DBS
University of Minnesota • Parkinson
Résumé
DBS est développé par University of Minnesota. Le traitement est actuellement en Phase 1. Il est associé à Parkinson. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Phase 1
Objectif scientifique de l’étude
classification automatique vérifiableIl mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT07340073, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassification scientifique multi-axes
ne pas confondre statut et résultatUn essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifAucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
56 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2026-07-08 | PublicationComparison of Two Methods of Deep Brain Stimulation Lead Reconstruction and Their Prediction Capacities. | Neuromodulation : journal of the International Neuromodulation Society |
| 2026-07-08 | PublicationBetween Surgery and Science: Patient Journeys in Deep Brain Stimulation Local Field Potential Research. | Neuromodulation : journal of the International Neuromodulation Society |
| 2026-07-14 | PublicationRewiring reward in addiction: a systematic review of human evidence for deep brain stimulation and lesion approaches in substance use disorders. | Acta neurochirurgica |
| 2026-07-14 | PublicationImplanted Devices for Management of Drug-Resistant Epilepsy: Background and MR Imaging Considerations. | Neuroimaging clinics of North America |
| 2026-07-14 | PublicationPulvinar subdivisions and connectivity patterns across primate species: a comparative perspective. | Frontiers in neuroanatomy |
| 2026-07-15 | PublicationStrain-Sensitive Double-Network Organogel With Strong Adhesion for Movement Monitoring. | Macromolecular rapid communications |
| 2026-07-18 | PublicationHuman intracranial signal stability tracks anatomical accuracy after electrode reimplantation. | Journal of neural engineering |
| 2026-07-18 | PublicationTreatment strategies for motor fluctuations in Parkinson's disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America. | Frontiers in pharmacology |
| 2026-07-22 | PublicationGlycosylation penetrance of N-X-S/T sequons in antibody variable domains: a structural survey of 19,265 human antibody structures reassessing the histidine/glutamine suppression hypothesis. | mAbs |
| 2026-07-22 | PublicationLong Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording. | Frontiers in human neuroscience |
| 2026-07-22 | PublicationDeep brain stimulation for the treatment of patients with dystonia: advances towards network-based personalised care. | The Lancet. Neurology |
| 2026-08-08 | PublicationValidation of a Dried Blood Spot (DBS) Liquid Chromatography - High-Resolution Mass Spectrometry (LC-HRMS) workflow for simultaneous identification of emerging opioids. | Forensic science international |
| 2026-08-08 | Publication[Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health]. | Der Nervenarzt |
| 2026-08-08 | PublicationEffects of pulvinar and combined pulvinar/anterior thalamic deep-brain stimulation on sleep: preliminary results. | Journal of neurology |
| 2026-08-08 | PublicationLong-term neuropsychiatric outcomes after neuromodulation in epilepsy patients: a systematic review and meta-analysis. | Acta neurologica Belgica |
| 2026-08-08 | PublicationDeep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia. | Behavioral neuroscience |
| 2026-08-08 | PublicationFull recovery after severe bacterial encephalitis and brain abscess following deep brain stimulation surgery for Parkinson's disease. | Journal of Parkinson's disease |
| 2026-08-08 | PublicationEffect of LRRK2 G2385R Variant on Subthalamic Deep Brain Stimulation Efficacy in Parkinson's Disease in a Han Chinese Population. | Frontiers in neurology |
| 2026-08-08 | PublicationSix-Year Single Centre Experience with Frameless, Fiducial-Less Deep Brain Stimulation in Parkinsons Disease: Accuracy, Outcomes, and Clinical Feasibility. | Stereotactic and functional neurosurgery |
| 2026-08-13 | PublicationRegional gray matter volumes are not predictive of axial symptom response to subthalamic deep brain stimulation in Parkinsonian patients. | Parkinsonism & related disorders |
| 2026-08-13 | PublicationConnectivity-Based Analysis of the Stimulation Effects of Globus Pallidus Interna Deep Brain Stimulation in Parkinson's Disease: A Focus on Freezing of Gait. | Journal of movement disorders |
