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DBS

University of Minnesota Parkinson

Suivi actif Phase 1

Résumé

DBS est développé par University of Minnesota. Le traitement est actuellement en Phase 1. Il est associé à Parkinson. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.

À vérifier

À vérifier
Phase 1
University of Minnesota
Non renseigné
Deep brain stimulation (DBS) is a surgical implant procedure for the treatment of Parkinson's Disease (PD) utilizing medical devices approved by the FDA. A novel approach to current DBS approaches is called "Coordinated Reset" DBS (CR-DBS) which uses different patterns of stimulation at lower currents and can address the limitations of traditional DBS (T-DBS) that uses continuous high amplitude and high frequency stimulation. This study will evaluate the safety and short-term efficacy of CR-DBS in PD. The results from this study will significantly advance the development of CR-DBS for the treatment of PD. Findings in this study will also provide the rationale for further development of this novel DBS approach for other neurological and psychiatric disorders.
2026-09-11

Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique

Phase 1
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé

Objectif scientifique de l’étude

classification automatique vérifiable
À vérifier Confiance automatique : 0%

Description affichée depuis l’essai compatible NCT07340073, afin d’éviter le mélange entre plusieurs indications d’une même molécule.

Contrôle de cohérence : 85/100

L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.

Transparence et qualité de la fiche

données vérifiables
ClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-09-11
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source Donnée normalisée automatiquement Interprétation algorithmique

Classification scientifique multi-axes

ne pas confondre statut et résultat
État de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable

Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.

Indicateurs factuels

sans score subjectif
Phase enregistréePhase 1
Études associées1
Publications associées52
Statut consolidéSuivi actif

Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.

Historique factuel de la molécule

56 événement(s) daté(s)

Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.

