Nelly Pitteloud — Biomedical Watch V2

Traitements3programmes

Essais1liés

Publications30liées

SourceDBlocale

Traitements

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
0.9% NaClDown syndrome (DS) is the most common chromosomal disorder; with the increasing life expectancy, about 80% of DS adults reach age 65 years old. Early Alzheimer's disease (AD) is the most common cause of death within this population. DS individuals already show AD neuropathology by the age of 30, while it becomes clinically recognized in their late forties. DS subjects also exhibit olfaction defects in adulthood. To date, there is no treatment available for the cognitive or olfactory defects in DS. The development of an effective treatment targeting cognitive dysfunction in DS adolescents/adults would be warranted. GnRH, a decapeptide secreted by hypothalamic neurons is the pilot light of reproduction in all mammals. Pulsatile GnRH acts on the gonadotrophs via the GnRH receptor (GNRHR) in the pituitary gland to stimulate LH and FSH, which themselves will act on the gonads to produce gametes and steroids. However, GNRHR are also expressed in cerebral cortex, hippocampus, amygdala, habenula, olfactory structures, and adrenal gland, suggesting that GnRH may have a role beyond reproduction. Recently, GnRH has been shown to be involved in the process of ageing and lifespan control. Notably, in murine models, GnRH acts as an anti-ageing factor, independent of sex hormones. While ageing is characterized by hypothalamic inflammation and diminished neurogenesis, particularly in the hypothalamus and the hippocampus, GnRH was able to promote adult neurogenesis. The regulation of GnRH secretion is complex and involves hormonal, neuronal input, and environmental factors. Prévot et al. recently explored cognition within the Ts65Dn model and showed an age-dependent loss of the ability to recognize new objects. Also, these mice exhibit defects in olfaction. Given the role of GnRH in anti-aging mice model, pulsatile GnRH or continuous GnRH infusion (leading to desensitization of the GNRHR) were given to the Ts65Dn mice for two weeks. Amazingly, pulsatile but not continuous GnRH therapy was able to recover cognitive and olfaction defects.	Alzheimer	Phase 2	Immunomodulation	Switzerland	À vérifier
GnRH, gonadorelin acetateDown syndrome (DS) is the most common chromosomal disorder; with the increasing life expectancy, about 80% of DS adults reach age 65 years old. Early Alzheimer's disease (AD) is the most common cause of death within this population. DS individuals already show AD neuropathology by the age of 30, while it becomes clinically recognized in their late forties. DS subjects also exhibit olfaction defects in adulthood. To date, there is no treatment available for the cognitive or olfactory defects in DS. The development of an effective treatment targeting cognitive dysfunction in DS adolescents/adults would be warranted. GnRH, a decapeptide secreted by hypothalamic neurons is the pilot light of reproduction in all mammals. Pulsatile GnRH acts on the gonadotrophs via the GnRH receptor (GNRHR) in the pituitary gland to stimulate LH and FSH, which themselves will act on the gonads to produce gametes and steroids. However, GNRHR are also expressed in cerebral