Fiche traitement
Insulin
Wake Forest University Health Sciences • Alzheimer
Suivi actif
Phase 2
Résumé
Insulin est développé par Wake Forest University Health Sciences. Le traitement est actuellement en Phase 2. Il est associé à Alzheimer. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
À vérifier
Phase 2
Wake Forest University Health Sciences
United States
Exercise is predicted to have positive effect among patients with hepatocellular carcinoma (HCC). However, little attention has been paid to the role of physical activity with wearable device in the management of HCC patients in the aspect of improvement in insulin resistance.
We designed this study to investigate whether personalized exercise with mobile health program improves insulin resistance without decompensation in HCC patients with insulin resistance.
2026-08-24
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Phase 2
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
À vérifier
Confiance automatique : 0%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT04649671, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-08-24
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeArrêtée
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréePhase 2
Études associées18
Publications associées67
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
123 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 1997-07-01 | Début de l’étudeNCT00001669 | Registre d’essai clinique |
| 1998-10-21 | Début de l’étudeNCT00001853 | Registre d’essai clinique |
| 2000-04-01 | Fin de l’étude prévue / enregistréeNCT00001669 | Registre d’essai clinique |
| 2006-11-01 | Début de l’étudeNCT00720161 | Registre d’essai clinique |
| 2011-07-01 | Fin de l’étude prévue / enregistréeNCT00720161 | Registre d’essai clinique |
| 2012-09-17 | Début de l’étudeNCT05372159 | Registre d’essai clinique |
| 2012-12-01 | Début de l’étudeNCT01752803 | Registre d’essai clinique |
| 2014-02-01 | Début de l’étudeNCT02041104 | Registre d’essai clinique |
| 2015-07-01 | Fin de l’étude prévue / enregistréeNCT01752803 | Registre d’essai clinique |
| 2018-04-01 | Fin de l’étude prévue / enregistréeNCT02041104 | Registre d’essai clinique |
| 2021-03-02 | Début de l’étudeNCT04649671 | Registre d’essai clinique |
| 2021-07-01 | Début de l’étudeNCT04304261 | Registre d’essai clinique |
| 2021-10-14 | Début de l’étudeNCT04656210 | Registre d’essai clinique |
| 2022-02-15 | Début de l’étudeNCT04740580 | Registre d’essai clinique |
| 2023-03-02 | Fin de l’étude prévue / enregistréeNCT04649671 | Registre d’essai clinique |
| 2024-02-01 | Début de l’étudeNCT06132477 | Registre d’essai clinique |
| 2024-04-30 | Fin de l’étude prévue / enregistréeNCT04304261 | Registre d’essai clinique |
| 2024-08-08 | Début de l’étudeNCT06555952 | Registre d’essai clinique |
| 2026-01-09 | Début de l’étudeNCT07273409 | Registre d’essai clinique |
| 2026-07-01 | Début de l’étudeNCT07719322 | Registre d’essai clinique |
| 2026-07-08 | Création de l’enregistrementNCT04656210 | Registre d’essai clinique |
| 2026-07-08 | PublicationCurrent perspectives on the pathogenesis of multiple sclerosis: A minireview. | Endocrine regulations |
| 2026-07-12 | PublicationLuseogliflozin restores GIP responsiveness in diabetic male mice with preserved β-cell function. | Physiological reports |
| 2026-07-12 | PublicationRGD-functionalized cannabidiol lipid nanoparticles improve brain delivery and alleviate cognitive and metabolic dysfunction via gut-brain axis modulation in an Alzheimer's disease model. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie |
| 2026-07-12 | PublicationGamma-aminobutyric acid supplementation combined with gonadotropin-releasing hormone analog therapy versus gonadotropin-releasing hormone analog therapy alone for linear growth in children with growth retardation: a retrospective cohort study. | Translational pediatrics |
| 2026-07-13 | Dernière mise à jour du registreNCT04656210 | Registre d’essai clinique |
| 2026-07-14 | PublicationEvaluation of insulin, leptin, ghrelin, and adiponectin levels in type 2 diabetic patients receiving combined metformin-sulfonylurea therapy. | Biomeditsinskaia khimiia |
| 2026-07-14 | PublicationMeta-analysis of the effects of exercise intervention on glucose metabolism and body composition in patients with type 2 diabetes mellitus. | Frontiers in endocrinology |
