Elizabeth Donner — Biomedical Watch V2

Traitements2programmes

Essais1liés

Publications4liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Epidiolex 100 mg/mL Oral SolutionThe goal of this clinical trial is to learn the best way to switch children with Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome (DS) taking 'artisanal' (non pharmaceutical-grade) cannabidiol (CBD) to Epidiolex for treatment of seizures. The main questions it aims to answer are: * How well does a gradual switch from 'artisanal' CBD to Epidiolex work? * Does the same dose of Epidiolex as 'artisanal' CBD work best? * What side-effects or medical problems do participants have when switching from 'artisanal' CBD to Epidiolex? Researchers will examine how successful switching from 'artisanal' CBD to Epidiolex is. Participants will: * Gradually increase their dose of Epidiolex and reduce their dose of 'artisanal' CBD until they are taking just Epidiolex * Visit the clinic five times over 20 weeks for checkups and tests * Keep a diary of their seizures, symptoms and the number of times they use a rescue seizure medication	Épilepsie	Phase 4	Traitement symptomatique	Canada	À vérifier
Epidiolex 100 mg/mL Oral SolutionThe goal of this clinical trial is to learn the best way to switch children with Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome (DS) taking 'artisanal' (non pharmaceutical-grade) cannabidiol (CBD) to Epidiolex for treatment of seizures. The main questions it aims to answer are: * How well does a gradual switch from 'artisanal' CBD to Epidiolex work? * Does the same dose of Epidiolex as 'artisanal' CBD work best? * What side-effects or medical problems do participants have when switching from 'artisanal' CBD to Epidiolex? Researchers will examine how successful switching from 'artisanal' CBD to Epidiolex is. Participants will: * Gradually increase their dose of Epidiolex and reduce their dose of 'artisanal' CBD until they are taking just Epidiolex * Visit the clinic five times over 20 weeks for checkups and tests * Keep a diary of their seizures, symptoms and the number of times they use a rescue seizure medication	Épilepsie	Phase 4	Traitement symptomatique	Canada	À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
Epidiolex 100 mg/mL Oral Solution	Épilepsie	Phase 4	NCT06924827	CANN-SWITCH — A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex	NOT_YET_RECRUITING

Publications

4

Molécule	Indication / population	Titre	Journal	Date
Epidiolex 100 mg/mL Oral Solution		Caregiver-reported outcomes with real-world use of cannabidiol in Lennox-Gastaut syndrome and Dravet syndrome from the BECOME survey.	Epilepsy research
Epidiolex 100 mg/mL Oral Solution		Clinically Meaningful Reduction in Drop Seizures in Patients with Lennox-Gastaut Syndrome Treated with Cannabidiol: Post Hoc Analysis of Phase 3 Clinical Trials.	CNS drugs
Epidiolex 100 mg/mL Oral Solution		[Low Abuse Potential of Plant-Derived Highly Purified Cannabidiol: A Narrative Review].	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Epidiolex 100 mg/mL Oral Solution		Co-Creation of the EpiCom Clinical Trial: Bringing the Tuberous Sclerosis Complex Patient Community, Healthcare Professionals, and the Pharmaceutical Industry Together.	The patient