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8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| [Prehabilitation training program for patients with head and neck tum… Isometric Lingual Strength Exercises · PMID 41670720 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Oropharyngeal dysphagia secondary to head and neck cancer is common and significantly impacts quality of life, morbidit… | HNO 2026-08-16 13:43:19 | Source |
| Therapeutic frontiers in ALS: iPSC-based drug discovery, cell therapy… Tofersen · PMID 42359165 | Sclérose latérale amyotrophique | Immunomodulation · Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Three converging therapeutic paradigms-iPSC-based drug discovery, cell transplantation, and gene therapy-have substanti… | Regenerative therapy 2026-08-16 13:43:18 | Source |
| Tofersen Treatment in -ALS: Real-World Evidence from a Retrospective… Tofersen · PMID 42548788 | Sclérose latérale amyotrophique | Ralentissement de la progression | Publication | PubMed | Voir la publication source To evaluate the effectiveness of Tofersen in patients with superoxide dismutase 1 gene () patients in France in a real-… | Mayo Clinic proceedings. Innovations, quality & outcom… 2026-08-16 13:43:18 | Source |
| Cross-disease genetic and epigenetic architecture of the locus shows… Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and… | Maladie d’Alzheimer · Maladie de Parkinson · Sclérose latérale amyotr… | Remyélinisation | Publication | PubMed | Voir la publication source Myelin oligodendrocyte basic protein () is an abundant oligodendrocyte gene implicated in multiple neurodegenerative di… | bioRxiv : the preprint server for biology 2026-08-16 13:43:17 | Source |
| Ginsenoside compound K inhibited the gelation of GGGGCC repeats and r… Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and… | Sclérose latérale amyotrophique | Thérapie génique | Publication | PubMed | Voir la publication source GGGGCC repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontote… | International journal of biological macromolecules 2026-08-16 13:43:17 | Source |
| VCP modulation ameliorates pathological features in C9orf72 models. Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and… | Sclérose latérale amyotrophique | Thérapie cellulaire | Publication | PubMed | Voir la publication source Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases linked… | Cell death & disease 2026-08-16 13:43:17 | Source |
| Distinct spatial patterns of perivascular spaces enlargement for mult… 18F-florbetaben · PMID 42385334 | Maladie d’Alzheimer · Maladie de Parkinson · Sclérose latérale amyotr… | À vérifier | Publication | PubMed | Voir la publication source This study examines how amyloid-β and vascular pathology independently and jointly relate to regional perivascular spac… | The journal of prevention of Alzheimer's disease 2026-08-16 13:43:13 | Source |
| Quantification of global gray matter amyloid-β plaque from F-Florbeta… 18F-florbetaben · PMID 42591921 | Maladie d’Alzheimer · Maladie de Parkinson · Sclérose latérale amyotr… | À vérifier | Publication | PubMed | Voir la publication source Multiple standardized uptake value ratio (SUVR) and Centiloid (CL) thresholds exist for amyloid‑β (Aβ) positron emissio… | Alzheimer's & dementia (Amsterdam, Netherlands) 2026-08-16 13:43:13 | Source |
| The role of cardiac PET imaging in cardiac amyloidosis. 18F-florbetaben · PMID 42218056 | Maladie d’Alzheimer · Maladie de Parkinson · Sclérose latérale amyotr… | À vérifier | Publication | PubMed | Voir la publication source Cardiac amyloidosis is an increasingly recognized infiltrative cardiomyopathy characterized by extracellular deposition… | Seminars in nuclear medicine 2026-08-16 13:43:13 | Source |
| A Statewide Clinic-to-Clinic Pediatric Subspecialty Telemedicine Mode… telemedicine program · PMID 42596105 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source To describe the implementation, scale, and stakeholder experience of a statewide clinic-to-clinic pediatric subspecialt… | Telemedicine journal and e-health : the official journ… 2026-08-16 13:43:07 | Source |
| Pilot Evaluation of the REAL-HEART Structured Telemedicine Program in… telemedicine program · PMID 42599261 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Journal of the American Medical Directors Association 2026-08-16 13:43:07 | Source |
| The impact of an intensive care telemedicine program on weaning from… telemedicine program · PMID 42568095 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source ICU patients commonly require invasive mechanical ventilation. Although weaning from ventilation is crucial for patient… | Critical care (London, England) 2026-08-16 13:43:07 | Source |
| The Impact of RNA Polymerase III-Related Leukodystrophy on Nonaffecte… Fosigotifator · PMID 41518854 | Sclérose latérale amyotrophique | Thérapie génique | Publication | PubMed | Voir la publication source RNA polymerase III-related hypomyelinating leukodystrophy (POLR3-HLD) is a rare, neurodegenerative, brain white matter… | Pediatric neurology 2026-08-16 13:43:07 | Source |
| Functional testing for interstitial lung disease in 2026. remote pulmonary function testing · PMID 42158974 | Sclérose latérale amyotrophique | Thérapie génique | Publication | PubMed | Voir la publication source This review synthesizes the role of functional testing in the care of interstitial lung disease (ILD), evaluating the c… | Current opinion in pulmonary medicine 2026-08-16 13:43:05 | Source |
| Remote exercise assessment in pulmonary hypertension. remote pulmonary function testing · PMID 42093162 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source In pulmonary arterial hypertension (PAH), assessment of exercise provides important prognostic information. Recently, d… | Current opinion in pulmonary medicine 2026-08-16 13:43:05 | Source |
| Anthelmintic resistance on meat goat properties in Queensland and New… Monepantel · PMID 41819959 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Gastrointestinal nematode (GIN) infection has serious deleterious effects on the health of goats, and costs Australian… | Veterinary parasitology, regional studies and reports 2026-08-16 13:43:04 | Source |
| A randomized double-blind sham-controlled preliminary study of a 5-we… Transcranial Magnetic Stimulation · PMID 42389422 | Sclérose latérale amyotrophique | Traitement symptomatique | Publication | PubMed | Voir la publication source Gambling disorder (GD) has increased in prevalence particularly in Indonesia where online gambling predominates. Gambli… | Addictive behaviors reports 2026-08-16 13:43:02 | Source |
| Assessing the correlation between sensorimotor evoked potential and c… Transcranial Magnetic Stimulation · PMID 42593026 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Stroke is a leading cause of death and disability worldwide, with 35-80% of survivors developing cognitive impairment t… | Annals of human biology 2026-08-16 13:43:02 | Source |
| Treatment of posttraumatic stress disorder (PTSD). Transcranial Magnetic Stimulation · PMID 42284478 | Sclérose latérale amyotrophique | Thérapie génique | Publication | PubMed | Voir la publication source The present review summarises recommendations for the management of posttraumatic stress disorder (PTSD) based on a con… | Dialogues in clinical neuroscience 2026-08-16 13:43:02 | Source |
| Pressure-induced suppression of supramolecular dynamics in hydrogen-b… Memantine · PMID 42447528 | Maladie d’Alzheimer · Migraine · Sclérose latérale amyotrophique · Sc… | À vérifier | Publication | PubMed | Voir la publication source Determining how pressure and temperature compete to govern supramolecular organization in hydrogen-bonded liquids remai… | Spectrochimica acta. Part A, Molecular and biomolecula… 2026-08-16 13:43:00 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||