| 2026-07-14 | PublicationEXPRESS: Comparing the Efficacy of Transmucosal and Subcutaneous Glucagon Administration in Response to Insulin-Induced Hypoglycemia in Healthy Cats. | Journal of feline medicine and surgery |
| 2026-07-14 | PublicationInsulin Regulates CD36-Dependent Fatty Acid Uptake but Not Mitochondrial Oxidation in Sertoli Cells. | Andrology |
| 2026-07-14 | PublicationDevelopment of zein-based nanoparticles for oral co-delivery of insulin and liraglutide and preliminary in vivo evaluation in Danio rerio. | International journal of biological macromolecules |
| 2026-07-14 | PublicationOccult Necrotizing Fasciitis Presenting as a Severe Hyperosmolar Hyperglycemic State in a Patient With Newly Diagnosed Type 2 Diabetes Mellitus. | Cureus |
| 2026-07-14 | PublicationEfficacy and Adherence to a Supervised Aerobic Exercise Training Intervention in Night-Shift Hospital Nurses: A Randomized Controlled Trial. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology |
| 2026-07-15 | PublicationHuman umbilical cord-derived mesenchymal stem cells ameliorate muscle dysfunction and metabolic dysregulation in the CuZnSOD null mouse model of sarcopenia. | Experimental gerontology |
| 2026-07-18 | PublicationSPG302 mitigates diabetic retinal neuropathy and inner retinal damage in a genetic mouse model of diabetes. | Experimental eye research |
| 2026-07-18 | Publication36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. | Critical care (London, England) |
| 2026-07-22 | PublicationGastrointestinal adverse reactions and metabolism-nutrition disorders associated with hypomethylating agents: a pharmacovigilance study with exploratory mechanistic analysis. | Frontiers in nutrition |
| 2026-07-22 | PublicationCase Report: Early-onset euglycemic diabetic ketoacidosis following henagliflozin initiation in a treatment-naive patient. | Frontiers in endocrinology |
| 2026-07-22 | PublicationNebivolol treatment improves hypertension-induced endothelial cell dysfunction by reducing TGF-β1-dependent senescence and normalizing mitochondrial indices. | Journal of hypertension |
| 2026-07-22 | PublicationRegulation of ovarian function in domestic animals: translational insights into human ovarian dynamics and dysfunction. | Frontiers in endocrinology |
| 2026-07-23 | PublicationLycopene attenuates dexamethasone induced depression like behavior and immunological dysfunction via restoration of neuro-immune-metabolic homeostasis in rats. | Scientific reports |
| 2026-08-01 | Début de l’étudeNCT07753018 | Registre d’essai clinique |
| 2026-08-05 | Création de l’enregistrementNCT01752803 | Registre d’essai clinique |
| 2026-08-08 | Création de l’enregistrementNCT02041104 | Registre d’essai clinique |
| 2026-08-08 | PublicationAmylin Coexisting With Peptide YY (PYY) and Amylin/PYY Cells Correspond to Subpopulations of Glucagon- and Glucagon-Like Peptide-1-Immunoreactive Cells in the Japanese Eel (Anguilla japonica) Pancreas. | Anatomia, histologia, embryologia |
| 2026-08-08 | PublicationAcute effects of "exercise snacks" on postprandial glucose and insulin responses in populations at metabolic risk: a meta-analysis with exploratory meta-regression and vascular outcomes. | Frontiers in endocrinology |
| 2026-08-08 | PublicationTime to Insulin Initiation Among Patients With Type 2 Diabetes Treated With Second-Line Antidiabetic Drugs. | Diabetes, obesity & metabolism |
| 2026-08-08 | PublicationErsodetug for Refractory Hypoglycemia Due to Malignant Insulin-Secreting Tumors. | The Journal of clinical endocrinology and metabolism |
| 2026-08-13 | Création de l’enregistrementNCT07753018 | Registre d’essai clinique |
| 2026-08-13 | Création de l’enregistrementNCT04304261 | Registre d’essai clinique |
| 2026-08-13 | Création de l’enregistrementNCT07756294 | Registre d’essai clinique |
| 2026-08-13 | PublicationChlorogenic acid inhibits intestinal lipid uptake and promotes adipose lipid catabolism via epithelium-derived exosomes in ob/ob mice. | Frontiers in physiology |
| 2026-08-13 | PublicationBeyond GLP-1: Amylin-Based Pharmacotherapy and the Search for Better-Tolerated Weight-Loss Drugs. | Pharmacological research |
| 2026-08-13 | PublicationHow Common Is Hypercortisolism in Patients With Type 2 Diabetes? Risk Factors, Epidemiology, and Making a Diagnosis Using a Dexamethasone Suppression Test. | Diabetes, obesity & metabolism |
| 2026-08-13 | PublicationTiming of transcutaneous acupoint electrical stimulation for postoperative recovery in geriatric patients with gastrointestinal tumors: study protocol for a randomized controlled trial. | Frontiers in medicine |
