M.D. Anderson Cancer Center — Biomedical Watch V2

Traitements45programmes

Essais20liés

Publications22liées

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Traitements

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
ACT-Together (Acting on Cancer Testing-Together)To determine the feasibility of a group-based education intervention to improve adherence to recommend surveillance and risk reducing procedures, with a focus at medically underserved women and racial/ethnic minorities with BRCA 1 and 2.	Cancer	Non applicable	À vérifier	United States	À vérifier
An Evaluation of the Implementation of the Care and Monitoring at Home Program- A New Paradigm for Acute Care Management of Cancer PatientsTo understand the experience of patients receiving care in the Care and Monitoring at Home program at MD Anderson. Researchers intend to use this information to study and possibly improve the hospital care at home program.	Cancer	À vérifier	À vérifier	United States	À vérifier
AzacitidineThis phase II trial studies how well enasidenib and azacitidine work in treating patients with IDH2 gene mutation and acute myeloid leukemia that has come back (recurrent) or does not respond to treatment (refractory). Enasidenib and azacitidine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.	Cancer	Phase 2	À vérifier	United States	À vérifier
Bintrafusp AlfaThis phase I trial is to find out the best dose, possible benefits, and/or side effects of hypofractionated radiation therapy and bintrafusp alfa in treating patients with bile duct cancer that has spread to other places in the body (advanced intrahepatic cholangiocarcinoma). Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Immunotherapy with bintrafusp alfa, a bifunctional fusion protein composed of the monoclonal antibody avelumab and TGF-beta, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The combination of hypofractionated radiation therapy and bintrafusp alfa may help to control intrahepatic cholangiocarcinoma.	Cancer	Phase 1		United States	À vérifier
BronchoscopyThis trial studies how well radial-probe endobronchial ultrasound works in detecting the complete or partial collapse of the lung in patients undergoing peripheral bronchoscopy. Diagnostic procedures, such as radial-probe endobronchial ultrasound and bronchoscopy, use a thin, tube-like instrument inserted through the nose or mouth to view and take pictures of the inside of the trachea, air passages, and lungs.	Cancer	À vérifier	À vérifier	United States	À vérifier
CetuximabThe purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat, pembrolizumab monotherapy, and the EXTREME regimen (cetuximab + cisplatin or carboplatin + 5-fluorouracil) as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).	Cancer, Parkinson	Phase 1	À vérifier	United States	À vérifier
CytarabineSelinexor has shown single-agent activity in a current phase I study enrolling patients with relapsed/refractory AML with durable complete remissions (CR), complete remissions with incomplete hematologic recovery (CRi), partial remissions (PR), and stable disease (SD) observed. Furthermore, common toxicities included nausea, fatigue, and anorexia and were manageable with supportive care agents. Additionally, CLAG chemotherapy has proven activity in relapsed and refractory AML, and has been shown to be a relatively well tolerated regimen without significant non-hematologic toxicity. Given the established role of CLAG chemotherapy, the single agent activity of selinexor, and their non-overlapping toxicities, the investigators propose a phase I/II open label study of selinexor in combination with CLAG for the treatment of patients with relapsed/refractory AML.	Cancer, Myasthénie	Phase 1/2	Traitement symptomatique	United States	À vérifier
Development of Brief Positive Affect Treatment (PAT) for Caregivers of Patients With Advanced CancerTo learn more about the experience and wellbeing of people who provide care for cancer patients.	Cancer	À vérifier	À vérifier	United States	À vérifier
DiscussionThis clinical trial evaluates the feasibility of exercise during chemotherapy in older women with stage I-III breast cancer. Previous studies have reported that exercise may reduce the chemotherapy-toxicity risk. This trial may help researchers learn if engaging in a physical activity program is feasible in patients receiving chemotherapy for breast cancer.	Cancer	Non applicable	À vérifier	United States	À vérifier
