Vue transversale globale
Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
Filtrer toute la vue
Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
· 41 visibles sur cette page
dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Social participation and self-reported physical, cognitive, and fall-… Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis · PMID 42531681 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The relationship between social participation and health-related outcomes remains underexplored among individuals with… | Multiple sclerosis and related disorders 2026-08-13 14:17:53 | Source |
| Clinicians' and patients' perspectives of a mobility technician role… Ambulation Study in Multiple Sclerosis · PMID 42591059 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Hospitalized older patients are predominantly sedentary, risking functional decline. Nurses and physical therapists are… | Journal of hospital medicine 2026-08-13 14:17:52 | Source |
| Effect of external versus internal focus of attention instructions on… Ambulation Study in Multiple Sclerosis · PMID 42584733 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Considering the increased dependency on conscious control processes for gait control in people with multiple sclerosis(… | Neurological sciences : official journal of the Italia… 2026-08-13 14:17:52 | Source |
| A tumor microenvironment-responsive calcium overload nanoplatform ind… Fingolimod · PMID 42576991 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source PANoptosis, a newly characterized form of inflammatory programmed cell death that integrates multiple cell death modali… | Materials today. Bio 2026-08-13 14:17:50 | Source |
| Natalizumab and Tyruko (natalizumab biosimilar) for treating highly a… Fingolimod · PMID 42579606 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Multiple sclerosis is an immune-mediated inflammatory disease, causing long-term disability in young adults. Most cases… | Health technology assessment (Winchester, England) 2026-08-13 14:17:50 | Source |
| A combined cuff electrode array for organ-specific selective stimulat… Selective vagus nerve stimulation · PMID 37138728 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Previously developed spatially-selective Vagus Nerve Stimulation (sVNS) allows the targeting of specific nerve fascicle… | Frontiers in medical technology 2026-08-08 01:00:58 | Source |
| Towards spatially selective efferent neuromodulation: anatomical and… Selective vagus nerve stimulation · PMID 39183636 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Spatially selective vagus nerve stimulation (sVNS) offers a promising approach for addressing heart disease with enhanc… | The Journal of physiology 2026-08-08 01:00:58 | Source |
| Adsorption characteristics of erythropoietin in two β2-microglobulin… Darbepoetin · PMID 42509492 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source To compare the erythropoietin adsorption characteristics of two adsorption devices, Lixelle and FILTOR, used for the tr… | Journal of artificial organs : the official journal of… 2026-08-08 01:00:56 | Source |
| Drugs and Cell-Based Therapies for the Prevention and Treatment of Ne… Darbepoetin · PMID 42556987 | Hypertension artérielle | Neuroprotection · Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source The international burden of neonatal brain injury (NBI) remains significant with enormous potential for therapeutic int… | Clinics in perinatology 2026-08-08 01:00:56 | Source |
| Concordance of care processes between medical records and patient sel… TRANSIT — TRANSforming InTerprofessional Cardiovascular Prevention in Primary Care · PMID 3126… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Despite the increasing use of medical records to measure quality of care, studies have shown that their validity is sub… | BMC family practice 2026-08-08 01:00:55 | Source |
| Facilitating Implementation of Interprofessional Collaborative Practi… TRANSIT — TRANSforming InTerprofessional Cardiovascular Prevention in Primary Care · PMID 2636… | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Implementing interprofessional collaborative practices in primary care is challenging, and research about its facilitat… | Journal of healthcare management / American College of… 2026-08-08 01:00:55 | Source |
| Computed tomography-guided ozone neurolysis lowers blood pressure. ReD — Sympathetic Activity and Renal Denervation · PMID 41123061 | Hypertension artérielle | Traitement symptomatique | Publication | PubMed | Voir la publication source The regulation of blood pressure is closely linked to sympathetic activity. This retrospective study analyzed 142 hyper… | Journal of hypertension 2026-08-08 01:00:54 | Source |
| Peripheral blood mesenchymal stem cell-derived exosomes improve renal… ReD — Sympathetic Activity and Renal Denervation · PMID 40910352 | Hypertension artérielle | Remyélinisation indirecte / réparation · Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source To investigate the role of self-peripheral blood mesenchymal stem cell (PBMSC)-derived exosomes (Exos) in enhancing ren… | Clinical and translational medicine 2026-08-08 01:00:54 | Source |
| Remote Glucose Monitoring Engagement and Glycemic Control in Type 2 D… Diabetes and Hypertension Self Management Program · PMID 42532053 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Suboptimal glycemic control remains a significant public health challenge among adults with type 2 diabetes and prediab… | JMIR formative research 2026-08-08 01:00:53 | Source |
| Support needs for chronic disease self-management among persons atten… Diabetes and Hypertension Self Management Program · PMID 42549738 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source With the increasing burden of non-communicable chronic diseases, it is important to empower people to self-manage their… | South African family practice : official journal of th… 2026-08-08 01:00:53 | Source |
| A randomized, double-blind, multicenter, phase III study on the effic… Fimasartan/Amlodipine · PMID 36451242 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source To assess the efficacy and safety of a combination therapy involving fimasartan, amlodipine, and rosuvastatin in patien… | Clinical hypertension 2026-08-08 01:00:51 | Source |
| Simultaneous Analysis of a Combination of Anti-Hypertensive Drugs, Fi… Fimasartan/Amlodipine · PMID 36287856 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Fimasartan, amlodipine, and hydrochlorothiazide are commonly used in combination therapies as antihypertensive drugs. T… | Toxics 2026-08-08 01:00:51 | Source |
| Study protocol for the sheMATTERS study (iMproving cArdiovascular hea… sheMATTERS — Breastfeeding and Postpartum Cardiovascular Health · PMID 36703104 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Individuals with hypertensive disorders of pregnancy (HDP) have an elevated lifetime risk of chronic hypertension, meta… | BMC pregnancy and childbirth 2026-08-08 01:00:51 | Source |
| Assessment of periodontal regeneration with blood derivatives: a syst… Rosuvastatin · PMID 42547721 | Hypertension artérielle | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source This systematic review and network meta-analysis (NMA) evaluated the efficacy of autologous blood-derived products comp… | Odontology 2026-08-08 01:00:49 | Source |
| Gilteritinib-Associated Hypertriglyceridemia During Acute Myeloid Leu… Rosuvastatin · PMID 42534179 | Hypertension artérielle | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Acute myeloid leukemia (AML) harboring a FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation is… | Cureus 2026-08-08 01:00:49 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||