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Assiut University
Traitements, essais et publications liés.
Traitements34programmes
Essais18liés
Publications27liées
SourceDBlocale
Traitements
34| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| Assessment of Blood Indices in Systemic Lupus ErythematosusThis case-control study aims to explore the relationship between specific blood indices (lymphocyte-monocyte ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index) and disease activity in patients with systemic lupus erythematosus (SLE). The study includes 70 SLE patients and 70 healthy controls, matched for age and gender, recruited from Assiut University Hospital. Disease activity is assessed using the SLEDAI-2K score, and blood indices are analyzed to determine correlations with disease activity. | Lupus | À vérifier | Immunomodulation | À vérifier | |
| Clinical Utility of Serum Ribonuclease 1(RNASE1) as a Biomarker of Lupus Nephritis.This study will identify the level of serum Riboneuclease 1 in systemic lupus patients and compare between its level in lupus nephritis and non nephritis. | Lupus | À vérifier | À vérifier | À vérifier | |
| cortical resectionsThe aim of the study is to evaluate safety and efficacy of epilepsy surgery in the form of cortical resections in patients with refractory epilepsy and to review outcomes of resection procedures in focal epilepsy. | Épilepsie | À vérifier | À vérifier | À vérifier | |
| CPR_AUCR2026 — Cerebroplacental Ratio (CPR) and Amniotic-Umbilical-to-Cerebral Ratio (AUCR), in in Women With Hypertensive Disorders of Pregnancy.The primary aim of this study is to evaluate the predictive value of the Amniotic-Umbilical-to-Cerebral Ratio (AUCR) in predicting composite adverse perinatal outcomes in women with hypertensive disorders of pregnancy and to compare its predictive performance with the traditional Cerebroplacental Ratio (CPR) | Hypertension | À vérifier | À vérifier | À vérifier | |
| Dextrose 5% in waterKetamine and lidocaine infusion for refractory chronic migraine: Comparative Study | Migraine | Phase 1 | À vérifier | À vérifier | |
| Evaluation of Slit2 in Systemic Lupus Erythematosus and Systemic Sclerosis Patients1.Assessment of slit2 level in SLE patients and its correlation with disease activity. 2-Assessment of slit2 level in SSC patients and its correlation with disease activity | Lupus | À vérifier | À vérifier | À vérifier | |
| Greater Auricular Nerve BlockMigraine is one of the most prevalent neurological disorders worldwide and remains a leading cause of disability, particularly among individuals of working age. Chronic migraine affects approximately 1-2% of the global population and is associated with substantial impairment in quality of life, reduced work productivity, and increased healthcare utilization . Despite recent advances in migraine management, including calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies and gepants, many patients continue to experience inadequate symptom control, treatment intolerance, or limited access to these therapies . Consequently, peripheral nerve blocks have emerged as effective non-pharmacological treatment options for patients with refractory migraine and other primary headache disorders . Among the available interventional techniques, the greater occipital nerve block (GONB) is one of the most widely used procedures for both acute and preventive treatment of migraine. The therapeutic effect of GONB is believed to result from modulation of nociceptive transmission within the trigeminocervical complex, thereby reducing central sensitization and interrupting convergence between cervical and trigeminal afferents. Several randomized clinical trials and systematic reviews have demonstrated that GONB significantly reduces headache intensity, headache frequency, analgesic consumption, and migraine-related disability while maintaining an excellent safety profile . Migraine pain often involves overlapping sensory territories supplied by interconnected peripheral nerves. The greater auricular nerve (GAN), a superficial sensory branch of the cervical plexus arising from the C2 and C3 spinal nerves, supplies the skin over the parotid region, mastoid process, lower auricle, and angle of the mandible . Because cervical sensory afferents converge with trigeminal nociceptive pathways within the trigeminocervical complex, the GAN may contribute to peripheral nociceptive transmission involved in migraine pathophysiology . Combined blockade of multiple cervical sensory nerves may therefore provide broader interruption of peripheral nociceptive input, potentially enhancing analgesic efficacy and reducing central sensitization . Ultrasound-guided GONB has been shown to produce greater procedural accuracy and consistent clinical outcomes than landmark-guided techniques . Despite the increasing use of peripheral nerve blocks in headache medicine, evidence regarding the additional benefit of combining a greater auricular nerve block with the standard greater occipital nerve block remains limited. To the best of our knowledge, no prospective randomized double-blind clinical trial has directly compared ultrasound-guided combined GONB and GAN block with GONB alone in patients with chronic migraine. | Migraine | Phase 4 | Traitement symptomatique | À vérifier | |
| greater occipital nerve blockMigraine is one of the most prevalent neurological disorders worldwide and remains a leading cause of disability, particularly among individuals of working age. Chronic migraine affects approximately 1-2% of the global population and is associated with substantial impairment in quality of life, reduced work productivity, and increased healthcare utilization . Despite recent advances in migraine management, including calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies and gepants, many patients continue to experience inadequate symptom control, treatment intolerance, or limited access to these therapies . Consequently, peripheral nerve blocks have emerged as effective non-pharmacological treatment options for patients with refractory migraine and other primary headache disorders . Among the available interventional techniques, the greater occipital nerve block (GONB) is one of the most widely used procedures for both acute and preventive treatment of migraine. The therapeutic effect of GONB is believed to result from modulation of nociceptive transmission within the trigeminocervical complex, thereby reducing central sensitization and interrupting convergence between cervical and trigeminal afferents. Several