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Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Efficacy of a high-frequency repetitive transcranial magnetic stimula… Active stimulation · PMID 42572071 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source With the widespread popularity of online gaming, gaming addiction has come under scrutiny. While there is ongoing resea… | European archives of psychiatry and clinical neuroscie… 2026-08-13 14:20:32 | Source |
| Observed changes in clinical proxy measures of airway protection afte… Active stimulation · PMID 42564086 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Although spinal cord stimulation (SCS) has been investigated for cough and respiratory motor output after neurological… | Frontiers in neurology 2026-08-13 14:20:32 | Source |
| Associations between lifestyle factors and 2.5-year clinical outcomes… RehaMS — Exercise Therapy in Multiple Sclerosis · PMID 42573837 | Sclérose en plaques | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Healthy lifestyle factors are associated with better health outcomes in people with multiple sclerosis (pwMS). Whether… | Neurological sciences : official journal of the Italia… 2026-08-13 14:20:31 | Source |
| Ventricular-vascular coupling at rest and immediately following maxim… RehaMS — Exercise Therapy in Multiple Sclerosis · PMID 42583774 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) may impair ventricular-vascular coupling (VVC), a measure of the interaction between the cardia… | Physiological reports 2026-08-13 14:20:31 | Source |
| Impact of community-led cancer advocacy program on cancer health outr… Control · PMID 42591091 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Immigrants of African Descent (IAD) are a subset of the population in the United States with unique healthcare needs an… | Frontiers in health services 2026-08-13 14:20:30 | Source |
| When prediction fails: a computational complexity view of stress. Control · PMID 42591092 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Living organisms are increasingly understood as predictive systems that anticipate near-future, fitness-relevant demand… | Frontiers in veterinary science 2026-08-13 14:20:30 | Source |
| Transcutaneous vagus nerve stimulation in sleep disorders: current ev… tVNS · PMID 42534922 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Frontiers in pain research (Lausanne, Switzerland) 2026-08-13 14:20:29 | Source |
| tVNS and obesity-related inflammation: a prospective sham-controlled… tVNS · PMID 42552546 | Sclérose en plaques | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Overweight and obesity are characterized by detrimental effects on energy metabolism and an increase in adipose tissue,… | BMC psychology 2026-08-13 14:20:29 | Source |
| A Systematic Review of Stimulation Parameters Used in Transcutaneous… tSCS · PMID 42584386 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Transcutaneous spinal cord stimulation (tSCS) has been shown to be an effective enhancement for upper extremity (UE) mo… | Neuromodulation : journal of the International Neuromo… 2026-08-13 14:20:28 | Source |
| Prehospital Validation of the Scale to Identify Large Vessel Occlusio… tSCS · PMID 42574293 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Timely identification and transfer of patients with large vessel occlusion (LVO) to thrombectomy-capable stroke centers… | Cerebrovascular diseases (Basel, Switzerland) 2026-08-13 14:20:28 | Source |
| Nutritional supplementation of vitamin A and health-related outcomes… Impact of Vitamin A Supplementation on Immune System in Multiple Sclerosis Patients · PMID 312… | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) is a chronic immune mediated disease which affects the central nervous system (CNS), having a s… | Medicine 2026-08-13 14:20:27 | Source |
| Impact of vitamin A supplementation on RAR gene expression in multipl… MS — Impact of Vitamin A on Gene Expression, in Multiple Sclerosis Patient · PMID 23955709 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Vitamin A and its derivatives have been shown to modulate the immune system via retinoic acid receptor (RAR). This stud… | Journal of molecular neuroscience : MN 2026-08-13 14:20:26 | Source |
| The Effect of Vitamin A Supplementation on FoxP3 and TGF-β Gene Expre… MS — Impact of Vitamin A on Gene Expression, in Multiple Sclerosis Patient · PMID 25985851 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) is an autoinflammatory condition of the central nervous system with impaired T helper (Th)17 an… | Journal of molecular neuroscience : MN 2026-08-13 14:20:26 | Source |
| Identification and characterization of anti-chikungunya virus compoun… Bazedoxifene Acetate · PMID 42575252 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus for which no specific antiviral therapy is current… | Virologica Sinica 2026-08-13 14:20:24 | Source |
| Therapeutic Potential of Compounds with High Affinity to BAG2 in Inhi… Bazedoxifene Acetate · PMID 40893173 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Targeting the distinct genetic and protein expression profiles of keloids necessitates the identification of novel ther… | Biologics : targets & therapy 2026-08-13 14:20:24 | Source |
| Treatment persistence in paediatric-onset multiple sclerosis: A Swedi… Natalizumab 300 MG in 15 ML Injection · PMID 42218618 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Comparative studies in paediatric-onset multiple sclerosis (PoMS) that also include highly effective monoclonal antibod… | Multiple sclerosis (Houndmills, Basingstoke, England) 2026-08-13 14:20:22 | Source |
| A multimodal precision-prevention approach combining lifestyle interv… MetFORMIN 1000 Mg Oral Tablet · PMID 38297399 | Maladie d’Alzheimer | Thérapie génique | Publication | PubMed | Voir la publication source Combining multimodal lifestyle interventions and disease-modifying drugs (novel or repurposed) could provide novel prec… | Alzheimer's research & therapy 2026-08-13 14:20:20 | Source |
| Clemastine fumarate promotes myelin repair in a nonhuman primate mode… Clemastine Fumarate · PMID 41719338 | Sclérose en plaques | Remyélinisation | Publication | PubMed | Voir la publication source Promotion of remyelination has become a new therapeutic avenue, to prevent neuronal degeneration and promote recovery i… | Proceedings of the National Academy of Sciences of the… 2026-08-13 14:20:20 | Source |
| Green spectrofluorimetric determination of clemastine using nitrogen… Clemastine Fumarate · PMID 42052183 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source A novel, environmentally sustainable spectrofluorimetric method was developed for the determination of clemastine fumar… | RSC advances 2026-08-13 14:20:20 | Source |
| Pharmacokinetic comparison between fixed-dose combination and loose c… MetFORMIN 1000 Mg Oral Tablet · PMID 41579170 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Enavogliflozin is a sodium‒glucose cotransporter 2 inhibitor that can be administered in combination with metformin in… | Naunyn-Schmiedeberg's archives of pharmacology 2026-08-13 14:20:20 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||