| 2026-08-13 | PublicationTranscranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease. | Movement disorders : official journal of the Movement Disorder Society |
| 2026-08-13 | PublicationImplantation of Deep Brain Stimulator Through Polyetheretherketone (PEEK) Cranioplasty. | The Journal of craniofacial surgery |
| 2026-08-13 | PublicationDirect Substantia Nigra Deep Brain Stimulation in Parkinson's Disease: Efficacy, Safety, and the Frequency-Response Relationship. | Brain stimulation |
| 2026-08-13 | PublicationNeurostimulation systems for deep brain stimulation: in vitro evaluation of magnetic resonance imaging-related heating at 1.5 tesla. | Journal of magnetic resonance imaging : JMRI |
| 2026-08-13 | PublicationClosing the Loop With Cortical Sensing: The Development of Adaptive Deep Brain Stimulation for Essential Tremor Using the Activa PC+S. | Frontiers in neuroscience |
| 2026-08-16 | PublicationPractice trends and the outcome of neuromodulation therapies in epilepsy: A single-center study. | Epilepsia open |
| 2026-08-16 | PublicationA comprehensive review of deep brain stimulation for drug-resistant epilepsy. | Frontiers in neurology |
| 2026-08-16 | PublicationThalamic neuromodulation for pediatric drug-resistant epilepsy: a case series evaluating deep brain stimulation and responsive neurostimulation. | Journal of neurosurgery. Pediatrics |
| 2026-08-16 | PublicationPulvinar and anterior nucleus of the thalamus dual-network neuromodulation for complex epilepsies. | Epilepsia |
| 2026-08-16 | PublicationDeep brain stimulation of the thalamus for intractable epilepsy (FRANCE study): A randomized clinical trial. | Epilepsia |
| 2026-08-16 | PublicationBed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial. | Cell reports. Medicine |
| 2026-08-16 | PublicationEfficacy and Safety of Bilateral Deep Brain Stimulation (DBS) for Severe Alzheimer's Disease: A Comparative Analysis of Fornix Versus Basal Ganglia of Meynert. | CNS neuroscience & therapeutics |
| 2026-08-16 | PublicationCACNA1C -Related Channelopathy Presenting With Adult-Onset Combined Dystonia-Parkinsonism: A Novel Neurological Presentation. | American journal of medical genetics. Part A |
| 2026-08-16 | PublicationImmune Spatial Organization Predicts Distant Metastasis Risk in Aggressive Localized Prostate Cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research |
| 2026-08-16 | Publication[Central invasive neuromodulation for the treatment of chronic pain : Epidural motor cortex stimulation and deep brain stimulation]. | Schmerz (Berlin, Germany) |
| 2026-08-16 | PublicationSurgical management of super-refractory status epilepticus (SRSE): a structured narrative review with considerations on refractory status epilepticus (RSE). | Epilepsy & behavior : E&B |
| 2026-08-16 | PublicationMotor evoked potentials as markers of internal capsule current spread during deep brain stimulation for Parkinson's disease. | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology |
| 2026-08-16 | PublicationEstablished and emerging neuromodulation for drug-resistant epilepsy. | Clinical neurology and neurosurgery |
| 2026-08-16 | PublicationPostoperative outcomes in patients with dementia undergoing deep brain stimulation: A retrospective matched cohort study. | Clinical neurology and neurosurgery |
| 2026-08-16 | PublicationImplantation of autologous peripheral nerve tissue to the nucleus basalis of Meynert in patients with Parkinson's disease during deep brain stimulation surgery: a 2-year report of safety, feasibility, and clinical response. | Journal of neurosurgery |
| 2026-08-16 | PublicationAn alternative scalp incision for deep brain stimulation surgery: A long term follow-up study. | Clinical neurology and neurosurgery |
| 2026-08-16 | PublicationBasal ganglia neurophysiological markers of non-motor symptoms in Parkinson's disease: A systematic review. | Journal of Parkinson's disease |
| 2026-08-16 | PublicationA technology framework for distributed preoperative planning and medical training in deep brain stimulation. | Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society |
| 2026-09-01 | PublicationQuantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation. | Movement disorders : official journal of the Movement Disorder Society |
