Fiche traitement
0.9% NaCl
Nelly Pitteloud • Alzheimer
Suivi actif
Phase 2
Résumé
0.9% NaCl est développé par Nelly Pitteloud. Le traitement est actuellement en Phase 2. Il est associé à Alzheimer. Son objectif thérapeutique principal est Immunomodulation. Le statut actuel est : suivi actif.
À vérifier
Immunomodulation
Phase 2
Nelly Pitteloud
Switzerland
Down syndrome (DS) is the most common chromosomal disorder; with the increasing life expectancy, about 80% of DS adults reach age 65 years old. Early Alzheimer's disease (AD) is the most common cause of death within this population. DS individuals already show AD neuropathology by the age of 30, while it becomes clinically recognized in their late forties. DS subjects also exhibit olfaction defects in adulthood.
To date, there is no treatment available for the cognitive or olfactory defects in DS. The development of an effective treatment targeting cognitive dysfunction in DS adolescents/adults would be warranted.
GnRH, a decapeptide secreted by hypothalamic neurons is the pilot light of reproduction in all mammals. Pulsatile GnRH acts on the gonadotrophs via the GnRH receptor (GNRHR) in the pituitary gland to stimulate LH and FSH, which themselves will act on the gonads to produce gametes and steroids. However, GNRHR are also expressed in cerebral cortex, hippocampus, amygdala, habenula, olfactory structures, and adrenal gland, suggesting that GnRH may have a role beyond reproduction.
Recently, GnRH has been shown to be involved in the process of ageing and lifespan control. Notably, in murine models, GnRH acts as an anti-ageing factor, independent of sex hormones. While ageing is characterized by hypothalamic inflammation and diminished neurogenesis, particularly in the hypothalamus and the hippocampus, GnRH was able to promote adult neurogenesis.
The regulation of GnRH secretion is complex and involves hormonal, neuronal input, and environmental factors.
Prévot et al. recently explored cognition within the Ts65Dn model and showed an age-dependent loss of the ability to recognize new objects. Also, these mice exhibit defects in olfaction. Given the role of GnRH in anti-aging mice model, pulsatile GnRH or continuous GnRH infusion (leading to desensitization of the GNRHR) were given to the Ts65Dn mice for two weeks. Amazingly, pulsatile but not continuous GnRH therapy was able to recover cognitive and olfaction defects.
2024-02-09
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Phase 2
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
Immunomodulation
Confiance automatique : 66%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Indices détectés : inflamm → Immunomodulation
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Aucune incohérence majeure détectée entre la maladie, l’objectif et la description.
Transparence et qualité de la fiche
données vérifiablesClassificationCohérente automatiquement
Confiance de la fiche100 %
Source principaleSource officielle ou publication indexée
Dernière vérification2024-02-09
Anomalies détectées0
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeStatut inconnu
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréePhase 2
Études associées0
Publications associées13
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
14 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2024-02-09 | Dernière mise à jour des données0.9% NaCl | Biomedical Watch |
| 2026-07-08 | PublicationSuperhydrophilic zwitterionic poly(ethyl methacrylate)--poly(carboxybetaine methacrylate) copolymers with highly stable self-assemblies in physiological media. | RSC advances |
| 2026-07-08 | PublicationSubchronic comparative assessment of graded ferrous sulfate doses on biochemical, histological, and multiorgan micromorphological changes in wistar rats. | Open veterinary journal |
| 2026-07-08 | PublicationSustainable soil improvement strategies for coral islands: Synergistic application of sludge/carboxymethyl cellulose-derived hydrogel and biochar. | International journal of biological macromolecules |
| 2026-07-10 | PublicationA multifunctional sodium alginate/chitosan composite hydrogel for saline-alkali soil remediation: Synthesis, characterization, and proof-of-concept for promoting crop growth. | International journal of biological macromolecules |
| 2026-07-12 | PublicationEffectiveness and safety of intra-articular hyaluronic acid SEMICAL GEL-B CROSS therapy in knee osteoarthritis (SEM-ART1): Study protocol for a randomized, placebo controlled, double-blind, cross-over clinical trial. | PloS one |
