache, cognitive dysfunction, mood disturbances and seizures. The pathophysiology of juvenile NPSLE is not yet fully known, but immunological and inflammatory factors, such as autoantibodies, cytokine and prothrombotic states are widely described . The of autoantibodies in the onset of specific clinical manifestations has also been recognized. Juvenile NPSLE manifestations are often difficult to diagnose (. Nineteen neuropsychiatric syndromes have been identified associated with SLE, can be divided into central and peripheral manifestations. Lupus À vérifier Immunomodulation Egypt À vérifier
EEGSystemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Approximately 40% of neuropsychiatric SLE (NPSLE) cases are a consequence of the disease itself; other causes of NPSLE are infections, metabolic disorders, and side effects of drugs. The American College of Rheumatology identified 19 neuropsychiatric syndromes in SLE patients that can be divided into central and peripheral nervous system manifestations. Although this classification includes syndromes with no clear pathophysiological mechanism and is not specific for neuropsychiatric events caused exclusively by SLE, it helps the physician to recognize any neurological involvement . The most common clinical manifestations of juvenile neuropsychiatric SLE (NPSLE) are headache, cognitive dysfunction, mood disturbances and seizures. The pathophysiology of juvenile NPSLE is not yet fully known, but immunological and inflammatory factors, such as autoantibodies, cytokine and prothrombotic states are widely described . The of autoantibodies in the onset of specific clinical manifestations has also been recognized. Juvenile NPSLE manifestations are often difficult to diagnose (. Nineteen neuropsychiatric syndromes have been identified associated with SLE, can be divided into central and peripheral manifestations. Épilepsie Non applicable Immunomodulation United States À vérifier
AdalimumabThis is a phase 2 study to assess the ability of adalimumab as compared to placebo to reduce or prevent progression of synuclein-related neurodegeneration in persons with idiopathic REM Sleep Behavior Disorder (RBD). The Primary Endpoint will be change from baseline in expression of the Parkinson Disease Related Pattern (PDRP) will be assessed using change in 18-flurodeoxyglucose (FDG) Positron Emission Tomography (PET) imaging. Parkinson Phase 2 Ralentissement de la progression United States, Canada À vérifier
Serotonergic PsychedelicThis is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic psychedelic. The goal of this observational study is to learn how the brain's information processing changes during and following administration of serotonergic psychedelics (psilocybin, N,N-Dimethyltryptamine/DMT, Lystergic Acid Diethylamide/LSD, etc.) for people with and without mental illness receiving serotonergic psychedelics through any clinical trial at Yale University. The main questions it aims to answer are: 1. Do serotonergic psychedelics cause the brain to rely on new information more than previously learned information while under the influence? What about 1 day, 5-14 days, and 4-6 weeks after use? 2. Do serotonergic psychedelics cause long-lasting side-effects in how people perceive (see, hear, feel, etc.) the world and how easily people change their beliefs? 3. How does the brain's electrical activity change after using serotonergic psychedelics? How does the balance between excitation and inhibition change while under their effect? 4. Can changes in how the brain uses information predict who will benefit from a psychedelic and who will have side effects from psychedelics? Researchers will compare with people given placebos to see what changes in brain processing are unique to serotonergic psychedelics. Participants will have the opportunity to do some combination of the following: 1. Online computer assessments consisting of games and questionnaires that probe how participants think. 2. Magnetoencephalography (MEG) or electroencephalography (EEG) with eyes closed and with repeated clicks, images, or sensations delivered. 3. A magnetic resonance imaging (MRI) scan. 4. Semi-structured qualitative interviews about their experience after taking a serotonergic psychedelic recorded via Zoom. Migraine À vérifier À vérifier United States À vérifier
EXPLORE-MG2 — Exploring Outcomes and Characteristics of Myasthenia Gravis 2The goal of this prospective observational study is to create a network repository of clinical data and biological samples to help researchers learn more about myasthenia gravis. Myasthénie À vérifier À vérifier United States À vérifier