Enasidenib MesylateThis phase II trial studies how well enasidenib and azacitidine work in treating patients with IDH2 gene mutation and acute myeloid leukemia that has come back (recurrent) or does not respond to treatment (refractory). Enasidenib and azacitidine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.	Cancer	Phase 2	À vérifier	United States	À vérifier
EncorafenibThe purpose of this study is to learn about the effects of three study medicines (encorafenib, binimetinib, and pembrolizumab) given together for the treatment of melanoma that: * is advanced or metastatic (spread to other parts of the body); * has a certain type of abnormal gene called "BRAF"; and * has not received prior treatment. All participants in this study will receive pembrolizumab at the study clinic once every 3 weeks as an intravenous (IV) infusion (given directly into a vein). In addition, half of the participants will take encorafenib and binimetinib orally (by mouth) at home every day. Participants may receive pembrolizumab for up to two years. Those participants taking encorafenib and binimetinib can continue until their melanoma is no longer responding. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.	Cancer	Phase 1	À vérifier	United States	À vérifier
endorectal coiMultiparametric MRI (mpMRI) of the prostate is an important tool for diagnosis of clinically significant prostate cancer (csPCa) in men with an elevated serum prostate specific antigen, which can decrease the rate of unnecessary biopsies and reduce the incidence of over-diagnosis of non-csPCa. Furthermore, there is evidence that MRI is more accurate in detecting high-grade (Gleason grade group ≥3) versus low grade cancers (Gleason grade group \<2) and therefore may serve as a useful adjunct to prostate-specific antigen (PSA) testing, digital rectal examination, and prostatic biopsy to detect cancers that require definitive treatment as opposed to active surveillance. Many investigators, including our group, have shown the utility of preoperative mpMRI to assess the local extent of prostate cancer and for surgical planning.	Cancer	Non applicable	À vérifier	United States	À vérifier
Evaluation of Hereditary Cancer Educational VideosTo learn if educational videos can help participants be more informed about hereditary cancers (ones that run in the family).	Cancer	À vérifier	À vérifier	United States	À vérifier
Expressive Writing for the Management of Stress in Cancer SurvivorsThis clinical trial evaluates the effect of expressive writing for the management of stress in cancer survivors. Cancer diagnosis and treatment are associated with increased stress in cancer survivors related to concerns about family, career, relationships, finances, side effects of treatment, and death. This stress can be further exacerbated by social upheavals such as the COVID-19 pandemic. For safety reasons, many patients are isolated with restricted access to in-person health care and reduced social interaction with family and friends. Together with the economic uncertainties that come with this pandemic, these factors are likely to increase cancer survivors' stress levels. Expressive writing may provide a medium through which cancer survivors confront stressors and find meaning in their experience. The goal of this trial is to learn more about the experiences of cancer survivors during stressful times.	Cancer	Non applicable	À vérifier	United States	À vérifier
Feasibility of Combined Genomics/Transcriptomics for Patients With LymphomaTo learn more about the usefulness of molecular testing with the Molecular Functional (MF) Portrait (a commercial test conducted by the sponsor of this study, BostonGene) in guiding lymphoma care.	Cancer	Non applicable	À vérifier	United States	À vérifier
FilgrastimThis phase Ib/II trial studies the best dose and side effects of venetoclax and how well it works when given with combination chemotherapy in treating patients with newly diagnosed acute myeloid leukemia or acute myeloid leukemia that has come back or does not respond to treatment. Venetoclax may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fludarabine, cytarabine, filgrastim and idarubicin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax together with combination chemotherapy may work better in treating patients with acute myeloid leukemia.	Cancer	Phase 1/2	À vérifier	United States	À vérifier