DateÉvénementSource
2026-07-08PublicationComparison of Two Methods of Deep Brain Stimulation Lead Reconstruction and Their Prediction Capacities.Neuromodulation : journal of the International Neuromodulation Society
2026-07-08PublicationBetween Surgery and Science: Patient Journeys in Deep Brain Stimulation Local Field Potential Research.Neuromodulation : journal of the International Neuromodulation Society
2026-07-14PublicationRewiring reward in addiction: a systematic review of human evidence for deep brain stimulation and lesion approaches in substance use disorders.Acta neurochirurgica
2026-07-14PublicationImplanted Devices for Management of Drug-Resistant Epilepsy: Background and MR Imaging Considerations.Neuroimaging clinics of North America
2026-07-14PublicationPulvinar subdivisions and connectivity patterns across primate species: a comparative perspective.Frontiers in neuroanatomy
2026-07-15PublicationStrain-Sensitive Double-Network Organogel With Strong Adhesion for Movement Monitoring.Macromolecular rapid communications
2026-07-18PublicationHuman intracranial signal stability tracks anatomical accuracy after electrode reimplantation.Journal of neural engineering
2026-07-18PublicationTreatment strategies for motor fluctuations in Parkinson's disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America.Frontiers in pharmacology
2026-07-22PublicationGlycosylation penetrance of N-X-S/T sequons in antibody variable domains: a structural survey of 19,265 human antibody structures reassessing the histidine/glutamine suppression hypothesis.mAbs
2026-07-22PublicationLong Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording.Frontiers in human neuroscience
2026-07-22PublicationDeep brain stimulation for the treatment of patients with dystonia: advances towards network-based personalised care.The Lancet. Neurology
2026-08-08PublicationValidation of a Dried Blood Spot (DBS) Liquid Chromatography - High-Resolution Mass Spectrometry (LC-HRMS) workflow for simultaneous identification of emerging opioids.Forensic science international
2026-08-08Publication[Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health].Der Nervenarzt
2026-08-08PublicationEffects of pulvinar and combined pulvinar/anterior thalamic deep-brain stimulation on sleep: preliminary results.Journal of neurology
2026-08-08PublicationLong-term neuropsychiatric outcomes after neuromodulation in epilepsy patients: a systematic review and meta-analysis.Acta neurologica Belgica
2026-08-08PublicationDeep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia.Behavioral neuroscience
2026-08-08PublicationFull recovery after severe bacterial encephalitis and brain abscess following deep brain stimulation surgery for Parkinson's disease.Journal of Parkinson's disease
2026-08-08PublicationEffect of LRRK2 G2385R Variant on Subthalamic Deep Brain Stimulation Efficacy in Parkinson's Disease in a Han Chinese Population.Frontiers in neurology
2026-08-08PublicationSix-Year Single Centre Experience with Frameless, Fiducial-Less Deep Brain Stimulation in Parkinsons Disease: Accuracy, Outcomes, and Clinical Feasibility.Stereotactic and functional neurosurgery
2026-08-13PublicationRegional gray matter volumes are not predictive of axial symptom response to subthalamic deep brain stimulation in Parkinsonian patients.Parkinsonism & related disorders
2026-08-13PublicationConnectivity-Based Analysis of the Stimulation Effects of Globus Pallidus Interna Deep Brain Stimulation in Parkinson's Disease: A Focus on Freezing of Gait.Journal of movement disorders
2026-08-13PublicationTranscranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society
2026-08-13PublicationImplantation of Deep Brain Stimulator Through Polyetheretherketone (PEEK) Cranioplasty.The Journal of craniofacial surgery
2026-08-13PublicationDirect Substantia Nigra Deep Brain Stimulation in Parkinson's Disease: Efficacy, Safety, and the Frequency-Response Relationship.Brain stimulation
2026-08-13PublicationNeurostimulation systems for deep brain stimulation: in vitro evaluation of magnetic resonance imaging-related heating at 1.5 tesla.Journal of magnetic resonance imaging : JMRI
2026-08-13PublicationClosing the Loop With Cortical Sensing: The Development of Adaptive Deep Brain Stimulation for Essential Tremor Using the Activa PC+S.Frontiers in neuroscience
2026-08-16PublicationPractice trends and the outcome of neuromodulation therapies in epilepsy: A single-center study.Epilepsia open
2026-08-16PublicationA comprehensive review of deep brain stimulation for drug-resistant epilepsy.Frontiers in neurology
