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Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Sedentary Behavior and Physical Activity in Individuals With Bipolar… Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention · PMID 42545207 | Maladie d’Alzheimer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Higher time in sedentary behavior and insufficient physical activity are very common in bipolar disorder (BD). Whereas… | Bipolar disorders 2026-08-08 00:57:09 | Source |
| Daturaolone from L. Inhibits acetylcholinesterase and monoamine oxida… Donepezil · PMID 42555879 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Daturaolone is an amyrin-type triterpenoid isolated from L. which was evaluated in the current study as a multitarget i… | Natural product research 2026-08-08 00:57:05 | Source |
| Valorization of 2-aminoethoxydiphenyl borate as a neurotherapeutic ag… Donepezil · PMID 42541674 | Maladie d’Alzheimer | Neuroprotection · Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source In Alzheimer's disease (AD), amyloid beta (Aβ) plaques and hyperphosphorylated tau tangles drive neurodegeneration and… | Inflammopharmacology 2026-08-08 00:57:05 | Source |
| Antibiofilm action of ozonated sunflower oil against bacteria isolate… 0.9% NaCl · PMID 42524657 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source This study aimed to characterize the antibiofilm action of ozone-enriched sunflower oil (O) against pathogens associate… | Animal reproduction 2026-08-08 00:57:03 | Source |
| Inhaled sphingosine reduces bronchial Pseudomonas aeruginosa burden d… 0.9% NaCl · PMID 42562866 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Pseudomonas aeruginosa infection remains a major challenge in donor lung management and post-transplant respiratory car… | Scientific reports 2026-08-08 00:57:03 | Source |
| Effects of extending interval between presynchronization and breeding… GnRH, gonadorelin acetate · PMID 42564643 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Small size of follicle, which may be due to summer, and high progesterone (P4) could hamper the ovulatory response to g… | Veterinary and animal science 2026-08-08 00:57:01 | Source |
| The diagnostic value and optimal cutoff of basal luteinizing hormone… GnRH, gonadorelin acetate · PMID 42564140 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source To investigate the diagnostic value and explore optimal cutoff value of the basal luteinizing hormone (LH) level for ce… | Frontiers in endocrinology 2026-08-08 00:57:01 | Source |
| Ultrasound-Guided Stellate Ganglion and Interscalene Blocks for Refra… Stellate ganglion block · PMID 42550561 | Maladie de Parkinson | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Parsonage-Turner syndrome (PTS) is an uncommon inflammatory brachial plexopathy; pediatric and bilateral cases are rare… | Pain medicine case reports 2026-08-08 00:56:58 | Source |
| Ultrasound-guided stellate ganglion block as a rescue sympathetic mod… Stellate ganglion block · PMID 42553945 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Saudi journal of anaesthesia 2026-08-08 00:56:58 | Source |
| Dose optimization of apomorphine sublingual film for treating "OFF" e… APL-130277 · PMID 34763305 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Apomorphine sublingual film is approved for the "on-demand" treatment of "OFF" episodes in Parkinson's disease (PD). Pa… | Parkinsonism & related disorders 2026-08-08 00:56:57 | Source |
| Indirect comparison of apomorphine sublingual film and levodopa inhal… APL-130277 · PMID 35068168 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source To compare efficacy of apomorphine sublingual film (APL) and levodopa inhalation powder (CVT-301) for 'on-demand' treat… | Journal of comparative effectiveness research 2026-08-08 00:56:57 | Source |
| Performance of the SmartMe&You serious video games for home telemonit… In-Home Care for Patients With Parkinson's Disease · PMID 42477234 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Unsupervised serious video games on the SmartMe&You home telemonitoring platform may enable the assessment of cognitive… | GeroScience 2026-08-08 00:56:57 | Source |
| Quality management and specifications of multidisciplinary Parkinson'… In-Home Care for Patients With Parkinson's Disease · PMID 42565841 | Maladie de Parkinson | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Parkinson's disease multidisciplinary complex therapy (PD-MCT) has emerged as an effective, standardized inpatient trea… | Journal of neural transmission (Vienna, Austria : 1996) 2026-08-08 00:56:57 | Source |
| Challenges of Pain in Parkinson's Disease: Results from the OCEAN Stu… Opicapone · PMID 42259665 | Maladie de Parkinson | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Pain is a common non-motor symptom in Parkinson's disease (PD) and is often associated to fluctuations. The OpiCapone E… | Movement disorders : official journal of the Movement… 2026-08-08 00:56:55 | Source |
| Effect of COMT and UGT1A Variants on Clinical Response to Opicapone i… Opicapone · PMID 42473901 | Maladie de Parkinson | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopamin… | Movement disorders clinical practice 2026-08-08 00:56:55 | Source |
| Efficacy of citicoline as an add-on therapy in Parkinson's disease: a… Levodopa (L-DOPA) + Standard care · PMID 42561742 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Citicoline is a promising therapeutic option for improving both motor and non-motor symptoms in Parkinson's disease (PD… | Parkinsonism & related disorders 2026-08-08 00:56:55 | Source |
| Juvenile Parkinson's disease: Symptom burden and treatment challenges. Levodopa (L-DOPA) + Standard care · PMID 42555091 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Juvenile Parkinson's disease (JPD) is a rare condition characterized by the onset of parkinsonian motor symptoms before… | Journal of Parkinson's disease 2026-08-08 00:56:55 | Source |
| Decoding pre-movement neural activity from thalamic LFPs for adaptive… Deep brain stimulation surgery · PMID 42404288 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source To advance adaptive deep brain stimulation for tremor disorders, we investigated the feasibility of using machine learn… | Neurocomputing 2026-08-08 00:56:54 | Source |
| Full recovery after severe bacterial encephalitis and brain abscess f… Deep brain stimulation surgery · PMID 42530887 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Encephalitis and cerebral abscesses are rare, serious complications of deep brain stimulation (DBS) surgery. We report… | Journal of Parkinson's disease 2026-08-08 00:56:54 | Source |
| HYpofractionated, dose-redistributed RAdiotherapy (HYDRA) versus conv… conventional treatment plan · PMID 41685200 | Cancer | À vérifier | Publication | PubMed | Voir la publication source (Chemo)radiotherapy for squamous cell carcinoma of the oropharynx, hypopharynx, and larynx results in significant treat… | Clinical and translational radiation oncology 2026-08-08 00:56:53 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||