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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Estimating the cost-effectiveness of tumor treating fields for locall… Nab-paclitaxel · PMID 42517235 | Cancer | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Locally advanced pancreatic cancer (LAPC) is associated with limited survival, high symptom burden, and few therapeutic… | Journal of medical economics 2026-08-16 13:08:51 | Source |
| Neoadjuvant Early Stereotactic Body Radiation Therapy Followed by Che… Nab-paclitaxel · PMID 42571456 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Optimal neoadjuvant therapy for borderline resectable pancreatic cancer/locally advanced pancreatic cancer (BRPC/LAPC)… | Advances in radiation oncology 2026-08-16 13:08:51 | Source |
| ATR-FTIR spectroscopy coupled with multivariate analysis for monitori… Semaglutide · PMID 42330703 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Therapeutic peptides represent an important class of biomolecules with great clinical and economic significance, howeve… | Spectrochimica acta. Part A, Molecular and biomolecula… 2026-08-16 13:08:44 | Source |
| Comparison of lifestyle, surgery, and semaglutide for weight manageme… Semaglutide · PMID 42495930 | Cancer | À vérifier | Publication | PubMed | Voir la publication source To compare sleeve gastrectomy, semaglutide therapy, and the Diet, Exercise, Accompany and Refresh (DEAR) weight managem… | Journal of obstetrics and gynaecology : the journal of… 2026-08-16 13:08:44 | Source |
| Design, synthesis, and stability evaluation of semaglutide-derived la… Semaglutide · PMID 42578506 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Glucagon-like peptide-1 receptor (GLP-1R) ligands including semaglutide play an important role in drug discovery. Herei… | Journal of enzyme inhibition and medicinal chemistry 2026-08-16 13:08:44 | Source |
| Revisited case for intranasal neuropeptide Y based therapeutics: From… Saline Intranasal Delivery · PMID 41818915 | Maladie d’Alzheimer | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Compelling evidence from a variety of approaches attributes manifold benefits to NPY in the brain. NPY can reduce stres… | Neuropeptides 2026-08-16 13:08:42 | Source |
| Safety survey of intranasal glutathione. Intranasal glutathione - (in)GSH · PMID 23240940 | Maladie de Parkinson | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Glutathione depletion has been documented in several disease states, and exogenous administration has been hypothesized… | Journal of alternative and complementary medicine (New… 2026-08-16 13:08:41 | Source |
| Therapeutic Silencing of Tmprss6 Reduces Iron-Induced Inflammation an… deferiprone · PMID 42240074 | Maladie de Parkinson · Sclérose latérale amyotrophique · Sclérose lat… | Neuroprotection · Ralentissement de la progression · Immunomodulation · Thérapi… | Publication | PubMed | Voir la publication source Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffectiv… | American journal of hematology 2026-08-16 13:08:40 | Source |
| Trace Elements Dyshomeostasis and Toxic Metals Neurotoxicity in Neuro… deferiprone · PMID 42332177 | Maladie d’Alzheimer · Maladie de Parkinson · Sclérose latérale amyotr… | Remyélinisation indirecte / réparation · Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lat… | Biological trace element research 2026-08-16 13:08:40 | Source |
| Transcutaneous auricular vagus nerve stimulation combined with ciprof… Sham Transcutaneous Electrical Stimulation of Vagus Nerve · PMID 42384896 | Maladie de Parkinson | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Transcutaneous auricular vagus nerve stimulation (taVNS) provides targeted modulation of the autonomic nervous system a… | Annals of medicine 2026-08-16 13:08:39 | Source |
| Effect of transcutaneous auricular vagus nerve stimulation on postope… Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve · PMID 42455519 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Postoperative pain after thoracic surgery remains common and challenging. Transcutaneous auricular vagus nerve stimulat… | Annals of medicine 2026-08-16 13:08:38 | Source |
| Transcutaneous auricular vagus nerve stimulation and stress regulatio… Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve · PMID 42339759 | Maladie de Parkinson | Immunomodulation | Publication | PubMed | Voir la publication source Chronic stress exposure contributes to the onset and maintenance of a wide range of mental and physical disorders. Non-… | Stress (Amsterdam, Netherlands) 2026-08-16 13:08:38 | Source |
| Transcutaneous auricular vagus nerve stimulation for postoperative na… Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve · PMID 42434858 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Postoperative nausea and vomiting (PONV) are common adverse events following gynecological laparoscopic surgery. This s… | Annals of medicine 2026-08-16 13:08:38 | Source |
| A Rare Case of Homicidal Asphyxia Involving Combined Mechanisms By Mu… Abdominal compression · PMID 41709776 | Maladie de Parkinson | Thérapie génique | Publication | PubMed | Voir la publication source Mechanical asphyxia is well documented in forensic pathology; however, deaths resulting from the simultaneous action of… | The American journal of forensic medicine and pathology 2026-08-16 13:08:36 | Source |
| Comparison of breath hold and abdominal compression for liver SABR on… Abdominal compression · PMID 42470848 | Maladie de Parkinson | Thérapie génique | Publication | PubMed | Voir la publication source Respiratory motion is a challenge for accurate stereotactic ablative radiotherapy (SABR) to the liver. This study compa… | Physica medica : PM : an international journal devoted… 2026-08-16 13:08:36 | Source |
| Multi-lead Monitoring to Deduce Translations and Rotations of the Hea… Abdominal compression · PMID 41850495 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source To investigate the time-resolved translations and rotations of the heart through respiration and their impact on target… | International journal of radiation oncology, biology,… 2026-08-16 13:08:36 | Source |
| Impact of COVID‑19 infection on subsequent prescriptions of autonomic… Midodrine · PMID 41560500 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Autonomic dysfunction, including orthostatic hypotension and postural tachycardia syndrome, has emerged as a COVID-19 c… | Annals of medicine 2026-08-16 13:08:33 | Source |
| Risk Factors for Adverse Drug Reactions of Augmented Mean Arterial Pr… Midodrine · PMID 42341613 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Spinal cord injury guidelines recommend a mean arterial pressure (MAP) of 85-90 mmHg for the first 7 d. Vasopressors ar… | The Journal of surgical research 2026-08-16 13:08:33 | Source |
| The effect of fludrocortisone and midodrine on ambulatory blood press… Midodrine · PMID 41542998 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Fludrocortisone and midodrine are frequently used to raise blood pressure (BP) in patients with vasovagal syncope (VVS)… | Blood pressure 2026-08-16 13:08:33 | Source |
| Exosome-like nanoparticles derived from co-decoction enhance oral bio… 5-Fluorouracil (5-FU) · PMID 42495154 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The low oral bioavailability of bioactive components from the herb pair severely restricts its clinical application in… | International journal of pharmaceutics: X 2026-08-16 13:08:31 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||