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TMS

Universitat Oberta de Catalunya • SEP

Suivi actif Non applicable

Résumé

TMS est développé par Universitat Oberta de Catalunya. Le traitement est actuellement en Non applicable. Il est associé à SEP. Son objectif thérapeutique principal est Traitement symptomatique. Le statut actuel est : suivi actif.

À vérifier

Traitement symptomatique
Non applicable
Universitat Oberta de Catalunya
Non renseigné
Multiple Sclerosis (MS) is a chronic neurological disease impacting 2.8 million individuals globally, with fatigue being its most debilitating symptom, reported by 75% of patients. Despite its prevalence, the pathophysiology of MS-related fatigue remains poorly understood, and current pharmacological treatments have limited effectiveness. This research addresses this critical gap by investigating two non-invasive brain stimulation (NIBS) techniquestranscranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)as innovative, effective and scalable therapeutic approaches for MS fatigue. The study employs a parallel, randomized, triple-blind, multicentric, sham-controlled design to assess and compare the short- and long-term efficacy of TMS and tDCS in addressing MS-related fatigue. 80 participants will be recruited from multiple centers in Spain and randomly assigned to one of four experimental groups: TMS, tDCS, Sham-TMS, Sham-tDCS. Each intervention will consist of 20 sessions, conducted daily from Monday to Friday, over 4 weeks. The left dorsolateral prefrontal cortex (DLPFC, F3 following the 10/20 system for EEG) was selected as the stimulation site based on its involvement in MS-related self-reported fatigue and in cognitive fatigability. For TMS experimental groups, intermittent theta-burst protocol (iTBS) will be used to increase the cortical excitability of the stimulated area. iTBS delivers a total of 600 pulses, organised into 50 Hz triplets repeated at 5 Hz, with 2second blocks of pulses, interleaved with 8 seconds of rest, repeated 20 times (total duration: 190s). The intensity of stimulation will be individually tailored based on the active motor threshold (aMT), setting it at 80% of the aMT. The sham stimulation will follow the same protocol, but using a sham coil (placebo). For tDCS experimental groups anodal tDCS will be applied (increasing cortical excitability) with the anode over the left DLPFC (F3), and the cathode over the contralateral supraorbital area. The intensity will be 2mA, and the duration of the stimulation will be 20min per session. For tDCS placebo condition, the sham option available on the device will be selected. Primary outcomes include changes in fatigue levels measured through MS validated self-report scales (Modified Fatigue Impact Scale-MFIS; Fatigue Scale for Motor and Cognitive Functions-FSMC); secondary outcomes include depression (Beck Depression Inventory-II, BDI-II), quality of life (Multiple Sclerosis Quality of Life, MSQOL-54), functional independence (Functional Independence Measure, FIM), and cognitive fatigability (Symbol Digit Modalities Test, SDMT). All the outcomes will be assessed at baseline, at the end of the intervention, and six months after the end of the treatment (6 months follow-up). This project promotes personalized precision medicine and innovative new treatment methods. This research is expected to expand scientific knowledge on NIBS efficacy in MS, establish evidence-based clinical practices, and set the foundation for cost-effective, patient-centered therapies. The study also addresses gender-specific responses to treatment, ensuring inclusive therapeutic strategies. Furthermore, it has the potential to benefit other neurological conditions characterized by fatigue, such as stroke, chronic fatigue syndrome or Parkinsons disease, showing significant social, clinical, and economic impact.
2026-09-21

Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique

Non applicable
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé

Objectif scientifique de l’étude

classification automatique vérifiable
Traitement symptomatique Confiance automatique : 95%

Description affichée depuis l’essai compatible NCT07842302, afin d’éviter le mélange entre plusieurs indications d’une même molécule.

Aucune incohérence majeure détectée entre la maladie, l’objectif et la description.

Transparence et qualité de la fiche

données vérifiables
ClassificationCohérente automatiquement
Confiance de la fiche100 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-09-21
Anomalies détectées0
Validation humaineValidation humaine non effectuée
Donnée issue d’une source Donnée normalisée automatiquement Interprétation algorithmique

Classification scientifique multi-axes

ne pas confondre statut et résultat
État de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable

Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.

Indicateurs factuels

sans score subjectif
Phase enregistréeNon applicable
Études associées1
Publications associées45
Statut consolidéSuivi actif

Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.