randomized clinical trials and systematic reviews have demonstrated that GONB significantly reduces headache intensity, headache frequency, analgesic consumption, and migraine-related disability while maintaining an excellent safety profile . Migraine pain often involves overlapping sensory territories supplied by interconnected peripheral nerves. The greater auricular nerve (GAN), a superficial sensory branch of the cervical plexus arising from the C2 and C3 spinal nerves, supplies the skin over the parotid region, mastoid process, lower auricle, and angle of the mandible . Because cervical sensory afferents converge with trigeminal nociceptive pathways within the trigeminocervical complex, the GAN may contribute to peripheral nociceptive transmission involved in migraine pathophysiology . Combined blockade of multiple cervical sensory nerves may therefore provide broader interruption of peripheral nociceptive input, potentially enhancing analgesic efficacy and reducing central sensitization . Ultrasound-guided GONB has been shown to produce greater procedural accuracy and consistent clinical outcomes than landmark-guided techniques . Despite the increasing use of peripheral nerve blocks in headache medicine, evidence regarding the additional benefit of combining a greater auricular nerve block with the standard greater occipital nerve block remains limited. To the best of our knowledge, no prospective randomized double-blind clinical trial has directly compared ultrasound-guided combined GONB and GAN block with GONB alone in patients with chronic migraine. | Migraine | Phase 4 | Traitement symptomatique | Turkey (Türkiye) | À vérifier |
| Lidocaine Intravenous InfusionKetamine and lidocaine infusion for refractory chronic migraine: Comparative Study | Migraine | Phase 1 | À vérifier | À vérifier | |
| Multimodal Biomarkers in Individual With Cognitive Impairment and DementiaMemory problems can range from normal aging to mild cognitive impairment (MCI) to dementia. This study looks at three ways of measuring what is happening in the brain at each of these stages: a blood test (GFAP), a brain MRI scan, and a brain wave test (EEG). The goal is to see whether combining these three tests can help doctors tell the difference between normal aging, MCI, and dementia more accurately, and whether this approach works well in an Egyptian population, including all common causes of dementia (not only Alzheimer's disease). Adults aged 50 to 85 will be placed into one of three groups: those with normal memory, those with mild memory problems (MCI), and those with dementia. Everyone will have a memory and thinking assessment, a blood draw, a brain MRI, and a brain wave (EEG) recording. No new medication or treatment is given as part of this study; it involves only assessment and testing. The information gathered may help doctors diagnose memory problems earlier and more accurately in the future. | Alzheimer | À vérifier | À vérifier | À vérifier | |
| Neutrophil Extracellular Traps and Lupus NephritisLupus Nephritis is one of the most severe organ manifestations of systemic lupus erythematosus and represents a major cause of morbidity, chronic kidney disease, and long-term mortality. Despite significant advances in immunosuppressive therapies, a substantial proportion of patients fail to achieve sustained renal remission or progress to end-stage renal disease, highlighting the need for improved understanding of disease mechanisms and more reliable biomarkers for disease monitoring and therapeutic response | Lupus | À vérifier | À vérifier | À vérifier | |
| Non Invasive Assessment of Subclinical Atherosclerosis and Cardiovascular Risk Using TYG Index in Lupus NephritisSystemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by loss of immune tolerance, autoantibody production, immune complex deposition, and complement activation, resulting in widespread inflammation and organ damage. Renal involvement, known as lupus nephritis (LN), occurs in approximately 40-60% of SLE patients and represents one of the most severe disease manifestations, significantly contributing to morbidity and mortality.Lupus nephritis arises from immune complex deposition in glomerular and tubulointerstitial structures, causing inflammatory and proliferative lesions that can progress to chronic kidney disease or end-stage renal disease. The ISN/RPS classification provides a standardized histopathological framework essential for prognosis and guiding treatment decisions. In addition to renal complications, patients with SLE and LN are at substantially increased risk of premature cardiovascular disease, which cannot be fully explained by traditional cardiovascular risk factors.Persistent systemic inflammation, endothelial dysfunction, dyslipidemia, and insulin resistance accelerate atherosclerosis in these patients. Subclinical vascular changes, including increased carotid intima-media thickness (CIMT) and carotid plaque formation, often precede overt cardiovascular events, underscoring the importance of early cardiovascular risk assessment The triglyceride-glucose (TyG) index is a validated surrogate marker of insulin resistance, correlating with endothelial dysfunction, subclinical atherosclerosis, and increased CIMT Elevated TyG index may therefore serve as a simple, non-invasive tool for early cardiovascular risk stratification in patients with lupus nephritis | Lupus | À vérifier | Immunomodulation | Egypt | À vérifier |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic PatientsThis observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy volunteers. Meibomian glands are specialized glands in the eyelids that produce the lipid layer of tears, preventing tear evaporation. Systemic inflammation in rheumatologic conditions may affect these glands, leading to dry eye symptoms and ocular surface damage. A total of 150 participants (120 rheumatologic patients and 30 healthy controls) will be evaluated in a single cross-sectional examination. Rheumatologic diagnoses include Rheumatoid Arthritis, Systemic Lupus Erythematosus, Sjogren's Syndrome, Ankylosing Spondylitis, and Psoriatic Arthritis. Participants will undergo a standardized series of non-invasive and minimally invasive eye examinations, including: * An ocular symptom questionnaire (Ocular Surface Disease Index) * Non-contact infrared meibography to assess meibomian gland loss (Meiboscore) * Non-invasive tear break-up time (NIBUT) and tear meniscus height measurements * Slit-lamp biomicroscopy and corneal fluorescein staining The study also examines how meibomian gland alterations correlate with systemic disease activity scores and inflammatory blood markers. | Lupus | À vérifier | Immunomodulation + Traitement symptomatique | À vérifier | |
| OnabotulinumtoxinAChronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life. Management typically includes acute and preventive treatments, but effectiveness can be limited due to medication overuse or delayed onset of action. OnabotulinumtoxinA injections provide proven long-term preventive benefits, while Greater Occipital Nerve (GON) block offers rapid but short-term relief. Although both treatments are used individually, evidence on the combined effect is limited. This randomized controlled trial aims to evaluate the efficacy and safety of combining OnabotulinumtoxinA injections with GON block, assessing improvements in headache frequency, severity, and patient quality of life compared to single therapy. | Migraine | Phase 4 | À vérifier | Egypt | À vérifier |
| RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple SclerosisThe goal of this prospective observational cohort study is to determine the frequency of progression independent of relapse activity (PIRA) and identify its clinical, radiological, neuroaxonal, and functional predictors in patients with early relapsing-remitting multiple sclerosis (RRMS). The study aims to facilitate early identification of patients at increased risk of disability progression independent of relapses and to support individualized therapeutic decision-making. The main questions it aims to answer are: What is the frequency of PIRA in patients with early RRMS? Which demographic and clinical characteristics are associated with the development of PIRA? Which MRI biomarkers, including lesion burden, brain atrophy, spinal cord involvement, and paramagnetic rim lesions (where available), are associated with PIRA? Can optical coherence tomography (OCT) measurements, including peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) thickness, predict PIRA? Are serum biomarkers, including neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP), associated with an increased risk of PIRA? Which baseline factors independently predict disability progression? Participants will undergo comprehensive baseline and follow-up assessments, including collection of demographic and clinical data, neurological examination with Expanded Disability Status Scale (EDSS) scoring, brain and spinal cord MRI, OCT assessment, laboratory evaluation of serum biomarkers (where available), and validated functional and patient-reported outcome measures. Participants will be followed longitudinally to identify confirmed disability accumulation (CDA) and classify disability progression as PIRA or relapse-associated worsening (RAW). The primary outcome is the occurrence of PIRA, defined as confirmed disability accumulation independent of clinical relapses during follow-up. Secondary outcomes include identification of independent clinical, imaging, OCT, and laboratory predictors of PIRA and evaluation of their association with long-term disability progression. The findings may improve early risk stratification and support timely initiation of high-efficacy disease-modifying therapies in patients with early RRMS. | SEP | À vérifier | Ralentissement de la progression | Egypt | À vérifier |
| Serum MPO-DNA Complexes as a Biomarker of Disease Activity in Systemic Lupus ErythematosusSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune system dysregulation and inflammation affecting multiple organs. A key mechanism in its development involves the excessive formation and impaired clearance of neutrophil extracellular traps (NETs), which release myeloperoxidase-DNA (MPO-DNA) complexes into the circulation. Although standard laboratory markers like complement proteins (C3, C4) and anti-dsDNA antibodies are routinely used, they often show inconsistent sensitivity in monitoring disease activity and flare-ups. The primary purpose of this observational study is to evaluate serum MPO-DNA complexes as a circulating biomarker of NET formation in patients with systemic lupus erythematosus. The study aims to: * Measure serum MPO-DNA complex levels in active SLE patients compared to age- and sex-matched inactive SLE controls. * Assess the correlation between MPO-DNA complex levels and clinical disease activity measured by the SLE Disease Activity Index 2000 (SLEDAI-2K) score. * Evaluate the diagnostic accuracy of MPO-DNA complexes compared to conventional inflammatory and immunological markers (ESR, CRP, C3, C4, and anti-dsDNA). Participants will undergo routine clinical assessments and standard blood sampling to measure routine laboratory parameters and circulating MPO-DNA complex levels via enzyme-linked immunosorbent assay (ELISA). | Lupus | À vérifier | Immunomodulation | À vérifier | |
| The Role Of Vestibular Rehabilitation Therapy In Management Of Vestibular Migraine Patients1. To assess the criteria of positional vertigo in vestibular migraine patients 2. To assess the effect of vestibular rehabilitation therapy in management of positional vertigo in vestibular migraine patients | Migraine | À vérifier | À vérifier | À vérifier | |
| Ultrasound-guided pulsed radiofrequency (PRF)Migraine is a common chronic neurovascular disorder ranked among the leading causes of disability worldwide, and its global burden has continued to rise over the past three decades, with prevalence increasing substantially between 1990 and 2021the global number of prevalent cases, incident cases, and DALYs for migraine increased by 58%, 42%, and 58% respectively from 1990 to 2021 (1). In 2021, migraine affected an estimated 1.2 billion people globally, and although tension-type headache was more prevalent, migraine caused greater disability (2). Chronic migraine, defined as headache occurring on 15 or more days per month for more than three months, with migrainous features on at least 8 days, represents a particularly disabling subtype that is frequently refractory to standard pharmacological prophylaxis (3). Pharmacologic treatment of chronic migraine often has limited efficacy, prompting growing interest in interventional and peripheral neuromodulatory approaches (4). OnabotulinumtoxinA is currently the only FDA-approved interventional prophylactic therapy for chronic migraine, with efficacy established by class-one evidence from the PREEMPT clinical program (5). Although onabotulinumtoxinA is traditionally known for inhibiting muscle contraction, its efficacy in chronic migraine is now attributed to inhibition of SNARE-mediated vesicle trafficking