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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| The colloidal stability of albumin-based drug delivery systems has a… paclitaxel albumin-stabilized nanoparticle formulation · PMID 41556287 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Human serum albumin (HSA) has attracted significant attention in drug delivery since the approval of Abraxane in 2005.… | Drug delivery 2026-08-16 13:14:28 | Source |
| Multimodality imaging features of primary mammary angiosarcoma: a cas… 18F-FDG · PMID 42569372 | Cancer · Épilepsie · Épilepsie | Thérapie génique | Publication | PubMed | Voir la publication source Primary angiosarcoma of the breast is an uncommon and aggressive vascular malignancy that typically affects young women… | Radiology case reports 2026-08-16 13:14:27 | Source |
| Unveiling the unexpected: Skeletal sarcoidosis with an extraosseous s… 18F-FDG · PMID 42491317 | Cancer · Épilepsie · Épilepsie | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Sarcoidosis is a chronic granulomatous, multisystem disease of uncertain etiology that affects various organ systems, a… | Radiology case reports 2026-08-16 13:14:27 | Source |
| Finger-cuff and oscillometric versus intra-arterial blood pressure me… ARMFIN — Arm and Finger Measurement for Blood Pressure Surveillance · PMID 42476889 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Arterial blood pressure monitoring is mandatory in all patients having surgery. Intra-arterial blood pressure monitorin… | British journal of anaesthesia 2026-08-16 13:14:26 | Source |
| Intervals for Oscillometric Arterial Pressure Monitoring during Nonca… ARMFIN — Arm and Finger Measurement for Blood Pressure Surveillance · PMID 42102346 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Guidelines recommend measuring arterial pressure at least every 5 min during surgery. However, it remains unknown wheth… | Anesthesiology 2026-08-16 13:14:26 | Source |
| Validation of Minimally Invasive and Noninvasive Hemodynamic Monitori… ARMFIN — Arm and Finger Measurement for Blood Pressure Surveillance · PMID 42560156 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Minimally invasive cardiac output (CO) monitoring technologies lack validation in the adolescent population. We aimed t… | Pediatric critical care medicine : a journal of the So… 2026-08-16 13:14:26 | Source |
| Acute myocardial infarction in a patient with HAM/TSP evaluated for c… Effectiveness of Entresto (Sacubitril/Valsartan) in Japanese Patients With Hypertension · PMID… | Hypertension artérielle | Traitement symptomatique | Publication | PubMed | Voir la publication source Antihypertensive therapy plays a crucial role in managing cardiovascular disease but may sometimes cause significant hy… | Journal of medical case reports 2026-08-16 13:14:25 | Source |
| Design and Rationale of the Home Blood Pressure Telemonitoring Linked… LINKED-BP — Home Blood Pressure Telemonitoring LINKED With Community Health Workers to Improve… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Disparities in hypertension outcomes persist among Black and Hispanic adults and persons living in poverty in the Unite… | American journal of hypertension 2026-08-16 13:14:25 | Source |
| Prescription patterns of sacubitril/valsartan among patients with hyp… Effectiveness of Entresto (Sacubitril/Valsartan) in Japanese Patients With Hypertension · PMID… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Sacubitril/valsartan (S/V) is an established therapy for heart failure that has been recently approved for hypertension… | Frontiers in cardiovascular medicine 2026-08-16 13:14:25 | Source |
| Randomized-controlled trial of sacubitril/valsartan and amlodipine co… Effectiveness of Entresto (Sacubitril/Valsartan) in Japanese Patients With Hypertension · PMID… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source This multicenter, randomized, double-blind, parallel-group, active-controlled study aimed to demonstrate a superior BP-… | Hypertension research : official journal of the Japane… 2026-08-16 13:14:25 | Source |
| Angiotensinogen Reconsidered: Evolving Perspectives in Hypertension R… Zilebesiran · PMID 41853854 | Hypertension artérielle | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Hypertension is the leading modifiable risk factor for cardiovascular disease, stroke, chronic kidney disease, and prem… | Hypertension (Dallas, Tex. : 1979) 2026-08-16 13:14:21 | Source |
| Breakthrough drugs in the treatment of hypertension-related disease. Zilebesiran · PMID 42443375 | Hypertension artérielle | Ralentissement de la progression | Publication | PubMed | Voir la publication source As populations age, the long-term cumulative burden of lifestyle-related diseases has become a major determinant of age… | Hypertension research : official journal of the Japane… 2026-08-16 13:14:21 | Source |
| Hypertension at an Inflection Point: Aggressive Targets Meet Novel Me… Zilebesiran · PMID 42307497 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Hypertension management is at an inflection point. Over the past 4 years, landmark trials have definitively established… | Journal of the American College of Cardiology 2026-08-16 13:14:21 | Source |
| The Impact of Celiprolol in Vascular Ehlers-Danlos Syndrome: A System… Alternate IV Antihypertensive Regimen · PMID 40559232 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Ehlers-Danlos syndrome (EDS) is a group of connective tissue disorders characterized by mutations affecting collagen an… | Medical sciences (Basel, Switzerland) 2026-08-16 13:14:20 | Source |
| Efficacy and Safety of a Generic Clevidipine in Hypertensive Urgencie… Clevidipine Injection · PMID 41085098 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Hypertensive crises require rapid blood pressure control to prevent stroke and myocardial injury. Despite Cleviprex's e… | Journal of clinical hypertension (Greenwich, Conn.) 2026-08-16 13:14:17 | Source |
| Efficacy and safety of clevidipine emulsion injection compared with n… Clevidipine Injection · PMID 41231022 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Clevidipine emulsion injection is an ultra-short-acting, intravenous calcium-channel blocker that produces a rapid and… | Journal of hypertension 2026-08-16 13:14:17 | Source |
| Simultaneous Quantitation of Clevidipine and Its Active Metabolite H1… Clevidipine Injection · PMID 35464212 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Clevidipine is an ultrashort-acting dihydropyridine calcium antagonist, which can control blood pressure accurately. It… | Frontiers in chemistry 2026-08-16 13:14:17 | Source |
| Assessment of knowledge, attitude, and practice of healthcare provide… Medication Self-Management Technology for Older Adults · PMID 42295998 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Snakebite envenomation remains a critical health challenge across the culturally and ecologically diverse sub-Saharan A… | Annals of medicine 2026-08-16 13:14:13 | Source |
| Health literacy, medication adherence, and quality-of-life scores in… Medication Self-Management Technology for Older Adults · PMID 42312418 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source This study examined the association of health literacy with quality-of-life outcomes among Jordanian adults with chroni… | The Libyan journal of medicine 2026-08-16 13:14:13 | Source |
| Self-reported health status and blood pressure medication use among p… Medication Self-Management Technology for Older Adults · PMID 42522968 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source While existing studies established an association between self-reported health status and healthcare service utilisatio… | Blood pressure 2026-08-16 13:14:13 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||