| 2026-08-13 | PublicationADDRESS-LC: study protocol for a phase 2, triple-blind, randomised, placebo-controlled trial to evaluate the efficacy and safety of bezisterim (NE3107) in adults with long COVID. | BMJ open |
| 2026-08-13 | PublicationMetabolomic Insights on Obesity and Diabetes from Feeding Diets Varying in Carbohydrate-Fat Ratios in Zucker Diabetic Fatty (ZDF) and Lean Zucker (Z) Rats. | International journal of molecular sciences |
| 2026-08-13 | PublicationRecent advances in the medical management of thyroid eye disease. | Current opinion in endocrinology, diabetes, and obesity |
| 2026-08-13 | PublicationBeyond Weight Loss: Gut Microenvironment Modulation to Enhance Cardiometabolic Outcomes and Long-Term Adherence During Incretin-Based Therapy. | Journal of clinical medicine |
| 2026-08-13 | PublicationMechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects. | Endocrinology, diabetes & metabolism |
| 2026-08-16 | Création de l’enregistrementNCT07642635 | Registre d’essai clinique |
| 2026-08-16 | Création de l’enregistrementNCT07719322 | Registre d’essai clinique |
| 2026-08-16 | Création de l’enregistrementNCT00001853 | Registre d’essai clinique |
| 2026-08-16 | Création de l’enregistrementNCT07273409 | Registre d’essai clinique |
| 2026-08-16 | Création de l’enregistrementNCT05372159 | Registre d’essai clinique |
| 2026-08-16 | PublicationAgouti signalling protein and triglyceride-glucose index in early pregnancy with gestational diabetes: a prospective cohort study. | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology |
| 2026-08-16 | PublicationEffects of Pulsed Electromagnetic Field Application on Glucose Metabolism in Rats. | Bioelectromagnetics |
| 2026-08-16 | PublicationCurrent Clinical Evidence on Nose-to-Brain Drug Delivery. | Drug discovery today |
| 2026-08-16 | PublicationA novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma. | Orphanet journal of rare diseases |
| 2026-08-16 | PublicationNutritional considerations for glucagon-like peptide-based therapies: An Asian Indian consensus recommendation. | Obesity pillars |
| 2026-08-16 | PublicationInvestigating the effects of antidepressants on measures of insulin resistance in major depressive disorder: A systematic review. | Journal of affective disorders |
| 2026-08-16 | PublicationGender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study. | Diabetologia |
| 2026-08-16 | PublicationExamining the molecular mechanisms of topiramate in alleviating insulin resistance: A study on C2C12 myocytes and 3T3L-1 adipocytes. | Endocrine |
| 2026-08-16 | Publication12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial. | Journal of the International Society of Sports Nutrition |
| 2026-08-16 | PublicationExercise Resistance in Obese Male NZO Mice Manifests as Local Muscle Remodelling Without Glycaemic Improvements. | Diabetes, obesity & metabolism |
| 2026-08-16 | PublicationRetigabine alleviates cognitive deficits, decreases neuropathology and activates the AKT/GSK-3β pathway in APP/PS1 transgenic mice. | Behavioural brain research |
| 2026-08-16 | Publication[Associations of insulin resistance and pancreatic beta-cell function with plasma glucose level in type 2 diabetes]. | Zhonghua yi xue za zhi |
| 2026-08-16 | PublicationThe multivariate genetic architecture of psychiatric and insulin resistance multimorbidity. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology |
| 2026-08-16 | PublicationComparative efficacy of intralesional therapies for keloid scars: a network meta-analysis. | Annals of medicine |
| 2026-08-16 | PublicationMetabolic Syndrome and Its Correlates in Systemic Lupus Erythematosus Patients: A Hidden Clinical Challenge. | Annals of African medicine |
| 2026-08-16 | PublicationDHEA model of PCOS selectively alters reproductive but not metabolic or behavioral phenotypes in female Long-Evans rats. | Physiology & behavior |
| 2026-08-16 | PublicationEndoscopic ultrasound-guided radiofrequency ablation of pancreatic insulinoma. | Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery |
| 2026-08-16 | PublicationEndoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA): Are We Getting Evidence-Based Results? A Systematic Review According to the Levels of Evidence. | Medicina (Kaunas, Lithuania) |
| 2026-08-16 | PublicationAssessment of left ventricle strain of cardiovascular-asymptomatic patients of type 2 diabetes mellitus with preserved cardiovascular function through Dobutamine stress echocardiography. | Irish journal of medical science |
