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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Concurrent herpetic hypertensive anterior uveitis and cytomegalovirus… The Link Between Human Cytomegalovirus (HCMV) and Hypertension · PMID 42017386 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Melanoma differentiation-associated gene 5 dermatomyositis (MDA-5 DM) is a rare subtype of dermatomyositis. Cytomegalov… | Reumatismo 2026-08-08 01:00:47 | Source |
| Cytomegalovirus (CMV), oxidative stress, and inflammation: implicatio… The Link Between Human Cytomegalovirus (HCMV) and Hypertension · PMID 40736759 | Hypertension artérielle | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Cytomegalovirus (CMV) drives immunosenescence, while its reactivation is associated with inflammation and oxidative str… | Biogerontology 2026-08-08 01:00:47 | Source |
| COmmuNity-engaged SimULation Training for Blood Pressure Control (CON… CONSULT-BP — COmmuNity-engaged SimULation Training for Blood Pressure Control · PMID 33592827 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Healthcare professionals have negative implicit biases toward minority and poor patients. Few communication skills inte… | Medicine 2026-08-08 01:00:46 | Source |
| Hypertension and myocardial fibrosis: A systematic review and meta-an… Perindopril (T1) · PMID 42296937 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Hypertension (HTN) is a major risk factor for myocardial fibrosis (MF), a key contributor to cardiac dysfunction. This… | Clinical radiology 2026-08-08 01:00:45 | Source |
| Takotsubo syndrome in a cancer patient treated with a combination of… Perindopril (T1) · PMID 39104513 | Cancer | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Takotsubo syndrome (TTS) is characterized by transient regional left ventricular (LV) dysfunction occurring in individu… | European heart journal. Case reports 2026-08-08 01:00:45 | Source |
| Selection and potential of cholesterol-lowering indigenous probiotic:… Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors · PMID 41168307 | Hypertension artérielle | Neuroprotection | Publication | PubMed | Voir la publication source Atherosclerosis, a prevalent cardiovascular disorder, is ineffectively managed by statins, highlighting the need for na… | Scientific reports 2026-08-08 01:00:40 | Source |
| Watermelon Nutritional Composition with a Focus on L-Citrulline and I… Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors · PMID 41156475 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Nitric oxide is a gaseous molecule endogenously produced by endothelial cells, which stands out for its vascular tone r… | Nutrients 2026-08-08 01:00:40 | Source |
| Prevalence and prognostic significance of untreated, uncontrolled and… doublepres — The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Pro… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The prevalence of untreated, uncontrolled and resistant hypertension and their specific prognosis among American adults… | Blood pressure 2026-08-08 01:00:38 | Source |
| Scleroderma Renal Crisis and Posterior Reversible Encephalopathy Synd… enalapril · PMID 42543578 | Hypertension artérielle | Immunomodulation | Publication | PubMed | Voir la publication source Scleroderma renal crisis (SRC) and posterior reversible encephalopathy syndrome (PRES) are rare but severe complication… | Internal medicine (Tokyo, Japan) 2026-08-08 01:00:38 | Source |
| Spironolactone therapy in resistant hypertension comorbid with mild o… doublepres — The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Pro… | Hypertension artérielle | Traitement symptomatique | Publication | PubMed | Voir la publication source Mild obstructive sleep apnea (OSA) is often underdiagnosed but contributes to treatment-resistant hypertension through… | Medicine 2026-08-08 01:00:38 | Source |
| Blood pressure knowledge in hypertensive hemodialysis patients. Improving Blood Pressure Control in End-Stage Renal Disease Through a Supportive-Educative Nur… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The major purpose of this quantitative study was to determine if a supportive educative nursing intervention incorporat… | CANNT journal = Journal ACITN 2026-08-08 01:00:36 | Source |
| Improving blood pressure control in end stage renal disease through a… Improving Blood Pressure Control in End-Stage Renal Disease Through a Supportive-Educative Nur… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Hypertension in patients on hemodialysis (HD) contributes significantly to their morbidity and mortality. This study ex… | Nephrology nursing journal : journal of the American N… 2026-08-08 01:00:36 | Source |
| Late-Onset Infectious Keratitis over 10 Years after Intracorneal Ring… Telemedicine · PMID 42564943 | Hypertension artérielle | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Intracorneal ring segments (ICRS) are employed to manage keratoconus but carry the risk of late-onset complications suc… | Case reports in ophthalmology 2026-08-08 01:00:35 | Source |
| Telemedicine Critical Care Billing For Hospitalized Medicare Fee-For-… Telemedicine · PMID 42565664 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Expanded coverage for telehealth during the COVID-19 pandemic allowed providers to bill for telemedicine services that… | Critical care medicine 2026-08-08 01:00:35 | Source |
| Implementing virtual diabetes self-management education in two health… VIDA — Virtual Diabetes Group Visits Across Health Systems · PMID 42433307 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Group-based diabetes self-management education (DSME) has long been shown to improve health outcomes, but how to effect… | Frontiers in clinical diabetes and healthcare 2026-08-08 01:00:34 | Source |
| A Custom-Built Intravoxel Incoherent Motion Diffusion Magnetic Resona… Magnetic Resonance Imaging for Evaluating Kidney Function · PMID 42538664 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source In this study, we present a custom -developed, Python -based graphical user interface designed to address the limitatio… | Experimental and clinical transplantation : official j… 2026-08-08 01:00:33 | Source |
| Multiparametric MR Imaging for Detecting Early Chronic Kidney Disease… Magnetic Resonance Imaging for Evaluating Kidney Function · PMID 42560709 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Conventional renal function markers, such as estimated glomerular filtration rate (eGFR), often fail to reflect occult… | Journal of magnetic resonance imaging : JMRI 2026-08-08 01:00:33 | Source |
| A Proposed Model of a Pragmatic Surgical Approach in Women Affected b… myoma removal · PMID 41517627 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source : Uterine fibroids are the most common benign neoplasms of the female genital tract, with a prevalence of 20% to 40% am… | Journal of clinical medicine 2026-08-08 01:00:32 | Source |
| Feasibility and effectiveness of hysteroscopic myomectomy for type 3… myoma removal · PMID 41560938 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source This study aimed to evaluate the feasibility and effectiveness of hysteroscopic myomectomy for treating International F… | Frontiers in surgery 2026-08-08 01:00:32 | Source |
| Renal Denervation to Treat Hypertension: A Clinical State-of-the-Art… Paradise Ultrasound Renal Denervation Treatment · PMID 40702973 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Hypertension represents the leading risk factor for death globally, affecting one in two adults. Despite dozens of inex… | American journal of hypertension 2026-08-08 01:00:31 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||