2026-08-16PublicationThalamic neuromodulation for pediatric drug-resistant epilepsy: a case series evaluating deep brain stimulation and responsive neurostimulation.Journal of neurosurgery. Pediatrics
2026-08-16PublicationPulvinar and anterior nucleus of the thalamus dual-network neuromodulation for complex epilepsies.Epilepsia
2026-08-16PublicationDeep brain stimulation of the thalamus for intractable epilepsy (FRANCE study): A randomized clinical trial.Epilepsia
2026-08-16PublicationBed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.Cell reports. Medicine
2026-08-16PublicationEfficacy and Safety of Bilateral Deep Brain Stimulation (DBS) for Severe Alzheimer's Disease: A Comparative Analysis of Fornix Versus Basal Ganglia of Meynert.CNS neuroscience & therapeutics
2026-08-16PublicationCACNA1C -Related Channelopathy Presenting With Adult-Onset Combined Dystonia-Parkinsonism: A Novel Neurological Presentation.American journal of medical genetics. Part A
2026-08-16PublicationImmune Spatial Organization Predicts Distant Metastasis Risk in Aggressive Localized Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research
2026-08-16Publication[Central invasive neuromodulation for the treatment of chronic pain : Epidural motor cortex stimulation and deep brain stimulation].Schmerz (Berlin, Germany)
2026-08-16PublicationSurgical management of super-refractory status epilepticus (SRSE): a structured narrative review with considerations on refractory status epilepticus (RSE).Epilepsy & behavior : E&B
2026-08-16PublicationMotor evoked potentials as markers of internal capsule current spread during deep brain stimulation for Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2026-08-16PublicationEstablished and emerging neuromodulation for drug-resistant epilepsy.Clinical neurology and neurosurgery
2026-08-16PublicationPostoperative outcomes in patients with dementia undergoing deep brain stimulation: A retrospective matched cohort study.Clinical neurology and neurosurgery
2026-08-16PublicationImplantation of autologous peripheral nerve tissue to the nucleus basalis of Meynert in patients with Parkinson's disease during deep brain stimulation surgery: a 2-year report of safety, feasibility, and clinical response.Journal of neurosurgery
2026-08-16PublicationAn alternative scalp incision for deep brain stimulation surgery: A long term follow-up study.Clinical neurology and neurosurgery
2026-08-16PublicationBasal ganglia neurophysiological markers of non-motor symptoms in Parkinson's disease: A systematic review.Journal of Parkinson's disease
2026-08-16PublicationA technology framework for distributed preoperative planning and medical training in deep brain stimulation.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
2026-09-01PublicationQuantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation.Movement disorders : official journal of the Movement Disorder Society
2026-09-01PublicationBilateral subthalamic nucleus deep brain stimulation improves certain aspects of postural control in Parkinson's disease, whereas medication does not.Movement disorders : official journal of the Movement Disorder Society
2026-09-01PublicationBilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy.Movement disorders : official journal of the Movement Disorder Society
2026-09-11PublicationEffects of theta burst stimulation on the Parkinsonian gait disorder and cortical gait-network activity.Journal of Parkinson's disease
2026-09-11PublicationChronic adaptive deep brain stimulation in Parkinson's disease: ADAPT-START findings and programming principles.NPJ Parkinson's disease
2026-09-11Dernière mise à jour des donnéesDBSBiomedical Watch
2026-09-14Création de l’enregistrementNCT07340073Registre d’essai clinique
2026-09-14PublicationPallidal and subthalamic stimulations modulate inter-hemispheric interaction and asymmetry in Parkinson's disease.Molecular psychiatry
2026-09-14PublicationDifferential Effects of High and Low Frequency Subthalamic Nucleus Deep Brain Stimulation on Force Steadiness in Patients with Parkinson's Disease: An Exploratory Study.Neurology and therapy
2026-09-14PublicationSubthalamic Nucleus Deep Brain Stimulation Enhanced Long-Latency Reflex II in Parkinson's Disease Through Rapid Subthalamic-Cortical Modulation.Movement disorders : official journal of the Movement Disorder Society
2026-10-10Début de l’étudeNCT07340073Registre d’essai clinique
2031-07-01Fin de l’étude prévue / enregistréeNCT07340073Registre d’essai clinique

Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés

1 essai(s)
NCT Titre Phase Statut administratif Pays Sponsor
NCT07340073 CR DBS PD — Coordinated Reset Deep Brain Stimulation for Parkinson's Disease Phase 1 NOT_YET_RECRUITING Non communiqué University of Minnesota

Publications liées

52 publication(s)

Publications liées

52 publication(s)
Titre PMID DOI Journal Date
Pallidal and subthalamic stimulations modulate inter-hemispheric interaction and asymmetry in Parkinson's disease. Voir source 41904270 10.1038/s41380-026-03557-9 Molecular psychiatry
Differential Effects of High and Low Frequency Subthalamic Nucleus Deep Brain Stimulation on Force Steadiness in Patients with Parkinson's Disease: An Exploratory Study. Voir source 42252378 10.1007/s40120-026-00976-2 Neurology and therapy
Subthalamic Nucleus Deep Brain Stimulation Enhanced Long-Latency Reflex II in Parkinson's Disease Through Rapid Subthalamic-Cortical Modulation. Voir source 42595494 10.1002/mds.70508 Movement disorders : official journal of the Movement Disorder Society
Effects of theta burst stimulation on the Parkinsonian gait disorder and cortical gait-network activity. Voir source 40383539 10.1177/1877718X251320941 Journal of Parkinson's disease
Chronic adaptive deep brain stimulation in Parkinson's disease: ADAPT-START findings and programming principles. Voir source 41741462 10.1038/s41531-026-01269-z NPJ Parkinson's disease
Quantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation. Voir source 16001401 10.1002/mds.20556 Movement disorders : official journal of the Movement Disorder Society
Bilateral subthalamic nucleus deep brain stimulation improves certain aspects of postural control in Parkinson's disease, whereas medication does not. Voir source 16671073 10.1002/mds.20905 Movement disorders : official journal of the Movement Disorder Society
Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy. Voir source 23038611 10.1002/mds.25127 Movement disorders : official journal of the Movement Disorder Society
Practice trends and the outcome of neuromodulation therapies in epilepsy: A single-center study. Voir source 31440731 10.1002/epi4.12345 Epilepsia open
A comprehensive review of deep brain stimulation for drug-resistant epilepsy. Voir source 42582085 10.3389/fneur.2026.1884342 Frontiers in neurology
Thalamic neuromodulation for pediatric drug-resistant epilepsy: a case series evaluating deep brain stimulation and responsive neurostimulation. Voir source 42537226 10.3171/2026.3.PEDS25489 Journal of neurosurgery. Pediatrics
Pulvinar and anterior nucleus of the thalamus dual-network neuromodulation for complex epilepsies. Voir source 42541350 10.1002/epi.70416 Epilepsia
Deep brain stimulation of the thalamus for intractable epilepsy (FRANCE study): A randomized clinical trial. Voir source 41902639 10.1002/epi.70211 Epilepsia
Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial. Voir source 41923626 10.1016/j.xcrm.2026.102711 Cell reports. Medicine
Efficacy and Safety of Bilateral Deep Brain Stimulation (DBS) for Severe Alzheimer's Disease: A Comparative Analysis of Fornix Versus Basal Ganglia of Meynert. Voir source 40243219 10.1111/cns.70285 CNS neuroscience & therapeutics
CACNA1C -Related Channelopathy Presenting With Adult-Onset Combined Dystonia-Parkinsonism: A Novel Neurological Presentation. Voir source 41978253 10.1002/ajmg.a.70168 American journal of medical genetics. Part A
Immune Spatial Organization Predicts Distant Metastasis Risk in Aggressive Localized Prostate Cancer. Voir source 42113020 10.1158/1078-0432.CCR-25-4900 Clinical cancer research : an official journal of the American Association for Cancer Research
[Central invasive neuromodulation for the treatment of chronic pain : Epidural motor cortex stimulation and deep brain stimulation]. Voir source 42059911 10.1007/s00482-026-00942-9 Schmerz (Berlin, Germany)
Surgical management of super-refractory status epilepticus (SRSE): a structured narrative review with considerations on refractory status epilepticus (RSE). Voir source 42308793 10.1016/j.yebeh.2026.111170 Epilepsy & behavior : E&B
Motor evoked potentials as markers of internal capsule current spread during deep brain stimulation for Parkinson's disease. Voir source 42335751 10.1016/j.clinph.2026.2111979 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Established and emerging neuromodulation for drug-resistant epilepsy. Voir source 42335862 10.1016/j.clineuro.2026.109548 Clinical neurology and neurosurgery
Postoperative outcomes in patients with dementia undergoing deep brain stimulation: A retrospective matched cohort study. Voir source 42537546 10.1016/j.clineuro.2026.109600 Clinical neurology and neurosurgery
Implantation of autologous peripheral nerve tissue to the nucleus basalis of Meynert in patients with Parkinson's disease during deep brain stimulation surgery: a 2-year report of safety, feasibility, and clinical response. Voir source 42600181 10.3171/2026.3.JNS251474 Journal of neurosurgery
An alternative scalp incision for deep brain stimulation surgery: A long term follow-up study. Voir source 42190495 10.1016/j.clineuro.2026.109510 Clinical neurology and neurosurgery
Basal ganglia neurophysiological markers of non-motor symptoms in Parkinson's disease: A systematic review. Voir source 42334335 10.1177/1877718X261459224 Journal of Parkinson's disease