| 2026-08-16 | PublicationMetabolic Dysfunction After Initiation of Androgen Receptor Pathway Inhibitors in Prostate Cancer. | JAMA oncology |
| 2026-08-16 | Publication[Endocrine late-effects and bone mineral density after combined treatment of malignant brain tumors in childhood and adolescence]. | Problemy endokrinologii |
| 2026-08-16 | PublicationA novel insulin-like growth factor II-based masking domain for conditional activation of therapeutic antibodies. | mAbs |
| 2026-08-16 | PublicationVA-ECMO and HIET for toxic cardiogenic shock in an elderly patient following severe poly-intoxication: A case report. | Toxicology reports |
| 2026-08-16 | PublicationCausal relationship between epigenetic markers and type 2 diabetes in West African populations: a Mendelian randomisation analysis. | Diabetologia |
| 2026-08-16 | PublicationQuality of Diabetes Care Among Older Adults in Germany-Results of the Study on Health of Older People 2022/2023 Compared With Previous National Health Surveys. | Diabetes, obesity & metabolism |
| 2026-08-16 | PublicationHealth impact of seven herpesviruses on (pre)diabetes incidence and HbA: results from the KORA cohort. | Diabetologia |
| 2026-08-16 | PublicationShared pathophysiology and therapeutic repurposing in Alzheimer's disease and type 2 diabetes: a critical review of convergent mechanisms and clinical challenges. | Bioorganic chemistry |
| 2026-08-16 | PublicationThe effects of acute ketone monoester supplementation on brain insulin responsiveness and cognitive performance: Results of a randomized, double-blind, placebo-controlled crossover trial in older men with overweight. | Metabolism: clinical and experimental |
| 2026-08-16 | PublicationEvaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review. | American journal of physiology. Endocrinology and metabolism |
| 2026-08-16 | PublicationGlycohypoxia: a hypothesis linking chronic hyperglycemia to functional hypoxia and diabetic complications in type 2 diabetes. | Medical gas research |
| 2026-08-16 | PublicationShort-term sodium-glucose cotransporter 2 inhibition with ipragliflozin enhances engraftment and function in murine islet transplantation. | Transplant immunology |
| 2026-08-16 | PublicationA Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent-Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design. | Diabetes, obesity & metabolism |
| 2026-08-16 | Publicationreduces kynurenine levels and alleviates obesity and related metabolic disorders in model mice. | Gut microbes |
| 2026-08-16 | PublicationMulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling. | Journal of ethnopharmacology |
| 2026-08-16 | PublicationEffect of Sphingosine-1-Phosphate Receptor Modulators on Insulin Resistance: A Review. | The Annals of pharmacotherapy |
| 2026-08-24 | Dernière mise à jour des donnéesInsulin | Biomedical Watch |
| 2026-08-26 | Création de l’enregistrementNCT00001669 | Registre d’essai clinique |
| 2026-08-26 | Dernière mise à jour du registreNCT07756294 | Registre d’essai clinique |
| 2026-09-01 | Création de l’enregistrementNCT00720161 | Registre d’essai clinique |
| 2026-09-01 | Création de l’enregistrementNCT06555952 | Registre d’essai clinique |
| 2026-09-01 | Début de l’étudeNCT07642635 | Registre d’essai clinique |
| 2026-09-01 | Début de l’étudeNCT07756294 | Registre d’essai clinique |
| 2026-09-11 | Création de l’enregistrementNCT07589764 | Registre d’essai clinique |
| 2026-09-11 | Création de l’enregistrementNCT04740580 | Registre d’essai clinique |
| 2026-09-14 | Création de l’enregistrementNCT04649671 | Registre d’essai clinique |
| 2026-09-14 | Création de l’enregistrementNCT06132477 | Registre d’essai clinique |
| 2026-10-01 | Début de l’étudeNCT07589764 | Registre d’essai clinique |
| 2027-08-01 | Fin de l’étude prévue / enregistréeNCT07753018 | Registre d’essai clinique |
| 2027-10-01 | Fin de l’étude prévue / enregistréeNCT07589764 | Registre d’essai clinique |
| 2027-12-31 | Fin de l’étude prévue / enregistréeNCT04740580 | Registre d’essai clinique |
| 2027-12-31 | Fin de l’étude prévue / enregistréeNCT06555952 | Registre d’essai clinique |
| 2027-12-31 | Fin de l’étude prévue / enregistréeNCT05372159 | Registre d’essai clinique |
| 2028-04-01 | Fin de l’étude prévue / enregistréeNCT07756294 | Registre d’essai clinique |
| 2029-01-01 | Fin de l’étude prévue / enregistréeNCT04656210 | Registre d’essai clinique |