flexible AIR coilMultiparametric MRI (mpMRI) of the prostate is an important tool for diagnosis of clinically significant prostate cancer (csPCa) in men with an elevated serum prostate specific antigen, which can decrease the rate of unnecessary biopsies and reduce the incidence of over-diagnosis of non-csPCa. Furthermore, there is evidence that MRI is more accurate in detecting high-grade (Gleason grade group ≥3) versus low grade cancers (Gleason grade group \<2) and therefore may serve as a useful adjunct to prostate-specific antigen (PSA) testing, digital rectal examination, and prostatic biopsy to detect cancers that require definitive treatment as opposed to active surveillance. Many investigators, including our group, have shown the utility of preoperative mpMRI to assess the local extent of prostate cancer and for surgical planning.	Cancer	Non applicable	À vérifier	United States	À vérifier
Hyperpolarized 13-C-pyruvateTo learn if Hyperpolarized C-Pyruvate Magnetic Resonance (HP-MR) Spectroscopic Imaging can help doctors detect low-risk (benign) and high-risk (malignant) cysts.	Cancer	Phase 1	À vérifier	United States	À vérifier
Hypofractionated Radiation TherapyThis phase I/II trial studies the safety, side effects and best dose of M3814 and to see how well it works when given together with radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced). M3814 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving M3814 and hypofractionated radiation therapy together may be safe, tolerable and/or more effective than radiation therapy alone in treating patients with locally advanced pancreatic cancer.	Cancer	Phase 1	À vérifier	United States	À vérifier
IdarubicinThis phase Ib/II trial studies the best dose and side effects of venetoclax and how well it works when given with combination chemotherapy in treating patients with newly diagnosed acute myeloid leukemia or acute myeloid leukemia that has come back or does not respond to treatment. Venetoclax may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fludarabine, cytarabine, filgrastim and idarubicin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax together with combination chemotherapy may work better in treating patients with acute myeloid leukemia.	Cancer	Phase 1/2	À vérifier	United States	À vérifier
Longitudinal Evaluation of Women Undergoing Pelvic Surgery for the Treatment of Gynecologic CancerThe study investigates whether certain characteristics of gynecological cancer can help researchers predict how well a patient recovers from surgery to remove the lower colon, rectum, and bladder, and create openings through which urine and stool are passed out of the body (pelvic exenteration). Comparing the types of surgery completed and procedures used may help researchers to determine which are most effective and safe in patients with a history of gynecologic cancer.	Cancer	À vérifier	Traitement symptomatique	United States	À vérifier
Oral CladribineThe goal of Part 1 of this clinical research study is to find the highest tolerable dose of cladribine that can be given in combination with low dose cytarabine (LDAC) and venetoclax to patients who have AML. The goal of Part 2 of this clinical research study is to learn if the dose of cladribine found in Part 1, when combined with LDAC and venetoclax, can help to control the disease.	Cancer	Phase 1/2	À vérifier	United States	À vérifier
PegfilgrastimThis phase Ib/II trial studies the best dose and side effects of venetoclax and how well it works when given with combination chemotherapy in treating patients with newly diagnosed acute myeloid leukemia or acute myeloid leukemia that has come back or does not respond to treatment. Venetoclax may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fludarabine, cytarabine, filgrastim and idarubicin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax together with combination chemotherapy may work better in treating patients with acute myeloid leukemia.	Cancer	Phase 1/2	À vérifier	United States	À vérifier
Psycho-Spiritual Management for Patients With Advanced Cancer and Their Family CaregiversThe goal of this behavioral research study is to learn about the effects of two different supportive care programs on patients' and their family caregivers' psychological wellbeing and overall quality of life.	Cancer	Non applicable	À vérifier	United States	À vérifier
Radial Probe Endobronchial UltrasoundThis trial studies how well radial-probe endobronchial ultrasound works in detecting the complete or partial collapse of the lung in patients undergoing peripheral bronchoscopy. Diagnostic procedures, such as radial-probe endobronchial ultrasound and bronchoscopy, use a thin, tube-like instrument inserted through the nose or mouth to view and take pictures of the inside of the trachea, air passages, and lungs.	Cancer	À vérifier	À vérifier	United States	À vérifier
