Centre Hospitalier Universitaire de Liege — Biomedical Watch V2

Traitements2programmes

Essais1liés

Publications3liées

SourceDBlocale

Traitements

2

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
SydeDuchenne Muscular Dystrophy (DMD) is a rare genetic disorder caused by the absence of dystrophin, leading to progressive muscle degeneration. Symptoms typically begin in early childhood and result in loss of ambulation by early adolescence, followed by cardiorespiratory complications. Although early treatment, including corticosteroids and emerging therapies, can slow disease progression, sensitive tools to monitor functional decline-particularly in non-ambulant patients-remain limited. Current assessments rely primarily on clinical scales and hospital-based evaluations, which may not detect subtle changes or reflect real-life function. Digital outcome measures derived from wearable sensors offer a promising approach for continuous, objective monitoring in daily life. This study aims to evaluate the feasibility, reliability, clinical validity, and sensitivity of digital measures to assess upper limb function in non-ambulant patients with genetically confirmed DMD. The Syde device, previously validated in ambulant DMD patients, will be investigated for its applicability in this population.	Myopathies	Non applicable	Ralentissement de la progression + Traitement symptomatique	Belgium	À vérifier
SydeDuchenne Muscular Dystrophy (DMD) is a rare genetic disorder caused by the absence of dystrophin, leading to progressive muscle degeneration. Symptoms typically begin in early childhood and result in loss of ambulation by early adolescence, followed by cardiorespiratory complications. Although early treatment, including corticosteroids and emerging therapies, can slow disease progression, sensitive tools to monitor functional decline-particularly in non-ambulant patients-remain limited. Current assessments rely primarily on clinical scales and hospital-based evaluations, which may not detect subtle changes or reflect real-life function. Digital outcome measures derived from wearable sensors offer a promising approach for continuous, objective monitoring in daily life. This study aims to evaluate the feasibility, reliability, clinical validity, and sensitivity of digital measures to assess upper limb function in non-ambulant patients with genetically confirmed DMD. The Syde device, previously validated in ambulant DMD patients, will be investigated for its applicability in this population.	Myopathies	Non applicable	Ralentissement de la progression + Traitement symptomatique	Belgium	À vérifier

Essais cliniques

1

Molécule	Indication / population	Phase	NCT	Titre	Statut
Syde	Myopathies	Non applicable	NCT07664124	Acti-nRoll — Digital Monitoring of Upper Limb Function in Non-Ambulant DMD	NOT_YET_RECRUITING

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Syde		Wearable sensors in paediatric neurology.	Developmental medicine and child neurology
Syde		Operational control mechanism and pilot-scale demonstration of integrated fixed-film activated sludge partial nitritation/anammox system.	Bioresource technology
Syde		Stride-level measurement of gait as an early sensitive marker of disability progression in ambulatory patients with multiple sclerosis.	EClinicalMedicine