Fiche traitement
CBD
University of Calgary • Alzheimer, SEP
Suivi actif
Phase 2
Résumé
CBD est développé par University of Calgary. Le traitement est actuellement en Phase 2. Il est associé à Alzheimer, SEP. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
À vérifier
Phase 2
University of Calgary
Canada
CALM-IT is a Randomized, double-blind, placebo-controlled cross-over clinical trial. Safety and efficacy of cannabidiol (CBD) capsules assessed for managing agitation in patients with AD and to identify novel biomarkers of agitation severity and treatment response.
2026-09-02
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Phase 2
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
À vérifier
Confiance automatique : 0%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-09-02
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeStatut inconnu
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréePhase 2
Études associées1
Publications associées27
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
31 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2023-09-27 | Début de l’étudeNCT06014424 | Registre d’essai clinique |
| 2026-07-08 | PublicationLong-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-Year Retrospective Analysis of Prospectively Collected Patient-Reported Outcomes in 241 Treatment-Refractory Patients. | Biomedicines |
| 2026-07-12 | PublicationRGD-functionalized cannabidiol lipid nanoparticles improve brain delivery and alleviate cognitive and metabolic dysfunction via gut-brain axis modulation in an Alzheimer's disease model. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie |
| 2026-07-14 | PublicationA young pregnant woman with oesophageal cancer who responded to carboplatin plus nab-paclitaxel therapy. | Clinical journal of gastroenterology |
| 2026-07-18 | PublicationAge-dependent effects of cannabidiol on cortical hyperexcitability in an experimental model of malformation of cortical development. | Experimental neurology |
| 2026-08-08 | PublicationA multi-centre, tolerability study of a cannabidiol-enriched Cannabis Herbal Extract for chronic headaches in adolescents: The CAN-CHA protocol. | PloS one |
| 2026-08-08 | PublicationCannabidiol to reduce persistent post-surgical pain following total knee arthroplasty: protocol for a multi-centre, randomized, controlled pilot trial. | Pilot and feasibility studies |
| 2026-08-08 | PublicationArtificial Intelligence-enhanced Cannabidiol (CBD) Drug Delivery Systems: Integrating Machine Learning and Nanotechnology for Precision Therapeutic Optimization. | Mini reviews in medicinal chemistry |
| 2026-08-08 | PublicationSynergistic effects of hydropriming and differential gamma radiation on the physiomorphic attributes of L. | International journal of radiation biology |
| 2026-08-08 | Publication[Low Abuse Potential of Plant-Derived Highly Purified Cannabidiol: A Narrative Review]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan |
| 2026-08-08 | PublicationMedical cannabis improved self-reported spasticity rating in patients with chronic spinal cord injury: a placebo-controlled, double-blind, crossover pilot clinical trial. | Therapeutic advances in neurological disorders |
| 2026-08-13 | PublicationCannabidiol attenuates seizure progression and recognition memory deficit induced by hippocampal HCN knockdown in the kindling model of epilepsy in male rats. | Neuropharmacology |
| 2026-08-13 | PublicationEffects of pimavanserin, xanomeline and highly-purified plant-derived cannabidiol on MK-801-induced behaviours in mice relevant to psychosis. | Journal of psychopharmacology (Oxford, England) |
| 2026-08-16 | Création de l’enregistrementNCT06014424 | Registre d’essai clinique |
| 2026-08-16 | PublicationMotor function of the opossum sphincter of Oddi. | The Journal of clinical investigation |
| 2026-08-16 | PublicationMaternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age. | Pharmacology, biochemistry, and behavior |
| 2026-08-16 | PublicationCannabidiol Attenuates Heroin Seeking in Male Rats Associated With Normalization of Discrete Neurobiological Signatures Within the Nucleus Accumbens With Subregional Specificity. | Biological psychiatry |