UlixertinibTo find the recommended dose of ulixertinib that can be given in combination with cetuximab and/or encorafenib to patients with unresectable/metastatic CRC and who have received EGFR or BRAF-directed therapy in the past.	Cancer	Phase 1	À vérifier	United States	À vérifier
BronchoscopyThis trial studies how well radial-probe endobronchial ultrasound works in detecting the complete or partial collapse of the lung in patients undergoing peripheral bronchoscopy. Diagnostic procedures, such as radial-probe endobronchial ultrasound and bronchoscopy, use a thin, tube-like instrument inserted through the nose or mouth to view and take pictures of the inside of the trachea, air passages, and lungs.	Cancer	À vérifier	À vérifier	United States	À vérifier
Hyperpolarized 13-C-pyruvateTo learn if Hyperpolarized C-Pyruvate Magnetic Resonance (HP-MR) Spectroscopic Imaging can help doctors detect low-risk (benign) and high-risk (malignant) cysts.	Cancer	Phase 1	À vérifier	United States	À vérifier
Psycho-Spiritual Management for Patients With Advanced Cancer and Their Family CaregiversThe goal of this behavioral research study is to learn about the effects of two different supportive care programs on patients' and their family caregivers' psychological wellbeing and overall quality of life.	Cancer	Non applicable	À vérifier	United States	À vérifier
Development of Brief Positive Affect Treatment (PAT) for Caregivers of Patients With Advanced CancerTo learn more about the experience and wellbeing of people who provide care for cancer patients.	Cancer	À vérifier	À vérifier	United States	À vérifier
An Evaluation of the Implementation of the Care and Monitoring at Home Program- A New Paradigm for Acute Care Management of Cancer PatientsTo understand the experience of patients receiving care in the Care and Monitoring at Home program at MD Anderson. Researchers intend to use this information to study and possibly improve the hospital care at home program.	Cancer	À vérifier	À vérifier	United States	À vérifier
DiscussionThis clinical trial evaluates the feasibility of exercise during chemotherapy in older women with stage I-III breast cancer. Previous studies have reported that exercise may reduce the chemotherapy-toxicity risk. This trial may help researchers learn if engaging in a physical activity program is feasible in patients receiving chemotherapy for breast cancer.	Cancer	Non applicable	À vérifier	United States	À vérifier
Evaluation of Hereditary Cancer Educational VideosTo learn if educational videos can help participants be more informed about hereditary cancers (ones that run in the family).	Cancer	À vérifier	À vérifier	United States	À vérifier
Feasibility of Combined Genomics/Transcriptomics for Patients With LymphomaTo learn more about the usefulness of molecular testing with the Molecular Functional (MF) Portrait (a commercial test conducted by the sponsor of this study, BostonGene) in guiding lymphoma care.	Cancer	Non applicable	À vérifier	United States	À vérifier
CytarabineSelinexor has shown single-agent activity in a current phase I study enrolling patients with relapsed/refractory AML with durable complete remissions (CR), complete remissions with incomplete hematologic recovery (CRi), partial remissions (PR), and stable disease (SD) observed. Furthermore, common toxicities included nausea, fatigue, and anorexia and were manageable with supportive care agents. Additionally, CLAG chemotherapy has proven activity in relapsed and refractory AML, and has been shown to be a relatively well tolerated regimen without significant non-hematologic toxicity. Given the established role of CLAG chemotherapy, the single agent activity of selinexor, and their non-overlapping toxicities, the investigators propose a phase I/II open label study of selinexor in combination with CLAG for the treatment of patients with relapsed/refractory AML.	Cancer	Phase 1/2	Traitement symptomatique	United States	À vérifier
flexible AIR coilMultiparametric MRI (mpMRI) of the prostate is an important tool for diagnosis of clinically significant prostate cancer (csPCa) in men with an elevated serum prostate specific antigen, which can decrease the rate of unnecessary biopsies and reduce the incidence of over-diagnosis of non-csPCa. Furthermore, there is evidence that MRI is more accurate in detecting high-grade (Gleason grade group ≥3) versus low grade cancers (Gleason grade group \<2) and therefore may serve as a useful adjunct to prostate-specific antigen (PSA) testing, digital rectal examination, and prostatic biopsy to detect cancers that require definitive treatment as opposed to active surveillance. Many investigators, including our group, have shown the utility of preoperative mpMRI to assess the local extent of prostate cancer and for surgical planning.	Cancer	Non applicable	À vérifier	United States	À vérifier