A technology framework for distributed preoperative planning and medical training in deep brain stimulation. Voir source 40157051 10.1016/j.compmedimag.2025.102533 Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Regional gray matter volumes are not predictive of axial symptom response to subthalamic deep brain stimulation in Parkinsonian patients. Voir source 39546883 10.1016/j.parkreldis.2024.107193 Parkinsonism & related disorders
Connectivity-Based Analysis of the Stimulation Effects of Globus Pallidus Interna Deep Brain Stimulation in Parkinson's Disease: A Focus on Freezing of Gait. Voir source 40738500 10.14802/jmd.25005 Journal of movement disorders
Transcranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease. Voir source 39133053 10.1002/mds.29967 Movement disorders : official journal of the Movement Disorder Society
Implantation of Deep Brain Stimulator Through Polyetheretherketone (PEEK) Cranioplasty. Voir source 42584182 10.1097/SCS.0000000000013255 The Journal of craniofacial surgery
Direct Substantia Nigra Deep Brain Stimulation in Parkinson's Disease: Efficacy, Safety, and the Frequency-Response Relationship. Voir source 42586498 10.1016/j.brs.2026.103186 Brain stimulation
Neurostimulation systems for deep brain stimulation: in vitro evaluation of magnetic resonance imaging-related heating at 1.5 tesla. Voir source 11891968 10.1002/jmri.10069 Journal of magnetic resonance imaging : JMRI
Closing the Loop With Cortical Sensing: The Development of Adaptive Deep Brain Stimulation for Essential Tremor Using the Activa PC+S. Voir source 34955714 10.3389/fnins.2021.749705 Frontiers in neuroscience
Validation of a Dried Blood Spot (DBS) Liquid Chromatography - High-Resolution Mass Spectrometry (LC-HRMS) workflow for simultaneous identification of emerging opioids. Voir source 42561820 10.1016/j.forsciint.2026.113094 Forensic science international
[Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health]. Voir source 42554808 10.1007/s00115-026-01999-8 Der Nervenarzt
Effects of pulvinar and combined pulvinar/anterior thalamic deep-brain stimulation on sleep: preliminary results. Voir source 42493672 10.1007/s00415-026-14012-8 Journal of neurology
Long-term neuropsychiatric outcomes after neuromodulation in epilepsy patients: a systematic review and meta-analysis. Voir source 42530840 10.1007/s13760-026-03113-w Acta neurologica Belgica
Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia. Voir source 40489147 10.1037/bne0000625 Behavioral neuroscience
Full recovery after severe bacterial encephalitis and brain abscess following deep brain stimulation surgery for Parkinson's disease. Voir source 42530887 10.1177/1877718X261470302 Journal of Parkinson's disease
Effect of LRRK2 G2385R Variant on Subthalamic Deep Brain Stimulation Efficacy in Parkinson's Disease in a Han Chinese Population. Voir source 31824408 10.3389/fneur.2019.01231 Frontiers in neurology
Six-Year Single Centre Experience with Frameless, Fiducial-Less Deep Brain Stimulation in Parkinsons Disease: Accuracy, Outcomes, and Clinical Feasibility. Voir source 42525602 10.1159/000552756 Stereotactic and functional neurosurgery
Glycosylation penetrance of N-X-S/T sequons in antibody variable domains: a structural survey of 19,265 human antibody structures reassessing the histidine/glutamine suppression hypothesis. Voir source 42482306 10.1080/19420862.2026.2703349 mAbs
Long Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording. Voir source 35754768 10.3389/fnhum.2022.916627 Frontiers in human neuroscience
Deep brain stimulation for the treatment of patients with dystonia: advances towards network-based personalised care. Voir source 42456686 10.1016/S1474-4422(26)00192-4 The Lancet. Neurology
Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation. Voir source 42330982 10.1088/1741-2552/ae805e Journal of neural engineering
Treatment strategies for motor fluctuations in Parkinson's disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America. Voir source 41415581 10.3389/fphar.2025.1725248 Frontiers in pharmacology
Strain-Sensitive Double-Network Organogel With Strong Adhesion for Movement Monitoring. Voir source 42448635 10.1002/marc.70366 Macromolecular rapid communications
Rewiring reward in addiction: a systematic review of human evidence for deep brain stimulation and lesion approaches in substance use disorders. Voir source 42446584 10.1007/s00701-026-06979-0 Acta neurochirurgica
Implanted Devices for Management of Drug-Resistant Epilepsy: Background and MR Imaging Considerations. Voir source 41932786 10.1016/j.nic.2025.11.005 Neuroimaging clinics of North America
Pulvinar subdivisions and connectivity patterns across primate species: a comparative perspective. Voir source 42130669 10.3389/fnana.2026.1794659 Frontiers in neuroanatomy
Comparison of Two Methods of Deep Brain Stimulation Lead Reconstruction and Their Prediction Capacities. Voir source 40539948 10.1016/j.neurom.2025.04.013 Neuromodulation : journal of the International Neuromodulation Society
Between Surgery and Science: Patient Journeys in Deep Brain Stimulation Local Field Potential Research. Voir source 41910515 10.1016/j.neurom.2026.03.002 Neuromodulation : journal of the International Neuromodulation Society

Sources officielles

liens de recherche

Dernière mise à jour des données : 2026-09-11

Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.