| 2029-07-01 | Fin de l’étude prévue / enregistréeNCT07719322 | Registre d’essai clinique |
| 2030-07-01 | Fin de l’étude prévue / enregistréeNCT06132477 | Registre d’essai clinique |
| 2030-12-01 | Fin de l’étude prévue / enregistréeNCT07642635 | Registre d’essai clinique |
| 2033-05-31 | Fin de l’étude prévue / enregistréeNCT07273409 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
18 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT04649671 | The Effect of Mobile Health-based Exercise on Hepatocellular Carcinoma Patients With Insulin Resistance | Non applicable | TERMINATED | South Korea | Samsung Medical Center |
| NCT06132477 | Impact GLP-1 Agonists Following Bariatric | Phase 4 | RECRUITING | United States | University of Missouri-Columbia |
| NCT07589764 | ROAR HMB — Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS | Phase 1 | NOT_YET_RECRUITING | United States | Duke University |
| NCT04740580 | Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease | Phase 1 | ACTIVE_NOT_RECRUITING | United States | Baylor College of Medicine |
| NCT00720161 | Metformin in Children With Motor Deficit | Non applicable | COMPLETED | Belgium | Universitaire Ziekenhuizen KU Leuven |
| NCT06555952 | GSEBP — MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors | Non applicable | RECRUITING | United States | Clinical Nutrition Research Center, Illinois Institute of Technology |
| NCT00001669 | A 48-Week (24-Week Baseline Followed by a 24-Week Treatment) Phase II Pilot Study of the Tolerability and Effect/Efficacy of Subcutaneously Administered Insulin-Like Growth Factor-1 (rhIGF) (CEP-151) in Multiple Sclerosis (MS) Patients | Phase 2 | COMPLETED | United States | National Institute of Neurological Disorders and Stroke (NINDS) |
| NCT07642635 | Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individuals With Duchenne Muscular Dystrophy | Phase 1/2 | NOT_YET_RECRUITING | United States | Vanderbilt University Medical Center |
| NCT07719322 | Non Invasive Assessment of Subclinical Atherosclerosis and Cardiovascular Risk Using TYG Index in Lupus Nephritis | À vérifier | NOT_YET_RECRUITING | Egypt | Assiut University |
| NCT00001853 | Diabetes and Heart Disease Risk in Blacks | À vérifier | RECRUITING | United States | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| NCT07273409 | PANTODON — Pancreatic Neuroendocrine Tumour - Optimal Surgical Debulking or Not | Non applicable | RECRUITING | Sweden | Uppsala University |
| NCT05372159 | VMAP — Vanderbilt Memory and Aging Project | À vérifier | ACTIVE_NOT_RECRUITING | United States | Vanderbilt University Medical Center |
| NCT07753018 | Effects of Curcumin-Piperine Supplementation in Fibromyalgia | Phase 2 | NOT_YET_RECRUITING | Egypt | Ain Shams University |
| NCT04304261 | Effects of SGLT2i on the Cognitive Function in T2DM Patient (ESCDP) | Phase 3 | COMPLETED | China | Third Military Medical University |
| NCT07756294 | REVITAA-ALZ — Restoring Vascular and Insulin Function To Augment Anti-Amyloid Therapy in Alzheimer's Disease | Phase 2 | NOT_YET_RECRUITING | United States | Wake Forest University Health Sciences |
| NCT02041104 | Impact of Consumption of Beta-glucans on the Intestinal Microbiota and Glucose and Lipid Metabolism | NA | COMPLETED | Slovenia | Mlinotest Zivilska Industrija d.d. |
| NCT01752803 | RCT Examining Effects of Probiotics in T2DM Individuals | NA | UNKNOWN | Malaysia | Universiti Kebangsaan Malaysia Medical Centre |
| NCT04656210 | Myotonic Dystrophy - Vascular and Cognition | À vérifier | ACTIVE_NOT_RECRUITING | France | University Hospital, Lille |
Publications liées
67 publication(s)Publications liées
67 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Agouti signalling protein and triglyceride-glucose index in early pregnancy with gestational diabetes: a prospective cohort study. Voir source | 42101196 | 10.1080/01443615.2026.2665634 | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology | |
| Effects of Pulsed Electromagnetic Field Application on Glucose Metabolism in Rats. Voir source | 42504996 | 10.1002/bem.70067 | Bioelectromagnetics | |
| Current Clinical Evidence on Nose-to-Brain Drug Delivery. Voir source | 42580438 | 10.1016/j.drudis.2026.104765 | Drug discovery today | |
| A novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma. Voir source | 41612354 | 10.1186/s13023-025-04161-w | Orphanet journal of rare diseases | |