Expressive Writing for the Management of Stress in Cancer SurvivorsThis clinical trial evaluates the effect of expressive writing for the management of stress in cancer survivors. Cancer diagnosis and treatment are associated with increased stress in cancer survivors related to concerns about family, career, relationships, finances, side effects of treatment, and death. This stress can be further exacerbated by social upheavals such as the COVID-19 pandemic. For safety reasons, many patients are isolated with restricted access to in-person health care and reduced social interaction with family and friends. Together with the economic uncertainties that come with this pandemic, these factors are likely to increase cancer survivors' stress levels. Expressive writing may provide a medium through which cancer survivors confront stressors and find meaning in their experience. The goal of this trial is to learn more about the experiences of cancer survivors during stressful times.	Cancer	Non applicable	À vérifier	United States	À vérifier
EncorafenibThe purpose of this study is to learn about the effects of three study medicines (encorafenib, binimetinib, and pembrolizumab) given together for the treatment of melanoma that: * is advanced or metastatic (spread to other parts of the body); * has a certain type of abnormal gene called "BRAF"; and * has not received prior treatment. All participants in this study will receive pembrolizumab at the study clinic once every 3 weeks as an intravenous (IV) infusion (given directly into a vein). In addition, half of the participants will take encorafenib and binimetinib orally (by mouth) at home every day. Participants may receive pembrolizumab for up to two years. Those participants taking encorafenib and binimetinib can continue until their melanoma is no longer responding. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.	Cancer	Phase 3	À vérifier	United States, Argentina, Austria, Belgium, Brazil, Bulgaria, Canada, Czechia, Finland, France, Germany, Greece, Hungary, Israel, Italy, Mexico, New Zealand, Norway, Poland, Russia, …	À vérifier
CetuximabThe purpose of this study was to evaluate the efficacy and safety of pembrolizumab plus epacadostat, pembrolizumab monotherapy, and the EXTREME regimen (cetuximab + cisplatin or carboplatin + 5-fluorouracil) as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).	Cancer	Phase 1	À vérifier	United States	À vérifier
AzacitidineThis phase II trial studies how well enasidenib and azacitidine work in treating patients with IDH2 gene mutation and acute myeloid leukemia that has come back (recurrent) or does not respond to treatment (refractory). Enasidenib and azacitidine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.	Cancer	Phase 2	À vérifier	United States	À vérifier
Hypofractionated Radiation TherapyThis phase I/II trial studies the safety, side effects and best dose of M3814 and to see how well it works when given together with radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced). M3814 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving M3814 and hypofractionated radiation therapy together may be safe, tolerable and/or more effective than radiation therapy alone in treating patients with locally advanced pancreatic cancer.	Cancer	Non applicable	À vérifier	Canada	À vérifier
Bintrafusp AlfaThis phase I trial is to find out the best dose, possible benefits, and/or side effects of hypofractionated radiation therapy and bintrafusp alfa in treating patients with bile duct cancer that has spread to other places in the body (advanced intrahepatic cholangiocarcinoma). Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Immunotherapy with bintrafusp alfa, a bifunctional fusion protein composed of the monoclonal antibody avelumab and TGF-beta, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The combination of hypofractionated radiation therapy and bintrafusp alfa may help to control intrahepatic cholangiocarcinoma.	Cancer	Phase 1		United States	À vérifier
