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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Spatially resolved label-free FTIR imaging reveals compartment-specif… Sacubitril/valsartan · PMID 42456519 | Hypertension artérielle | Ralentissement de la progression | Publication | PubMed | Voir la publication source Cardiorenal syndrome (CRS) involves complex and spatially heterogeneous remodeling in both cardiac and renal tissues. C… | Spectrochimica acta. Part A, Molecular and biomolecula… 2026-08-16 13:12:29 | Source |
| A pharmacokinetic and pharmacodynamic drug interaction between rosuva… Valsartan 160 mg + Rosuvastatin 20 mg · PMID 25767372 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Valsartan, an angiotensin-receptor blocker, and rosuvastatin, a competitive inhibitor of the 3-hydroxy-3-methylglutaryl… | Drug design, development and therapy 2026-08-16 13:12:27 | Source |
| Effect of Amlodipine/Valsartan Versus Nebivolol/Valsartan Fixed Dose… Amlodipine 10 mg + Valsartan 160 mg · PMID 30390203 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Although hypertensive drugs may have the same effect on peripheral blood pressure, they vary in their effect on central… | High blood pressure & cardiovascular prevention : the… 2026-08-16 13:12:26 | Source |
| Effectiveness of Chlorthalidone Plus Amiloride for the Prevention of… Chlorthalidone plus amiloride · PMID 27965209 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Prehypertension is associated with higher cardiovascular risk, target organ damage, and incidence of hypertension. The… | Journal of the American Heart Association 2026-08-16 13:12:21 | Source |
| Autonomic neural control of dynamic cerebral autoregulation in humans. Trimethaphan · PMID 12356635 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The purpose of the present study was to determine the role of autonomic neural control of dynamic cerebral autoregulati… | Circulation 2026-08-16 13:12:16 | Source |
| Dynamic autoregulation of cutaneous circulation: differential control… Trimethaphan · PMID 15749747 | Hypertension artérielle | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source The purpose of this project was to test the hypothesis that, independent of neural control, glabrous and nonglabrous cu… | American journal of physiology. Heart and circulatory… 2026-08-16 13:12:16 | Source |
| Evidence of a myogenic response in vasomotor control of forearm and p… Trimethaphan · PMID 15090486 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Previous investigations of autoregulatory mechanisms in the control of skin blood flow suffer from the possibility of i… | Journal of applied physiology (Bethesda, Md. : 1985) 2026-08-16 13:12:16 | Source |
| Nightmare-focused interventions and suicide prevention: clarifying th… Prazosin · PMID 42223475 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Sleep 2026-08-16 13:12:14 | Source |
| Prazosin-Related Reductions in Daily Craving Mediate Treatment-Relate… Prazosin · PMID 42572561 | Hypertension artérielle | Traitement symptomatique | Publication | PubMed | Voir la publication source Prazosin has been shown to reduce drinking, particularly in individuals with alcohol withdrawal symptoms, possibly due… | Biological psychiatry global open science 2026-08-16 13:12:14 | Source |
| Effects of sympathomodulation on pulse wave properties in heart failu… Renal denervation · PMID 41222588 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source One important contributor to the pathogenesis and perpetuation of HFpEF is unfavorable pulse wave reflection, frequentl… | Clinical research in cardiology : official journal of… 2026-08-16 13:12:09 | Source |
| The onset of hypertension in metabolic syndrome is independent of ren… Renal denervation · PMID 42448569 | Hypertension artérielle | Ralentissement de la progression | Publication | PubMed | Voir la publication source Increased sympathetic tone and hypertension are hallmarks of metabolic syndrome and contribute to chronic kidney diseas… | Life science alliance 2026-08-16 13:12:09 | Source |
| Assessment of the safety and effectiveness of catheter-based renal de… Renal Denervation (Symplicity Spyral™) · PMID 41568449 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Renal denervation (RDN) has emerged as a potential therapeutic option for resistant hypertension (HT), which remains a… | Clinical and experimental hypertension (New York, N.Y.… 2026-08-16 13:12:08 | Source |
| Effects of renal denervation on the incidence and severity of cardiov… The Paradise® Renal Denervation Ultrasound System · PMID 39210082 | Hypertension artérielle | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Renal denervation (RDN) is a neuromodulation therapy performed in patients with hypertension using an intraarterial cat… | Hypertension research : official journal of the Japane… 2026-08-16 13:12:07 | Source |
| Renal nerves in physiology, pathophysiology and interoception. The Paradise® Renal Denervation Ultrasound System · PMID 39363020 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Sympathetic efferent renal nerves have key roles in the regulation of kidney function and blood pressure. Increased ren… | Nature reviews. Nephrology 2026-08-16 13:12:07 | Source |
| Effect of Adding Erector Spinae Plane Block to a Multimodal Analgesic… Sham Procedure · PMID 42604369 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source Available evidence regarding the effect of erector spinae plane block (ESPB) as a component of multimodal analgesia on… | Journal of pain research 2026-08-16 13:12:04 | Source |
| Long-term outcomes of genicular artery embolization for knee osteoart… Sham Procedure · PMID 42009866 | Cancer · Hypertension artérielle · Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source To determine if genicular artery embolization (GAE) is more effective in relieving pain symptoms after 12 months compar… | European radiology 2026-08-16 13:12:04 | Source |
| Preclinical Pharmacokinetics of Erdafitinib, an FGFR Tyrosine Kinase… Telmisartan · PMID 42187041 | Maladie d’Alzheimer · Hypertension artérielle · Hypertension artériel… | Thérapie génique | Publication | PubMed | Voir la publication source Erdafitinib is a pan-FGFR tyrosine inhibitor approved for urothelial carcinoma, with growing interest in its broader an… | Rapid communications in mass spectrometry : RCM 2026-08-16 13:12:04 | Source |
| Aspirin protects trophoblast function against hypoxia-induced oxidati… Aspirin (acetylsalicylic acid) · PMID 42241790 | Migraine | Neuroprotection · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Preeclampsia (PE, a pregnancy-specific hypertensive disorder) is characterized by placental hypoxia, oxidative stress,… | Reproductive biology 2026-08-16 13:12:02 | Source |
| Acoustic Coupling for Double-Blind Human Low-Intensity Focused Ultras… sham device · PMID 42115110 | Migraine | Thérapie génique | Publication | PubMed | Voir la publication source Low-intensity focused ultrasound (LIFU) is a non-invasive neuromodulation technique with the potential for precise targ… | Ultrasound in medicine & biology 2026-08-16 13:12:01 | Source |
| Clinical Efficacy of Pulsed Electromagnetic Field Therapy on Thumb Ca… sham device · PMID 41015912 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Thumb carpometacarpal (CMC) osteoarthritis (OA) is a common source of hand pain with limited nonoperative treatment opt… | Hand (New York, N.Y.) 2026-08-16 13:12:01 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||