cortex, hippocampus, amygdala, habenula, olfactory structures, and adrenal gland, suggesting that GnRH may have a role beyond reproduction. Recently, GnRH has been shown to be involved in the process of ageing and lifespan control. Notably, in murine models, GnRH acts as an anti-ageing factor, independent of sex hormones. While ageing is characterized by hypothalamic inflammation and diminished neurogenesis, particularly in the hypothalamus and the hippocampus, GnRH was able to promote adult neurogenesis. The regulation of GnRH secretion is complex and involves hormonal, neuronal input, and environmental factors. Prévot et al. recently explored cognition within the Ts65Dn model and showed an age-dependent loss of the ability to recognize new objects. Also, these mice exhibit defects in olfaction. Given the role of GnRH in anti-aging mice model, pulsatile GnRH or continuous GnRH infusion (leading to desensitization of the GNRHR) were given to the Ts65Dn mice for two weeks. Amazingly, pulsatile but not continuous GnRH therapy was able to recover cognitive and olfaction defects.	Alzheimer	Phase 2	Immunomodulation	Switzerland	À vérifier
GnRH, gonadorelin acetateDown syndrome (DS) is the most common chromosomal disorder; with the increasing life expectancy, about 80% of DS adults reach age 65 years old. Early Alzheimer's disease (AD) is the most common cause of death within this population. DS individuals already show AD neuropathology by the age of 30, while it becomes clinically recognized in their late forties. DS subjects also exhibit olfaction defects in adulthood. To date, there is no treatment available for the cognitive or olfactory defects in DS. The development of an effective treatment targeting cognitive dysfunction in DS adolescents/adults would be warranted. GnRH, a decapeptide secreted by hypothalamic neurons is the pilot light of reproduction in all mammals. Pulsatile GnRH acts on the gonadotrophs via the GnRH receptor (GNRHR) in the pituitary gland to stimulate LH and FSH, which themselves will act on the gonads to produce gametes and steroids. However, GNRHR are also expressed in cerebral cortex, hippocampus, amygdala, habenula, olfactory structures, and adrenal gland, suggesting that GnRH may have a role beyond reproduction. Recently, GnRH has been shown to be involved in the process of ageing and lifespan control. Notably, in murine models, GnRH acts as an anti-ageing factor, independent of sex hormones. While ageing is characterized by hypothalamic inflammation and diminished neurogenesis, particularly in the hypothalamus and the hippocampus, GnRH was able to promote adult neurogenesis. The regulation of GnRH secretion is complex and involves hormonal, neuronal input, and environmental factors. Prévot et al. recently explored cognition within the Ts65Dn model and showed an age-dependent loss of the ability to recognize new objects. Also, these mice exhibit defects in olfaction. Given the role of GnRH in anti-aging mice model, pulsatile GnRH or continuous GnRH infusion (leading to desensitization of the GNRHR) were given to the Ts65Dn mice for two weeks. Amazingly, pulsatile but not continuous GnRH therapy was able to recover cognitive and olfaction defects.	Alzheimer	Phase 2	Immunomodulation	Switzerland	À vérifier

