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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Leveraging Signal Detection and Mendelian Randomization in Spontaneou… Tecfidera · PMID 41941166 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Drug-induced amnesia is underrecognized due to absence of label indications. This study utilized the FAERS database to… | Current medicinal chemistry 2026-08-13 14:19:53 | Source |
| Retinal atrophy in multiple sclerosis is similar with extended versus… Tysabri · PMID 42571199 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Retinal ganglion cell + inner plexiform layer (GCIPL) atrophy reflects global neurodegeneration and disability in multi… | Multiple sclerosis journal - experimental, translation… 2026-08-13 14:19:53 | Source |
| Shared Genomic Architecture Between Schizophrenia and Multiple Sclero… Tecfidera · PMID 42427667 | Lupus · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Multiple Sclerosis (MS) pathogenesis is contingent upon the hyper-proliferative infiltration of peripheral macrophages… | bioRxiv : the preprint server for biology 2026-08-13 14:19:53 | Source |
| Comparative Effectiveness of Diroximel Fumarate vs. Dimethyl Fumarate… Vumerity · PMID 42060157 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Diroximel fumarate (DRF) and dimethyl fumarate (DMF) are established disease-modifying therapies for relapsing multiple… | Advances in therapy 2026-08-13 14:19:52 | Source |
| Comparative Efficacy and Safety of Ebastine 20 mg, Ebastine 10 mg and… Desloratadine given orally · PMID 28511488 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Acute and chronic urticaria can result in severely impaired quality of life from pruritus and associated sleep lessness… | Journal of clinical and diagnostic research : JCDR 2026-08-13 14:19:51 | Source |
| The effect of desloratadine on ischemia reperfusion induced oxidative… Desloratadine given orally · PMID 32524906 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source To examine the effect of desloratadine on kidney ischemia-reperfusion (I/R) injury in albino Wistar male rats using bio… | Renal failure 2026-08-13 14:19:51 | Source |
| Evaluation of the effects of A-PRF and oral dexamethasone use on post… Dexamethasone given orally · PMID 42421033 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source The aim of this study was to compare the effects of advanced platelet-rich-fibrin (A-PRF) and oral dexamethasone on pos… | BMC oral health 2026-08-13 14:19:50 | Source |
| Safety analyses of the INAVO120 randomised phase III trial of inavoli… Dexamethasone given orally · PMID 42202490 | Cancer | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source INAVO120 (NCT04191499) demonstrated significantly improved progression-free/overall survival with inavolisib plus palbo… | ESMO open 2026-08-13 14:19:50 | Source |
| A Case Report of Venezuelan Suntiger Tarantula (Psalmopoeus Irminia)… Diphenhydramine IV · PMID 37635034 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Tarantula envenomations are encountered infrequently but may increase with increased exotic animal ownership. This case… | The Journal of emergency medicine 2026-08-13 14:19:49 | Source |
| The Role of Cetirizine in the Changing Landscape of IV Antihistamines… Diphenhydramine IV · PMID 34862952 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Since 1955, the only available H antihistamines for intravenous administration have been first-generation formulations… | Advances in therapy 2026-08-13 14:19:49 | Source |
| Immune Checkpoint Inhibitor Therapy Induced Hypophysitis; A Tertiary… Methylprednisolone IV · PMID 41879139 | Cancer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The number of patients receiving immune checkpoint inhibitor (ICI) therapy for cancer is expected to increase further;… | Clinical endocrinology 2026-08-13 14:19:48 | Source |
| Probable Autoimmune Encephalitis Presenting With Catatonia in a Young… Methylprednisolone IV · PMID 40952037 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source ObjectiveTo describe a case of probable autoimmune encephalitis initially misdiagnosed as a primary psychiatric disorde… | International journal of psychiatry in medicine 2026-08-13 14:19:48 | Source |
| Relative increase of memory B-cell subsets under s.c. B-cell-depletin… Ocrelizumab IV · PMID 42375380 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Monoclonal antibodies targeting CD20-expressing B cells constitute effective therapies for people with multiple scleros… | Frontiers in immunology 2026-08-13 14:19:46 | Source |
| Subcutaneous Ocrelizumab for the Treatment of Relapsing Forms of Mult… Ocrelizumab IV · PMID 42545439 | Sclérose en plaques | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source The aim of this study was to evaluate the budget impact of introducing the subcutaneous (SC) form of ocrelizumab for pa… | PharmacoEconomics - open 2026-08-13 14:19:46 | Source |
| Enhancing everyday memory and participation in multiple sclerosis: A… Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study… | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Cognitive dysfunction in individuals with multiple sclerosis (MS) is associated with limitations in daily activities an… | Multiple sclerosis journal - experimental, translation… 2026-08-13 14:19:44 | Source |
| Managing fatigue in Parkinson's disease: Preparing for a randomized c… Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study… | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source BackgroundFatigue in Parkinson's disease (PD) is a common, debilitating symptom often overlooked in research and clinic… | Journal of Parkinson's disease 2026-08-13 14:19:44 | Source |
| Subcategorisation of Data for AI Models in Healthcare: A Case Study i… AI software · PMID 42587605 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Accurate data subcategorising is vital for reliability and traceability in the training and validation of all artificia… | Diagnostics (Basel, Switzerland) 2026-08-13 14:19:43 | Source |
| Zero Risk Is Impossible: Confidentiality and Artificial Intelligence… AI software · PMID 42577012 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Most journals' and publishers' guidelines regarding the use of artificial intelligence (AI) in peer review contain a si… | JMA journal 2026-08-13 14:19:43 | Source |
| Comorbidities for Predicting Progression Independent of Relapse Activ… RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multip… | Hypertension artérielle · Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Progression independent of relapse activity (PIRA) has been shown to account for a majority of the disability accumulat… | European journal of neurology 2026-08-13 14:19:42 | Source |
| Longitudinal changes in serum protein levels are associated with disa… RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multip… | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Early identification of patients with multiple sclerosis (MS) at risk of transitioning from relapsing-remitting multipl… | Multiple sclerosis and related disorders 2026-08-13 14:19:42 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||