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National Institutes of Health Clinical Center
Bethesda — United States
Essais liés90clinical trials
VilleBethesdalocalisation
PaysUnited Stateslocalisation
SourcelocaleCSV/MySQL
Informations
centreSynchronisé depuis ClinicalTrials.gov — NCT04431024
Essais cliniques associés
90| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| 177Lu-DOTA-EB-TATE | Cancer | Phase 1/2 | NCT06991738 | 177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer | NOT_YET_RECRUITING |
| Pomalidomide | Cancer | Phase 1 | NCT04902443 | Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV | RECRUITING |
| A Natural History Study of RYR1-Related Disorders | Myopathies | À vérifier | NCT06287762 | A Natural History Study of RYR1-Related Disorders | RECRUITING |
| The Effect of Diet and Exercise on ImmuNotherapy and the Microbiome (EDEN) | Cancer | Non applicable | NCT04866810 | The Effect of Diet and Exercise on ImmuNotherapy and the Microbiome (EDEN) | SUSPENDED |
| pacritinib | Cancer | Phase 1/2 | NCT06303193 | Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms | RECRUITING |
| Natural History Study of Parathyroid Disorders | Cancer | À vérifier | NCT04969926 | Natural History Study of Parathyroid Disorders | RECRUITING |
| NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid Tumors | Cancer | À vérifier | NCT07489378 | NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid Tumors | RECRUITING |
| Childhood-Onset Essential Hypertension Natural History Study | Hypertension | À vérifier | NCT06778239 | Childhood-Onset Essential Hypertension Natural History Study | RECRUITING |
| Natural History Protocol for Movement Disorders | Parkinson | À vérifier | NCT05413291 | Natural History Protocol for Movement Disorders | RECRUITING |
| Investigational Use of Neuromuscular Ultrasound | Myopathies | À vérifier | NCT05237973 | Investigational Use of Neuromuscular Ultrasound | RECRUITING |
| A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases | Myopathies | À vérifier | NCT01417533 | A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases | COMPLETED |
| Data Collection, Clinical Care and Interventions in CCR, NCI | Cancer | À vérifier | NCT00923065 | Data Collection, Clinical Care and Interventions in CCR, NCI | ENROLLING_BY_INVITATION |
| Lu-177-DOTATATE | Cancer | Phase 1/2 | NCT04086485 | Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET) | RECRUITING |
| Allogeneic stem cell transplant | Cancer | Phase 1 | NCT01087294 | Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation | COMPLETED |
| Bevacizumab | Cancer | Phase 2 | NCT05797246 | Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP) | ACTIVE_NOT_RECRUITING |
| Tumor Related Epilepsy | Épilepsie | À vérifier | NCT02639325 | Tumor Related Epilepsy | RECRUITING |
| Study of Direct Brain Recording and Stimulation for Memory Enhancement | Épilepsie | À vérifier | NCT04095026 | Study of Direct Brain Recording and Stimulation for Memory Enhancement | ENROLLING_BY_INVITATION |
| 18F-Fluoro-L-dopa | Parkinson | À vérifier | NCT00024622 | PET Scanning in Parkinson s Disease | COMPLETED |
| Convection enhanced delivery/AAV2-GDNF | Parkinson | Phase 1 | NCT01621581 | AAV2-GDNF for Advanced Parkinson s Disease | COMPLETED |
| Cilostazol | SEP | Phase 1/2 | NCT03109288 | Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS) | RECRUITING |
| Methylprednisolone | SEP | Phase 2 | NCT02784210 | Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques | RECRUITING |
| Genetic and Physical Study of Childhood Nerve and Muscle Disorders | Myopathies | À vérifier | NCT01568658 | Genetic and Physical Study of Childhood Nerve and Muscle Disorders | ACTIVE_NOT_RECRUITING |
| Adult and Juvenile Myositis | Myopathies | À vérifier | NCT00017914 | Adult and Juvenile Myositis | RECRUITING |
| Biopsy Procedure | Cancer | Phase 1 | NCT03502733 | Testing the Combination of Copanlisib, Nivolumab and Ipilimumab in Patients With Advanced Cancer and Lymphoma | ACTIVE_NOT_RECRUITING |
| Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST) | Hypertension | À vérifier | NCT02055209 | Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST) | COMPLETED |
| Diabetes and Heart Disease Risk in Blacks | Hypertension | À vérifier | NCT00001853 | Diabetes and Heart Disease Risk in Blacks | RECRUITING |
| Genetic Studies of Lysosomal Storage Disorders | Parkinson | À vérifier | NCT00001215 | Genetic Studies of Lysosomal Storage Disorders | ENROLLING_BY_INVITATION |
| 13N-Ammonia | Parkinson | À vérifier | NCT03648905 | Clinical Laboratory Evaluation of Chronic Autonomic Failure | COMPLETED |
| Cyclophosphamide | Cancer | Phase 2 | NCT07524530 | Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood Cancers | NOT_YET_RECRUITING |