| Nutritional considerations for glucagon-like peptide-based therapies: An Asian Indian consensus recommendation. Voir source | 42529748 | 10.1016/j.obpill.2026.100296 | Obesity pillars | |
| Investigating the effects of antidepressants on measures of insulin resistance in major depressive disorder: A systematic review. Voir source | 42323987 | 10.1016/j.jad.2026.122156 | Journal of affective disorders | |
| Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study. Voir source | 42322375 | 10.1007/s00125-026-06775-6 | Diabetologia | |
| Examining the molecular mechanisms of topiramate in alleviating insulin resistance: A study on C2C12 myocytes and 3T3L-1 adipocytes. Voir source | 38308786 | 10.1007/s12020-024-03706-6 | Endocrine | |
| 12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial. Voir source | 42218768 | 10.1080/15502783.2026.2679718 | Journal of the International Society of Sports Nutrition | |
| Exercise Resistance in Obese Male NZO Mice Manifests as Local Muscle Remodelling Without Glycaemic Improvements. Voir source | 42410330 | 10.1111/dom.71068 | Diabetes, obesity & metabolism | |
| Retigabine alleviates cognitive deficits, decreases neuropathology and activates the AKT/GSK-3β pathway in APP/PS1 transgenic mice. Voir source | 42480871 | 10.1016/j.bbr.2026.116391 | Behavioural brain research | |
| [Associations of insulin resistance and pancreatic beta-cell function with plasma glucose level in type 2 diabetes]. Voir source | 12126540 | Zhonghua yi xue za zhi | ||
| The multivariate genetic architecture of psychiatric and insulin resistance multimorbidity. Voir source | 42435748 | 10.1016/j.euroneuro.2026.112906 | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology | |
| Comparative efficacy of intralesional therapies for keloid scars: a network meta-analysis. Voir source | 41860092 | 10.1080/07853890.2026.2619295 | Annals of medicine | |
| Metabolic Syndrome and Its Correlates in Systemic Lupus Erythematosus Patients: A Hidden Clinical Challenge. Voir source | 41439507 | 10.4103/aam.aam_210_25 | Annals of African medicine | |
| DHEA model of PCOS selectively alters reproductive but not metabolic or behavioral phenotypes in female Long-Evans rats. Voir source | 42398846 | 10.1016/j.physbeh.2026.115435 | Physiology & behavior | |
| Endoscopic ultrasound-guided radiofrequency ablation of pancreatic insulinoma. Voir source | 42417742 | 10.1590/0102-67202025000052e1921 | Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery | |
| Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA): Are We Getting Evidence-Based Results? A Systematic Review According to the Levels of Evidence. Voir source | 42512924 | 10.3390/medicina62071382 | Medicina (Kaunas, Lithuania) | |
| Assessment of left ventricle strain of cardiovascular-asymptomatic patients of type 2 diabetes mellitus with preserved cardiovascular function through Dobutamine stress echocardiography. Voir source | 41212505 | 10.1007/s11845-025-04148-3 | Irish journal of medical science | |
| Metabolic Dysfunction After Initiation of Androgen Receptor Pathway Inhibitors in Prostate Cancer. Voir source | 42593785 | 10.1001/jamaoncol.2026.2790 | JAMA oncology | |
| [Endocrine late-effects and bone mineral density after combined treatment of malignant brain tumors in childhood and adolescence]. Voir source | 33586390 | 10.14341/probl12680 | Problemy endokrinologii | |
| A novel insulin-like growth factor II-based masking domain for conditional activation of therapeutic antibodies. Voir source | 42093183 | 10.1080/19420862.2026.2668187 | mAbs | |
| VA-ECMO and HIET for toxic cardiogenic shock in an elderly patient following severe poly-intoxication: A case report. Voir source | 42434173 | 10.1016/j.toxrep.2026.102307 | Toxicology reports | |
| Causal relationship between epigenetic markers and type 2 diabetes in West African populations: a Mendelian randomisation analysis. Voir source | 42032377 | 10.1007/s00125-026-06716-3 | Diabetologia | |
| Quality of Diabetes Care Among Older Adults in Germany-Results of the Study on Health of Older People 2022/2023 Compared With Previous National Health Surveys. Voir source | 42581634 | 10.1111/dom.71184 | Diabetes, obesity & metabolism | |
| Health impact of seven herpesviruses on (pre)diabetes incidence and HbA: results from the KORA cohort. Voir source | 35538159 | 10.1007/s00125-022-05704-7 | Diabetologia | |
| Shared pathophysiology and therapeutic repurposing in Alzheimer's disease and type 2 diabetes: a critical review of convergent mechanisms and clinical challenges. Voir source | 42247872 | 10.1016/j.bioorg.2026.110044 | Bioorganic chemistry | |