| 2026-09-01 | PublicationBilateral subthalamic nucleus deep brain stimulation improves certain aspects of postural control in Parkinson's disease, whereas medication does not. | Movement disorders : official journal of the Movement Disorder Society |
| 2026-09-01 | PublicationBilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy. | Movement disorders : official journal of the Movement Disorder Society |
| 2026-09-11 | PublicationEffects of theta burst stimulation on the Parkinsonian gait disorder and cortical gait-network activity. | Journal of Parkinson's disease |
| 2026-09-11 | PublicationChronic adaptive deep brain stimulation in Parkinson's disease: ADAPT-START findings and programming principles. | NPJ Parkinson's disease |
| 2026-09-11 | Dernière mise à jour des donnéesDBS | Biomedical Watch |
| 2026-09-14 | Création de l’enregistrementNCT07340073 | Registre d’essai clinique |
| 2026-09-14 | PublicationPallidal and subthalamic stimulations modulate inter-hemispheric interaction and asymmetry in Parkinson's disease. | Molecular psychiatry |
| 2026-09-14 | PublicationDifferential Effects of High and Low Frequency Subthalamic Nucleus Deep Brain Stimulation on Force Steadiness in Patients with Parkinson's Disease: An Exploratory Study. | Neurology and therapy |
| 2026-09-14 | PublicationSubthalamic Nucleus Deep Brain Stimulation Enhanced Long-Latency Reflex II in Parkinson's Disease Through Rapid Subthalamic-Cortical Modulation. | Movement disorders : official journal of the Movement Disorder Society |
| 2026-10-10 | Début de l’étudeNCT07340073 | Registre d’essai clinique |
| 2031-07-01 | Fin de l’étude prévue / enregistréeNCT07340073 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT07340073 | CR DBS PD — Coordinated Reset Deep Brain Stimulation for Parkinson's Disease | Phase 1 | NOT_YET_RECRUITING | Non communiqué | University of Minnesota |
Publications liées
52 publication(s)Publications liées
52 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Pallidal and subthalamic stimulations modulate inter-hemispheric interaction and asymmetry in Parkinson's disease. Voir source | 41904270 | 10.1038/s41380-026-03557-9 | Molecular psychiatry | |
| Differential Effects of High and Low Frequency Subthalamic Nucleus Deep Brain Stimulation on Force Steadiness in Patients with Parkinson's Disease: An Exploratory Study. Voir source | 42252378 | 10.1007/s40120-026-00976-2 | Neurology and therapy | |
| Subthalamic Nucleus Deep Brain Stimulation Enhanced Long-Latency Reflex II in Parkinson's Disease Through Rapid Subthalamic-Cortical Modulation. Voir source | 42595494 | 10.1002/mds.70508 | Movement disorders : official journal of the Movement Disorder Society | |
| Effects of theta burst stimulation on the Parkinsonian gait disorder and cortical gait-network activity. Voir source | 40383539 | 10.1177/1877718X251320941 | Journal of Parkinson's disease | |
| Chronic adaptive deep brain stimulation in Parkinson's disease: ADAPT-START findings and programming principles. Voir source | 41741462 | 10.1038/s41531-026-01269-z | NPJ Parkinson's disease | |
| Quantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation. Voir source | 16001401 | 10.1002/mds.20556 | Movement disorders : official journal of the Movement Disorder Society | |
| Bilateral subthalamic nucleus deep brain stimulation improves certain aspects of postural control in Parkinson's disease, whereas medication does not. Voir source | 16671073 | 10.1002/mds.20905 | Movement disorders : official journal of the Movement Disorder Society | |
| Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy. Voir source | 23038611 | 10.1002/mds.25127 | Movement disorders : official journal of the Movement Disorder Society | |
| Practice trends and the outcome of neuromodulation therapies in epilepsy: A single-center study. Voir source | 31440731 | 10.1002/epi4.12345 | Epilepsia open | |
| A comprehensive review of deep brain stimulation for drug-resistant epilepsy. Voir source | 42582085 | 10.3389/fneur.2026.1884342 | Frontiers in neurology | |
| Thalamic neuromodulation for pediatric drug-resistant epilepsy: a case series evaluating deep brain stimulation and responsive neurostimulation. Voir source | 42537226 | 10.3171/2026.3.PEDS25489 | Journal of neurosurgery. Pediatrics | |
