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Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Response to letter regarding: 'comparison of opioid-free versus opioi… Opioid free anesthetics · PMID 42033097 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Annals of medicine 2026-08-16 13:15:31 | Source |
| Response to letter regarding enhancing the evidence for opioid-free a… Opioid free anesthetics · PMID 41940455 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Annals of medicine 2026-08-16 13:15:31 | Source |
| CXCR4 coordinates adhesion, migration, and development of human NK ce… Plerixafor · PMID 42550609 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Natural killer (NK) cells undergo stepwise differentiation from multipotent progenitors within secondary lymphoid tissu… | JCI insight 2026-08-16 13:15:30 | Source |
| Effects of Stromal Cell-Derived Factor 1 on Osteoblast Activity Durin… Plerixafor · PMID 42594265 | Cancer | À vérifier | Publication | PubMed | Voir la publication source This study aimed to clarify the relationship between stromal cell‑derived factor 1 (SDF‑1) and osteoblast-related respo… | Clinical and experimental dental research 2026-08-16 13:15:30 | Source |
| PAMD-Ch17, a Polymeric Analog of Plerixafor, Induces Mitochondrial Dy… Plerixafor · PMID 41893624 | Cancer | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source PAMD-Ch17 is a polymer composed of the CXCR4 inhibitor AMD3100/Plerixafor with a cholesterol modification. In previous… | Molecular cancer therapeutics 2026-08-16 13:15:30 | Source |
| 3D computed tomography airway geometry for predicting bronchoscopic a… Radial Probe Endobronchial Ultrasound · PMID 42291365 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Bronchoscopic diagnosis of peripheral pulmonary nodules (PPNs) using radial probe endobronchial ultrasound (rEBUS) has… | Translational lung cancer research 2026-08-16 13:15:28 | Source |
| A multimodal bronchoscopic approach for diagnosing peripheral ground-… Bronchoscopy · PMID 42566914 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Ground-glass nodules (GGNs) remain challenging to diagnose using endobronchial ultrasound-guided transbronchial biopsy… | Annals of medicine 2026-08-16 13:15:27 | Source |
| Landscape of the upper and lower airway microbiota in children with c… Bronchoscopy · PMID 42388029 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Community-acquired pneumonia (CAP) is one of the most common causes of death in children. Obtaining lower airway sample… | Virulence 2026-08-16 13:15:27 | Source |
| Low, plasma level‑informed native curcumin concentrations fail to ind… Turmeric · PMID 41858052 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Curcumin, a dietary polyphenol derived from turmeric, has been widely studied for its anti-cancer properties, yet its e… | Pharmaceutical biology 2026-08-16 13:15:27 | Source |
| Rarely reported cases of hepatotoxicity associated with turmeric- and… Turmeric · PMID 42364655 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The United States Pharmacopeia (USP) Dietary Supplement Admission Evaluation and Labeling Expert Committee (DSAEL EC) r… | Pharmaceutical biology 2026-08-16 13:15:27 | Source |
| Remimazolam for sedation in flexible bronchoscopy: A systematic revie… Bronchoscopy · PMID 42313074 | Cancer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Remimazolam is a novel benzodiazepine increasingly used for procedural sedation and general anaesthesia. Its role in cl… | Pulmonology 2026-08-16 13:15:27 | Source |
| Optimal dose window, formulation efficacy, and molecular mechanisms o… Turmeric · PMID 42447971 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Approximately 25% of the global adult population is affected by metabolic dysfunction-associated steatotic liver diseas… | Journal of ethnopharmacology 2026-08-16 13:15:26 | Source |
| The sex hormone system in carriers of BRCA1/2 mutations: a case-contr… Breast Imaging Studies in Women at High Genetic Risk of Breast Cancer: Menstrual Cycle Study ·… | Cancer | À vérifier | Publication | PubMed | Voir la publication source Penetrance for breast cancer, ovarian cancer, or both in carriers of BRCA1/BRCA2 mutations is disproportionately high.… | The Lancet. Oncology 2026-08-16 13:15:25 | Source |
| Addition of pulsed electric field ablation to SBRT for lung tumors: e… Stereotactic Body Radiation Therapy (SBRT) · PMID 41783980 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Treatment indications for oligometastatic/oligoprogressive lung tumors are growing. Safety and lack of detrimental effe… | Lung cancer management 2026-08-16 13:15:24 | Source |
| Workflow and dosimetric results for direct-to-unit single-fraction ad… Stereotactic Body Radiation Therapy (SBRT) · PMID 42592074 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Direct-to-unit (DTU) workflows coupled with online adaptive radiation therapy can streamline stereotactic body radiatio… | Clinical and translational radiation oncology 2026-08-16 13:15:24 | Source |
| Sphingosine-1-Phosphate Receptor 3 Confers Tumor Metastasis in Lung C… AZD9291 · PMID 42039707 | Cancer | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source The third-generation EGFR tyrosine kinase inhibitor (TKI) osimertinib (AZD9291) has significantly improved the survival… | MedComm 2026-08-16 13:15:22 | Source |
| A fast method for the quantification of bortezomib in serum and rat n… bortezomib · PMID 42526316 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Bortezomib is a proteasome inhibitor used to treat cancers such as Multiple Myeloma and Mantle Cell Lymphoma. Due to it… | Journal of pharmaceutical and biomedical analysis 2026-08-16 13:15:18 | Source |
| Proliferative glomerulonephritis with monoclonal IgG3 deposits: A cas… bortezomib · PMID 42519182 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) caused by IgG3-dominant is rare and i… | Journal of translational autoimmunity 2026-08-16 13:15:18 | Source |
| Selinexor combined bortezomib, lenalidomide, and dexamethasone for ne… bortezomib · PMID 42544613 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source This study aimed to evaluate the efficacy and safety of selinexor combined with bortezomib, lenalidomide, and dexametha… | Annals of medicine 2026-08-16 13:15:18 | Source |
| Preclinical evaluation of zirconium-89 labeled anti-Trop2 antibody-dr… Sacituzumab govitecan-hziy · PMID 39878898 | Cancer | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Trophoblast cell-surface antigen 2 (Trop2) is overexpressed in various solid tumors and contributes to tumor progressio… | European journal of nuclear medicine and molecular ima… 2026-08-16 13:15:14 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||