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Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Dose optimization of sacubitril/valsartan in Chinese chronic heart fa… Sacubitril/valsartan · PMID 42558440 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source In routine clinical practice, many patients with chronic heart failure (CHF) treated with sacubitril/valsartan do not a… | Frontiers in pharmacology 2026-08-08 01:00:29 | Source |
| In symptomatic HF, sacubitril-valsartan vs. dapagliflozin and torsemi… Sacubitril/valsartan · PMID 42546309 | Hypertension artérielle | Traitement symptomatique | Publication | PubMed | Voir la publication source GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text]. | Annals of internal medicine 2026-08-08 01:00:29 | Source |
| Additive beneficial effects of valsartan combined with rosuvastatin i… Valsartan 160 mg + Rosuvastatin 20 mg · PMID 26023311 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source We compared the efficacy and safety of valsartan and rosuvastatin combination therapy with each treatment alone in hype… | Korean circulation journal 2026-08-08 01:00:28 | Source |
| Effect of Amlodipine/Nebivolol combination therapy on central BP and… Amlodipine 10 mg + Valsartan 160 mg · PMID 35286492 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Pulse wave velocity (PWV) and central blood pressure (CBP) have been intoduced into managment of hypertensive patients.… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-08-08 01:00:27 | Source |
| Effect of Fixed-dose Combination Amlodipine/Valsartan in Comparison t… Amlodipine 10 mg + Valsartan 160 mg · PMID 36998137 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Nebivolol has a dual mechanism of action, exerting a moderate b- blockade effect and reducing peripheral arterial resis… | Current hypertension reviews 2026-08-08 01:00:27 | Source |
| Pharmacokinetic Drug Interactions Between Amlodipine, Valsartan, and… Amlodipine 10 mg + Valsartan 160 mg + Rosuvastatin 20 mg · PMID 31119689 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Amlodipine, valsartan, and rosuvastatin are among the medications widely coadministered for the treatment of hyperlipid… | Advances in therapy 2026-08-08 01:00:26 | Source |
| Effects of Antihypertensive Treatment on Left and Right Ventricular G… Chlorthalidone plus amiloride · PMID 37297980 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Hypertension is highly prevalent in patients with obstructive sleep apnea (OSA), and fluid retention with its nighttime… | Journal of clinical medicine 2026-08-08 01:00:25 | Source |
| Effects of chlorthalidone plus amiloride compared with amlodipine on… Chlorthalidone plus amiloride · PMID 37466401 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source To compare the effects of chlortalidone plus amiloride and amlodipine on blood pressure (BP) variability in patients wi… | Blood pressure monitoring 2026-08-08 01:00:25 | Source |
| A village health worker intervention to reduce cardiovascular disease… Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Press… | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Cardiovascular disease (CVD) is a leading cause of death in low-income countries and those affected by armed conflict,… | Conflict and health 2026-08-08 01:00:24 | Source |
| Artificial Intelligence and Advanced Digital Health for Hypertension:… Machine Learning to Reduce Hypertension Treatment Clinical Inertia · PMID 41010987 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source : Hypertension remains the leading global risk factor for cardiovascular morbidity and mortality, with suboptimal contr… | Medicina (Kaunas, Lithuania) 2026-08-08 01:00:22 | Source |
| Complete autonomic blockade reveals nitric oxide contribution to bloo… Trimethaphan · PMID 39090323 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Hypertension is one of the major causes of cardiovascular morbidity and mortality in the USA and disproportionately aff… | Clinical autonomic research : official journal of the… 2026-08-08 01:00:22 | Source |
| Protective effect of biogenic selenium nanoparticles against diquat-i… Trimethaphan · PMID 36257488 | Hypertension artérielle | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Selenium nanoparticles (SeNPs) with unique biological properties have been suggested as a safer and more effective plat… | Food and chemical toxicology : an international journa… 2026-08-08 01:00:22 | Source |
| Prazosin Monotherapy for Adolescent Posttraumatic Stress Disorder: A… Prazosin · PMID 42538895 | Hypertension artérielle | Traitement symptomatique | Publication | PubMed | Voir la publication source Pediatric posttraumatic stress disorder (PTSD) is a debilitating condition that is associated with significant function… | Focus (American Psychiatric Publishing) 2026-08-08 01:00:21 | Source |
| Predicting pHmax and Salt Disproportionation Risk for Basic Drugs. Prazosin · PMID 42487463 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Pharmaceutical salts are commonly used to enhance the bioavailability of poorly water-soluble drugs. The maximum solubi… | Molecular pharmaceutics 2026-08-08 01:00:21 | Source |
| Proceedings of the 3rd IPLeiria's International Health Congress : Lei… Mobilizing Community Hypertension Access Pilot · PMID 27409075 | Hypertension artérielle · Lupus · Sclérose en plaques · Cancer | Remyélinisation indirecte / réparation · Ralentissement de la progression · Imm… | Publication | PubMed | Voir la publication source S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the… | BMC health services research 2026-08-08 01:00:20 | Source |
| Implementation of Digital Device-Assisted and Nurse-Led Case Manageme… Salt-meter · PMID 41569800 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Self-management plays a vital role in noncommunicable disease prevention and control. However, it has been challenging… | JMIR research protocols 2026-08-08 01:00:16 | Source |
| Sodium Content of Street and Restaurant Foods in Nigeria: A Multileve… Salt-meter · PMID 42514417 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source : Street and restaurant foods constitute a major component of daily diets in low-resource settings due to their afforda… | Nutrients 2026-08-08 01:00:16 | Source |
| A Vagal-Renal-Splenic Reflex Suppresses Renal Sympathetic Nerve Activ… Renal denervation · PMID 42555213 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Acute kidney injury (AKI) is associated with maladaptive increases in renal sympathetic nerve activity (RSNA) and frequ… | Journal of the American Society of Nephrology : JASN 2026-08-08 01:00:15 | Source |
| Cardiometabolic Multimorbidity and Sympathetic Overactivity: Translat… Renal denervation · PMID 42554390 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Cardiometabolic multimorbidity, encompassing type 2 diabetes, hypertension, and metabolic dysfunction-associated steato… | JACC. Asia 2026-08-08 01:00:15 | Source |
| Renal Denervation in Cardiovascular Diseases: Mechanisms, Evidence, a… Renal Denervation (Symplicity Spyral™) · PMID 42144689 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Renal denervation (RDN) is a minimally invasive technique that disrupts renal sympathetic nerve activity, reducing symp… | Catheterization and cardiovascular interventions : off… 2026-08-08 01:00:14 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||