AnakinraThe goal of this clinical trial is to find out whether two existing medications-anakinra and tocilizumab-can effectively treat a rare and life-threatening brain condition called NORSE (New-Onset Refractory Status Epilepticus). NORSE causes continuous seizures in previously healthy children and adults and does not respond to standard treatments. It often leads to long-term disability or death. Doctors currently use anakinra and tocilizumab as second-line treatments when first-line therapies fail, but there is no clear evidence showing which drug works better or when it should be given. This study aims to answer those questions. The study will enroll patients across 33 hospitals in the United States, Canada, Europe, and Asia. It includes two groups: 1. Randomized Cohort Patients will be randomly assigned to receive either anakinra or tocilizumab within the first 7 days of their illness. Only patients whose doctors were already planning to use one of these medications as part of standard care will be eligible for randomization. Researchers will monitor their recovery and compare outcomes between the two treatments. 2. Observational Cohort Patients who cannot be randomized-usually because they were diagnosed too late-will still be followed to study how the timing of treatment affects recovery. Participants will: * Receive one of the two medications (depending on their group assignment). * Take part in follow-up assessments over the course of one year, including medical evaluations and surveys. Some participants may be followed annually beyond one year. * Optionally participate in a 60-minute interview to share their or their caregiver's experience with NORSE. Épilepsie Phase 3 À vérifier United States, Canada, France, Italy, South Korea, Sweden, United Kingdom À vérifier
DREAM — Identifying and Characterizing Preclinical MSThe purpose of this research study is to try and identify risk factors and biologic changes that suggest that someone may go on to develop multiple sclerosis before a person has shown any symptoms of the disease. SEP À vérifier Traitement symptomatique United States À vérifier
Brave-Mind — Behavioral Resources and Awareness for Veterans With Episodic Migraine: Impact on Neurological Disability and Quality of Life- PilotThe current study will evaluate effectiveness of cognitive behavioral therapy for migraine compared to migraine education (ME) to improve migraine-related quality of life in the real-world setting of the Veterans Health Administration (VHA). Migraine Non applicable À vérifier United States À vérifier
[ 18F]3F4APThe overall objective is to obtain an assessment of the pharmacokinetics of \[18F\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR). SEP Phase 1 À vérifier United States À vérifier
Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their CaregiversThis study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers. Heart rate (HR), heart rate variability (HRV), and brain activity will be measured as participant-caregiver dyads listen to preferred and improvised music performed by professional musicians. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), behavioral, surveys, and physiological monitoring to study the impact of live music on anxiety in AD and inter-dyad synchrony. Alzheimer Non applicable À vérifier United States À vérifier

Essais cliniques

14
MoléculeIndication / populationPhaseNCTTitreStatut
Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers Alzheimer Non applicable NCT06940687 Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers ACTIVE_NOT_RECRUITING
[ 18F]3F4AP SEP Phase 1 NCT06999434 Exploring the Utility of [18F]3F4AP for Demyelination Imaging RECRUITING
Trastuzumab deruxtecan Cancer Phase 2 NCT06750484 Trial of Trastuzumab Deruxtecan in Previously Treated HER2 RECRUITING
Brave-Mind — Behavioral Resources and Awareness for Veterans With Episodic Migraine: Impact on Neurological Disability and Quality of Life- Pilot Migraine Non applicable NCT07792291 Brave-Mind — Behavioral Resources and Awareness for Veterans With Episodic Migraine: Impact on Neurological Disability and Quality of Life- Pilot NOT_YET_RECRUITING
DREAM — Identifying and Characterizing Preclinical MS SEP À vérifier NCT05787795 DREAM — Identifying and Characterizing Preclinical MS RECRUITING
Anakinra Épilepsie Phase 3 NCT07281027 COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" NOT_YET_RECRUITING
EXPLORE-MG2 — Exploring Outcomes and Characteristics of Myasthenia Gravis 2 Myasthénie À vérifier NCT06002945 EXPLORE-MG2 — Exploring Outcomes and Characteristics of Myasthenia Gravis 2 COMPLETED
Serotonergic Psychedelic Migraine À vérifier NCT06624137 Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics TERMINATED
Psilocybin Migraine Phase 1 NCT06464367 Mechanistic Studies of Psilocybin in Headache Disorders RECRUITING
Adalimumab Parkinson Phase 2 NCT06996652 PRISMS — An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD) RECRUITING