| aldesleukin | Cancer | Phase 1 | NCT06253520 | Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer | ACTIVE_NOT_RECRUITING |
| Stereotactic Body Radiation Therapy (SBRT) | Cancer | Phase 1 | NCT04235777 | Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies | ACTIVE_NOT_RECRUITING |
| TSLPR-CART | Cancer | Phase 1 | NCT07572136 | Anti-CRLF2-R/TSLPR Chimeric Antigen Receptor T Cells (TSLPR-CART) in Participants With Recurrent or Refractory CRLF2-R/TSLPR-Overexpressing B-Cell Acute Lymphoblastic Leukemia (B-ALL) | NOT_YET_RECRUITING |
| Belinostat | Cancer | Phase 2 | NCT06406465 | A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicity | RECRUITING |
| 11C-MC1 | Sclérose latérale amyotrophique | Phase 1 | NCT04396873 | PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease | RECRUITING |
| EA-KAFO | Myopathies | Non applicable | NCT01961557 | Evaluating a New Knee-Ankle-Foot Brace to Improve Gait in Children With Movement Disorders | COMPLETED |
| Study of Inherited Neurological Disorders | Myopathies | À vérifier | NCT00004568 | Study of Inherited Neurological Disorders | RECRUITING |
| Patient-Centered Assessment of Symptoms and Outcomes | Myopathies | À vérifier | NCT03952624 | Patient-Centered Assessment of Symptoms and Outcomes | ACTIVE_NOT_RECRUITING |
| Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus | Lupus | Phase 1/2 | NCT06032923 | Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus | RECRUITING |
| N-803 | Cancer | Phase 2 | NCT07686380 | IL-15 Superagonist With or Without Vaccine in Biochemically Recurrent Prostate Cancer After Previous Stereotactic Body Radiation Therapy | NOT_YET_RECRUITING |
| IL-12 GEMys | Cancer | Phase 1 | NCT07672483 | IL-12 Genetically Engineered Myeloid Cells in Participants With Relapsed, Refractory Solid Tumors | NOT_YET_RECRUITING |
| Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection | Cancer | À vérifier | NCT04431024 | Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome | RECRUITING |
| Anti-CD19 CAR PBL | Cancer | À vérifier | NCT00068003 | Harvesting Cells for Experimental Cancer Treatments | ENROLLING_BY_INVITATION |
| PRGN-2012 | Cancer | Phase 2 | NCT07756840 | Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP) | NOT_YET_RECRUITING |
| Mobile Sensor Technologies to Assess General Symptomology of People With Cancer | Cancer | À vérifier | NCT04465214 | Mobile Sensor Technologies to Assess General Symptomology of People With Cancer | COMPLETED |
| A Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Ind | Cancer | Non applicable | NCT05621291 | A Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymph... | RECRUITING |
| Clinical and Physiological Studies of Tremor Syndromes | Parkinson | À vérifier | NCT03027310 | Clinical and Physiological Studies of Tremor Syndromes | COMPLETED |
| Deep Brain Stimulation management | Parkinson | Non applicable | NCT02119611 | Deep Brain Stimulation Therapy in Movement Disorders | RECRUITING |
| Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System | SEP | À vérifier | NCT00794352 | Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System | RECRUITING |
| Ferumoxytol | SEP | Phase 1 | NCT02511028 | In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging | COMPLETED |
| Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation | Sclérose latérale amyotrophique | À vérifier | NCT01925196 | Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation | COMPLETED |
| Acamprosate calcium | Sclérose latérale amyotrophique | Phase 1 | NCT07204977 | Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS) | ACTIVE_NOT_RECRUITING |
| Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | Sclérose latérale amyotrophique | À vérifier | NCT03225144 | Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | RECRUITING |
| Extension assist knee ankle foot orthosis (EA-KAFO) | Myopathies | À vérifier | NCT06998134 | Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults | RECRUITING |
| Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy | Myopathies | À vérifier | NCT01851447 | Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy | ACTIVE_NOT_RECRUITING |
| Data Collection of Standard Care of Patients in the EMG Section | Myopathies | À vérifier | NCT05041387 | Data Collection of Standard Care of Patients in the EMG Section | RECRUITING |
| FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM) | Myopathies | Phase 2 | NCT07111065 | FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM) | RECRUITING |
| Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases Including Juvenile Dermatomyositis | Myopathies | À vérifier | NCT00059748 | Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases Including Juvenile Dermatomyositis | COMPLETED |
| Biospecimen Collection | SEP | Phase 1 | NCT03816345 | Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO | RECRUITING |