Essais cliniques

Molécule	Indication / population	Phase	NCT	Titre	Statut
GnRH, gonadorelin acetate	Alzheimer	Phase 2	NCT04390646	GnRH Therapy on Cognition in Down Syndrome	RECRUITING

Publications

Molécule	Titre	Journal
0.9% NaCl	Hypertonic saline protects the axo-myelinic interface acutely after contusive SCI and improves postural stability and balance as revealed by motion sequencing (MoSeq).	Experimental neurology
0.9% NaCl	Loss of NGAL protects against albumin-induced kidney inflammation and fibrosis.	Renal failure
GnRH, gonadorelin acetate	Protocol flexibility in PCOS: a combination of controlled ovarian stimulation and endometrial preparation strategies shows no impact on live birth outcomes after frozen embryo transfer-a retrospective cohort study.	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
GnRH, gonadorelin acetate	Relugolix combination therapy in symptomatic adenomyosis and uterine fibroids: a case series.	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
GnRH, gonadorelin acetate	Investigation of Adverse Events Associated with Predicted GnRHR Agonists Using the FAERS Database.	International journal of molecular sciences
0.9% NaCl	Antibiofilm action of ozonated sunflower oil against bacteria isolated from the uterus of mares susceptible to endometritis.	Animal reproduction
0.9% NaCl	Inhaled sphingosine reduces bronchial Pseudomonas aeruginosa burden during porcine ex vivo lung perfusion and shows tissue delivery in explanted human lungs.	Scientific reports
GnRH, gonadorelin acetate	The diagnostic value and optimal cutoff of basal luteinizing hormone for central precocious puberty in premenarcheal girls stratified by weight status.	Frontiers in endocrinology
GnRH, gonadorelin acetate	Effects of extending interval between presynchronization and breeding protocols and prostaglandin F2α administration before breeding protocol on reproductive performance of Holstein dairy cows during summer.	Veterinary and animal science
0.9% NaCl	Therapeutic potential of flavonoids and rutin against inflammation-induced on a huntington animal model.	PloS one
0.9% NaCl	In vivo tolerability of topical telavancin versus vancomycin in a murine ocular model.	The Journal of antimicrobial chemotherapy
GnRH, gonadorelin acetate	Regulation of ovarian function in domestic animals: translational insights into human ovarian dynamics and dysfunction.	Frontiers in endocrinology
GnRH, gonadorelin acetate	Optimizing ovulation synchronization in Holstein heifers: implementing a half-dose GnRH analogue (Buserelin Acetate) in a nanofabricated form within the ovsynch protocol to enhance the ovarian activity and reproductive performance outcomes.	Frontiers in veterinary science
GnRH, gonadorelin acetate	Incidence study of precocious puberty in the population of the state of Goiás: did the COVID-19 pandemic modify the epidemiology?	Jornal de pediatria
GnRH, gonadorelin acetate	Pulmonary alveolar proteinosis diagnosed during leuprorelin acetate therapy for ovarian endometrioma: a case report.	BMC pulmonary medicine
0.9% NaCl	Development of a nalmefene formulation suitable for a community-use auto-injector.	British journal of clinical pharmacology
GnRH, gonadorelin acetate	Cell-free MSC secretome therapy ameliorates diabetic testicular injury via antioxidant mechanisms.	Journal of molecular histology
GnRH, gonadorelin acetate	Diagnostic utility of basal luteinizing hormone in evaluating central precocious puberty.	Journal of the Endocrine Society
GnRH, gonadorelin acetate	Outcomes of GnRH Agonist Therapy in Boys with Central Precocious Puberty: A Systematic Review of Final Height and Long-Term Health Effects.	International journal of preventive medicine
0.9% NaCl	Effectiveness and safety of intra-articular hyaluronic acid SEMICAL GEL-B CROSS therapy in knee osteoarthritis (SEM-ART1): Study protocol for a randomized, placebo controlled, double-blind, cross-over clinical trial.	PloS one
0.9% NaCl	Retrospective evaluation of the treatment of term newborns with hypernatraemic dehydration over the last decade.	BMJ paediatrics open
GnRH, gonadorelin acetate	Gamma-aminobutyric acid supplementation combined with gonadotropin-releasing hormone analog therapy versus gonadotropin-releasing hormone analog therapy alone for linear growth in children with growth retardation: a retrospective cohort study.	Translational pediatrics
GnRH, gonadorelin acetate	Clinical features and reproductive outcomes after first frozen embryo transfer in patients with different ultrasound-diagnosed adenomyosis subtypes following ultralong gonadotropin-releasing hormone agonist pretreatment: a retrospective cohort study.	BMC pregnancy and childbirth
0.9% NaCl	A multifunctional sodium alginate/chitosan composite hydrogel for saline-alkali soil remediation: Synthesis, characterization, and proof-of-concept for promoting crop growth.	International journal of biological macromolecules
GnRH, gonadorelin acetate	Obesity Alters the Estrogen-Induced Luteinizing Hormone Surge in Ovariectomized Ewes.	Biology of reproduction
0.9% NaCl	Superhydrophilic zwitterionic poly(ethyl methacrylate)--poly(carboxybetaine methacrylate) copolymers with highly stable self-assemblies in physiological media.	RSC advances
GnRH, gonadorelin acetate	Single-nuclei RNA sequencing reveals heterogeneity within developing GnRH3 neurons in zebrafish.	Journal of neuroendocrinology
GnRH, gonadorelin acetate	A survey on treatment satisfaction with leuprorelin acetate in girls with central precocious puberty.	Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
0.9% NaCl	Subchronic comparative assessment of graded ferrous sulfate doses on biochemical, histological, and multiorgan micromorphological changes in wistar rats.	Open veterinary journal
0.9% NaCl	Sustainable soil improvement strategies for coral islands: Synergistic application of sludge/carboxymethyl cellulose-derived hydrogel and biochar.	International journal of biological macromolecules