BOTOX Migraine Phase 2 NCT00660192 Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches COMPLETED
EEG Épilepsie Non applicable NCT06934356 Subcortical Arousal in Perceptual Awareness RECRUITING
EEG Lupus À vérifier NCT06449794 Neuropsycatric Disorders Among Children With Systemic Lupus Erythematosus in Sohag University Hospital UNKNOWN
The EXPLORE MG Registry for Myasthenia Gravis Myasthénie À vérifier NCT03792659 The EXPLORE MG Registry for Myasthenia Gravis RECRUITING

Publications

27
MoléculeIndication / populationTitreJournalDate
[11C]PIB Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers. Medical physics
[11C]PIB Evaluation of increased oxidative stress in the brain of patients with early Alzheimer's disease by Cu-ATSM PET/MRI. Journal of neural transmission (Vienna, Austria : 1996)
[11C]PIB Cognitive training effects in mild cognitive impairment with and without amyloid pathology. Dementia & neuropsychologia
Serotonergic Psychedelic Decoding the serotonin-alcohol crosstalk: the role of central serotonergic dysregulation in alcohol use disorder. Pharmacological reports : PR
Serotonergic Psychedelic Proliferative Effects of the Psychedelic N,N-Dimethyltryptamine (DMT) in Human Neural Stem Cells. ACS chemical neuroscience
Serotonergic Psychedelic Feasibility and Tolerability of Psilocybin for Phantom Limb Pain. The journal of pain
Adalimumab Increasing formulary adoption of adalimumab biosimilars and differential cost-sharing in Medicare Part D plans. The Journal of dermatological treatment
Adalimumab Experimental and computational analysis of glycan processing at increased monoclonal antibody productivities. Metabolic engineering communications
Adalimumab Performance evaluation of an adalimumab biosimilar autoinjector and its reference device: comparative use human factors study in patients with rheumatoid arthritis and juvenile idiopathic arthritis. Drug delivery
Behavioral task Cuprizone-induced demyelination model mice exhibit antisocial maltreating behavior: an experimental animal study. Encephalitis (Seoul, Korea)
Behavioral task Effects of Youth Sport Participation on Neural Processing During Response Inhibition in Children. Medicine and science in sports and exercise
Behavioral task Identifying coping strategies that regulate negative climate emotions without reducing pro-environmental behavior. Journal of affective disorders
Eye Tracking Patterns of attentional and cognitive biases in community trauma survivors: an eye tracking study. European journal of psychotraumatology
Eye Tracking Eye-tracking and behavioral measures of mind-wandering relate to depressive symptoms in children: a preliminary study. Journal of experimental child psychology
EEG A Time-Frequency Decoupled Contrastive Learning Framework for Electroencephalography-Based Parkinson's Disease Diagnosis. International journal of neural systems
EEG Automatic Seizure Detection using Hierarchical Spectral-Temporal Feature Learning with an Imbalance-Aware Transformer. International journal of neural systems
EEG ETAS reduces wake time after sleep onset in healthy adults who are dissatisfied with their sleep: A randomized, placebo-controlled, double-blind crossover study. Sleep medicine: X
EEG EEG-Guided Sevoflurane Anesthesia and Emergence Delirium in Children: A Randomized Controlled Trial. Paediatric anaesthesia
EEG EXPRESS: Baseline Electrophysiology versus Oxidative Metabolism as Traits of Inter-Network Differences in Neurometabolic Association. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
EEG Cross-task, explainable and real-time decoding of human emotion states by integrating gray and white matter intracranial neural activity. Nature computational science
EEG Efficacy of oxcarbazepine in treating focal epilepsy based on resting-state EEG functional connectivity and power spectral analyses. Acta epileptologica
EEG EEG emotion recognition using a channel-aware feature encoder and XGBoost classifier. Computer methods in biomechanics and biomedical engineering
EEG Successful transcranial motor evoked potentials monitoring under remimazolam-based anaesthesia: Case reports of two patients. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
EEG Todd's Paralysis Simulating Acute Ischemic Stroke: A Case Report. Cureus
EEG A randomised controlled trial comparing the effects of transcranial pulse stimulation and EEG neurofeedback on sustained attention and depressive symptoms in young adults. International journal of clinical and health psychology : IJCHP
The EXPLORE MG Registry for Myasthenia Gravis Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability. Annals of clinical and translational neurology
The EXPLORE MG Registry for Myasthenia Gravis Steroid-Sparing Effect of Efgartigimod in Generalized Myasthenia Gravis: Study Protocol for a Single-Arm, Open-Label Clinical Trial. Neurology and therapy