| 2026-08-16 | PublicationDifferential Pulse Voltammetric Analysis of Cannabidiol on Fluorine-Doped Tin Oxide (FTO) Electrode Interface: Quantification in Pharmaceutical Oil with Assessment of Electrode Surface Stability. | Sensors (Basel, Switzerland) |
| 2026-08-16 | PublicationInvestigation into the oral toxicity profile of TruCBN™. | Toxicology reports |
| 2026-08-16 | PublicationBiosensing technologies for cannabinoid monitoring in pain management: Current methods, clinical needs, and translational challenges. | Journal of pharmaceutical and biomedical analysis |
| 2026-08-16 | PublicationCaregiver-reported outcomes with real-world use of cannabidiol in Lennox-Gastaut syndrome and Dravet syndrome from the BECOME survey. | Epilepsy research |
| 2026-08-16 | PublicationClinically Meaningful Reduction in Drop Seizures in Patients with Lennox-Gastaut Syndrome Treated with Cannabidiol: Post Hoc Analysis of Phase 3 Clinical Trials. | CNS drugs |
| 2026-08-16 | PublicationCannabidiolic acid (CBDA) and CBDA-rich extracts modulatory effects on voltage-dependent NaV1.2 sodium channels. | Phytomedicine : international journal of phytotherapy and phytopharmacology |
| 2026-08-16 | PublicationDevelopment and pharmacokinetic evaluation of a phospholipid complex self-nanoemulsifying drug delivery system (PLC-SNEDDS) for enhanced oral bioavailability of cannabidiol. | Drug delivery |
| 2026-08-16 | PublicationCross-disease genetic and epigenetic architecture of the locus shows convergence in ALS-PSP. | bioRxiv : the preprint server for biology |
| 2026-08-16 | PublicationInsulation-tipped nano knife-assisted primary precut versus conventional cannulation for biliary access: a multicenter randomized trial on efficacy and safety. | Surgical endoscopy |
| 2026-08-16 | PublicationMulti-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. | Cannabis and cannabinoid research |
| 2026-08-16 | PublicationPilot study on cannabis-induced alterations in platelet function: implications for transfusion medicine. | Platelets |
| 2026-09-02 | Dernière mise à jour des donnéesCBD | Biomedical Watch |
| 2026-09-14 | PublicationExploring the caregiver journey through randomized controlled trials in dravet syndrome: insights from a cross-sectional survey. | Epilepsy & behavior : E&B |
| 2026-12-29 | Fin de l’étude prévue / enregistréeNCT06014424 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT06014424 | CALM-IT — Cannabidiol Medication Intervention Trial | Phase 2 | RECRUITING | Canada | Sunnybrook Health Sciences Centre |
Publications liées
27 publication(s)Publications liées
27 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Exploring the caregiver journey through randomized controlled trials in dravet syndrome: insights from a cross-sectional survey. Voir source | 42570405 | 10.1016/j.yebeh.2026.111183 | Epilepsy & behavior : E&B | |
| Motor function of the opossum sphincter of Oddi. Voir source | 6822661 | 10.1172/jci110761 | The Journal of clinical investigation | |
| Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age. Voir source | 39481653 | 10.1016/j.pbb.2024.173902 | Pharmacology, biochemistry, and behavior | |
| Cannabidiol Attenuates Heroin Seeking in Male Rats Associated With Normalization of Discrete Neurobiological Signatures Within the Nucleus Accumbens With Subregional Specificity. Voir source | 40992584 | 10.1016/j.biopsych.2025.08.023 | Biological psychiatry | |
| Differential Pulse Voltammetric Analysis of Cannabidiol on Fluorine-Doped Tin Oxide (FTO) Electrode Interface: Quantification in Pharmaceutical Oil with Assessment of Electrode Surface Stability. Voir source | 42590669 | 10.3390/s26154893 | Sensors (Basel, Switzerland) | |
| Investigation into the oral toxicity profile of TruCBN™. Voir source | 42383225 | 10.1016/j.toxrep.2026.102296 | Toxicology reports | |
| Biosensing technologies for cannabinoid monitoring in pain management: Current methods, clinical needs, and translational challenges. Voir source | 42551182 | 10.1016/j.jpba.2026.117673 | Journal of pharmaceutical and biomedical analysis | |
| Caregiver-reported outcomes with real-world use of cannabidiol in Lennox-Gastaut syndrome and Dravet syndrome from the BECOME survey. Voir source | 38183688 | 10.1016/j.eplepsyres.2023.107280 | Epilepsy research | |
| Clinically Meaningful Reduction in Drop Seizures in Patients with Lennox-Gastaut Syndrome Treated with Cannabidiol: Post Hoc Analysis of Phase 3 Clinical Trials. Voir source | 40775196 | 10.1007/s40263-025-01201-8 | CNS drugs | |
