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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Expanding preventive options for pediatric migraine: the use of anti-… Fremanezumab · PMID 42433932 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Translational pediatrics 2026-08-08 00:59:19 | Source |
| Tumor expression of CGRP confers sensitivity to growth inhibition by… Fremanezumab · PMID 42498203 | Migraine · Cancer | À vérifier | Publication | PubMed | Voir la publication source Calcitonin gene related peptide (CGRP) is a neuropeptide exerting key neuromodulatory, vasoactive and immune functions… | European journal of pharmacology 2026-08-08 00:59:19 | Source |
| An MEG-Compatible Electromagnetic-Tracking System for Monitoring Orof… Static magnetic helmet · PMID 26571510 | Migraine | À vérifier | Publication | PubMed | Voir la publication source We describe a novel motion-tracking system, called MASK (magnetoarticulography for the assessment of speech kinematics)… | IEEE transactions on bio-medical engineering 2026-08-08 00:59:17 | Source |
| Source localization using virtual magnetoencephalography helmets: A s… Static magnetic helmet · PMID 36148152 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Magnetoencephalography (MEG) source estimation of brain electromagnetic fields is an ill-posed problem. A virtual MEG h… | Frontiers in neuroscience 2026-08-08 00:59:17 | Source |
| Improving detection of low-abundant pharmaceuticals and neurotransmit… Acetaminophen/Paracetamol · PMID 42448886 | Lupus · Migraine | À vérifier | Publication | PubMed | Voir la publication source Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a powerful tool for mapping the sp… | Analytical and bioanalytical chemistry 2026-08-08 00:59:16 | Source |
| Membrane-Targeted Consequences of Acetaminophen Toxicity and Off-Targ… Acetaminophen/Paracetamol · PMID 42511577 | Lupus · Migraine | Remyélinisation indirecte / réparation · Immunomodulation | Publication | PubMed | Voir la publication source Acetaminophen (paracetamol, APAP) is a widely used analgesic and antipyretic drug. Under normal physiological condition… | International journal of molecular sciences 2026-08-08 00:59:16 | Source |
| Blocking the CGRP Receptor: Differences across Human Vascular Beds. Telcagepant · PMID 37630989 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Multiple drugs targeting the calcitonin gene-related peptide (CGRP) receptor have been developed for the treatment of m… | Pharmaceuticals (Basel, Switzerland) 2026-08-08 00:59:15 | Source |
| CGRP receptor antagonists (gepants). Telcagepant · PMID 38307667 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Small molecule calcitonin gene-related peptide (CGRP) receptor antagonists are commonly referred to as gepants. The fir… | Handbook of clinical neurology 2026-08-08 00:59:15 | Source |
| Species-specific functions of CSRP3 in satellite cell-driven muscle r… SCS · PMID 42566102 | Migraine | Remyélinisation indirecte / réparation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Skeletal muscle function deteriorates with injury, disease, or aging. While stem cell therapies offer therapeutic poten… | Cell regeneration (London, England) 2026-08-08 00:59:14 | Source |
| Spinal cord stimulation effects on restless legs syndrome: A single c… SCS · PMID 42566390 | Migraine | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Restless legs syndrome (RLS) is a lifelong disorder characterized by recurrent, uncomfortable sensations and irresistib… | Stereotactic and functional neurosurgery 2026-08-08 00:59:14 | Source |
| Non-O blood groups as independent predictors of chronic subdural hema… Middle Meningeal Artery embolization · PMID 42566780 | Migraine | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Recurrence after surgical treatment of chronic subdural hematoma (CSDH) remains insufficiently understood. Microvascula… | Journal of neurosurgery 2026-08-08 00:59:13 | Source |
| Traumatic intracranial pseudoaneurysms of cortical middle cerebral ar… Middle Meningeal Artery embolization · PMID 42559449 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Traumatic intracranial pseudoaneurysms (TIPAs) are exceedingly rare, representing <1% of all intracranial aneurysms, an… | Surgical neurology international 2026-08-08 00:59:13 | Source |
| Dual Stellate Ganglion Blocks for Managing Treatment-Resistant Anxiet… Sham Procedure · PMID 42550523 | Cancer · Hypertension artérielle · Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Anxiety disorders are associated with a high burden of illness. In patients with treatment-resistant anxiety disorder,… | Pain physician 2026-08-08 00:59:12 | Source |
| Novel neonatal hypoxic-ischemic model demonstrates glial activation a… Sham Procedure · PMID 42547840 | Cancer · Hypertension artérielle · Migraine | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Neonatal global hypoxic-ischemic cerebral injury is a leading cause of infant mortality and lifelong disability. Curren… | Pediatric research 2026-08-08 00:59:12 | Source |
| Onabotulinumtoxin A Is an Effective Preventative Treatment of Chronic… Rimegepant · PMID 42541839 | Migraine | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Despite high efficacy and favorable safety profile in adults, Onabotulinumtoxin A (ONA) injections have not been Food a… | Pediatric neurology 2026-08-08 00:59:11 | Source |
| [Effectiveness and Risk of Recurrence of Pulsed Radiofrequency in Tri… Pulsed Radiofrequency of the Sphenopalatine Ganglion · PMID 42216458 | Migraine | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Percutaneous pulsed radiofrequency (PPRF) is a minimally invasive neuromodulation technique used in chronic pain manage… | Revista de neurologia 2026-08-08 00:59:11 | Source |
| Chronic Migraine Resistance: A Case Report Highlights an Overlooked F… eletriptan · PMID 42450884 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Chronic migraine may seem treatment-resistant when underlying medication-overuse headache (MOH) and psychosocial stress… | Healthcare (Basel, Switzerland) 2026-08-08 00:59:10 | Source |
| Eletriptan HBr-loaded solid lipid nanoparticle-integrated microneedle… eletriptan · PMID 42307459 | Migraine | Immunomodulation | Publication | PubMed | Voir la publication source Eletriptan hydrobromide (EHBr) exhibits poor oral bioavailability due to extensive first-pass metabolism by CYP3A4 and… | Journal of drug targeting 2026-08-08 00:59:10 | Source |
| Debris Flow Detection System Based on Tree-Topology Optical Fiber Net… Flow Detection System · PMID 42515294 | Migraine | À vérifier | Publication | PubMed | Voir la publication source This report proposes a debris flow detection system based on an optical fiber network. Optical communication devices, i… | Sensors (Basel, Switzerland) 2026-08-08 00:59:09 | Source |
| SFARP: a multi-layered real-time security framework for hybrid ARP an… Flow Detection System · PMID 41365983 | Migraine | À vérifier | Publication | PubMed | Voir la publication source The rapid expansion of Software-Defined Internet of Things (SD-IoT) networks has amplified both scalability and vulnera… | Scientific reports 2026-08-08 00:59:09 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||