in sensory as well as motor nerve terminals (6). However, treatment with onabotulinumtoxinA, while effective, must be repeated every three months for sustained relief and can impose a significant financial burden on patients (7), which has driven exploration of alternative peripheral procedures targeting the same pericranial sensory nerve distribution. Greater occipital nerve block and PRF have shown efficacy in reducing migraine frequency, intensity, and duration, with pulsed radiofrequency treatment thought to reduce conduction in nociceptive fibers through a neuromodulatory, non-neurodestructive mechanism (8). Randomized data comparing GON block with GON-PRF found that VAS pain scores were significantly lower in the PRF group than the GON block group at six months follow-up (9), and longer-term cohort data have shown durable benefit of GON-targeted radiofrequency techniques over twelve months of follow-up (10). Beyond the occipital nerve, radiofrequency ablation of pericranial nerves including the supratrochlear and supraorbital nerves has emerged as a promising option for headache conditions refractory to pharmacologic treatment, with a favorable and largely self-limited side-effect profile (7). Case reports have further demonstrated good therapeutic response to PRF in patients whose chronic migraine remained refractory even after botulinum toxin injection (10). Despite this growing evidence base, direct head-to-head comparisons between combined GON-supratrochlear nerve PRF and onabotulinumtoxinA injection, the two leading peripheral interventional strategies covering the trigeminal and occipital sensory distribution, remain scarce. Given the cost, repeated dosing requirement, and resource burden associated with botulinum toxin therapy, and the emerging durability data for PRF, a direct comparative study is warranted to determine which modality offers superior and more sustained efficacy, better safety, and greater cost-effectiveness for patients with chronic migraine. | Migraine | Phase 4 | Traitement symptomatique | À vérifier | |
| cortical resectionsThe aim of the study is to evaluate safety and efficacy of epilepsy surgery in the form of cortical resections in patients with refractory epilepsy and to review outcomes of resection procedures in focal epilepsy. | Épilepsie | À vérifier | À vérifier | À vérifier | |
| Assessment of Blood Indices in Systemic Lupus ErythematosusThis case-control study aims to explore the relationship between specific blood indices (lymphocyte-monocyte ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index) and disease activity in patients with systemic lupus erythematosus (SLE). The study includes 70 SLE patients and 70 healthy controls, matched for age and gender, recruited from Assiut University Hospital. Disease activity is assessed using the SLEDAI-2K score, and blood indices are analyzed to determine correlations with disease activity. | Lupus | À vérifier | Immunomodulation | À vérifier | |
| Evaluation of Slit2 in Systemic Lupus Erythematosus and Systemic Sclerosis Patients1.Assessment of slit2 level in SLE patients and its correlation with disease activity. 2-Assessment of slit2 level in SSC patients and its correlation with disease activity | Lupus | À vérifier | À vérifier | À vérifier | |
| The Role Of Vestibular Rehabilitation Therapy In Management Of Vestibular Migraine Patients1. To assess the criteria of positional vertigo in vestibular migraine patients 2. To assess the effect of vestibular rehabilitation therapy in management of positional vertigo in vestibular migraine patients | Migraine | À vérifier | À vérifier | À vérifier | |
| OnabotulinumtoxinAChronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life. Management typically includes acute and preventive treatments, but effectiveness can be limited due to medication overuse or delayed onset of action. OnabotulinumtoxinA injections provide proven long-term preventive benefits, while Greater Occipital Nerve (GON) block offers rapid but short-term relief. Although both treatments are used individually, evidence on the combined effect is limited. This randomized controlled trial aims to evaluate the efficacy and safety of combining OnabotulinumtoxinA injections with GON block, assessing improvements in headache frequency, severity, and patient quality of life compared to single therapy. | Migraine | Non applicable | À vérifier | Egypt | À vérifier |
| RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple SclerosisThe goal of this prospective observational cohort study is to determine the frequency of progression independent of relapse activity (PIRA) and identify its clinical, radiological, neuroaxonal, and functional predictors in patients with early relapsing-remitting multiple sclerosis (RRMS). The study aims to facilitate early identification of patients at increased risk of disability progression independent of relapses and to support individualized therapeutic decision-making. The main questions it aims to answer are: What is the frequency of PIRA in patients with early RRMS? Which demographic and clinical characteristics are associated with the development of PIRA? Which MRI biomarkers, including lesion burden, brain atrophy, spinal cord involvement, and paramagnetic rim lesions (where available), are associated with PIRA? Can optical coherence tomography (OCT) measurements, including peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) thickness, predict PIRA? Are serum biomarkers, including neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP), associated with an increased risk of PIRA? Which baseline factors independently predict disability progression? Participants will undergo comprehensive baseline and follow-up assessments, including collection of demographic and clinical data, neurological examination with Expanded Disability Status Scale (EDSS) scoring, brain and spinal cord MRI, OCT assessment, laboratory evaluation of serum biomarkers (where available), and validated functional and patient-reported outcome measures. Participants will be followed longitudinally to identify confirmed disability accumulation (CDA) and classify disability progression as PIRA or relapse-associated worsening (RAW). The primary outcome is the occurrence of PIRA, defined as confirmed disability accumulation independent of clinical relapses during follow-up. Secondary outcomes include identification of independent clinical, imaging, OCT, and laboratory predictors of PIRA and evaluation of their association with long-term disability progression. The findings may improve early risk stratification and support timely initiation of high-efficacy disease-modifying therapies in patients with early RRMS. | SEP | À vérifier | Ralentissement de la progression | Egypt | À vérifier |
