Fiche traitement
rTMS
Fujian Medical University Union Hospital • Alzheimer
Suivi actif
Non applicable
Résumé
rTMS est développé par Fujian Medical University Union Hospital. Le traitement est actuellement en Non applicable. Il est associé à Alzheimer. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
À vérifier
Non applicable
Fujian Medical University Union Hospital
China
This study is grounded in the regulatory mechanisms of the glymphatic system and applies repetitive transcranial magnetic stimulation (rTMS) to the treatment of Alzheimer's disease (AD). The clinical efficacy and safety of rTMS will be systematically evaluated. Furthermore, transcranial magnetic stimulation-evoked potentials (TMS-EEG) and functional near-infrared spectroscopy (fNIRS) will be employed to investigate, from the perspectives of synaptic plasticity and neurovascular coupling, the mechanisms by which rTMS influences glymphatic function. Collectively, this work aims to provide new insights into both the therapeutic effectiveness and the underlying mechanisms of rTMS in AD.
2026-08-27
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Non applicable
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
À vérifier
Confiance automatique : 0%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT07324161, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-08-27
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeNon applicable
Études associées1
Publications associées18
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
22 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2025-04-16 | Début de l’étudeNCT07324161 | Registre d’essai clinique |
| 2026-07-08 | PublicationHigh-Frequency Repetitive Transcranial Magnetic Stimulation Improves Oxidative Stress, Iron Metabolism, and Synaptic Plasticity in the Visual Cortex of Amblyopic Rats: Association With the NRF2/GPX4 Pathway. | Journal of integrative neuroscience |
| 2026-07-08 | PublicationEfficacy of non-invasive brain stimulation in Alzheimer's disease: An umbrella review of meta-analyses. | Neuroscience and biobehavioral reviews |
| 2026-07-12 | PublicationDeterminants of Repetitive Transcranial Magnetic Stimulation Efficacy in Tobacco Use Disorder: A Pre-Registered Study. | medRxiv : the preprint server for health sciences |
| 2026-07-14 | PublicationComparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis. | Pain and therapy |
| 2026-07-14 | PublicationThe Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive-Like Behavior in Mice. | Brain and behavior |
| 2026-07-18 | PublicationRight‑DLPFC rTMS Transiently Modulates Risky Decision-Making and EEG Oscillatory Activity. | Brain and behavior |
| 2026-07-23 | PublicationPersonalized non-invasive combined magnetic and electrical stimulation of the default mode network in mild AD patients (CMES-AD): a multicentric randomized sham-controlled trial protocol. | Alzheimer's research & therapy |
| 2026-07-23 | PublicationMechanisms of open and hidden placebo in stroke recovery: targeting neuroplasticity insights of the placebo effect - study protocol for a controlled, parallel, randomised clinical trial. | BMJ open |
| 2026-07-23 | PublicationComparative efficacy and safety of photobiomodulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation in Alzheimer's disease: a network meta-analysis of randomized controlled trials. | Lasers in medical science |
| 2026-08-08 | Publication[Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health]. | Der Nervenarzt |
| 2026-08-08 | Publication"Additive Effects of Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation on Robotic Therapy for Upper Extremity Recovery After Chronic Ischemic Stroke: A Randomized, Double-Blind, Sham-Controlled Trial". | Archives of physical medicine and rehabilitation |
| 2026-08-13 | PublicationPotential Epigenetic Mechanisms of High-Frequency rTMS in the Treatment of Major Depression: A Brief Report of Current Evidence. | Noro psikiyatri arsivi |
| 2026-08-13 | PublicationEfficacy and acceptability of noninvasive brain stimulation for treating posttraumatic stress disorder symptoms: A network meta-analysis of randomized controlled trials. | Acta psychiatrica Scandinavica |
| 2026-08-13 | PublicationEfficacy of a high-frequency repetitive transcranial magnetic stimulation for craving reduction in adolescents with gaming disorder: a 4-week randomized control trial with 24-week follow-up. | European archives of psychiatry and clinical neuroscience |
| 2026-08-16 | PublicationTreatment of posttraumatic stress disorder (PTSD). | Dialogues in clinical neuroscience |
| 2026-08-16 | PublicationA randomized double-blind sham-controlled preliminary study of a 5-week protocol of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) for gambling disorder in Indonesia. | Addictive behaviors reports |
| 2026-08-16 | PublicationEfficacy and durability of therapies for neurogenic lower urinary tract dysfunction: A network meta-analysis of Botulinum Toxin a, instillations, and neuromodulation. | Toxicon : official journal of the International Society on Toxinology |
