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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Metformin enhances hippocampal excitatory synaptic transmission and p… Metformin · PMID 42486330 | Maladie d’Alzheimer | Neuroprotection | Publication | PubMed | Voir la publication source Early stages of Alzheimer's disease (AD) are characterized by synaptic dysfunction and alterations in synaptic plastici… | Neuropharmacology 2026-07-23 12:26:08 | Source |
| Chidamide‑augmented BEAM conditioning and maintenance in first-remiss… Chidamide · PMID 42471476 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Bone marrow transplantation 2026-07-23 12:26:04 | Source |
| Single cell and bulk transcriptomics reveal metabolic reprogramming b… Doxorubicin Hydrochloride · PMID 42471432 | Cancer · Sclérose en plaques | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Cardiogenic shock (CS) patients receiving extracorporeal membrane oxygenation (ECMO) exhibit profound immune and metabo… | Scientific reports 2026-07-23 12:26:02 | Source |
| A bifunctional fusion protein simultaneously targeting PD-L1 and TGF-… paclitaxel · PMID 42485683 | Cancer | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Oral squamous cell carcinoma (OSCC) is characterized by a profoundly immunosuppressive tumor microenvironment (TME), wh… | Oral oncology 2026-07-23 12:25:56 | Source |
| A human iPSC-derived 3D spinal cord organoid model to study radiation… radiation therapy · PMID 42486482 | Cancer | Neuroprotection · Thérapie cellulaire | Publication | PubMed | Voir la publication source Radiation therapy remains a cornerstone in the treatment of primary and metastatic tumors; however, its efficacy is lim… | Stem cells translational medicine 2026-07-23 12:25:55 | Source |
| Tumefactive demyelinating disorders as neoplasm mimics: description o… radiation therapy · PMID 42486941 | Cancer | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Tumefactive demyelinating lesions (TDLs) are a rare form of idiopathic inflammatory demyelinating disease of the centra… | Neurological sciences : official journal of the Italia… 2026-07-23 12:25:55 | Source |
| De-escalation to ticagrelor monotherapy versus 12 months of dual anti… Ticagrelor 90 mg twice per day · PMID 39226909 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Dual antiplatelet therapy (DAPT) for 12 months is the standard of care after coronary stenting in patients with acute c… | Lancet (London, England) 2026-07-23 12:25:53 | Source |
| Low-Dose Rivaroxaban to Prevent Left Ventricular Thrombosis After Ant… Ticagrelor 90 mg twice per day · PMID 41739450 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Anterior acute myocardial infarction is associated with increased risk of left ventricular (LV) thrombus. The benefit a… | JAMA cardiology 2026-07-23 12:25:53 | Source |
| Neural changes to transcranial alternating current stimulation in the… Transcranial electrical stimulation · PMID 42453709 | Migraine | Thérapie génique | Publication | PubMed | Voir la publication source Applying transcranial alternating current stimulation (tACS) at the gamma range to the frontal and parietal regions can… | AIMS neuroscience 2026-07-23 12:25:52 | Source |
| Antithrombotic Drug Eruptions in Dermatology Practice: Selection Bias… Cilostazol · PMID 42465709 | Migraine · Sclérose en plaques · Migraine · Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Antithrombotic agents are among the most frequently prescribed medications in elderly patients and are essential for th… | Cureus 2026-07-23 12:25:50 | Source |
| Pharmacogenetic mechanism of cilostazol-induced headaches: Splicing-m… Cilostazol · PMID 42485569 | Migraine · Sclérose en plaques · Migraine · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Cilostazol, a phosphodiesterase 3 inhibitor, causes intolerable headaches in over one third of patients, frequently lea… | British journal of pharmacology 2026-07-23 12:25:50 | Source |
| Contrast-Enhanced Ultrasound and High Sensitive Doppler for Monitorin… Chordate System S211 in treatment mode · PMID 37330354 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source To monitor fibroid microvascularity using contrast-enhanced ultrasound (CEUS) and a new high-sensitive Doppler mode (SM… | Academic radiology 2026-07-23 12:25:44 | Source |
| Interventional Nerve Procedures for Pain Related to Head-and-Neck Can… Greater occipital nerve radiofrequency · PMID 42233128 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source To systematically review the evidence on the use of peripheral nerve interventions, including anaesthetic blocks, neuro… | Indian journal of palliative care 2026-07-23 12:25:42 | Source |
| Ultrasound-Guided Pulsed Radiofrequency of the Proximal Greater Occip… Greater occipital nerve radiofrequency · PMID 42478409 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Neurology India 2026-07-23 12:25:42 | Source |
| Effectiveness and Safety of Adjunctive Cenobamate in People with Foca… BLESS — Cenobamate in Adults With Focal-Onset Seizures · PMID 38850402 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Despite new anti-seizure medications (ASMs) being introduced into clinical practice, about one-third of people with epi… | Neurology and therapy 2026-07-23 12:25:40 | Source |
| Effectiveness and safety of adjunctive cenobamate in people with foca… BLESS — Cenobamate in Adults With Focal-Onset Seizures · PMID 40088187 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Cenobamate is an antiseizure medication (ASM) with a dual mechanism of action that was recently approved for the treatm… | Epilepsia 2026-07-23 12:25:40 | Source |
| Non-invasive differentiation between aplastic anemia and myelodysplas… retrospective analysis of a panel result · PMID 42485818 | Épilepsie | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Given the highly overlapping pancytopenic phenotypes, non-invasive differentiation between aplastic anemia (AA) and mye… | Current research in translational medicine 2026-07-23 12:25:38 | Source |
| The relationship of EBER, EGFR, p16, and E-cadherin expressions with… retrospective analysis of a panel result · PMID 42487012 | Épilepsie | Thérapie cellulaire | Publication | PubMed | Voir la publication source Laryngeal squamous cell carcinoma (LSCC) is a tumor characterized by high biological heterogeneity. According to our li… | European archives of oto-rhino-laryngology : official… 2026-07-23 12:25:38 | Source |
| Once-Nightly Pregabalin for Co-Occurring Nightmares, Poor Sleep, and… pregabalin · PMID 42483729 | Migraine | Ralentissement de la progression | Publication | PubMed | Voir la publication source Nightmares, nonrestorative sleep, and headaches co-occur, are common, underdiagnosed, and contribute to substantial dis… | Nature and science of sleep 2026-07-23 12:25:32 | Source |
| The effect of pregabalin on pain and function in knee osteoarthritis:… pregabalin · PMID 42481863 | Épilepsie · Sclérose en plaques · Épilepsie | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Knee osteoarthritis (OA) is a prevalent chronic condition characterized by joint pain and functional impairment. While… | Inflammopharmacology 2026-07-23 12:25:32 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||