| greater occipital nerve blockMigraine is one of the most prevalent neurological disorders worldwide and remains a leading cause of disability, particularly among individuals of working age. Chronic migraine affects approximately 1-2% of the global population and is associated with substantial impairment in quality of life, reduced work productivity, and increased healthcare utilization . Despite recent advances in migraine management, including calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies and gepants, many patients continue to experience inadequate symptom control, treatment intolerance, or limited access to these therapies . Consequently, peripheral nerve blocks have emerged as effective non-pharmacological treatment options for patients with refractory migraine and other primary headache disorders . Among the available interventional techniques, the greater occipital nerve block (GONB) is one of the most widely used procedures for both acute and preventive treatment of migraine. The therapeutic effect of GONB is believed to result from modulation of nociceptive transmission within the trigeminocervical complex, thereby reducing central sensitization and interrupting convergence between cervical and trigeminal afferents. Several randomized clinical trials and systematic reviews have demonstrated that GONB significantly reduces headache intensity, headache frequency, analgesic consumption, and migraine-related disability while maintaining an excellent safety profile . Migraine pain often involves overlapping sensory territories supplied by interconnected peripheral nerves. The greater auricular nerve (GAN), a superficial sensory branch of the cervical plexus arising from the C2 and C3 spinal nerves, supplies the skin over the parotid region, mastoid process, lower auricle, and angle of the mandible . Because cervical sensory afferents converge with trigeminal nociceptive pathways within the trigeminocervical complex, the GAN may contribute to peripheral nociceptive transmission involved in migraine pathophysiology . Combined blockade of multiple cervical sensory nerves may therefore provide broader interruption of peripheral nociceptive input, potentially enhancing analgesic efficacy and reducing central sensitization . Ultrasound-guided GONB has been shown to produce greater procedural accuracy and consistent clinical outcomes than landmark-guided techniques . Despite the increasing use of peripheral nerve blocks in headache medicine, evidence regarding the additional benefit of combining a greater auricular nerve block with the standard greater occipital nerve block remains limited. To the best of our knowledge, no prospective randomized double-blind clinical trial has directly compared ultrasound-guided combined GONB and GAN block with GONB alone in patients with chronic migraine. | Migraine | Phase 4 | Traitement symptomatique | À vérifier | |
| Clinical Utility of Serum Ribonuclease 1(RNASE1) as a Biomarker of Lupus Nephritis.This study will identify the level of serum Riboneuclease 1 in systemic lupus patients and compare between its level in lupus nephritis and non nephritis. | Lupus | À vérifier | À vérifier | À vérifier | |
| greater occipital nerve blockMigraine is one of the most prevalent neurological disorders worldwide and remains a leading cause of disability, particularly among individuals of working age. Chronic migraine affects approximately 1-2% of the global population and is associated with substantial impairment in quality of life, reduced work productivity, and increased healthcare utilization . Despite recent advances in migraine management, including calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies and gepants, many patients continue to experience inadequate symptom control, treatment intolerance, or limited access to these therapies . Consequently, peripheral nerve blocks have emerged as effective non-pharmacological treatment options for patients with refractory migraine and other primary headache disorders . Among the available interventional techniques, the greater occipital nerve block (GONB) is one of the most widely used procedures for both acute and preventive treatment of migraine. The therapeutic effect of GONB is believed to result from modulation of nociceptive transmission within the trigeminocervical complex, thereby reducing central sensitization and interrupting convergence between cervical and trigeminal afferents. Several randomized clinical trials and systematic reviews have demonstrated that GONB significantly reduces headache intensity, headache frequency, analgesic consumption, and migraine-related disability while maintaining an excellent safety profile . Migraine pain often involves overlapping sensory territories supplied by interconnected peripheral nerves. The greater auricular nerve (GAN), a superficial sensory branch of the cervical plexus arising from the C2 and C3 spinal nerves, supplies the skin over the parotid region, mastoid process, lower auricle, and angle of the mandible . Because cervical sensory afferents converge with trigeminal nociceptive pathways within the trigeminocervical complex, the GAN may contribute to peripheral nociceptive transmission involved in migraine pathophysiology . Combined blockade of multiple cervical sensory nerves may therefore provide broader interruption of peripheral nociceptive input, potentially enhancing analgesic efficacy and reducing central sensitization . Ultrasound-guided GONB has been shown to produce greater procedural accuracy and consistent clinical outcomes than landmark-guided techniques . Despite the increasing use of peripheral nerve blocks in headache medicine, evidence regarding the additional benefit of combining a greater auricular nerve block with the standard greater occipital nerve block remains limited. To the best of our knowledge, no prospective randomized double-blind clinical trial has directly compared ultrasound-guided combined GONB and GAN block with GONB alone in patients with chronic migraine. | Migraine | Non applicable | Traitement symptomatique | Turkey (Türkiye) | À vérifier |