| Pulvinar and anterior nucleus of the thalamus dual-network neuromodulation for complex epilepsies. Voir source | 42541350 | 10.1002/epi.70416 | Epilepsia | |
| Deep brain stimulation of the thalamus for intractable epilepsy (FRANCE study): A randomized clinical trial. Voir source | 41902639 | 10.1002/epi.70211 | Epilepsia | |
| Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial. Voir source | 41923626 | 10.1016/j.xcrm.2026.102711 | Cell reports. Medicine | |
| Efficacy and Safety of Bilateral Deep Brain Stimulation (DBS) for Severe Alzheimer's Disease: A Comparative Analysis of Fornix Versus Basal Ganglia of Meynert. Voir source | 40243219 | 10.1111/cns.70285 | CNS neuroscience & therapeutics | |
| CACNA1C -Related Channelopathy Presenting With Adult-Onset Combined Dystonia-Parkinsonism: A Novel Neurological Presentation. Voir source | 41978253 | 10.1002/ajmg.a.70168 | American journal of medical genetics. Part A | |
| Immune Spatial Organization Predicts Distant Metastasis Risk in Aggressive Localized Prostate Cancer. Voir source | 42113020 | 10.1158/1078-0432.CCR-25-4900 | Clinical cancer research : an official journal of the American Association for Cancer Research | |
| [Central invasive neuromodulation for the treatment of chronic pain : Epidural motor cortex stimulation and deep brain stimulation]. Voir source | 42059911 | 10.1007/s00482-026-00942-9 | Schmerz (Berlin, Germany) | |
| Surgical management of super-refractory status epilepticus (SRSE): a structured narrative review with considerations on refractory status epilepticus (RSE). Voir source | 42308793 | 10.1016/j.yebeh.2026.111170 | Epilepsy & behavior : E&B | |
| Motor evoked potentials as markers of internal capsule current spread during deep brain stimulation for Parkinson's disease. Voir source | 42335751 | 10.1016/j.clinph.2026.2111979 | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology | |
| Established and emerging neuromodulation for drug-resistant epilepsy. Voir source | 42335862 | 10.1016/j.clineuro.2026.109548 | Clinical neurology and neurosurgery | |
| Postoperative outcomes in patients with dementia undergoing deep brain stimulation: A retrospective matched cohort study. Voir source | 42537546 | 10.1016/j.clineuro.2026.109600 | Clinical neurology and neurosurgery | |
| Implantation of autologous peripheral nerve tissue to the nucleus basalis of Meynert in patients with Parkinson's disease during deep brain stimulation surgery: a 2-year report of safety, feasibility, and clinical response. Voir source | 42600181 | 10.3171/2026.3.JNS251474 | Journal of neurosurgery | |
| An alternative scalp incision for deep brain stimulation surgery: A long term follow-up study. Voir source | 42190495 | 10.1016/j.clineuro.2026.109510 | Clinical neurology and neurosurgery | |
| Basal ganglia neurophysiological markers of non-motor symptoms in Parkinson's disease: A systematic review. Voir source | 42334335 | 10.1177/1877718X261459224 | Journal of Parkinson's disease | |
| A technology framework for distributed preoperative planning and medical training in deep brain stimulation. Voir source | 40157051 | 10.1016/j.compmedimag.2025.102533 | Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society | |
| Regional gray matter volumes are not predictive of axial symptom response to subthalamic deep brain stimulation in Parkinsonian patients. Voir source | 39546883 | 10.1016/j.parkreldis.2024.107193 | Parkinsonism & related disorders | |
| Connectivity-Based Analysis of the Stimulation Effects of Globus Pallidus Interna Deep Brain Stimulation in Parkinson's Disease: A Focus on Freezing of Gait. Voir source | 40738500 | 10.14802/jmd.25005 | Journal of movement disorders | |
| Transcranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease. Voir source | 39133053 | 10.1002/mds.29967 | Movement disorders : official journal of the Movement Disorder Society | |
| Implantation of Deep Brain Stimulator Through Polyetheretherketone (PEEK) Cranioplasty. Voir source | 42584182 | 10.1097/SCS.0000000000013255 | The Journal of craniofacial surgery | |
| Direct Substantia Nigra Deep Brain Stimulation in Parkinson's Disease: Efficacy, Safety, and the Frequency-Response Relationship. Voir source | 42586498 | 10.1016/j.brs.2026.103186 | Brain stimulation | |