Historique factuel de la molécule

49 événement(s) daté(s)

Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.

DateÉvénementSource
2026-07-08PublicationHigh-Frequency Repetitive Transcranial Magnetic Stimulation Improves Oxidative Stress, Iron Metabolism, and Synaptic Plasticity in the Visual Cortex of Amblyopic Rats: Association With the NRF2/GPX4 Pathway.Journal of integrative neuroscience
2026-07-08PublicationClosed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.NeuroImage
2026-07-08PublicationEfficacy of non-invasive brain stimulation in Alzheimer's disease: An umbrella review of meta-analyses.Neuroscience and biobehavioral reviews
2026-07-08PublicationContinuous theta burst stimulation to the frontal pole durably decreases medial frontoamygdala connectivity.International review of psychiatry (Abingdon, England)
2026-07-10PublicationBeyond motor symptoms: efficacy of pharmacotherapies on motor, functional, and cognitive domains in Huntington's disease - a systematic review.European journal of pharmacology
2026-07-12PublicationDeterminants of Repetitive Transcranial Magnetic Stimulation Efficacy in Tobacco Use Disorder: A Pre-Registered Study.medRxiv : the preprint server for health sciences
2026-07-14PublicationComparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis.Pain and therapy
2026-07-14PublicationThe Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive-Like Behavior in Mice.Brain and behavior
2026-07-14PublicationPulvinar subdivisions and connectivity patterns across primate species: a comparative perspective.Frontiers in neuroanatomy
2026-07-18PublicationRight‑DLPFC rTMS Transiently Modulates Risky Decision-Making and EEG Oscillatory Activity.Brain and behavior
2026-07-18PublicationHeterogeneous Recruitment Curve Responses to Anodal Transcranial Direct Current Stimulation in Children With Unilateral Spastic Cerebral Palsy.Neurorehabilitation and neural repair
2026-07-23PublicationPersonalized non-invasive combined magnetic and electrical stimulation of the default mode network in mild AD patients (CMES-AD): a multicentric randomized sham-controlled trial protocol.Alzheimer's research & therapy
2026-07-23PublicationMechanisms of open and hidden placebo in stroke recovery: targeting neuroplasticity insights of the placebo effect - study protocol for a controlled, parallel, randomised clinical trial.BMJ open
2026-07-23PublicationComparative efficacy and safety of photobiomodulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation in Alzheimer's disease: a network meta-analysis of randomized controlled trials.Lasers in medical science
2026-08-08Publication[Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health].Der Nervenarzt
2026-08-08PublicationScrew-Thread Needle Mediated In Situ Delivery of Tangeretin@β-Cyclodextrin Sulfated Sodium Salt Complexes for the Therapy of Achilles Tendinitis.ACS applied bio materials
2026-08-08Publication"Additive Effects of Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation on Robotic Therapy for Upper Extremity Recovery After Chronic Ischemic Stroke: A Randomized, Double-Blind, Sham-Controlled Trial".Archives of physical medicine and rehabilitation
2026-08-08PublicationAccelerated DMN-targeted cTBS improves processing speed deficits in schizophrenia.Molecular psychiatry
2026-08-08PublicationTranscranial magnetic stimulation disrupts the inhibitory role of the right inferior frontal gyrus in bilingual language control.Brain and language
2026-08-08PublicationA network-based brain stimulation paradigm for alcohol use disorder with co-occurring major depressive disorder: a mini review targeting the ventral attention network.Frontiers in neurology
2026-08-08PublicationSpatiotemporal Brain Dynamics of Transitive and Intransitive Action Observation.Human brain mapping
2026-08-08PublicationLong-Lasting Changes of Repeated Anodal Transcranial Direct Current Stimulation in Decreasing Chronic Pain in Patients with Multiple Sclerosis: A Case Series.Brain sciences