| Cannabidiolic acid (CBDA) and CBDA-rich extracts modulatory effects on voltage-dependent NaV1.2 sodium channels. Voir source | 42419121 | 10.1016/j.phymed.2026.158491 | Phytomedicine : international journal of phytotherapy and phytopharmacology | |
| Development and pharmacokinetic evaluation of a phospholipid complex self-nanoemulsifying drug delivery system (PLC-SNEDDS) for enhanced oral bioavailability of cannabidiol. Voir source | 42487275 | 10.1080/10717544.2026.2702143 | Drug delivery | |
| Cross-disease genetic and epigenetic architecture of the locus shows convergence in ALS-PSP. Voir source | 41929081 | 10.64898/2026.03.25.714147 | bioRxiv : the preprint server for biology | |
| Insulation-tipped nano knife-assisted primary precut versus conventional cannulation for biliary access: a multicenter randomized trial on efficacy and safety. Voir source | 42377513 | 10.1007/s00464-026-12668-x | Surgical endoscopy | |
| Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes. Voir source | 37098174 | 10.1089/can.2022.0331 | Cannabis and cannabinoid research | |
| Pilot study on cannabis-induced alterations in platelet function: implications for transfusion medicine. Voir source | 41870043 | 10.1080/09537104.2026.2644368 | Platelets | |
| Cannabidiol attenuates seizure progression and recognition memory deficit induced by hippocampal HCN knockdown in the kindling model of epilepsy in male rats. Voir source | 42532179 | 10.1016/j.neuropharm.2026.111114 | Neuropharmacology | |
| Effects of pimavanserin, xanomeline and highly-purified plant-derived cannabidiol on MK-801-induced behaviours in mice relevant to psychosis. Voir source | 42345506 | 10.1177/02698811261456216 | Journal of psychopharmacology (Oxford, England) | |
| A multi-centre, tolerability study of a cannabidiol-enriched Cannabis Herbal Extract for chronic headaches in adolescents: The CAN-CHA protocol. Voir source | 39302982 | 10.1371/journal.pone.0290185 | PloS one | |
| Cannabidiol to reduce persistent post-surgical pain following total knee arthroplasty: protocol for a multi-centre, randomized, controlled pilot trial. Voir source | 42032682 | 10.1186/s40814-026-01822-w | Pilot and feasibility studies | |
| Artificial Intelligence-enhanced Cannabidiol (CBD) Drug Delivery Systems: Integrating Machine Learning and Nanotechnology for Precision Therapeutic Optimization. Voir source | 42565409 | 10.2174/0113895575460046260717064840 | Mini reviews in medicinal chemistry | |
| Synergistic effects of hydropriming and differential gamma radiation on the physiomorphic attributes of L. Voir source | 42566292 | 10.1080/09553002.2026.2710766 | International journal of radiation biology | |
| [Low Abuse Potential of Plant-Derived Highly Purified Cannabidiol: A Narrative Review]. Voir source | 40887246 | 10.1248/yakushi.25-00086 | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan | |
| Medical cannabis improved self-reported spasticity rating in patients with chronic spinal cord injury: a placebo-controlled, double-blind, crossover pilot clinical trial. Voir source | 42544174 | 10.1177/17562864261468464 | Therapeutic advances in neurological disorders | |
| Age-dependent effects of cannabidiol on cortical hyperexcitability in an experimental model of malformation of cortical development. Voir source | 42331276 | 10.1016/j.expneurol.2026.115879 | Experimental neurology | |
| A young pregnant woman with oesophageal cancer who responded to carboplatin plus nab-paclitaxel therapy. Voir source | 42440033 | 10.1007/s12328-026-02395-0 | Clinical journal of gastroenterology | |
| RGD-functionalized cannabidiol lipid nanoparticles improve brain delivery and alleviate cognitive and metabolic dysfunction via gut-brain axis modulation in an Alzheimer's disease model. Voir source | 42424917 | 10.1016/j.biopha.2026.119724 | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | |
| Long-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-Year Retrospective Analysis of Prospectively Collected Patient-Reported Outcomes in 241 Treatment-Refractory Patients. Voir source | 42351683 | 10.3390/biomedicines14061255 | Biomedicines |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-09-02
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.