| 2026-07-12 | PublicationRetrospective evaluation of the treatment of term newborns with hypernatraemic dehydration over the last decade. | BMJ paediatrics open |
| 2026-07-15 | PublicationDevelopment of a nalmefene formulation suitable for a community-use auto-injector. | British journal of clinical pharmacology |
| 2026-07-23 | PublicationTherapeutic potential of flavonoids and rutin against inflammation-induced on a huntington animal model. | PloS one |
| 2026-07-23 | PublicationIn vivo tolerability of topical telavancin versus vancomycin in a murine ocular model. | The Journal of antimicrobial chemotherapy |
| 2026-08-08 | PublicationAntibiofilm action of ozonated sunflower oil against bacteria isolated from the uterus of mares susceptible to endometritis. | Animal reproduction |
| 2026-08-08 | PublicationInhaled sphingosine reduces bronchial Pseudomonas aeruginosa burden during porcine ex vivo lung perfusion and shows tissue delivery in explanted human lungs. | Scientific reports |
| 2026-08-16 | PublicationHypertonic saline protects the axo-myelinic interface acutely after contusive SCI and improves postural stability and balance as revealed by motion sequencing (MoSeq). | Experimental neurology |
| 2026-08-16 | PublicationLoss of NGAL protects against albumin-induced kidney inflammation and fibrosis. | Renal failure |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
0 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| Aucun essai lié pour le moment. | |||||
Publications liées
13 publication(s)Publications liées
13 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Hypertonic saline protects the axo-myelinic interface acutely after contusive SCI and improves postural stability and balance as revealed by motion sequencing (MoSeq). Voir source | 42309341 | 10.1016/j.expneurol.2026.115881 | Experimental neurology | |
| Loss of NGAL protects against albumin-induced kidney inflammation and fibrosis. Voir source | 41877356 | 10.1080/0886022X.2026.2642530 | Renal failure | |
| Antibiofilm action of ozonated sunflower oil against bacteria isolated from the uterus of mares susceptible to endometritis. Voir source | 42524657 | 10.1590/1984-3143-AR2025-0116 | Animal reproduction | |
| Inhaled sphingosine reduces bronchial Pseudomonas aeruginosa burden during porcine ex vivo lung perfusion and shows tissue delivery in explanted human lungs. Voir source | 42562866 | 10.1038/s41598-026-65074-7 | Scientific reports | |
| Therapeutic potential of flavonoids and rutin against inflammation-induced on a huntington animal model. Voir source | 42461930 | 10.1371/journal.pone.0339016 | PloS one | |
| In vivo tolerability of topical telavancin versus vancomycin in a murine ocular model. Voir source | 42483981 | 10.1093/jac/dkag250 | The Journal of antimicrobial chemotherapy | |
| Development of a nalmefene formulation suitable for a community-use auto-injector. Voir source | 42448614 | 10.1002/bcp.70685 | British journal of clinical pharmacology | |
| Effectiveness and safety of intra-articular hyaluronic acid SEMICAL GEL-B CROSS therapy in knee osteoarthritis (SEM-ART1): Study protocol for a randomized, placebo controlled, double-blind, cross-over clinical trial. Voir source | 42424346 | 10.1371/journal.pone.0353120 | PloS one | |
| Retrospective evaluation of the treatment of term newborns with hypernatraemic dehydration over the last decade. Voir source | 42431691 | 10.1136/bmjpo-2026-004893 | BMJ paediatrics open | |
| A multifunctional sodium alginate/chitosan composite hydrogel for saline-alkali soil remediation: Synthesis, characterization, and proof-of-concept for promoting crop growth. Voir source | 42419537 | 10.1016/j.ijbiomac.2026.153405 | International journal of biological macromolecules | |
| Superhydrophilic zwitterionic poly(ethyl methacrylate)--poly(carboxybetaine methacrylate) copolymers with highly stable self-assemblies in physiological media. Voir source | 42416714 | 10.1039/d6ra04099c | RSC advances | |
| Subchronic comparative assessment of graded ferrous sulfate doses on biochemical, histological, and multiorgan micromorphological changes in wistar rats. Voir source | 42376110 | 10.5455/OVJ.2026.v16.i3.45 | Open veterinary journal | |
| Sustainable soil improvement strategies for coral islands: Synergistic application of sludge/carboxymethyl cellulose-derived hydrogel and biochar. Voir source | 42379437 | 10.1016/j.ijbiomac.2026.153318 | International journal of biological macromolecules |
Sources officielles
liens de rechercheDernière mise à jour des données : 2024-02-09
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.