Fiche traitement
Aerobic exercise
University of Nevada, Las Vegas • Parkinson
Suivi actif
Non applicable
Résumé
Aerobic exercise est développé par University of Nevada, Las Vegas. Le traitement est actuellement en Non applicable. Il est associé à Parkinson. Son objectif thérapeutique principal est Neuroprotection + Ralentissement de la progression + Immunomodulation. Le statut actuel est : suivi actif.
À vérifier
Neuroprotection + Ralentissement de la progression + Immunomodulation
Non applicable
University of Nevada, Las Vegas
United States
The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a progressive disease, halting or slowing the degeneration is an important research target. Halting or slowing the disease progress is known as neuroprotection. Exercise is an attractive therapeutic treatment for people with PD as it has a lot of multi-systemic benefits, but also there is a lot of evidence to suggest that it helps improve symptoms and slow the progression of the disease. Exercise has been theorized to decrease inflammation and, therefore, has a lot of promise as a neuroprotective agent in slowing or halting the degeneration in PD. Unfortunately, there is not a lot of research that has looked into the effect of exercise on the biological processes of inflammation. Thus, the purpose of this study is to investigate the biological evidence that underlies the positive effect of exercise in people with PD.
2024-08-29
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Non applicable
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
Neuroprotection
Ralentissement de la progression
Immunomodulation
Confiance automatique : 80%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Indices détectés : neuroprotect → Neuroprotection, progression → Ralentissement de la progression, inflamm → Immunomodulation, symptom → Traitement symptomatique
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT05854524, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Aucune incohérence majeure détectée entre la maladie, l’objectif et la description.
Transparence et qualité de la fiche
données vérifiablesClassificationCohérente automatiquement
Confiance de la fiche100 %
Source principaleSource officielle ou publication indexée
Dernière vérification2024-08-29
Anomalies détectées0
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeNon applicable
Études associées1
Publications associées15
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
20 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2024-08-29 | Début de l’étudeNCT05854524 | Registre d’essai clinique |
| 2024-08-29 | Dernière mise à jour des donnéesAerobic exercise | Biomedical Watch |
| 2026-07-14 | Création de l’enregistrementNCT05854524 | Registre d’essai clinique |
| 2026-07-14 | PublicationThe role of exercise intensity in motor and non-motor symptoms of Parkinson's disease: mechanisms, clinical evidence, and personalized exercise prescription parameters. | Frontiers in aging neuroscience |
| 2026-07-14 | PublicationMeta-analysis of the effects of exercise intervention on glucose metabolism and body composition in patients with type 2 diabetes mellitus. | Frontiers in endocrinology |
| 2026-07-14 | PublicationEffectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial. | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy |
| 2026-07-14 | PublicationEfficacy and Adherence to a Supervised Aerobic Exercise Training Intervention in Night-Shift Hospital Nurses: A Randomized Controlled Trial. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology |
| 2026-07-18 | PublicationEffectiveness of intermittent hypoxia on muscle recovery in rats: A systematic review. | Animal models and experimental medicine |
| 2026-07-18 | PublicationResistance Training Improves Cardiovascular Health in Postmenopausal Women: Systematic Review and Meta-Analysis. | Journal of applied physiology (Bethesda, Md. : 1985) |
| 2026-07-22 | PublicationAcute aerobic exercise modulates sweetness-related food preference in individuals with nicotine dependence: the mediating role of prefrontal cortical activity. | Frontiers in nutrition |
| 2026-07-22 | PublicationNon-Pharmacological Treatments of Migraine: Current Evidence and Clinical Practice. | Current pain and headache reports |
| 2026-08-08 | PublicationConcurrent cognitive and physical training for cognition in men with prostate cancer: a study protocol for a pilot randomized controlled trial. | Frontiers in medicine |
| 2026-08-08 | PublicationAerobic exercise and sleep-related outcomes in children and adolescents: A systematic review and meta-analysis of randomized controlled trials. | Medicine |
| 2026-08-13 | Dernière mise à jour du registreNCT05854524 | Registre d’essai clinique |
| 2026-08-13 | PublicationExercise and Ferroptosis in Neurodegenerative Diseases: Direct Evidence, Mechanistic Links, and Translational Gaps. | International journal of molecular sciences |
