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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Topical delivery of Lidocaine using spicules for local anesthesia. Lidocaine Hydrochloride · PMID 41402578 | Migraine · Myopathies · Migraine | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Topical anesthesia offers a painless alternative to injections but is limited by the low skin permeability of local ane… | Drug delivery and translational research 2026-08-16 13:25:53 | Source |
| Efficacy of dry needling in reducing spasticity after stroke: A syste… Dry Needling · PMID 42603654 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source To assess the effectiveness of dry needling (DN) in reducing spasticity among post-stroke patients through meta-analysi… | Complementary therapies in medicine 2026-08-16 13:25:50 | Source |
| Interventional Procedures in Sports. Dry Needling · PMID 42547150 | Myopathies | Immunomodulation · Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Image-guided percutaneous procedures are increasingly important in managing sports-related overuse and degenerative inj… | Radiologic clinics of North America 2026-08-16 13:25:50 | Source |
| Operational taxonomy as a determinant of classification stability in… Dry Needling · PMID 42235437 | Myopathies | Neuroprotection | Publication | PubMed | Voir la publication source Reproducibility in rehabilitation evidence synthesis is influenced not only by search strategy and adjudication archite… | International journal of medical informatics 2026-08-16 13:25:50 | Source |
| CACNA1C -Related Channelopathy Presenting With Adult-Onset Combined D… Xeomin Injectable Product · PMID 41978253 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Pathogenic variants in CACNA1C have been associated with cardiac arrhythmias and neurodevelopmental disorders, occasion… | American journal of medical genetics. Part A 2026-08-16 13:25:47 | Source |
| Late recovery of responsiveness after intra-thecal baclofen pump impl… infusion pump for intrathecal baclofen, Synchromed, Medtronic · PMID 31267188 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Patients with a prolonged disorder of consciousness (DoC) may present with severe spasticity and diffuse pain, which mi… | Acta neurochirurgica 2026-08-16 13:25:46 | Source |
| Wearable sensors in paediatric neurology. Syde · PMID 39888848 | Myopathies | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Wearable sensors have the potential to transform diagnosis, monitoring, and management of children who have neurologica… | Developmental medicine and child neurology 2026-08-16 13:25:41 | Source |
| Effects of carnosine supplementation on physical endurance: a placebo… Physical therapy · PMID 42308284 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Carnosine (β-alanine-L-histidine) is an endogenous dipeptide found in abundance in highly metabolic tissues such as ske… | Journal of the International Society of Sports Nutriti… 2026-08-16 13:25:37 | Source |
| Learning from Inuit perspectives on timimut ikajuqsivik/rehabilitatio… Physical therapy · PMID 42409750 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source The practice approaches and evidence base of timimut ikajuqtiit/rehabilitation professionals working with children are… | International journal of circumpolar health 2026-08-16 13:25:37 | Source |
| Instant analgesic effect of radial extracorporeal shock wave therapy… sham shockwave therapy · PMID 32046753 | Myopathies | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Primary dysmenorrhoea (PDM) is defined as a series of pain-dominated symptoms during and after menstruation without org… | Trials 2026-08-16 13:25:36 | Source |
| Association between radial extracorporeal shock wave therapy combined… Radial extracorporeal shock wave therapy (rESWT) · PMID 42264811 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Few studies have evaluated the combined effects of radial extracorporeal shock wave therapy (rESWT) and physical therap… | Journal of bodywork and movement therapies 2026-08-16 13:25:33 | Source |
| [Translated article] Short- and mid-term efficacy of extracorporeal s… Radial extracorporeal shock wave therapy (rESWT) · PMID 42023623 | Myopathies | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Trigger finger is a common condition managed through various conservative approaches. This study aimed to compare the s… | Revista espanola de cirugia ortopedica y traumatologia 2026-08-16 13:25:33 | Source |
| A matrix-adapted RNA extraction strategy for targeted RT-qPCR analysi… RNA extraction · PMID 42548905 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Human amniotic membrane (HAM) is a promising scaffold for periodontal tissue engineering, supporting favorable cellular… | Regenerative therapy 2026-08-16 13:25:30 | Source |
| Optimizing protocols for microRNA profiling of infant and toddler sto… RNA extraction · PMID 41715892 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Despite growing interest in profiling microRNAs (miRNAs) in infant and toddler stool, no studies have compared protocol… | RNA biology 2026-08-16 13:25:30 | Source |
| Salivary RANKL and OPG gene expression quantification during intermax… RNA extraction · PMID 42318067 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source This protocol describes a non-invasive workflow for quantifying salivary RANKL and OPG gene expression in orthodontic p… | MethodsX 2026-08-16 13:25:30 | Source |
| Human neutrophils synthesize thrombomodulin that does not promote thr… Monocytes and megacaryocytes culture and RNA extraction · PMID 1325211 | Myopathies | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Thrombomodulin (TM) is a surface glycoprotein that forms a 1:1 complex with thrombin, thereby interacting to form the b… | Blood 2026-08-16 13:25:29 | Source |
| The feasibility and acceptability of outdoor sessions as an add-on of… Effectiveness of Multicomponent Treatment for Fibromyalgia (FIBROWALK) · PMID 40316398 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source The given text describes a pilot randomized controlled trial aimed at evaluating the feasibility and acceptability of o… | Reumatologia clinica 2026-08-16 13:25:17 | Source |
| A randomized placebo-controlled phase 3 trial of an antisense oligonu… Drisapersen · PMID 29203355 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source This 48-week, randomized, placebo-controlled phase 3 study (DMD114044; NCT01254019) evaluated efficacy and safety of su… | Neuromuscular disorders : NMD 2026-08-16 13:25:16 | Source |
| Brain signatures of nociplastic pain: Fibromyalgia Index and descendi… Musculoskeletal Nociceptive Pain in Participants With Neuromuscular Disorders · PMID 40819274 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Nociplastic pain is defined by altered nociceptive processing in the absence of clear peripheral damage or somatosensor… | Brain : a journal of neurology 2026-08-16 13:25:16 | Source |
| Neuropathic and Nociplastic Pain Profiles are Common in Adult Chronic… Musculoskeletal Nociceptive Pain in Participants With Neuromuscular Disorders · PMID 38627292 | Myopathies | Neuroprotection · Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Chronic nonbacterial osteitis (CNO) is a rare musculoskeletal disease causing chronic bone pain. It is known that chron… | Calcified tissue international 2026-08-16 13:25:16 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||