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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Clinical Outcomes of Gradual Corticosteroid Tapering for Immune Check… prednisolone and mycophenolate mofetil · PMID 42598876 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Immune checkpoint inhibitor (ICI)-induced liver injury is a clinically important adverse event that may lead to interru… | Hepatology research : the official journal of the Japa… 2026-08-16 13:21:00 | Source |
| Effectiveness of tacrolimus in patients with lupus nephritis: A rando… prednisolone and mycophenolate mofetil · PMID 42057645 | Lupus | À vérifier | Publication | PubMed | Voir la publication source This systematic review and meta-analysis aimed to evaluate the efficacy and safety of tacrolimus in the treatment of lu… | Clinical nephrology 2026-08-16 13:21:00 | Source |
| Subconjunctival administration of allogeneic TNF-α/IL-1β licensed MSC… Low Dose Mesenchymal Stem Cells (MSCs) · PMID 42143505 | Lupus | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Mesenchymal stromal cells (MSCs) have shown enhanced therapeutic efficacy by cytokine pre-activation or licensing. Prev… | International immunopharmacology 2026-08-16 13:20:57 | Source |
| Kartogenin-loaded liposomes coated with alkylated hyaluronic acid for… Low Dose Mesenchymal Stem Cells (MSCs) · PMID 42425241 | Lupus | Remyélinisation indirecte / réparation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Kartogenin (KGN) is a potent inducer of chondrogenic differentiation, but its biomedical application is limited by poor… | International journal of pharmaceutics 2026-08-16 13:20:56 | Source |
| CAR-engineered cell therapies: current understandings and future pers… KYV-101 · PMID 41559435 | Lupus · Sclérose en plaques · Cancer | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Chimeric antigen receptor (CAR)-engineered cell therapies represent a significant breakthrough in immunotherapy, initia… | Molecular biomedicine 2026-08-16 13:20:55 | Source |
| A Time-Frequency Decoupled Contrastive Learning Framework for Electro… EEG · PMID 42281553 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Parkinson's disease (PD), a prototypical neurodegenerative disorder, poses significant challenges for early diagnosis.… | International journal of neural systems 2026-08-16 13:20:53 | Source |
| Automatic Seizure Detection using Hierarchical Spectral-Temporal Feat… EEG · PMID 42318682 | Maladie d’Alzheimer · Épilepsie · Lupus · Lupus · Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Epilepsy manifests as a chronic neurological condition marked by recurrent seizures. Recent advances in computational a… | International journal of neural systems 2026-08-16 13:20:53 | Source |
| ETAS reduces wake time after sleep onset in healthy adults who are di… EEG · PMID 42571331 | Maladie d’Alzheimer · Épilepsie · Lupus · Lupus · Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Poor sleep quality is strongly associated with health indicators. Specifically, it increases the risk of developing dis… | Sleep medicine: X 2026-08-16 13:20:53 | Source |
| CAR T cells for systemic autoimmune diseases. CD19 CAR-T cells · PMID 42225220 | Lupus | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Chimeric antigen receptor (CAR) T cells are an advanced cellular therapy produced by genetically modifying T cells to e… | Autoimmunity reviews 2026-08-16 13:20:47 | Source |
| Coated oncolytic viruses based "double strike" strategy triggering CD… CD19 CAR-T cells · PMID 41903308 | Cancer | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source The efficacy of chimeric antigen receptor T (CAR-T) cell therapy in solid tumors is limited by the scarcity of stable a… | Biomaterials 2026-08-16 13:20:47 | Source |
| Efficacy and Safety of Subcutaneous Belimumab in Anti-Double-Stranded… SC belimumab 200 mg · PMID 29671280 | Lupus | À vérifier | Publication | PubMed | Voir la publication source To investigate the efficacy and safety of belimumab, a human immunoglobulin monoclonal antibody against B lymphocyte st… | Arthritis & rheumatology (Hoboken, N.J.) 2026-08-16 13:20:46 | Source |
| Electrophysiology-MRI integration for epileptogenic zone detection an… CMR-Lupus Comprehensive Approach by Cardiovascular Magnetic Resonance Tomography · PMID 424310… | Lupus | À vérifier | Publication | PubMed | Voir la publication source (Invasive) electrophysiology and magnetic resonance imaging (MRI) are central to the presurgical evaluation of patients… | Clinical neurophysiology : official journal of the Int… 2026-08-16 13:20:45 | Source |
| Feasibility and Yield of a Diagnostic Protocol for Myocardial Infarct… CMR-Lupus Comprehensive Approach by Cardiovascular Magnetic Resonance Tomography · PMID 423420… | Lupus | À vérifier | Publication | PubMed | Voir la publication source Current guidelines recommend a structured diagnostic protocol to determine the underlying final diagnosis for myocardia… | The American journal of cardiology 2026-08-16 13:20:45 | Source |
| An explainable machine learning model for predicting in-hospital infe… Hydroxychloroquine · PMID 42557059 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Infection is a leading cause of mortality in patients with systemic lupus erythematosus (SLE), yet effective tools for… | Renal failure 2026-08-16 13:20:43 | Source |
| Divergent neurobehavioral effects of hydroxychloroquine and leflunomi… Hydroxychloroquine · PMID 42520888 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Rheumatoid arthritis (RA) is often associated with neuropsychiatric comorbidities; yet, little is known about the centr… | Neuropharmacology 2026-08-16 13:20:43 | Source |
| Treatment of discoid lupus erythematosus with crisaborole. Hydroxychloroquine · PMID 41808655 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Discoid lupus erythematosus (DLE) is a chronic autoimmune skin disorder that primarily affects sun-exposed areas and ma… | The Journal of dermatological treatment 2026-08-16 13:20:43 | Source |
| Mesenchymal stem cells preserve neuronal architecture by reprogrammin… MSC treatment · PMID 42413645 | Lupus | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Cerebral malaria (CM) is associated with disruption of the blood-brain barrier (BBB), neurovascular injury, and high mo… | Acta tropica 2026-08-16 13:20:36 | Source |
| Electrode material and electrical delivery mode shape the mechanisms… Electrochemotherapy · PMID 41966615 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Electrochemical treatment (ECT) ablates tumors by generating localized pH gradients and redox-active species at electro… | Bioelectrochemistry (Amsterdam, Netherlands) 2026-08-16 13:20:34 | Source |
| Pharmacokinetics of bleomycin in dogs treated with electrochemotherap… Electrochemotherapy · PMID 41879177 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Bleomycin (BLM) is a cytotoxic antibiotic used in veterinary oncology, primarily in electrochemotherapy (ECT), a local… | The veterinary quarterly 2026-08-16 13:20:34 | Source |
| Time-dependent stress responses determine bleomycin electrochemothera… Electrochemotherapy · PMID 42418914 | Cancer | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Electrochemotherapy (ECT), combining pulsed electric fields (PEFs) with cytotoxic drugs, enhances intracellular drug de… | Bioelectrochemistry (Amsterdam, Netherlands) 2026-08-16 13:20:34 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||