| 2026-08-13 | PublicationThe impact of exercise on improving sarcopenia in patients with liver cirrhosis: a systematic review and meta-analysis. | Frontiers in medicine |
| 2026-08-16 | PublicationThe combined effect of L-arginine and Vitamin C supplementation on nitrogen balance, body composition, maximal oxygen uptake, and anabolic-catabolic hormones in male bodybuilders: A randomized double-blind clinical trial. | Journal of diabetes and metabolic disorders |
| 2026-08-16 | PublicationBiological mechanisms of different exercise modalities in improving sleep disorders: A review. | IBRO neuroscience reports |
| 2026-08-16 | PublicationEffects of different caffeine doses on fat oxidation and cardiovascular response during exercise at FATmax in overweight/obese female college students. | Journal of the International Society of Sports Nutrition |
| 2026-12-30 | Fin de l’étude prévue / enregistréeNCT05854524 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT05854524 | PDex — Exercise Neuroprotection in Parkinson's Disease | Non applicable | RECRUITING | United States | University of Nevada, Las Vegas |
Publications liées
15 publication(s)Publications liées
15 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| The combined effect of L-arginine and Vitamin C supplementation on nitrogen balance, body composition, maximal oxygen uptake, and anabolic-catabolic hormones in male bodybuilders: A randomized double-blind clinical trial. Voir source | 42433304 | 10.1007/s40200-026-01987-4 | Journal of diabetes and metabolic disorders | |
| Biological mechanisms of different exercise modalities in improving sleep disorders: A review. Voir source | 42592515 | 10.1016/j.ibneur.2026.07.023 | IBRO neuroscience reports | |
| Effects of different caffeine doses on fat oxidation and cardiovascular response during exercise at FATmax in overweight/obese female college students. Voir source | 42120324 | 10.1080/15502783.2026.2670558 | Journal of the International Society of Sports Nutrition | |
| Exercise and Ferroptosis in Neurodegenerative Diseases: Direct Evidence, Mechanistic Links, and Translational Gaps. Voir source | 42589286 | 10.3390/ijms27156628 | International journal of molecular sciences | |
| The impact of exercise on improving sarcopenia in patients with liver cirrhosis: a systematic review and meta-analysis. Voir source | 42591090 | 10.3389/fmed.2026.1871179 | Frontiers in medicine | |
| Concurrent cognitive and physical training for cognition in men with prostate cancer: a study protocol for a pilot randomized controlled trial. Voir source | 42564176 | 10.3389/fmed.2026.1867637 | Frontiers in medicine | |
| Aerobic exercise and sleep-related outcomes in children and adolescents: A systematic review and meta-analysis of randomized controlled trials. Voir source | 42566600 | 10.1097/MD.0000000000050049 | Medicine | |
| Acute aerobic exercise modulates sweetness-related food preference in individuals with nicotine dependence: the mediating role of prefrontal cortical activity. Voir source | 42483644 | 10.3389/fnut.2026.1894892 | Frontiers in nutrition | |
| Non-Pharmacological Treatments of Migraine: Current Evidence and Clinical Practice. Voir source | 42484949 | 10.1007/s11916-026-01531-2 | Current pain and headache reports | |
| Effectiveness of intermittent hypoxia on muscle recovery in rats: A systematic review. Voir source | 42464793 | 10.1002/ame2.70248 | Animal models and experimental medicine | |
| Resistance Training Improves Cardiovascular Health in Postmenopausal Women: Systematic Review and Meta-Analysis. Voir source | 42470140 | 10.1152/japplphysiol.01180.2025 | Journal of applied physiology (Bethesda, Md. : 1985) | |
| The role of exercise intensity in motor and non-motor symptoms of Parkinson's disease: mechanisms, clinical evidence, and personalized exercise prescription parameters. Voir source | 42444985 | 10.3389/fnagi.2026.1831208 | Frontiers in aging neuroscience | |
| Meta-analysis of the effects of exercise intervention on glucose metabolism and body composition in patients with type 2 diabetes mellitus. Voir source | 42445881 | 10.3389/fendo.2026.1835096 | Frontiers in endocrinology | |
| Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial. Voir source | 42444374 | 10.1002/1744-9987.70175 | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy | |
| Efficacy and Adherence to a Supervised Aerobic Exercise Training Intervention in Night-Shift Hospital Nurses: A Randomized Controlled Trial. Voir source | 42444395 | 10.1096/fj.202504084RR | FASEB journal : official publication of the Federation of American Societies for Experimental Biology |
Sources officielles
liens de rechercheDernière mise à jour des données : 2024-08-29
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.