| 2026-08-16 | PublicationTreatment-characteristic brain structural changes in depression: A multi-center longitudinal observational study. | Journal of affective disorders |
| 2026-08-27 | Dernière mise à jour des donnéesrTMS | Biomedical Watch |
| 2026-09-01 | Création de l’enregistrementNCT07324161 | Registre d’essai clinique |
| 2029-04-30 | Fin de l’étude prévue / enregistréeNCT07324161 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT07324161 | Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Alzheimer's Disease | Non applicable | RECRUITING | China | Fujian Medical University Union Hospital |
Publications liées
18 publication(s)Publications liées
18 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Treatment of posttraumatic stress disorder (PTSD). Voir source | 42284478 | 10.1080/19585969.2026.2680838 | Dialogues in clinical neuroscience | |
| A randomized double-blind sham-controlled preliminary study of a 5-week protocol of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) for gambling disorder in Indonesia. Voir source | 42389422 | 10.1016/j.abrep.2026.100722 | Addictive behaviors reports | |
| Efficacy and durability of therapies for neurogenic lower urinary tract dysfunction: A network meta-analysis of Botulinum Toxin a, instillations, and neuromodulation. Voir source | 42203154 | 10.1016/j.toxicon.2026.109165 | Toxicon : official journal of the International Society on Toxinology | |
| Treatment-characteristic brain structural changes in depression: A multi-center longitudinal observational study. Voir source | 42456821 | 10.1016/j.jad.2026.122269 | Journal of affective disorders | |
| Potential Epigenetic Mechanisms of High-Frequency rTMS in the Treatment of Major Depression: A Brief Report of Current Evidence. Voir source | 42582898 | 10.29399/npa.29345 | Noro psikiyatri arsivi | |
| Efficacy and acceptability of noninvasive brain stimulation for treating posttraumatic stress disorder symptoms: A network meta-analysis of randomized controlled trials. Voir source | 38616056 | 10.1111/acps.13688 | Acta psychiatrica Scandinavica | |
| Efficacy of a high-frequency repetitive transcranial magnetic stimulation for craving reduction in adolescents with gaming disorder: a 4-week randomized control trial with 24-week follow-up. Voir source | 42572071 | 10.1007/s00406-026-02343-6 | European archives of psychiatry and clinical neuroscience | |
| [Neuromodulation as the fourth pillar in the treatment of depression : A position paper of the German Center for Mental Health]. Voir source | 42554808 | 10.1007/s00115-026-01999-8 | Der Nervenarzt | |
| "Additive Effects of Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation on Robotic Therapy for Upper Extremity Recovery After Chronic Ischemic Stroke: A Randomized, Double-Blind, Sham-Controlled Trial". Voir source | 42562200 | 10.1016/j.apmr.2026.07.026 | Archives of physical medicine and rehabilitation | |
| Personalized non-invasive combined magnetic and electrical stimulation of the default mode network in mild AD patients (CMES-AD): a multicentric randomized sham-controlled trial protocol. Voir source | 42482244 | 10.1186/s13195-026-02145-x | Alzheimer's research & therapy | |
| Mechanisms of open and hidden placebo in stroke recovery: targeting neuroplasticity insights of the placebo effect - study protocol for a controlled, parallel, randomised clinical trial. Voir source | 42486522 | 10.1136/bmjopen-2025-113119 | BMJ open | |
| Comparative efficacy and safety of photobiomodulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation in Alzheimer's disease: a network meta-analysis of randomized controlled trials. Voir source | 42487022 | 10.1007/s10103-026-04962-w | Lasers in medical science | |
| Right‑DLPFC rTMS Transiently Modulates Risky Decision-Making and EEG Oscillatory Activity. Voir source | 42458894 | 10.1002/brb3.71584 | Brain and behavior | |
| Comparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis. Voir source | 42435147 | 10.1007/s40122-026-00860-9 | Pain and therapy | |
| The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive-Like Behavior in Mice. Voir source | 42444411 | 10.1002/brb3.71596 | Brain and behavior | |
| Determinants of Repetitive Transcranial Magnetic Stimulation Efficacy in Tobacco Use Disorder: A Pre-Registered Study. Voir source | 42428110 | 10.64898/2026.06.23.26356059 | medRxiv : the preprint server for health sciences | |
| High-Frequency Repetitive Transcranial Magnetic Stimulation Improves Oxidative Stress, Iron Metabolism, and Synaptic Plasticity in the Visual Cortex of Amblyopic Rats: Association With the NRF2/GPX4 Pathway. Voir source | 42411431 | 10.31083/JIN48602 | Journal of integrative neuroscience | |
| Efficacy of non-invasive brain stimulation in Alzheimer's disease: An umbrella review of meta-analyses. Voir source | 42398685 | 10.1016/j.neubiorev.2026.106844 | Neuroscience and biobehavioral reviews |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-08-27
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.