| Neutrophil Extracellular Traps and Lupus NephritisLupus Nephritis is one of the most severe organ manifestations of systemic lupus erythematosus and represents a major cause of morbidity, chronic kidney disease, and long-term mortality. Despite significant advances in immunosuppressive therapies, a substantial proportion of patients fail to achieve sustained renal remission or progress to end-stage renal disease, highlighting the need for improved understanding of disease mechanisms and more reliable biomarkers for disease monitoring and therapeutic response | Lupus | À vérifier | À vérifier | À vérifier | |
| Non Invasive Assessment of Subclinical Atherosclerosis and Cardiovascular Risk Using TYG Index in Lupus NephritisSystemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by loss of immune tolerance, autoantibody production, immune complex deposition, and complement activation, resulting in widespread inflammation and organ damage. Renal involvement, known as lupus nephritis (LN), occurs in approximately 40-60% of SLE patients and represents one of the most severe disease manifestations, significantly contributing to morbidity and mortality.Lupus nephritis arises from immune complex deposition in glomerular and tubulointerstitial structures, causing inflammatory and proliferative lesions that can progress to chronic kidney disease or end-stage renal disease. The ISN/RPS classification provides a standardized histopathological framework essential for prognosis and guiding treatment decisions. In addition to renal complications, patients with SLE and LN are at substantially increased risk of premature cardiovascular disease, which cannot be fully explained by traditional cardiovascular risk factors.Persistent systemic inflammation, endothelial dysfunction, dyslipidemia, and insulin resistance accelerate atherosclerosis in these patients. Subclinical vascular changes, including increased carotid intima-media thickness (CIMT) and carotid plaque formation, often precede overt cardiovascular events, underscoring the importance of early cardiovascular risk assessment The triglyceride-glucose (TyG) index is a validated surrogate marker of insulin resistance, correlating with endothelial dysfunction, subclinical atherosclerosis, and increased CIMT Elevated TyG index may therefore serve as a simple, non-invasive tool for early cardiovascular risk stratification in patients with lupus nephritis | Lupus | À vérifier | Immunomodulation | Egypt | À vérifier |
| Ultrasound-guided pulsed radiofrequency (PRF)Migraine is a common chronic neurovascular disorder ranked among the leading causes of disability worldwide, and its global burden has continued to rise over the past three decades, with prevalence increasing substantially between 1990 and 2021the global number of prevalent cases, incident cases, and DALYs for migraine increased by 58%, 42%, and 58% respectively from 1990 to 2021 (1). In 2021, migraine affected an estimated 1.2 billion people globally, and although tension-type headache was more prevalent, migraine caused greater disability (2). Chronic migraine, defined as headache occurring on 15 or more days per month for more than three months, with migrainous features on at least 8 days, represents a particularly disabling subtype that is frequently refractory to standard pharmacological prophylaxis (3). Pharmacologic treatment of chronic migraine often has limited efficacy, prompting growing interest in interventional and peripheral neuromodulatory approaches (4). OnabotulinumtoxinA is currently the only FDA-approved interventional prophylactic therapy for chronic migraine, with efficacy established by class-one evidence from the PREEMPT clinical program (5). Although onabotulinumtoxinA is traditionally known for inhibiting muscle contraction, its efficacy in chronic migraine is now attributed to inhibition of SNARE-mediated vesicle trafficking in sensory as well as motor nerve terminals (6). However, treatment with onabotulinumtoxinA, while effective, must be repeated every three months for sustained relief and can impose a significant financial burden on patients (7), which has driven exploration of alternative peripheral procedures targeting the same pericranial sensory nerve distribution. Greater occipital nerve block and PRF have shown efficacy in reducing migraine frequency, intensity, and duration, with pulsed radiofrequency treatment thought to reduce conduction in nociceptive fibers through a neuromodulatory, non-neurodestructive mechanism (8). Randomized data comparing GON block with GON-PRF found that VAS pain scores were significantly lower in the PRF group than the GON block group at six months follow-up (9), and longer-term cohort data have shown durable benefit of GON-targeted radiofrequency techniques over twelve months of follow-up (10). Beyond the occipital nerve, radiofrequency ablation of pericranial nerves including the supratrochlear and supraorbital nerves has emerged as a promising option for headache conditions refractory to pharmacologic treatment, with a favorable and largely self-limited side-effect profile (7). Case reports have further demonstrated good therapeutic response to PRF in patients whose chronic migraine remained refractory even after botulinum toxin injection (10). Despite this growing evidence base, direct head-to-head comparisons between combined GON-supratrochlear nerve PRF and onabotulinumtoxinA injection, the two leading peripheral interventional strategies covering the trigeminal and occipital sensory distribution, remain scarce. Given the cost, repeated dosing requirement, and resource burden associated with botulinum toxin therapy, and the emerging durability data for PRF, a direct comparative study is warranted to determine which modality offers superior and more sustained efficacy, better safety, and greater cost-effectiveness for patients with chronic migraine. | Migraine | Phase 4 | Traitement symptomatique | À vérifier | |
| CPR_AUCR2026 — Cerebroplacental Ratio (CPR) and Amniotic-Umbilical-to-Cerebral Ratio (AUCR), in in Women With Hypertensive Disorders of Pregnancy.The primary aim of this study is to evaluate the predictive value of the Amniotic-Umbilical-to-Cerebral Ratio (AUCR) in predicting composite adverse perinatal outcomes in women with hypertensive disorders of pregnancy and to compare its predictive performance with the traditional Cerebroplacental Ratio (CPR) | Hypertension | À vérifier | À vérifier | À vérifier | |