2026-08-13PublicationSwallowing therapy for dysphagia in acute and subacute stroke.The Cochrane database of systematic reviews
2026-08-13PublicationPotential Epigenetic Mechanisms of High-Frequency rTMS in the Treatment of Major Depression: A Brief Report of Current Evidence.Noro psikiyatri arsivi
2026-08-13PublicationRemotely Supervised Home-Based tDCS in Treatment-Resistant Depression: Feasibility, Effectiveness and EEG Biomarkers of Response.Psychiatry research
2026-08-13PublicationEfficacy and acceptability of noninvasive brain stimulation for treating posttraumatic stress disorder symptoms: A network meta-analysis of randomized controlled trials.Acta psychiatrica Scandinavica
2026-08-13PublicationLow intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2026-08-13PublicationEfficacy of a high-frequency repetitive transcranial magnetic stimulation for craving reduction in adolescents with gaming disorder: a 4-week randomized control trial with 24-week follow-up.European archives of psychiatry and clinical neuroscience
2026-08-13PublicationSpinal cord stimulation for concurrent improvement of consciousness and spasticity following severe traumatic brain injury: a case study.Frontiers in neuroscience
2026-08-13PublicationReal-Time Brain-State-Coupled Corticocortical Paired Associative Stimulation of Cognitive Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience
2026-08-16PublicationThe consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2026-08-16PublicationTreatment of posttraumatic stress disorder (PTSD).Dialogues in clinical neuroscience
2026-08-16PublicationA randomized double-blind sham-controlled preliminary study of a 5-week protocol of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) for gambling disorder in Indonesia.Addictive behaviors reports
2026-08-16PublicationPseudotumoral multiple sclerosis: unveiling its clinical and imaging characteristics.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2026-08-16PublicationNeuroelectrophysiological clinical exploration of reward expectation and sensitivity abnormalities in adolescent melancholic MDD.Journal of affective disorders
2026-08-16PublicationBaseline neurochemical excitability and individual differences in motor learning and non-invasive brain stimulation outcomes.Cortex; a journal devoted to the study of the nervous system and behavior
2026-08-16PublicationEfficacy and durability of therapies for neurogenic lower urinary tract dysfunction: A network meta-analysis of Botulinum Toxin a, instillations, and neuromodulation.Toxicon : official journal of the International Society on Toxinology
2026-08-16PublicationTranscranial Magnetic Stimulation for the Treatment of Chemo Brain.Sensors (Basel, Switzerland)
2026-08-16PublicationEpigenome-wide analysis in West Africans identifies DNA methylation markers for circulating adiponectin.EBioMedicine
2026-08-16PublicationEstablished and emerging neuromodulation for drug-resistant epilepsy.Clinical neurology and neurosurgery
2026-08-16PublicationTMS to preSMA, but not rIFG, impacts strategy use in multi-attribute choice.Neuropsychologia
2026-08-16PublicationReward circuitry predicts the effects of fMRI-guided accelerated prolonged iTBS in treatment-resistant depression.Psychiatry research
2026-08-16PublicationAge-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated.Neurobiology of aging
2026-08-16PublicationMechanisms of taVNS-induced working memory enhancement: a multimodal fNIRS-HRV-MEP study.Cognitive neurodynamics
2026-08-16PublicationTreatment-characteristic brain structural changes in depression: A multi-center longitudinal observational study.Journal of affective disorders
2026-09-01Début de l’étudeNCT07842302Registre d’essai clinique
2026-09-21Dernière mise à jour des donnéesTMSBiomedical Watch
2026-09-27Création de l’enregistrementNCT07842302Registre d’essai clinique
2029-09-01Fin de l’étude prévue / enregistréeNCT07842302Registre d’essai clinique

Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés

1 essai(s)
NCT Titre Phase Statut administratif Pays Sponsor
NCT07842302 NIBS_MSf — Fighting Fatigue in Multiple Sclerosis: TMS vs. tDCS Efficacy. Non applicable NOT_YET_RECRUITING Non communiqué Universitat Oberta de Catalunya

Publications liées

45 publication(s)

Publications liées

45 publication(s)
Titre PMID DOI Journal Date
The consequences of the new European reclassification of non-invasive brain stimulation devices and the medical device regulations pose an existential threat to research and treatment: An invited opinion paper. Voir source 38679530 10.1016/j.clinph.2024.03.039 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Treatment of posttraumatic stress disorder (PTSD). Voir source 42284478 10.1080/19585969.2026.2680838 Dialogues in clinical neuroscience
A randomized double-blind sham-controlled preliminary study of a 5-week protocol of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) for gambling disorder in Indonesia. Voir source 42389422 10.1016/j.abrep.2026.100722 Addictive behaviors reports
Pseudotumoral multiple sclerosis: unveiling its clinical and imaging characteristics. Voir source 42341488 10.1016/j.jocn.2026.112127 Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Neuroelectrophysiological clinical exploration of reward expectation and sensitivity abnormalities in adolescent melancholic MDD. Voir source 42285528 10.1016/j.jad.2026.122128 Journal of affective disorders
Baseline neurochemical excitability and individual differences in motor learning and non-invasive brain stimulation outcomes. Voir source 42263535 10.1016/j.cortex.2026.05.009 Cortex; a journal devoted to the study of the nervous system and behavior
Efficacy and durability of therapies for neurogenic lower urinary tract dysfunction: A network meta-analysis of Botulinum Toxin a, instillations, and neuromodulation. Voir source 42203154 10.1016/j.toxicon.2026.109165 Toxicon : official journal of the International Society on Toxinology
Transcranial Magnetic Stimulation for the Treatment of Chemo Brain. Voir source 37836847 10.3390/s23198017 Sensors (Basel, Switzerland)
Epigenome-wide analysis in West Africans identifies DNA methylation markers for circulating adiponectin. Voir source 41793944 10.1016/j.ebiom.2026.106192 EBioMedicine
Established and emerging neuromodulation for drug-resistant epilepsy. Voir source 42335862 10.1016/j.clineuro.2026.109548 Clinical neurology and neurosurgery
TMS to preSMA, but not rIFG, impacts strategy use in multi-attribute choice. Voir source 42067129 10.1016/j.neuropsychologia.2026.109474 Neuropsychologia
Reward circuitry predicts the effects of fMRI-guided accelerated prolonged iTBS in treatment-resistant depression. Voir source 42537324 10.1016/j.psychres.2026.117349 Psychiatry research
Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated. Voir source 42372614 10.1016/j.neurobiolaging.2026.06.008 Neurobiology of aging
Mechanisms of taVNS-induced working memory enhancement: a multimodal fNIRS-HRV-MEP study. Voir source 42153185 10.1007/s11571-026-10465-9 Cognitive neurodynamics
Treatment-characteristic brain structural changes in depression: A multi-center longitudinal observational study. Voir source 42456821 10.1016/j.jad.2026.122269 Journal of affective disorders
Swallowing therapy for dysphagia in acute and subacute stroke. Voir source 42573047 10.1002/14651858.CD000323.pub4 The Cochrane database of systematic reviews
Potential Epigenetic Mechanisms of High-Frequency rTMS in the Treatment of Major Depression: A Brief Report of Current Evidence. Voir source 42582898 10.29399/npa.29345 Noro psikiyatri arsivi
Remotely Supervised Home-Based tDCS in Treatment-Resistant Depression: Feasibility, Effectiveness and EEG Biomarkers of Response. Voir source 42580014 10.1016/j.psychres.2026.117360 Psychiatry research
Efficacy and acceptability of noninvasive brain stimulation for treating posttraumatic stress disorder symptoms: A network meta-analysis of randomized controlled trials. Voir source 38616056 10.1111/acps.13688 Acta psychiatrica Scandinavica
Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN). Voir source 41622107 10.1016/j.clinph.2025.2111436 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Efficacy of a high-frequency repetitive transcranial magnetic stimulation for craving reduction in adolescents with gaming disorder: a 4-week randomized control trial with 24-week follow-up. Voir source 42572071 10.1007/s00406-026-02343-6 European archives of psychiatry and clinical neuroscience
Spinal cord stimulation for concurrent improvement of consciousness and spasticity following severe traumatic brain injury: a case study. Voir source 42582668 10.3389/fnins.2026.1866882 Frontiers in neuroscience