Longitudinal Evaluation of Women Undergoing Pelvic Surgery for the Treatment of Gynecologic CancerThe study investigates whether certain characteristics of gynecological cancer can help researchers predict how well a patient recovers from surgery to remove the lower colon, rectum, and bladder, and create openings through which urine and stool are passed out of the body (pelvic exenteration). Comparing the types of surgery completed and procedures used may help researchers to determine which are most effective and safe in patients with a history of gynecologic cancer.	Cancer	À vérifier	Traitement symptomatique	United States	À vérifier
CytarabineSelinexor has shown single-agent activity in a current phase I study enrolling patients with relapsed/refractory AML with durable complete remissions (CR), complete remissions with incomplete hematologic recovery (CRi), partial remissions (PR), and stable disease (SD) observed. Furthermore, common toxicities included nausea, fatigue, and anorexia and were manageable with supportive care agents. Additionally, CLAG chemotherapy has proven activity in relapsed and refractory AML, and has been shown to be a relatively well tolerated regimen without significant non-hematologic toxicity. Given the established role of CLAG chemotherapy, the single agent activity of selinexor, and their non-overlapping toxicities, the investigators propose a phase I/II open label study of selinexor in combination with CLAG for the treatment of patients with relapsed/refractory AML.	Cancer	Phase 1/2	Traitement symptomatique	United States	À vérifier
ACT-Together (Acting on Cancer Testing-Together)To determine the feasibility of a group-based education intervention to improve adherence to recommend surveillance and risk reducing procedures, with a focus at medically underserved women and racial/ethnic minorities with BRCA 1 and 2.	Cancer	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

Molécule	Indication / population	Phase	NCT	Titre	Statut
ACT-Together (Acting on Cancer Testing-Together)	Cancer	Non applicable	NCT06549153	ACT-Together (Acting on Cancer Testing-Together)	ACTIVE_NOT_RECRUITING
Cytarabine	Cancer	Phase 1/2	NCT03214562	Venetoclax With Combination Chemotherapy in Treating Patients With Newly Diagnosed or Relapsed or Refractory Acute Myeloid Leukemia	RECRUITING
Longitudinal Evaluation of Women Undergoing Pelvic Surgery for the Treatment of Gynecologic Cancer	Cancer	À vérifier	NCT00791635	Longitudinal Evaluation of Women Undergoing Pelvic Surgery for the Treatment of Gynecologic Cancer	ACTIVE_NOT_RECRUITING
Bintrafusp Alfa	Cancer	Phase 1	NCT04708067	Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma	ACTIVE_NOT_RECRUITING
Hypofractionated Radiation Therapy	Cancer	Non applicable	NCT06794125	PREVENT-LUNG — An Evaluation of Dose-escalation for Intrathoracic Tumours	RECRUITING
Azacitidine	Cancer	Phase 2	NCT03683433	Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation	RECRUITING
Cetuximab	Cancer	Phase 1	NCT05985954	Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy	RECRUITING
Psilocybin	Cancer	Phase 2	NCT06200155	Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy	RECRUITING
Encorafenib	Cancer	Phase 3	NCT04657991	A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma	ACTIVE_NOT_RECRUITING
Expressive Writing for the Management of Stress in Cancer Survivors	Cancer	Non applicable	NCT04776941	Expressive Writing for the Management of Stress in Cancer Survivors	RECRUITING
flexible AIR coil	Cancer	Non applicable	NCT05043012	Diagnostic Performance Of Non-Endorectal Coil Multiparametric Magnetic Resonance Imaging Of Prostate With Flexible AIR Coil (DoNEMAC Study)	RECRUITING
Cytarabine	Cancer	Phase 1/2	NCT07053020	A Phase 1b/2 Open-label, Dose-ranging Safety and Efficacy Study of Oral Cladribine in Patients With Acute Myeloid Leukemia (AML)	NOT_YET_RECRUITING
Feasibility of Combined Genomics/Transcriptomics for Patients With Lymphoma	Cancer	Non applicable	NCT05464823	Feasibility of Combined Genomics/Transcriptomics for Patients With Lymphoma	ACTIVE_NOT_RECRUITING
Evaluation of Hereditary Cancer Educational Videos	Cancer	À vérifier	NCT06157801	Evaluation of Hereditary Cancer Educational Videos	ACTIVE_NOT_RECRUITING
Discussion	Cancer	Non applicable	NCT05025059	Exercise During Chemotherapy in Older Women With Stage I-III Breast Cancer	ACTIVE_NOT_RECRUITING
An Evaluation of the Implementation of the Care and Monitoring at Home Program- A New Paradigm for Acute Care Management of Cancer Patients	Cancer	À vérifier	NCT05904899	An Evaluation of the Implementation of the Care and Monitoring at Home Program- A New Paradigm for Acute Care Management of Cancer Patients	SUSPENDED