| Multimodal Biomarkers in Individual With Cognitive Impairment and DementiaMemory problems can range from normal aging to mild cognitive impairment (MCI) to dementia. This study looks at three ways of measuring what is happening in the brain at each of these stages: a blood test (GFAP), a brain MRI scan, and a brain wave test (EEG). The goal is to see whether combining these three tests can help doctors tell the difference between normal aging, MCI, and dementia more accurately, and whether this approach works well in an Egyptian population, including all common causes of dementia (not only Alzheimer's disease). Adults aged 50 to 85 will be placed into one of three groups: those with normal memory, those with mild memory problems (MCI), and those with dementia. Everyone will have a memory and thinking assessment, a blood draw, a brain MRI, and a brain wave (EEG) recording. No new medication or treatment is given as part of this study; it involves only assessment and testing. The information gathered may help doctors diagnose memory problems earlier and more accurately in the future. | Alzheimer | À vérifier | À vérifier | À vérifier | |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic PatientsThis observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy volunteers. Meibomian glands are specialized glands in the eyelids that produce the lipid layer of tears, preventing tear evaporation. Systemic inflammation in rheumatologic conditions may affect these glands, leading to dry eye symptoms and ocular surface damage. A total of 150 participants (120 rheumatologic patients and 30 healthy controls) will be evaluated in a single cross-sectional examination. Rheumatologic diagnoses include Rheumatoid Arthritis, Systemic Lupus Erythematosus, Sjogren's Syndrome, Ankylosing Spondylitis, and Psoriatic Arthritis. Participants will undergo a standardized series of non-invasive and minimally invasive eye examinations, including: * An ocular symptom questionnaire (Ocular Surface Disease Index) * Non-contact infrared meibography to assess meibomian gland loss (Meiboscore) * Non-invasive tear break-up time (NIBUT) and tear meniscus height measurements * Slit-lamp biomicroscopy and corneal fluorescein staining The study also examines how meibomian gland alterations correlate with systemic disease activity scores and inflammatory blood markers. | Lupus | À vérifier | Immunomodulation + Traitement symptomatique | À vérifier | |
| Serum MPO-DNA Complexes as a Biomarker of Disease Activity in Systemic Lupus ErythematosusSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune system dysregulation and inflammation affecting multiple organs. A key mechanism in its development involves the excessive formation and impaired clearance of neutrophil extracellular traps (NETs), which release myeloperoxidase-DNA (MPO-DNA) complexes into the circulation. Although standard laboratory markers like complement proteins (C3, C4) and anti-dsDNA antibodies are routinely used, they often show inconsistent sensitivity in monitoring disease activity and flare-ups. The primary purpose of this observational study is to evaluate serum MPO-DNA complexes as a circulating biomarker of NET formation in patients with systemic lupus erythematosus. The study aims to: * Measure serum MPO-DNA complex levels in active SLE patients compared to age- and sex-matched inactive SLE controls. * Assess the correlation between MPO-DNA complex levels and clinical disease activity measured by the SLE Disease Activity Index 2000 (SLEDAI-2K) score. * Evaluate the diagnostic accuracy of MPO-DNA complexes compared to conventional inflammatory and immunological markers (ESR, CRP, C3, C4, and anti-dsDNA). Participants will undergo routine clinical assessments and standard blood sampling to measure routine laboratory parameters and circulating MPO-DNA complex levels via enzyme-linked immunosorbent assay (ELISA). | Lupus | À vérifier | Immunomodulation | À vérifier |
Essais cliniques
18| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Serum MPO-DNA Complexes as a Biomarker of Disease Activity in Systemic Lupus Erythematosus | Lupus | À vérifier | NCT07805863 | Serum MPO-DNA Complexes as a Biomarker of Disease Activity in Systemic Lupus Erythematosus | NOT_YET_RECRUITING |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients | Lupus | À vérifier | NCT07810569 | Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients | NOT_YET_RECRUITING |
| Multimodal Biomarkers in Individual With Cognitive Impairment and Dementia | Alzheimer | À vérifier | NCT07812480 | Multimodal Biomarkers in Individual With Cognitive Impairment and Dementia | NOT_YET_RECRUITING |
| CPR_AUCR2026 — Cerebroplacental Ratio (CPR) and Amniotic-Umbilical-to-Cerebral Ratio (AUCR), in in Women With Hypertensive Disorders of Pregnancy. | Hypertension | À vérifier | NCT07795320 | CPR_AUCR2026 — Cerebroplacental Ratio (CPR) and Amniotic-Umbilical-to-Cerebral Ratio (AUCR), in in Women With Hypertensive Disorders of Pregnancy. | NOT_YET_RECRUITING |
| Ultrasound-guided pulsed radiofrequency (PRF) | Migraine | Phase 4 | NCT07780136 | Comparison of the Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine | NOT_YET_RECRUITING |
| Non Invasive Assessment of Subclinical Atherosclerosis and Cardiovascular Risk Using TYG Index in Lupus Nephritis | Lupus | À vérifier | NCT07719322 | Non Invasive Assessment of Subclinical Atherosclerosis and Cardiovascular Risk Using TYG Index in Lupus Nephritis | NOT_YET_RECRUITING |
| Neutrophil Extracellular Traps and Lupus Nephritis | Lupus | À vérifier | NCT07721857 | Neutrophil Extracellular Traps and Lupus Nephritis | NOT_YET_RECRUITING |
| Optical coherence tomography (OCT) | Migraine | À vérifier | NCT05332431 | Optical Coherence Tomography Findings in Migraine | UNKNOWN |
| greater occipital nerve block | Migraine | Non applicable | NCT06243874 | Comparison of Occipital Nerve and Sphenopalatine Ganglion Blockade | COMPLETED |
| Clinical Utility of Serum Ribonuclease 1(RNASE1) as a Biomarker of Lupus Nephritis. | Lupus | À vérifier | NCT07763821 | Clinical Utility of Serum Ribonuclease 1(RNASE1) as a Biomarker of Lupus Nephritis. | NOT_YET_RECRUITING |
| ketamine infusion | Migraine | Phase 1 | NCT06935552 | Ketamine and Lidocaine Infusion in Refractory Chronic Migraine | NOT_YET_RECRUITING |
| greater occipital nerve block | Migraine | Phase 4 | NCT07763678 | Efficacy of Ultrasound-Guided Combined Greater Occipital Nerve Block and Greater Auricular Nerve Block Versus Greater Occipital Nerve Block Alone in the Management of Chronic Migraine | NOT_YET_RECRUITING |
| RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple Sclerosis | SEP | À vérifier | NCT07762040 | RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple Sclerosis | NOT_YET_RECRUITING |
| OnabotulinumtoxinA | Migraine | Non applicable | NCT07535723 | Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine | NOT_YET_RECRUITING |