Real-Time Brain-State-Coupled Corticocortical Paired Associative Stimulation of Cognitive Networks. Voir source 42586792 10.1523/JNEUROSCI.2386-24.2026 The Journal of neuroscience : the official journal of the Society for Neuroscience
[Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health]. Voir source 42554808 10.1007/s00115-026-01999-8 Der Nervenarzt
Screw-Thread Needle Mediated In Situ Delivery of Tangeretin@β-Cyclodextrin Sulfated Sodium Salt Complexes for the Therapy of Achilles Tendinitis. Voir source 42555530 10.1021/acsabm.6c00776 ACS applied bio materials
"Additive Effects of Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation on Robotic Therapy for Upper Extremity Recovery After Chronic Ischemic Stroke: A Randomized, Double-Blind, Sham-Controlled Trial". Voir source 42562200 10.1016/j.apmr.2026.07.026 Archives of physical medicine and rehabilitation
Accelerated DMN-targeted cTBS improves processing speed deficits in schizophrenia. Voir source 42557392 10.1038/s41380-026-03798-8 Molecular psychiatry
Transcranial magnetic stimulation disrupts the inhibitory role of the right inferior frontal gyrus in bilingual language control. Voir source 42561759 10.1016/j.bandl.2026.105818 Brain and language
A network-based brain stimulation paradigm for alcohol use disorder with co-occurring major depressive disorder: a mini review targeting the ventral attention network. Voir source 42564066 10.3389/fneur.2026.1810254 Frontiers in neurology
Spatiotemporal Brain Dynamics of Transitive and Intransitive Action Observation. Voir source 42565289 10.1002/hbm.70623 Human brain mapping
Long-Lasting Changes of Repeated Anodal Transcranial Direct Current Stimulation in Decreasing Chronic Pain in Patients with Multiple Sclerosis: A Case Series. Voir source 42512541 10.3390/brainsci16070767 Brain sciences
Personalized non-invasive combined magnetic and electrical stimulation of the default mode network in mild AD patients (CMES-AD): a multicentric randomized sham-controlled trial protocol. Voir source 42482244 10.1186/s13195-026-02145-x Alzheimer's research & therapy
Mechanisms of open and hidden placebo in stroke recovery: targeting neuroplasticity insights of the placebo effect - study protocol for a controlled, parallel, randomised clinical trial. Voir source 42486522 10.1136/bmjopen-2025-113119 BMJ open
Comparative efficacy and safety of photobiomodulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation in Alzheimer's disease: a network meta-analysis of randomized controlled trials. Voir source 42487022 10.1007/s10103-026-04962-w Lasers in medical science
Right‑DLPFC rTMS Transiently Modulates Risky Decision-Making and EEG Oscillatory Activity. Voir source 42458894 10.1002/brb3.71584 Brain and behavior
Heterogeneous Recruitment Curve Responses to Anodal Transcranial Direct Current Stimulation in Children With Unilateral Spastic Cerebral Palsy. Voir source 42464518 10.1177/15459683261464051 Neurorehabilitation and neural repair
Comparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis. Voir source 42435147 10.1007/s40122-026-00860-9 Pain and therapy
The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive-Like Behavior in Mice. Voir source 42444411 10.1002/brb3.71596 Brain and behavior
Pulvinar subdivisions and connectivity patterns across primate species: a comparative perspective. Voir source 42130669 10.3389/fnana.2026.1794659 Frontiers in neuroanatomy
Determinants of Repetitive Transcranial Magnetic Stimulation Efficacy in Tobacco Use Disorder: A Pre-Registered Study. Voir source 42428110 10.64898/2026.06.23.26356059 medRxiv : the preprint server for health sciences
Beyond motor symptoms: efficacy of pharmacotherapies on motor, functional, and cognitive domains in Huntington's disease - a systematic review. Voir source 42162688 10.1016/j.ejphar.2026.178993 European journal of pharmacology
High-Frequency Repetitive Transcranial Magnetic Stimulation Improves Oxidative Stress, Iron Metabolism, and Synaptic Plasticity in the Visual Cortex of Amblyopic Rats: Association With the NRF2/GPX4 Pathway. Voir source 42411431 10.31083/JIN48602 Journal of integrative neuroscience
Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback. Voir source 42392340 10.1016/j.neuroimage.2026.122102 NeuroImage
Efficacy of non-invasive brain stimulation in Alzheimer's disease: An umbrella review of meta-analyses. Voir source 42398685 10.1016/j.neubiorev.2026.106844 Neuroscience and biobehavioral reviews
Continuous theta burst stimulation to the frontal pole durably decreases medial frontoamygdala connectivity. Voir source 42379239 10.1080/09540261.2026.2687523 International review of psychiatry (Abingdon, England)

Sources officielles

liens de recherche

Dernière mise à jour des données : 2026-09-21

Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.