Development of Brief Positive Affect Treatment (PAT) for Caregivers of Patients With Advanced Cancer	Cancer	À vérifier	NCT05904782	Development of Brief Positive Affect Treatment (PAT) for Caregivers of Patients With Advanced Cancer	RECRUITING
Psycho-Spiritual Management for Patients With Advanced Cancer and Their Family Caregivers	Cancer	Non applicable	NCT06409065	Psycho-Spiritual Management for Patients With Advanced Cancer and Their Family Caregivers	RECRUITING
Hyperpolarized 13-C-pyruvate	Cancer	Phase 1	NCT05873699	Study Using Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging in Patients With Pancreatic Cysts Undergoing Surgical Resection	SUSPENDED
Bronchoscopy	Cancer	À vérifier	NCT03523689	Radial-Probe Endobronchial Ultrasound in Detecting Atelectasis in Patients Undergoing Peripheral Bronchoscopy	COMPLETED

Publications

Molécule	Titre	Journal
Hyperpolarized 13-C-pyruvate	Evaluating the metabolic effects of neoadjuvant treatment in clear cell renal cell carcinoma using hyperpolarized [1- C]pyruvate MRI.	Abdominal radiology (New York)
Hyperpolarized 13-C-pyruvate	Imaging post-reperfusion metabolism in porcine myocardial infarction with hyperpolarized C pyruvate MRI.	Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Hyperpolarized 13-C-pyruvate	Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back-to-Back Neuroimaging and Blood Analysis.	Magnetic resonance in medicine
Cytarabine	BMP and ERK signaling modulate AML-stroma interactions and contextually alter cytarabine sensitivity in AML cells.	Life sciences
Cytarabine	NAT10 drives chemoresistance in AML through ac4C-dependent stabilization of PLEKHA4.	Biochemical pharmacology
Radial Probe Endobronchial Ultrasound	3D computed tomography airway geometry for predicting bronchoscopic accessibility in peripheral pulmonary nodules: a prospective study.	Translational lung cancer research
Bronchoscopy	Remimazolam for sedation in flexible bronchoscopy: A systematic review and meta-analysis of randomised controlled trials.	Pulmonology
Bronchoscopy	Landscape of the upper and lower airway microbiota in children with community-acquired pneumonia.	Virulence
Bronchoscopy	A multimodal bronchoscopic approach for diagnosing peripheral ground-glass nodules using Cone-Beam computed tomography and cryobiopsy: a preliminary study.	Annals of medicine
Cetuximab	Internalization-Dependent EGFR-Targeted Photoactivation by Cetuximab-I21 Conjugates.	Journal of immunotherapy (Hagerstown, Md. : 1997)
Cetuximab	Incidence, treatment variation, and survival of synchronous head and neck and esophageal carcinomas: a descriptive nationwide cohort study in the Netherlands.	ESMO gastrointestinal oncology
Cetuximab	Novel bispecific T-cell engagers overcoming acquired EGFR resistance.	mAbs
Bronchoscopy	Risk of Early Deterioration in Emergency Department Patients Presenting with Non-Massive Hemoptysis: A Prospective Cohort Study.	Journal of clinical medicine
Bronchoscopy	Bronchoscopy-Guided Intratracheal Suture Repair of Recurrent Tracheoesophageal Fistula in an Adolescent.	Journal of clinical medicine
Cetuximab	Therapeutic resistance in HPV-positive oropharyngeal squamous cell carcinoma: molecular mechanisms, clinical challenges, and precision strategies.	Frontiers in genetics
Cetuximab	Outcomes and Prognostic Factors of Cetuximab-Based Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma.	Journal of clinical medicine
Cetuximab	Conversion strategies in RAS wild-type colorectal liver metastases: a systematic review and meta-analysis of first-line trials comparing regimens with anti-epidermal growth factor receptor inhibitors versus bevacizumab.	Critical reviews in oncology/hematology
Cetuximab	A Transgenic mouse tolerant to syngeneic cancer cells expressing truncated human epidermal growth factor receptor.	PloS one
Radial Probe Endobronchial Ultrasound	Diagnostic Yield and Safety of Radial Probe Endobronchial Ultrasound-Guided Transbronchial Lung Cryobiopsy with a Guide Sheath in Pulmonary Lesions < 3 cm.	Diagnostics (Basel, Switzerland)
Radial Probe Endobronchial Ultrasound	Advancing Transbronchial Lung Cryobiopsy in Interstitial Lung Disease with Adjunctive Tools and Smaller Cryoprobes.	Journal of clinical medicine
Bronchoscopy	Alternative to invasive bronchoscopy: validating tracheal aspirates for microbiome profiling in intensive care unit pneumonia patients.	Scientific reports
Bronchoscopy	Distinct cytokine and chemokine alterations in bronchoalveolar fluid from patients with systemic juvenile idiopathic arthritis associated lung disease (SJIA-LD).	Arthritis research & therapy