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8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Protective effect of alpha-lipoic acid against perfluorooctanoic acid… Alpha Lipoic Acid · PMID 42581560 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Male fertility is declining, and synthetic chemicals are a major candidate for causing it. This study investigated the… | Zygote (Cambridge, England) 2026-08-13 14:18:46 | Source |
| The Effects of Neurotropic B Vitamins, Vitamin D3, and Alpha-Lipoic A… Alpha Lipoic Acid · PMID 42588179 | Sclérose en plaques | Remyélinisation indirecte / réparation · Immunomodulation · Traitement symptoma… | Publication | PubMed | Voir la publication source Peripheral neuropathy (PN) is one of the most common disorders of the peripheral nervous system, affecting around 10% o… | Nutrients 2026-08-13 14:18:46 | Source |
| Cholesterol synthesis inhibitors effectively inhibit the replication… Simvastatin · PMID 42585695 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source The devastating impact of African swine fever (ASF) on the global pig industry has prompted an urgent need for the deve… | Virology 2026-08-13 14:18:43 | Source |
| Mechanisms and Predisposing Conditions for Statin-Induced New-Onset T… Simvastatin · PMID 42583924 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders arising from decreased insulin secretion… | Endocrinology, diabetes & metabolism 2026-08-13 14:18:43 | Source |
| An NLRP3 inflammasome inhibitor evoked dose-dependent anti-allodynia… pregabalin · PMID 42573969 | Cancer | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Patients receiving chemotherapy for cancer treatment may develop chemotherapy-induced peripheral neuropathy (CIPN), a t… | Inflammopharmacology 2026-08-13 14:18:41 | Source |
| Comparative Effectiveness, Safety, and Costs of Gabapentinoids in Old… pregabalin · PMID 42576615 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source It is unclear whether managing chronic pain with adjuvant gabapentin versus pregabalin can safely reduce long-term opio… | Journal of the American Geriatrics Society 2026-08-13 14:18:41 | Source |
| Efficacy of eltrombopag in combination with recombinant human thrombo… Platelet transfusion · PMID 42577528 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source To observe the efficacy and adverse reactions of eltrombopag combined with rhTPO in the treatment of lymphoma patients… | Frontiers in pharmacology 2026-08-13 14:18:36 | Source |
| Is Total Hip Arthroplasty Feasible in Patients with Severe Preoperati… Platelet transfusion · PMID 42590214 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Total hip arthroplasty (THA) routinely produces perioperative blood loss of 800-1200 mL, which raises concern that pati… | Journal of clinical medicine 2026-08-13 14:18:36 | Source |
| Intradural extramedullary ventral thoracic spinal ependymoma: illustr… spinal cord MRI follow-up · PMID 42574759 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Spinal cord ependymomas are typically intramedullary and rarely present as intradural extramedullary (IDEM) tumors. Her… | Journal of neurosurgery. Case lessons 2026-08-13 14:18:28 | Source |
| Presumed cervical subperiosteal vertebral hemorrhage in nine greyhoun… spinal cord MRI follow-up · PMID 42585564 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Spontaneous subperiosteal vertebral hemorrhages (SSVHs) are rarely documented in veterinary literature, with only a few… | Journal of veterinary internal medicine 2026-08-13 14:18:28 | Source |
| Polymorphism Controls B-Cell Repopulation Kinetics in People With Mul… Ocrelizumab · PMID 42579840 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Fc gamma receptor 3A () V158F polymorphism has been shown to modify the response to anti-CD20 therapy across several au… | Neurology(R) neuroimmunology & neuroinflammation 2026-08-13 14:18:18 | Source |
| Heterogeneity in Teriflunomide Treatment Arms: A Systematic Review an… Teriflunomide HMR1726 · PMID 42587259 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Teriflunomide is widely used as an active comparator in Phase 3 randomised trials for relapsing multiple sclerosis (RMS… | CNS drugs 2026-08-13 14:18:16 | Source |
| Tolebrutinib in nonrelapsing SPMS: regulatory divergence and the limi… Tolebrutinib · PMID 42567027 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Multiple sclerosis and related disorders 2026-08-13 14:18:14 | Source |
| Semaglutide as a potential neuroprotective agent for neurological and… Risk Factors in Early Multiple Sclerosis · PMID 42573665 | Maladie d’Alzheimer · Maladie de Parkinson · Sclérose en plaques | Neuroprotection · Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are established treatments for metabolic disease, with growing ev… | Molecular biology reports 2026-08-13 14:18:02 | Source |
| Comprehensive Genome Identification of the Gene Family in and Express… Ginseng · PMID 42589118 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Plant homeodomain (PHD) finger proteins are important histone modification readers that play broad roles in the epigene… | Biology 2026-08-13 14:18:00 | Source |
| Interfacial and Molecular Mechanisms of Pancreatic Lipase Modulation… Ginseng · PMID 42588448 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Pancreatic lipase activity depends strongly on interfacial conditions created by bile salts, motivating the search for… | Molecules (Basel, Switzerland) 2026-08-13 14:18:00 | Source |
| Decellularization of Cartilage Xenograft with Supercritical CO. Control Group · PMID 42590881 | Myasthénie · Sclérose en plaques | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Decellularized cartilage xenograft is an emerging alternative to autograft or allograft techniques, though its applicat… | Tissue engineering. Part C, Methods 2026-08-13 14:17:55 | Source |
| Efficacy of emotional working memory training on cognitive emotion re… Control Group · PMID 42590932 | Myasthénie · Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Problematic Internet Use (PIU) has been linked to emotional distress, cognitive impairments, and diminished academic pe… | Cognition & emotion 2026-08-13 14:17:55 | Source |
| Deep learning segmentation with uncertainty quantification for spinal… MRI · PMID 42591080 | Épilepsie · Migraine · Myopathies · Sclérose en plaques · Sclérose la… | Thérapie génique | Publication | PubMed | Voir la publication source Spinal tuberculosis is the most common extrapulmonary manifestation of tuberculosis. Magnetic resonance imaging (MRI),… | Frontiers in physiology 2026-08-13 14:17:54 | Source |
| Validation of open-source deep learning segmentation tools for automa… MRI · PMID 42591089 | Épilepsie · Migraine · Myopathies · Sclérose en plaques · Sclérose la… | À vérifier | Publication | PubMed | Voir la publication source Segmentation enables extraction of quantitative imaging features to enhance glioma diagnosis by volumetric measurements… | Frontiers in neurology 2026-08-13 14:17:54 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||