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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Widespread Glial Activation in Primary Progressive Multiple Sclerosis… [18F]PBR06 · PMID 33208611 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source A 64-year-old man with primary progressive multiple sclerosis (Expanded Disability Status Scale 3.5) underwent PET usin… | Clinical nuclear medicine 2026-07-18 15:48:49 | Source |
| SPG302 mitigates diabetic retinal neuropathy and inner retinal damage… Tazbentetol · PMID 42456876 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Diabetic retinopathy (DR) is a leading cause of vision loss stemming from vascular and neurodegenerative sequelae of im… | Experimental eye research 2026-07-18 15:48:47 | Source |
| Effects of respiratory muscle training on respiratory function in pat… Respiratory Complications in ALS · PMID 42455190 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Respiratory decline is prognostically important in amyotrophic lateral sclerosis (ALS), but the efficacy of respiratory… | Journal of neurology 2026-07-18 15:48:46 | Source |
| Interim Safety Profile From the Feasibility Study of the BrainGate Ne… BrainGate Neural Interface System · PMID 36639237 | Myopathies · Sclérose latérale amyotrophique · Sclérose latérale amyo… | Ralentissement de la progression | Publication | PubMed | Voir la publication source Brain-computer interfaces (BCIs) are being developed to restore mobility, communication, and functional independence to… | Neurology 2026-07-18 15:48:46 | Source |
| Neural Point-and-Click Communication by a Person With Incomplete Lock… BrainGate Neural Interface System · PMID 25385765 | Myopathies · Sclérose latérale amyotrophique · Sclérose latérale amyo… | À vérifier | Publication | PubMed | Voir la publication source A goal of brain-computer interface research is to develop fast and reliable means of communication for individuals with… | Neurorehabilitation and neural repair 2026-07-18 15:48:46 | Source |
| Nursing a Patient With Amyotrophic Lateral Sclerosis Stage 4B With Ep… Respiratory Complications in ALS · PMID 42461162 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Amyotrophic lateral sclerosis (ALS) is a rare motor neuron disease characterised by progressive muscle weakness, which… | Nursing in critical care 2026-07-18 15:48:46 | Source |
| Multimodality Risk Stratification in Athletes With Long QT Syndrome. Mexiletine · PMID 42460964 | Myopathies · Sclérose latérale amyotrophique · Sclérose latérale amyo… | Thérapie génique | Publication | PubMed | Voir la publication source Long QT syndrome has traditionally led to exercise restriction due to concerns for exertion-triggered arrhythmia and su… | JACC. Case reports 2026-07-18 15:48:44 | Source |
| Autoantibodies in small fiber neuropathy: frequency and clinical feat… skin biopsy · PMID 42467262 | Sclérose latérale amyotrophique | Traitement symptomatique | Publication | PubMed | Voir la publication source Small fiber neuropathy (SFN) is characterized by neuropathic pain and autonomic dysfunction. Emerging evidence suggests… | Journal of neurology 2026-07-18 15:48:43 | Source |
| Demodex-associated dermatoses after allogeneic HSCT: A retrospective… skin biopsy · PMID 42466733 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Journal of the European Academy of Dermatology and Ven… 2026-07-18 15:48:43 | Source |
| Baseline Differences in Cochlear Implant Candidates: Bilateral Tradit… Speech Analysis in ALS Patients · PMID 42452529 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Cochlear implant (CI) candidacy has expanded beyond traditional bilateral hearing loss (HL) to include single-sided dea… | Journal of clinical medicine 2026-07-18 15:48:41 | Source |
| Right‑DLPFC rTMS Transiently Modulates Risky Decision-Making and EEG… Sham rTMS of the brain · PMID 42458894 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Previous evidence suggests that inhibition of the right dorsolateral prefrontal cortex (DLPFC) increases risky decision… | Brain and behavior 2026-07-18 15:48:33 | Source |
| Psilocybin selectively rescues cognitive flexibility impairments caus… Psilocybin · PMID 42465498 | Maladie d’Alzheimer · Cancer · Migraine · Maladie de Parkinson · Sclé… | À vérifier | Publication | PubMed | Voir la publication source Psychedelic drugs show remarkable potential for treating psychiatric disorders, but the mechanisms underlying their the… | bioRxiv : the preprint server for biology 2026-07-18 15:48:32 | Source |
| Silence is golden: Documenting the speech production of participants… Psilocybin · PMID 42460632 | Maladie d’Alzheimer · Cancer · Migraine · Maladie de Parkinson · Sclé… | À vérifier | Publication | PubMed | Voir la publication source When administered alongside monitoring and support, psilocybin has shown promise in the treatment of multiple psychiatr… | Journal of psychopharmacology (Oxford, England) 2026-07-18 15:48:32 | Source |
| VRK1-Related Motor Neuropathy With Upper Motor Neuron Signs and Selec… ALS patients genetic characterization · PMID 42449472 | Sclérose latérale amyotrophique | Traitement symptomatique | Publication | PubMed | Voir la publication source Hereditary motor neuropathies (HMN) represent a heterogeneous group of disorders with wide clinical and genetic variabi… | Journal of the peripheral nervous system : JPNS 2026-07-18 15:48:30 | Source |
| White Matter Functional Dysregulation in Amyotrophic Lateral Sclerosi… ALS patients genetic characterization · PMID 42460529 | Sclérose latérale amyotrophique | Ralentissement de la progression | Publication | PubMed | Voir la publication source Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor system degenerat… | Current neuropharmacology 2026-07-18 15:48:30 | Source |
| Efgartigimod in Sjögren's disease: a phase 2, randomised, placebo-con… Efgartigimod IV · PMID 41997805 | Myasthénie | Traitement symptomatique | Publication | PubMed | Voir la publication source This study aimed to evaluate the efficacy and safety of intravenous (IV) efgartigimod in adults with Sjögren's disease… | Annals of the rheumatic diseases 2026-07-18 15:48:28 | Source |
| Povetacicept (ALPN-303; TACI vTD-Fc), an enhanced, potent dual inhibi… Efgartigimod IV · PMID 40547042 | Myasthénie | Immunomodulation | Publication | PubMed | Voir la publication source Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated autoimmune disease targeting the acetylcholine receptor (… | Frontiers in immunology 2026-07-18 15:48:28 | Source |
| Patient-reported outcomes in low anterior resection syndrome: a compa… Robotic-Assisted Surgery · PMID 42463577 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Despite recent advances in multimodal treatment strategies, radical tumor resection remains a cornerstone in the manage… | International journal of colorectal disease 2026-07-18 15:48:26 | Source |
| Robotic Surgery in Acute Care: A Systematic Review of Its Role in Vis… Robotic-Assisted Surgery · PMID 42465151 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Emergency laparotomies carry profound physiological morbidity, yet the adoption of minimally invasive surgery (MIS) in… | Cureus 2026-07-18 15:48:26 | Source |
| Human intracranial signal stability tracks anatomical accuracy after… Neurology Inpatient Clinical Education Trial · PMID 42330982 | Myasthénie | Traitement symptomatique | Publication | PubMed | Voir la publication source Deep brain stimulation (DBS) for neuropsychiatric disorders increasingly relies on patient personalized approaches. One… | Journal of neural engineering 2026-07-18 15:48:25 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||