| The Role Of Vestibular Rehabilitation Therapy In Management Of Vestibular Migraine Patients | Migraine | À vérifier | NCT05508139 | The Role Of Vestibular Rehabilitation Therapy In Management Of Vestibular Migraine Patients | UNKNOWN |
| Evaluation of Slit2 in Systemic Lupus Erythematosus and Systemic Sclerosis Patients | Lupus | À vérifier | NCT05105217 | Evaluation of Slit2 in Systemic Lupus Erythematosus and Systemic Sclerosis Patients | UNKNOWN |
| Assessment of Blood Indices in Systemic Lupus Erythematosus | Lupus | À vérifier | NCT06872086 | Assessment of Blood Indices in Systemic Lupus Erythematosus | NOT_YET_RECRUITING |
| cortical resections | Épilepsie | À vérifier | NCT04553354 | Cortical Resections in Drug Resistant Epilepsy | UNKNOWN |
Publications
27| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Dextrose 5% in water | Management of Recurrent Laryngeal Nerve Injury During Radiofrequency Ablation of Thyroid Nodules. | AACE clinical case reports | ||
| Dextrose 5% in water | Enteral free water vs. parenteral dextrose 5% in water for the treatment of hypernatremia in the intensive care unit: a retrospective cohort study from a mixed ICU. | Journal of anesthesia | ||
| Dextrose 5% in water | Contribution of intravenous medication diluent fluid composition on the development of dyschloremia in intensive care unit patients: A retrospective chart review. | SAGE open medicine | ||
| Lidocaine Intravenous Infusion | Evaluation of continuous intravenous lidocaine on brain relaxation, intraoperative opioid consumption, and surgeon's satisfaction in adult patients undergoing craniotomy tumor surgery: A randomized controlled trial. | Medicine | ||
| Lidocaine Intravenous Infusion | Could an intraoperative lidocaine intravenous infusion enhance patient recovery after functional endoscopic sinus surgery? | Minerva anestesiologica | ||
| Lidocaine Intravenous Infusion | Early Postoperative Analgesic Evaluation of Intravenous Lidocaine Infusion or a Combination of Intraperitoneal and Incisional Lidocaine Splash in Female Dogs Undergoing Ovariohysterectomy. | Veterinary sciences | ||
| Greater Auricular Nerve Block | Ultrasound-Guided Greater Auricular Nerve Block: A Pilot Study for Pain Management in Post-Auricular Injection. | Aesthetic plastic surgery | ||
| greater occipital nerve block | Peripheral nerve blocks in primary headaches and neuralgias: a six-country multicenter real-world study. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | ||
| greater occipital nerve block | Efficacy of Greater Occipital Nerve Block versus Sphenopalatine Ganglion Block for the Treatment of Postdural Puncture Headache after Spinal Anesthesia: A Randomized Clinical Trial. | Annals of African medicine | ||
| cortical resections | Spike-induced cytoarchitectonic changes in epileptic human cortex are reduced via MAP2K inhibition. | Brain communications | ||
| Assessment of Blood Indices in Systemic Lupus Erythematosus | Metabolic Syndrome and Its Correlates in Systemic Lupus Erythematosus Patients: A Hidden Clinical Challenge. | Annals of African medicine | ||
| RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple Sclerosis | Cognition beyond relapses: cognitive progression independent of relapse activity reflects early smoldering neurodegeneration in multiple sclerosis. | Multiple sclerosis and related disorders | ||
| Assessment of Blood Indices in Systemic Lupus Erythematosus | Galectin-3 in systemic lupus erythematosus: a meta-analysis. | Immunologic research | ||
| Assessment of Blood Indices in Systemic Lupus Erythematosus | Hormone levels of female patients with SLE after anti-CD19 CAR T-cell treatment do not indicate a signal of impaired ovarian reserve. | Rheumatology (Oxford, England) | ||
| OnabotulinumtoxinA | Botulinum Neurotoxin Treatment of Camptocormia- A Critical Review and Update. | Tremor and other hyperkinetic movements (New York, N.Y.) | ||
| OnabotulinumtoxinA | Health-Related Quality of Life Following Botulinum Toxin for Retrograde Cricopharyngeus Dysfunction. | The Laryngoscope | ||
| RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple Sclerosis | Longitudinal changes in serum protein levels are associated with disability progression in multiple sclerosis. | Multiple sclerosis and related disorders | ||
| RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple Sclerosis | Comorbidities for Predicting Progression Independent of Relapse Activity in Multiple Sclerosis Treated With B-Cell Depletion. | European journal of neurology | ||
| OnabotulinumtoxinA | Metoclopramide-Induced Hyperprolactinemia Mimicking Prolactinoma in a Young Woman Receiving Fragmented Care: A Case Report. | Cureus | ||
| The Role Of Vestibular Rehabilitation Therapy In Management Of Vestibular Migraine Patients | The effect of vestibular rehabilitation in the management of vestibular migraine in adults: A systematic review and meta-analysis. | Headache | ||
| The Role Of Vestibular Rehabilitation Therapy In Management Of Vestibular Migraine Patients | Normative Data for a Multi-Domain Concussion Assessment in the Female Community Sport of Ladies Gaelic Football. | Sports (Basel, Switzerland) | ||
| Assessment of Blood Indices in Systemic Lupus Erythematosus | Derived inflammatory indicators for identifying preeclampsia in pregnant patients with systemic lupus erythematosus: a case-control study. | BMC pregnancy and childbirth | ||
| Assessment of Blood Indices in Systemic Lupus Erythematosus | Integrated immune profiling identifies a coordinated T-cell activation and inflammatory signature in SLE. | Lupus science & medicine | ||
| Assessment of Blood Indices in Systemic Lupus Erythematosus | Gender-Based Differences in Clinical, Immunological and Disease Activity Profiles of Systemic Lupus Erythematosus Patients in Bangladesh. | Mymensingh medical journal : MMJ | ||
| Assessment of Blood Indices in Systemic Lupus Erythematosus | Peripheral blood immunoglobulin A level is independently negatively correlated with renal involvement in newly diagnosed childhood systemic lupus erythematosus: a single-center cross-sectional study based on 380 pediatric lupus nephritis patients in southwest China. | Clinical rheumatology | ||
| cortical resections | Hemispheric functional organization, as revealed by naturalistic neuroimaging, in pediatric epilepsy patients with cortical resections. | Proceedings of the National Academy of Sciences of the United States of America | ||
| cortical resections | Case Report: Focal, generalized, or both: does generalized network involvement preclude successful epilepsy surgery? | Frontiers in network physiology |