| Study of Systemic Lupus Erythematosus | Lupus | À vérifier | NCT00001372 | Study of Systemic Lupus Erythematosus | RECRUITING |
| Thyrogen | Cancer | Phase 2 | NCT03841617 | The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer | RECRUITING |
| azacytidine | Cancer | Phase 1/2 | NCT06694454 | Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC) | SUSPENDED |
| Biopsy Procedure | Cancer | Phase 2 | NCT06126276 | Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial) | RECRUITING |
| SX-682 | Cancer | Phase 1/2 | NCT07667400 | Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer | NOT_YET_RECRUITING |
| Romidepsin | Cancer | Phase 1 | NCT04447027 | Romidepsin, CC-486 (5-azacitidine), Dexamethasone, and Lenalidomide (RAdR) for Relapsed/Refractory T-cell Malignancies | COMPLETED |
| EP0057 | Cancer | Phase 1 | NCT02769962 | Trial of EP0057, a Nanoparticle Camptothecin With Olaparib in People With Relapsed/Refractory Small Cell Lung Cancer | TERMINATED |
| Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases | Cancer | À vérifier | NCT01445483 | Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases | COMPLETED |
| Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectabl | Cancer | À vérifier | NCT07619534 | Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain Metastases | NOT_YET_RECRUITING |
| 18F-DCFPyL | Cancer | Phase 2 | NCT03181867 | 18F-DCFPyL PET/CT in High Risk and Recurrent Prostate Cancer | ACTIVE_NOT_RECRUITING |
| Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer | Cancer | À vérifier | NCT00033137 | Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer | RECRUITING |
| Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer | Cancer | Non applicable | NCT04692675 | Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer | RECRUITING |
| aldesleukin | Cancer | Phase 1 | NCT06904066 | Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies | RECRUITING |
| WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study) | Hypertension | À vérifier | NCT02692846 | WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study) | COMPLETED |
| NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder | Migraine | À vérifier | NCT05669703 | NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder | RECRUITING |
| Mangafodipir | Épilepsie | Phase 1 | NCT02531880 | Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy | RECRUITING |
| A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders | Épilepsie | À vérifier | NCT06092346 | A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders | RECRUITING |
| Surgery as a Treatment for Medically Intractable Epilepsy | Épilepsie | À vérifier | NCT01273129 | Surgery as a Treatment for Medically Intractable Epilepsy | RECRUITING |
| MRI | Épilepsie | À vérifier | NCT02107989 | Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database | RECRUITING |
| Inherited Diseases, Caregiving, and Social Networks | Alzheimer | À vérifier | NCT01498263 | Inherited Diseases, Caregiving, and Social Networks | COMPLETED |
| 18F-PF974 | Alzheimer | Phase 1 | NCT07169630 | PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) | RECRUITING |
| Oxygen-15 Water | Parkinson | À vérifier | NCT00001258 | Studies of Frontal Lobe Brain Functioning in Schizophrenia | COMPLETED |
| 15-0 H20 | Parkinson | À vérifier | NCT00302146 | Positron Emission Tomography (PET) Imaging in People With Gaucher Mutations | COMPLETED |
| Medtronic Activa Tremor Control System | Parkinson | Non applicable | NCT01581580 | Deep Brain Stimulation Surgery for Movement Disorders | RECRUITING |
| Avelumab | Parkinson | Phase 2 | NCT03076554 | A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy | ACTIVE_NOT_RECRUITING |
| Laboratory tests | Épilepsie | À vérifier | NCT00060541 | Evaluation and Treatment of Neurosurgical Disorders | RECRUITING |
| Imaging Biomarkers in Parkinson s Disease | Parkinson | À vérifier | NCT01496599 | Imaging Biomarkers in Parkinson s Disease | COMPLETED |
| Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS) | SEP | À vérifier | NCT00001248 | Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS) | RECRUITING |
| Study of Families With Twins or Siblings Discordant for Rheumatic Disorders | Lupus | À vérifier | NCT00055055 | Study of Families With Twins or Siblings Discordant for Rheumatic Disorders | COMPLETED |
| 68-Gallium DOTATATE | Cancer | Phase 2 | NCT04074135 | Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors | RECRUITING |
| Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility | SEP | À vérifier | NCT01617395 | Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility | COMPLETED |
| tolebrutinib 60mg | SEP | Phase 2 | NCT04742400 | Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis | UNKNOWN |