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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Feasibility and preliminary outcomes of a remotely-delivered exercise… FERLAMS — Feasibility of Remote Exercise Training for Hispanics/Latinos With MS · PMID 42112098 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source There is limited evidence on the feasibility of remotely delivered exercise interventions for English-speaking Hispanic… | Multiple sclerosis journal - experimental, translation… 2026-08-13 14:20:07 | Source |
| Pilots' visual scan patterns and situation awareness in flight operat… High Fidelity Fixed-Base Simulator · PMID 25022158 | Maladie de Parkinson · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Situation awareness (SA) is considered an essential prerequisite for safe flying. If the impact of visual scanning patt… | Aviation, space, and environmental medicine 2026-08-13 14:20:06 | Source |
| Psychophysiological responses to takeover requests in conditionally a… High Fidelity Fixed-Base Simulator · PMID 33128991 | Maladie de Parkinson · Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source In SAE Level 3 automated driving, taking over control from automation raises significant safety concerns because driver… | Accident; analysis and prevention 2026-08-13 14:20:06 | Source |
| Anti-CD20 Therapies in Pediatric Acquired Demyelinating Syndromes: Ev… Ofatumumab approved dose · PMID 42334795 | Sclérose en plaques | Remyélinisation · Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Pediatric-acquired demyelinating syndromes, including multiple sclerosis (MS), aquaporin-4-IgG-positive neuromyelitis o… | CNS drugs 2026-08-13 14:20:04 | Source |
| Case Report of Combined Central and Peripheral Demyelination: Treated… Ofatumumab new dose · PMID 42207162 | Sclérose en plaques | Immunomodulation · Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Combined central and peripheral demyelination (CCPD) is a rare autoimmune-mediated disorder characterized by demyelinat… | Immunity, inflammation and disease 2026-08-13 14:20:04 | Source |
| Translating B-Cell and Plasma-Cell Targeting from Oncology to Autoimm… Ofatumumab approved dose · PMID 42244451 | Lupus · Sclérose en plaques · Cancer | Immunomodulation | Publication | PubMed | Voir la publication source B cells drive B-cell malignancies and diverse autoimmune diseases through autoantibody production, antigen presentation… | Clinical pharmacology and therapeutics 2026-08-13 14:20:04 | Source |
| Efficacy and Safety of Bendamustine Versus Fludarabine and Cyclophosp… Chemotherapy: fludarabine (FLU) · PMID 42063324 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire · Thé… | Publication | PubMed | Voir la publication source Chimeric antigen receptor T-cell (CAR-T) therapy has become an established treatment for hematological malignancies. Ly… | European journal of haematology 2026-08-13 14:20:02 | Source |
| Microbiota injury during conditioning for allogeneic hematopoietic st… Chemotherapy: fludarabine (FLU) · PMID 42487668 | Sclérose en plaques | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for hematological ma… | Journal of medicine and life 2026-08-13 14:20:02 | Source |
| Boric acid Attenuates premature ovarian insufficiency by Modulating o… Chemotherapy: cyclophosphamide (CYC) · PMID 42349090 | Sclérose en plaques | Neuroprotection | Publication | PubMed | Voir la publication source This study aimed to investigate whether boric acid (BA) exerts potential protective effects against cyclophosphamide (C… | European journal of obstetrics, gynecology, and reprod… 2026-08-13 14:20:01 | Source |
| Hepatoprotective effect of dipyridamole against cyclophosphamide-indu… Chemotherapy: cyclophosphamide (CYC) · PMID 42376399 | Sclérose en plaques | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Cyclophosphamide (Cyc) is an anticancer and immunomodulatory drug, but its use is associated with toxicity, including h… | Open veterinary journal 2026-08-13 14:20:01 | Source |
| Lurasidone hydrochloride-loaded microparticle-based long-acting injec… SYS6020 injection · PMID 42590962 | Non communiqué | À vérifier | Publication | PubMed | Voir la publication source Lurasidone hydrochloride is a promising antipsychotic agent. The currently marketed formulation (Latuda) of lurasidone… | Journal of microencapsulation 2026-08-13 14:20:00 | Source |
| Modified clomiphene citrate protocol versus gonadotropin-releasing ho… SYS6020 injection · PMID 42591084 | Non communiqué | À vérifier | Publication | PubMed | Voir la publication source The rising prevalence of infertility has substantially increased the demand for fertilization (IVF). While various cont… | Frontiers in endocrinology 2026-08-13 14:20:00 | Source |
| Emerging synthetic drugs for the management of hidradenitis suppurati… Remibrutinib oral treatment · PMID 42342652 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disorder affecting intertriginous regions. D… | Expert opinion on pharmacotherapy 2026-08-13 14:19:59 | Source |
| Remibrutinib impact on disease control, sleep, and quality of life: A… Remibrutinib oral treatment · PMID 42297099 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Chronic spontaneous urticaria (CSU) substantially reduces patients' quality of life (QoL); therefore, it is crucial to… | Annals of allergy, asthma & immunology : official publ… 2026-08-13 14:19:59 | Source |
| Cladribine treatment in pediatric-onset multiple sclerosis: real-worl… Disease-Modifying Therapies (DMTs) · PMID 42148068 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Pediatric-onset multiple sclerosis (POMS) poses unique therapeutic challenges due to high inflammatory activity, early… | Frontiers in immunology 2026-08-13 14:19:57 | Source |
| Efficacy and safety of ofatumumab in participants with relapsing mult… Disease-Modifying Therapies (DMTs) · PMID 42371147 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Initiating high-efficacy disease-modifying therapies (DMTs) early in relapsing multiple sclerosis (RMS) can reduce infl… | Journal of neurology 2026-08-13 14:19:57 | Source |
| Evaluating Efficacy Outcomes in Pediatric Multiple Sclerosis Patients… Avonex · PMID 40956912 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source This study evaluated the efficacy of the multiple sclerosis disease-modifying therapies, intramuscular interferon beta-… | Journal of child neurology 2026-08-13 14:19:56 | Source |
| Mixed Reality-Based Physical Therapy in Older Adults With Sarcopenia:… Mixed Reality Rehabilitation · PMID 40749218 | Maladie de Parkinson · Sclérose en plaques · Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Sarcopenia in older adults is associated with reduced muscle mass and function, leading to frailty, increased fall risk… | JMIR serious games 2026-08-13 14:19:56 | Source |
| The Effectiveness of Virtual Reality, Augmented Reality, and Mixed Re… Mixed Reality Rehabilitation · PMID 37598785 | Maladie de Parkinson · Sclérose en plaques · Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Extended reality (XR), including virtual reality, augmented reality, and mixed reality, has been increasingly used in p… | The Journal of arthroplasty 2026-08-13 14:19:56 | Source |
| Structure-Property Relationship Analysis of α-Keto Ester Prodrugs of… Diroximel Fumarate · PMID 42412905 | Sclérose en plaques | Neuroprotection | Publication | PubMed | Voir la publication source The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of the antioxidant re… | ACS chemical neuroscience 2026-08-13 14:19:55 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||