| The effects of acute ketone monoester supplementation on brain insulin responsiveness and cognitive performance: Results of a randomized, double-blind, placebo-controlled crossover trial in older men with overweight. Voir source | 42263845 | 10.1016/j.metabol.2026.156672 | Metabolism: clinical and experimental | |
| Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review. Voir source | 37971292 | 10.1152/ajpendo.00242.2023 | American journal of physiology. Endocrinology and metabolism | |
| Glycohypoxia: a hypothesis linking chronic hyperglycemia to functional hypoxia and diabetic complications in type 2 diabetes. Voir source | 41830794 | 10.4103/mgr.MEDGASRES-D-25-00137 | Medical gas research | |
| Short-term sodium-glucose cotransporter 2 inhibition with ipragliflozin enhances engraftment and function in murine islet transplantation. Voir source | 42442614 | 10.1016/j.trim.2026.102418 | Transplant immunology | |
| A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent-Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design. Voir source | 42203212 | 10.1111/dom.70785 | Diabetes, obesity & metabolism | |
| reduces kynurenine levels and alleviates obesity and related metabolic disorders in model mice. Voir source | 42434935 | 10.1080/19490976.2026.2701382 | Gut microbes | |
| Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling. Voir source | 42503322 | 10.1016/j.jep.2026.122237 | Journal of ethnopharmacology | |
| Effect of Sphingosine-1-Phosphate Receptor Modulators on Insulin Resistance: A Review. Voir source | 41482809 | 10.1177/10600280251407146 | The Annals of pharmacotherapy | |
| Chlorogenic acid inhibits intestinal lipid uptake and promotes adipose lipid catabolism via epithelium-derived exosomes in ob/ob mice. Voir source | 42591088 | 10.3389/fphys.2026.1896020 | Frontiers in physiology | |
| Beyond GLP-1: Amylin-Based Pharmacotherapy and the Search for Better-Tolerated Weight-Loss Drugs. Voir source | 42586227 | 10.1016/j.phrs.2026.108382 | Pharmacological research | |
| How Common Is Hypercortisolism in Patients With Type 2 Diabetes? Risk Factors, Epidemiology, and Making a Diagnosis Using a Dexamethasone Suppression Test. Voir source | 42591054 | 10.1111/dom.71171 | Diabetes, obesity & metabolism | |
| Timing of transcutaneous acupoint electrical stimulation for postoperative recovery in geriatric patients with gastrointestinal tumors: study protocol for a randomized controlled trial. Voir source | 40109717 | 10.3389/fmed.2025.1497647 | Frontiers in medicine | |
| ADDRESS-LC: study protocol for a phase 2, triple-blind, randomised, placebo-controlled trial to evaluate the efficacy and safety of bezisterim (NE3107) in adults with long COVID. Voir source | 42498469 | 10.1136/bmjopen-2026-118726 | BMJ open | |
| Metabolomic Insights on Obesity and Diabetes from Feeding Diets Varying in Carbohydrate-Fat Ratios in Zucker Diabetic Fatty (ZDF) and Lean Zucker (Z) Rats. Voir source | 42589668 | 10.3390/ijms27157017 | International journal of molecular sciences | |
| Recent advances in the medical management of thyroid eye disease. Voir source | 42590938 | 10.1097/MED.0000000000000972 | Current opinion in endocrinology, diabetes, and obesity | |
| Beyond Weight Loss: Gut Microenvironment Modulation to Enhance Cardiometabolic Outcomes and Long-Term Adherence During Incretin-Based Therapy. Voir source | 42590012 | 10.3390/jcm15155909 | Journal of clinical medicine | |
| Mechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects. Voir source | 42583924 | 10.1002/edm2.70305 | Endocrinology, diabetes & metabolism | |
| Amylin Coexisting With Peptide YY (PYY) and Amylin/PYY Cells Correspond to Subpopulations of Glucagon- and Glucagon-Like Peptide-1-Immunoreactive Cells in the Japanese Eel (Anguilla japonica) Pancreas. Voir source | 42559671 | 10.1111/ahe.70161 | Anatomia, histologia, embryologia | |
| Acute effects of "exercise snacks" on postprandial glucose and insulin responses in populations at metabolic risk: a meta-analysis with exploratory meta-regression and vascular outcomes. Voir source | 42558375 | 10.3389/fendo.2026.1912963 | Frontiers in endocrinology | |
| Time to Insulin Initiation Among Patients With Type 2 Diabetes Treated With Second-Line Antidiabetic Drugs. Voir source | 42563367 | 10.1111/dom.71182 | Diabetes, obesity & metabolism | |
