Beth Israel Deaconess Medical Center — Biomedical Watch V2

Traitements8programmes

Essais4liés

Publications6liées

SourceDBlocale

Traitements

8

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
DC Stimulator (Transcranial Direct Current Stimulator)The purpose of this study is to determine whether a painless and noninvasive procedure called Transcranial Direct Current Stimulation (tDCS) can be an effective therapy for the treatment of migraine and migraine-associated pain. Stimulation of the motor cortex with tDCS has already been shown to relieve pain in patients with other chronic pain syndromes, including traumatic spinal cord injury and fibromyalgia. Patients with migraine are usually extremely sensitive to pain. A treatment that targets the areas of the brain that are related to the experience of pain may also help decrease pain in patients with migraine. Pain control with this localized approach may help avoid the problems due to pain medications that affect all organs in the body. We hypothesize that 10 sessions of Transcranial Direct Current Stimulation (tDCS) applied over the area of the brain that controls pain and motor function will decrease pain and headache frequency in patients with migraine.	Migraine	NA	Traitement symptomatique	United States	À vérifier
Emgality 120 MG in 1 ML Prefilled SyringeThe purpose of this study is to understand better the mechanisms of action of calcitonin gene related peptide (CGRP) targeted monoclonal antibodies in migraine prevention. Specifically, the protocol will allow the investigators to determine whether the main site of action of this novel and recently-approved class of migraine prophylactic drugs act inside or outside the brain and if so, where.	Migraine	Phase 4	À vérifier	United States	À vérifier
Innovative Measures of Speech and Swallowing Dysfunction in Neurological DisordersThis study is evaluating the use of two painless, non-invasive technologies in the assessment of muscle health over time in both healthy volunteers and patients who have diseases that affect the nervous system.	Myasthénie	À vérifier	Traitement symptomatique	United States	À vérifier
Mind Body Intervention for Chronic Migraine HeadachesThe goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has been used in other similar conditions. We will also evaluate multiple measurement tools in order to optimize a follow-up pilot study evaluating the impact of the protocol on migraines.	Migraine	Non applicable	À vérifier	United States	À vérifier
Innovative Measures of Speech and Swallowing Dysfunction in Neurological DisordersThis study is evaluating the use of two painless, non-invasive technologies in the assessment of muscle health over time in both healthy volunteers and patients who have diseases that affect the nervous system.	Myasthénie	À vérifier	Traitement symptomatique	United States	À vérifier
DC Stimulator (Transcranial Direct Current Stimulator)The purpose of this study is to determine whether a painless and noninvasive procedure called Transcranial Direct Current Stimulation (tDCS) can be an effective therapy for the treatment of migraine and migraine-associated pain. Stimulation of the motor cortex with tDCS has already been shown to relieve pain in patients with other chronic pain syndromes, including traumatic spinal cord injury and fibromyalgia. Patients with migraine are usually extremely sensitive to pain. A treatment that targets the areas of the brain that are related to the experience of pain may also help decrease pain in patients with migraine. Pain control with this localized approach may help avoid the problems due to pain medications that affect all organs in the body. We hypothesize that 10 sessions of Transcranial Direct Current Stimulation (tDCS) applied over the area of the brain that controls pain and motor function will decrease pain and headache frequency in patients with migraine.	Migraine	NA	Traitement symptomatique	United States	À vérifier
Emgality 120 MG in 1 ML Prefilled SyringeThe purpose of this study is to understand better the mechanisms of action of calcitonin gene related peptide (CGRP) targeted monoclonal antibodies in migraine prevention. Specifically, the protocol will allow the investigators to determine whether the main site of action of this novel and recently-approved class of migraine prophylactic drugs act inside or outside the brain and if so, where.	Migraine	Phase 4	À vérifier	United States	À vérifier
Mind Body Intervention for Chronic Migraine HeadachesThe goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has been used in other similar conditions. We will also evaluate multiple measurement tools in order to optimize a follow-up pilot study evaluating the impact of the protocol on migraines.	Migraine	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

4

Molécule	Indication / population	Phase	NCT	Titre	Statut
Mind Body Intervention for Chronic Migraine Headaches	Migraine	Non applicable	NCT06690060	Mind Body Intervention for Chronic Migraine Headaches	RECRUITING
Emgality 120 MG in 1 ML Prefilled Syringe	Migraine	Phase 4	NCT04271202	Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Action	COMPLETED
DC Stimulator (Transcranial Direct Current Stimulator)	Migraine	NA	NCT00521196	Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)	COMPLETED
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders	Myasthénie	À vérifier	NCT02118805	Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders	COMPLETED

Publications

6

Molécule	Indication / population	Titre	Journal	Date
DC Stimulator (Transcranial Direct Current Stimulator)		In-Ear Transcranial Alternating Current Stimulation: Auditory Perception and Side Effects Depend on Electrode Montage, Frequency, and Direct Current-Offset.	Neuromodulation : journal of the International Neuromodulation Society
DC Stimulator (Transcranial Direct Current Stimulator)		Remotely Supervised Home-Based tDCS in Treatment-Resistant Depression: Feasibility, Effectiveness and EEG Biomarkers of Response.	Psychiatry research
DC Stimulator (Transcranial Direct Current Stimulator)		Reducing state anxiety with alpha-frequency transcranial alternating current stimulation.	Journal of affective disorders
DC Stimulator (Transcranial Direct Current Stimulator)		Adjunctive transcranial DC stimulation in the management of refractory drug-resistant focal epilepsy in POLG mitochondrial disease: A case series.	Seizure
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders		Management of chronic closed lock.	The British journal of oral & maxillofacial surgery
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders		Respiratory-Swallow Training and Variable Practice in Parkinson's Disease: A Clinical Trial Pilot Study.	Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)