Vue transversale globale
Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
Filtrer toute la vue
Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
· 41 visibles sur cette page
dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| An Initial Cost-Effectiveness Analysis of Magnetic Resonance-Guided L… Visualase Thermal Therapy System · PMID 32829333 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a new technology that provides a clinically e… | Pediatric neurosurgery 2026-08-16 13:20:31 | Source |
| Effects of variable power on tissue ablation dynamics during magnetic… Visualase Thermal Therapy System · PMID 28871860 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Magnetic resonance-guided laser-induced thermal therapy (MRgLITT) is a minimally invasive procedure used to treat vario… | International journal of hyperthermia : the official j… 2026-08-16 13:20:31 | Source |
| Intracranial MR-guided laser-induced thermal therapy: single-center e… Visualase Thermal Therapy System · PMID 26722845 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source OBJECTIVE MR-guided laser-induced thermal therapy (MRgLITT) can be used to treat intracranial tumors, epilepsy, and chr… | Journal of neurosurgery 2026-08-16 13:20:31 | Source |
| Fallopian tube nontuberculous mycobacterial infection caused by mimic… Debulking surgery · PMID 42542575 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source Fallopian tube carcinoma is frequently detected at an advanced stage, and its imaging findings and tumor marker profile… | Case reports in women's health 2026-08-16 13:20:30 | Source |
| Interval debulking with HIPEC in patient with VP shunt. Debulking surgery · PMID 42569202 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery has demonstrated survival benefit… | Gynecologic oncology reports 2026-08-16 13:20:30 | Source |
| Primary Peritoneal Perivesical Hemangiosarcoma in 16 Dogs (2020-2024). Debulking surgery · PMID 42525484 | Cancer | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Canine hemangiosarcoma (HSA) commonly arises in the spleen, heart, and skin, whereas primary peritoneal presentations a… | Veterinary medicine and science 2026-08-16 13:20:30 | Source |
| Irreversible electroporation in prostate cancer: efficacy, tumor immu… Irreversible electroporation (NanoKnife® ) · PMID 41809804 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Prostate cancer (PCa) endangers male health, with conventional treatments limited by poor efficacy and high complicatio… | Translational andrology and urology 2026-08-16 13:20:27 | Source |
| Robotic-Assisted Computed Tomography-Guided Percutaneous Bone Procedu… EPIONE device · PMID 42527616 | Cancer | À vérifier | Publication | PubMed | Voir la publication source To prospectively evaluate the feasibility, safety, and targeting accuracy of robotic-assisted CT-guided percutaneous bo… | Cardiovascular and interventional radiology 2026-08-16 13:20:26 | Source |
| Toward real-time alignment of 3D CT and 2D X-ray with multi-stage CNN… EPIONE device · PMID 42299683 | Cancer | À vérifier | Publication | PubMed | Voir la publication source 2D X-ray imaging is widely employed in image-guided interventions to provide real-time visualization of patient anatomy… | Computer assisted surgery (Abingdon, England) 2026-08-16 13:20:26 | Source |
| Cuttlefish Ink-Derived Melanin/MXene Composites: Boosting Stability a… Nano Knife · PMID 42178797 | Cancer | Remyélinisation indirecte / réparation · Immunomodulation | Publication | PubMed | Voir la publication source The advancement of MXene-based antibacterial platforms has been impeded by two critical limitations. Specifically, thes… | Small (Weinheim an der Bergstrasse, Germany) 2026-08-16 13:20:25 | Source |
| Exploring the Antimicrobial Potential of Vanadium-Based MXenes for Bi… Nano Knife · PMID 42145249 | Cancer | Neuroprotection | Publication | PubMed | Voir la publication source MXenes, a family of two-dimensional transition metal carbides, carbonitrides and nitrides, have emerged as highly inter… | MicrobiologyOpen 2026-08-16 13:20:25 | Source |
| Insulation-tipped nano knife-assisted primary precut versus conventio… Nano Knife · PMID 42377513 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Endoscopic retrograde cholangiopancreatography (ERCP) remains the gold standard for Common bile duct (CBD) stone manage… | Surgical endoscopy 2026-08-16 13:20:25 | Source |
| Computed tomography-ultrasonography (US) fusion for percutaneous neph… CT/US fusion · PMID 42174761 | Cancer | À vérifier | Publication | PubMed | Voir la publication source To assess whether computed tomography-ultrasonography (CT-US) fusion navigation, compared with conventional US guidance… | BJU international 2026-08-16 13:20:20 | Source |
| WFUMB Liver Ultrasound Fusion Imaging Technical Review and Position S… CT/US fusion · PMID 42471281 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Ultrasound fusion imaging is a hybrid technique that combines real-time ultrasonography (US) with pre-acquired computed… | Ultrasound in medicine & biology 2026-08-16 13:20:20 | Source |
| Efficacy of irreversible electroporation combined with immunotherapy… IRE plus checkpoint inhibitor · PMID 40698084 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Irreversible electroporation (IRE) has shown promise in improving survival outcomes and activating the immune response… | Frontiers in immunology 2026-08-16 13:20:18 | Source |
| Irreversible Electroporation Plus Anti-PD-1 Antibody versus Irreversi… IRE plus checkpoint inhibitor · PMID 34584438 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Irreversible electroporation (IRE) is shown to not only improve the prognosis of patients with locally advanced pancrea… | Journal of inflammation research 2026-08-16 13:20:18 | Source |
| Multiparametric MRI to Predict Response to Irreversible Electroporati… IRE plus checkpoint inhibitor · PMID 41266946 | Cancer | À vérifier | Publication | PubMed | Voir la publication source To investigate contrast-enhanced T1-weighted MRI and diffusion-weighted magnetic resonance imaging (DWI) for early pred… | Magnetic resonance in medicine 2026-08-16 13:20:18 | Source |
| Evaluating indeterminate bone lesions and lymph nodes on PSMA-PET: a… FocalOne · PMID 41493546 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Indeterminate lesions on prostate-specific membrane antigen (PSMA)-PET are challenging to address. We aimed to develop,… | European radiology 2026-08-16 13:20:14 | Source |
| Optimizing prostate biopsy decision making - (MUSIC-screen): A 1:1 ra… FocalOne · PMID 42476253 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Micro-ultrasound (microUS) represents a potential alternative to multiparametric magnetic resonance (mpMRI) in guiding… | Contemporary clinical trials 2026-08-16 13:20:14 | Source |
| Reply to the Letter to the Editor: PRECISE-guided biopsy de-escalatio… FocalOne · PMID 42484895 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | European radiology 2026-08-16 13:20:14 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||