| Neurostimulation systems for deep brain stimulation: in vitro evaluation of magnetic resonance imaging-related heating at 1.5 tesla. Voir source | 11891968 | 10.1002/jmri.10069 | Journal of magnetic resonance imaging : JMRI | |
| Closing the Loop With Cortical Sensing: The Development of Adaptive Deep Brain Stimulation for Essential Tremor Using the Activa PC+S. Voir source | 34955714 | 10.3389/fnins.2021.749705 | Frontiers in neuroscience | |
| Validation of a Dried Blood Spot (DBS) Liquid Chromatography - High-Resolution Mass Spectrometry (LC-HRMS) workflow for simultaneous identification of emerging opioids. Voir source | 42561820 | 10.1016/j.forsciint.2026.113094 | Forensic science international | |
| [Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health]. Voir source | 42554808 | 10.1007/s00115-026-01999-8 | Der Nervenarzt | |
| Effects of pulvinar and combined pulvinar/anterior thalamic deep-brain stimulation on sleep: preliminary results. Voir source | 42493672 | 10.1007/s00415-026-14012-8 | Journal of neurology | |
| Long-term neuropsychiatric outcomes after neuromodulation in epilepsy patients: a systematic review and meta-analysis. Voir source | 42530840 | 10.1007/s13760-026-03113-w | Acta neurologica Belgica | |
| Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia. Voir source | 40489147 | 10.1037/bne0000625 | Behavioral neuroscience | |
| Full recovery after severe bacterial encephalitis and brain abscess following deep brain stimulation surgery for Parkinson's disease. Voir source | 42530887 | 10.1177/1877718X261470302 | Journal of Parkinson's disease | |
| Effect of LRRK2 G2385R Variant on Subthalamic Deep Brain Stimulation Efficacy in Parkinson's Disease in a Han Chinese Population. Voir source | 31824408 | 10.3389/fneur.2019.01231 | Frontiers in neurology | |
| Six-Year Single Centre Experience with Frameless, Fiducial-Less Deep Brain Stimulation in Parkinsons Disease: Accuracy, Outcomes, and Clinical Feasibility. Voir source | 42525602 | 10.1159/000552756 | Stereotactic and functional neurosurgery | |
| Glycosylation penetrance of N-X-S/T sequons in antibody variable domains: a structural survey of 19,265 human antibody structures reassessing the histidine/glutamine suppression hypothesis. Voir source | 42482306 | 10.1080/19420862.2026.2703349 | mAbs | |
| Long Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording. Voir source | 35754768 | 10.3389/fnhum.2022.916627 | Frontiers in human neuroscience | |
| Deep brain stimulation for the treatment of patients with dystonia: advances towards network-based personalised care. Voir source | 42456686 | 10.1016/S1474-4422(26)00192-4 | The Lancet. Neurology | |
| Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation. Voir source | 42330982 | 10.1088/1741-2552/ae805e | Journal of neural engineering | |
| Treatment strategies for motor fluctuations in Parkinson's disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America. Voir source | 41415581 | 10.3389/fphar.2025.1725248 | Frontiers in pharmacology | |
| Strain-Sensitive Double-Network Organogel With Strong Adhesion for Movement Monitoring. Voir source | 42448635 | 10.1002/marc.70366 | Macromolecular rapid communications | |
| Rewiring reward in addiction: a systematic review of human evidence for deep brain stimulation and lesion approaches in substance use disorders. Voir source | 42446584 | 10.1007/s00701-026-06979-0 | Acta neurochirurgica | |
| Implanted Devices for Management of Drug-Resistant Epilepsy: Background and MR Imaging Considerations. Voir source | 41932786 | 10.1016/j.nic.2025.11.005 | Neuroimaging clinics of North America | |
| Pulvinar subdivisions and connectivity patterns across primate species: a comparative perspective. Voir source | 42130669 | 10.3389/fnana.2026.1794659 | Frontiers in neuroanatomy | |
| Comparison of Two Methods of Deep Brain Stimulation Lead Reconstruction and Their Prediction Capacities. Voir source | 40539948 | 10.1016/j.neurom.2025.04.013 | Neuromodulation : journal of the International Neuromodulation Society | |
| Between Surgery and Science: Patient Journeys in Deep Brain Stimulation Local Field Potential Research. Voir source | 41910515 | 10.1016/j.neurom.2026.03.002 | Neuromodulation : journal of the International Neuromodulation Society |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-09-11
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.