| Ersodetug for Refractory Hypoglycemia Due to Malignant Insulin-Secreting Tumors. Voir source | 42557582 | 10.1210/clinem/dgag318 | The Journal of clinical endocrinology and metabolism | |
| Lycopene attenuates dexamethasone induced depression like behavior and immunological dysfunction via restoration of neuro-immune-metabolic homeostasis in rats. Voir source | 42472869 | 10.1038/s41598-026-62143-9 | Scientific reports | |
| Gastrointestinal adverse reactions and metabolism-nutrition disorders associated with hypomethylating agents: a pharmacovigilance study with exploratory mechanistic analysis. Voir source | 42453671 | 10.3389/fnut.2026.1865637 | Frontiers in nutrition | |
| Case Report: Early-onset euglycemic diabetic ketoacidosis following henagliflozin initiation in a treatment-naive patient. Voir source | 42483676 | 10.3389/fendo.2026.1882272 | Frontiers in endocrinology | |
| Nebivolol treatment improves hypertension-induced endothelial cell dysfunction by reducing TGF-β1-dependent senescence and normalizing mitochondrial indices. Voir source | 42474349 | 10.1097/HJH.0000000000004391 | Journal of hypertension | |
| Regulation of ovarian function in domestic animals: translational insights into human ovarian dynamics and dysfunction. Voir source | 42483683 | 10.3389/fendo.2026.1863960 | Frontiers in endocrinology | |
| SPG302 mitigates diabetic retinal neuropathy and inner retinal damage in a genetic mouse model of diabetes. Voir source | 42456876 | 10.1016/j.exer.2026.111170 | Experimental eye research | |
| 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Voir source | 27885969 | 10.1186/s13054-016-1208-6 | Critical care (London, England) | |
| Human umbilical cord-derived mesenchymal stem cells ameliorate muscle dysfunction and metabolic dysregulation in the CuZnSOD null mouse model of sarcopenia. Voir source | 42447970 | 10.1016/j.exger.2026.113238 | Experimental gerontology | |
| Evaluation of insulin, leptin, ghrelin, and adiponectin levels in type 2 diabetic patients receiving combined metformin-sulfonylurea therapy. Voir source | 42446258 | 10.18097/PBMCE0047 | Biomeditsinskaia khimiia | |
| Meta-analysis of the effects of exercise intervention on glucose metabolism and body composition in patients with type 2 diabetes mellitus. Voir source | 42445881 | 10.3389/fendo.2026.1835096 | Frontiers in endocrinology | |
| EXPRESS: Comparing the Efficacy of Transmucosal and Subcutaneous Glucagon Administration in Response to Insulin-Induced Hypoglycemia in Healthy Cats. Voir source | 42444066 | 10.1177/1098612X261471152 | Journal of feline medicine and surgery | |
| Insulin Regulates CD36-Dependent Fatty Acid Uptake but Not Mitochondrial Oxidation in Sertoli Cells. Voir source | 42444333 | 10.1111/andr.70316 | Andrology | |
| Development of zein-based nanoparticles for oral co-delivery of insulin and liraglutide and preliminary in vivo evaluation in Danio rerio. Voir source | 42442575 | 10.1016/j.ijbiomac.2026.153507 | International journal of biological macromolecules | |
| Occult Necrotizing Fasciitis Presenting as a Severe Hyperosmolar Hyperglycemic State in a Patient With Newly Diagnosed Type 2 Diabetes Mellitus. Voir source | 42434630 | 10.7759/cureus.110616 | Cureus | |
| Efficacy and Adherence to a Supervised Aerobic Exercise Training Intervention in Night-Shift Hospital Nurses: A Randomized Controlled Trial. Voir source | 42444395 | 10.1096/fj.202504084RR | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | |
| Luseogliflozin restores GIP responsiveness in diabetic male mice with preserved β-cell function. Voir source | 42436594 | 10.14814/phy2.71016 | Physiological reports | |
| RGD-functionalized cannabidiol lipid nanoparticles improve brain delivery and alleviate cognitive and metabolic dysfunction via gut-brain axis modulation in an Alzheimer's disease model. Voir source | 42424917 | 10.1016/j.biopha.2026.119724 | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | |
| Gamma-aminobutyric acid supplementation combined with gonadotropin-releasing hormone analog therapy versus gonadotropin-releasing hormone analog therapy alone for linear growth in children with growth retardation: a retrospective cohort study. Voir source | 42433946 | 10.21037/tp-2026-1-0024 | Translational pediatrics | |
| Current perspectives on the pathogenesis of multiple sclerosis: A minireview. Voir source | 42365629 | 10.2478/enr-2026-0009 | Endocrine regulations |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-08-24
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