Vue transversale globale
Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
Filtrer toute la vue
Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
· 41 visibles sur cette page
dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| A randomized controlled trial comparing the efficacy of nifedipine an… Comparator Nifedipine 30 mg Extended-Release · PMID 37806651 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Postpartum hypertension is a common medical complication of pregnancy and is associated with increased healthcare use,… | American journal of obstetrics & gynecology MFM 2026-08-16 13:13:35 | Source |
| Comparative efficacy of generic nifedipine versus brand-name amlodipi… Comparator Nifedipine 30 mg Extended-Release · PMID 35674192 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The control rate of hypertension remains concerning, indicating the requirement for better management strategies. The c… | Journal of clinical hypertension (Greenwich, Conn.) 2026-08-16 13:13:35 | Source |
| Trial of Intrapartum Extended-Release Nifedipine to Prevent Severe Hy… Comparator Nifedipine 30 mg Extended-Release · PMID 36189646 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Preeclampsia is associated with maternal and perinatal morbidity. Besides acute therapy for severe hypertension, best p… | Hypertension (Dallas, Tex. : 1979) 2026-08-16 13:13:35 | Source |
| Causal relationship between epigenetic markers and type 2 diabetes in… Genetics of Type 2 Diabetes in West Africans · PMID 42032377 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Evidence for a causal role of DNA methylation sites (CpGs) in type 2 diabetes and glycaemic traits is limited due to th… | Diabetologia 2026-08-16 13:13:31 | Source |
| Epigenome-wide analysis in West Africans identifies DNA methylation m… Genetics of Type 2 Diabetes in West Africans · PMID 41793944 | Hypertension artérielle | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Adiponectin is a circulating adipokine involved in energy metabolism and inflammation, with reported protective effects… | EBioMedicine 2026-08-16 13:13:31 | Source |
| Integration of clinical and proteomic risk factors enhances prognosti… Genetics of Type 2 Diabetes in West Africans · PMID 41559749 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source BACKGROUND: Type 2 diabetes complications manifest across various organs, but are fundamentally rooted in vascular dysf… | Cardiovascular diabetology 2026-08-16 13:13:31 | Source |
| Exploring the role of social media and online communities in the infe… Impact of Online Medical Misinformation · PMID 41999203 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Infertility is a global health challenge with profound psychosocial consequences. Couples navigate this journey within… | Journal of psychosomatic obstetrics and gynaecology 2026-08-16 13:13:30 | Source |
| Impact of faculty and resident gender on milestone evaluations in ane… Impact of Online Medical Misinformation · PMID 42429203 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Anesthesia-specific milestone evaluations are intended to objectively assess performance in ACGME core competencies for… | Medical education online 2026-08-16 13:13:30 | Source |
| Leveraging near-peer teaching: the impact of cognitive and social con… Impact of Online Medical Misinformation · PMID 42157464 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Equipping future clinicians to recognize and reverse opioid overdoses requires experiential training and access to nalo… | Medical education online 2026-08-16 13:13:30 | Source |
| Effects of air pollution on disease activity in patients with rheumat… BATHE-Family Medicine · PMID 42557168 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source This study aimed to evaluate the associations of air pollution with disease activity and flare rate in patients with rh… | Annals of the rheumatic diseases 2026-08-16 13:13:29 | Source |
| Carotid body excision significantly changes ventilatory control in aw… Carotid body excision · PMID 3372424 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source We determined the effects of carotid body excision (CBX) on eupneic ventilation and the ventilatory responses to acute… | Journal of applied physiology (Bethesda, Md. : 1985) 2026-08-16 13:13:25 | Source |
| Effects of carotid body excision on recovery of respiratory function… Carotid body excision · PMID 15919075 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source In a previous study, we described the spontaneous recovery of respiratory motor function in adult rats subjected to a l… | Experimental neurology 2026-08-16 13:13:25 | Source |
| The effects of unilateral carotid body excision on ventilatory contro… Carotid body excision · PMID 6672918 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The purpose of this study was to determine whether or not unilateral carotid body excision (UCBE) alters normal respira… | Respiration physiology 2026-08-16 13:13:25 | Source |
| Ectopic ACTH-dependent Cushing syndrome in 3 hospitalized patients: l… Osilodrostat · PMID 42591670 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Severe Cushing syndrome (CS) is a rare diagnosis with high mortality, which limits the ability of endocrinologists to g… | JCEM case reports 2026-08-16 13:13:24 | Source |
| Is Hypercortisolism Treatable? Which Patients Should Be Treated and H… Osilodrostat · PMID 42533758 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source To provide a practical guide on when to suspect endogenous hypercortisolism, how to use the overnight 1-mg dexamethason… | Diabetes, obesity & metabolism 2026-08-16 13:13:24 | Source |
| Protracted osilodrostat-induced pan-adrenal steroidogenic suppression… Osilodrostat · PMID 42494874 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Osilodrostat, a potent 11β-hydroxylase inhibitor, is used for Cushing syndrome. Transient adrenal insufficiency during… | JCEM case reports 2026-08-16 13:13:24 | Source |
| Association between orthostatic blood pressure change and masked and… Home BP · PMID 42267569 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Exaggerated blood pressure (BP) response to orthostatic stimuli is indicative of cardiovascular frailty and may be asso… | Journal of hypertension 2026-08-16 13:13:23 | Source |
| Bu-Sui-Dan promotes angiogenesis to mitigate age-related osteoporosis… CBP · PMID 42364672 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Bu-Sui-Dan (BSD) is a traditional Chinese medicine formulation first recorded in the Song Dynasty text Shi Zhai Bai Yi… | Journal of ethnopharmacology 2026-08-16 13:13:23 | Source |
| Measurement of blood pressure in European Society of Hypertension Exc… Home BP · PMID 41855474 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Office blood pressure (BP) measurement is the cornerstone of hypertension diagnosis and risk stratification. Inaccurate… | Blood pressure 2026-08-16 13:13:23 | Source |
| Reassessing blood pressure control: the role of long-term blood press… Home BP · PMID 41924975 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source This review summarizes current evidence on visit-to-visit blood pressure variability (BPV) and blood pressure time in t… | Blood pressure 2026-08-16 13:13:23 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||