Fiche traitement
Bupivacaine
Saglik Bilimleri Universitesi • Migraine
Suivi actif
Non applicable
Résumé
Bupivacaine est développé par Saglik Bilimleri Universitesi. Le traitement est actuellement en Non applicable. Il est associé à Migraine. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
À vérifier
Non applicable
Saglik Bilimleri Universitesi
Turkey (Türkiye)
This multicenter, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the efficacy of repeated bilateral greater occipital nerve (GON) blockade in patients with chronic migraine and chronic tension-type headache. Greater occipital nerve blockade has been widely used as an interventional treatment for chronic headache disorders; however, evidence regarding its differential efficacy across chronic headache phenotypes remains limited.
Participants diagnosed with chronic migraine or chronic tension-type headache according to the International Headache Society criteria were randomized to receive bilateral GON blockade with 0.5% bupivacaine or placebo (0.9% saline). Injections were administered weekly during the first month and monthly during the following two months, resulting in a total of six injections over a three-month treatment period.
The primary outcome measure is the change in monthly headache frequency from baseline to Month 1. Secondary outcomes include changes in headache intensity, headache duration, disability scores, and other clinical headache parameters during follow-up.
2026-03-24
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Non applicable
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
À vérifier
Confiance automatique : 0%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT07497646, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-03-24
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeTerminée
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeNon applicable
Études associées1
Publications associées14
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
18 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2025-01-01 | Début de l’étudeNCT07497646 | Registre d’essai clinique |
| 2025-09-30 | Fin de l’étude prévue / enregistréeNCT07497646 | Registre d’essai clinique |
| 2026-03-24 | Dernière mise à jour des donnéesBupivacaine | Biomedical Watch |
| 2026-07-22 | PublicationCORR Insights®: Does Liposomal Bupivacaine Provide Superior Postoperative Analgesia Compared With Ropivacaine With Dexamethasone in Suprainguinal Fascia Iliaca Compartment Block for THA? A Randomized Controlled Trial. | Clinical orthopaedics and related research |
| 2026-08-08 | PublicationThree men in a boat: The comparison of the combination therapy of botulinum toxin and greater occipital nerve block with bupivacaine, with botulinum toxin monotherapy in the management of chronic migraine. | Clinical neurology and neurosurgery |
| 2026-08-08 | PublicationUltrasound-Guided Stellate Ganglion and Interscalene Blocks for Refractory Pediatric Parsonage-Turner Syndrome: A Case Report and Clinical Implications. | Pain medicine case reports |
| 2026-08-08 | PublicationAnesthetic Management of an Elective Cesarean Section in a Patient With Systemic Mastocytosis and Latex Allergy, Complicated by Incidental Intraoperative Wolff-Parkinson-White Pre-excitation: A Case Report. | Cureus |
| 2026-08-13 | Création de l’enregistrementNCT07497646 | Registre d’essai clinique |
| 2026-08-13 | PublicationEfficacy of 810 nm low-level laser therapy on muscle regeneration after bupivacaine-induced myonecrosis in a rabbit model. | Lasers in medical science |
| 2026-08-13 | PublicationLocal anesthetics and antibiotics display synergistic and antagonistic drug interactions against pathogens causing septic arthritis in horses. | American journal of veterinary research |
| 2026-08-16 | PublicationQuadratus Lumborum Block During Minimally Invasive Colorectal Surgery: A Tool for Enhanced Recovery. | Diseases of the colon and rectum |
| 2026-08-16 | PublicationThe true benefit of the regional block in orthognathic surgery lies in the preemptive effect. | Oral and maxillofacial surgery |
| 2026-08-16 | PublicationAn evaluation of peripheral nerve damage that may develop following intraneural bupivacaine, dexmedetomidine, and lidocaine injections: multifaceted analysis in an experimental model. | BMC anesthesiology |
| 2026-08-16 | PublicationDoes Liposomal Bupivacaine Provide Superior Postoperative Analgesia Compared With Ropivacaine With Dexamethasone in Suprainguinal Fascia Iliaca Compartment Block for THA? A Randomized Controlled Trial. | Clinical orthopaedics and related research |
| 2026-08-16 | PublicationEfficacy of Greater Occipital Nerve Block versus Sphenopalatine Ganglion Block for the Treatment of Postdural Puncture Headache after Spinal Anesthesia: A Randomized Clinical Trial. | Annals of African medicine |
| 2026-08-16 | PublicationChronic migraine prophylaxis: Comparative study between ultrasound-guided greater occipital nerve block and medical treatment. | Clinical neurology and neurosurgery |
| 2026-08-16 | PublicationManagement of refractory chronic migraine using ultrasound-guided pulsed radiofrequency of greater occipital nerve: Two case reports. | Medicine |
| 2026-08-16 | PublicationComparison between Perineural and Intravenous Dexamethasone on Duration of Analgesia in Supraclavicular Brachial Plexus Block - An Observational Study. | Annals of African medicine |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT07497646 | GONBLOCK-RCT — Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache | Non applicable | COMPLETED | Turkey (Türkiye) | Saglik Bilimleri Universitesi |
Publications liées
14 publication(s)Publications liées
14 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Quadratus Lumborum Block During Minimally Invasive Colorectal Surgery: A Tool for Enhanced Recovery. Voir source | 42228437 | 10.1097/DCR.0000000000004308 | Diseases of the colon and rectum | |
| The true benefit of the regional block in orthognathic surgery lies in the preemptive effect. Voir source | 41790271 | 10.1007/s10006-026-01522-y | Oral and maxillofacial surgery | |
| An evaluation of peripheral nerve damage that may develop following intraneural bupivacaine, dexmedetomidine, and lidocaine injections: multifaceted analysis in an experimental model. Voir source | 42251255 | 10.1186/s12871-026-03992-9 | BMC anesthesiology | |
| Does Liposomal Bupivacaine Provide Superior Postoperative Analgesia Compared With Ropivacaine With Dexamethasone in Suprainguinal Fascia Iliaca Compartment Block for THA? A Randomized Controlled Trial. Voir source | 42284069 | 10.1097/CORR.0000000000003907 | Clinical orthopaedics and related research | |
| Efficacy of Greater Occipital Nerve Block versus Sphenopalatine Ganglion Block for the Treatment of Postdural Puncture Headache after Spinal Anesthesia: A Randomized Clinical Trial. Voir source | 41656284 | 10.4103/aam.aam_376_25 | Annals of African medicine | |
| Chronic migraine prophylaxis: Comparative study between ultrasound-guided greater occipital nerve block and medical treatment. Voir source | 41875819 | 10.1016/j.clineuro.2026.109405 | Clinical neurology and neurosurgery | |
| Management of refractory chronic migraine using ultrasound-guided pulsed radiofrequency of greater occipital nerve: Two case reports. Voir source | 30407333 | 10.1097/MD.0000000000013127 | Medicine | |
| Comparison between Perineural and Intravenous Dexamethasone on Duration of Analgesia in Supraclavicular Brachial Plexus Block - An Observational Study. Voir source | 41574836 | 10.4103/aam.aam_288_25 | Annals of African medicine | |
| Efficacy of 810 nm low-level laser therapy on muscle regeneration after bupivacaine-induced myonecrosis in a rabbit model. Voir source | 42579184 | 10.1007/s10103-026-04989-z | Lasers in medical science | |
| Local anesthetics and antibiotics display synergistic and antagonistic drug interactions against pathogens causing septic arthritis in horses. Voir source | 39970538 | 10.2460/ajvr.24.08.0214 | American journal of veterinary research | |
| Three men in a boat: The comparison of the combination therapy of botulinum toxin and greater occipital nerve block with bupivacaine, with botulinum toxin monotherapy in the management of chronic migraine. Voir source | 36731164 | 10.1016/j.clineuro.2023.107609 | Clinical neurology and neurosurgery | |
| Ultrasound-Guided Stellate Ganglion and Interscalene Blocks for Refractory Pediatric Parsonage-Turner Syndrome: A Case Report and Clinical Implications. Voir source | 42550561 | Pain medicine case reports | ||
| Anesthetic Management of an Elective Cesarean Section in a Patient With Systemic Mastocytosis and Latex Allergy, Complicated by Incidental Intraoperative Wolff-Parkinson-White Pre-excitation: A Case Report. Voir source | 42564869 | 10.7759/cureus.112209 | Cureus | |
| CORR Insights®: Does Liposomal Bupivacaine Provide Superior Postoperative Analgesia Compared With Ropivacaine With Dexamethasone in Suprainguinal Fascia Iliaca Compartment Block for THA? A Randomized Controlled Trial. Voir source | 42484482 | 10.1097/CORR.0000000000003967 | Clinical orthopaedics and related research |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-03-24
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.