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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Central nervous system uptake of intranasal glutathione in Parkinson'… Intranasal glutathione - (in)GSH · PMID 28725693 | Maladie de Parkinson | Remyélinisation indirecte / réparation · Neuroprotection | Publication | PubMed | Voir la publication source Glutathione (GSH) is depleted early in the course of Parkinson's disease (PD), and deficiency has been shown to perpetu… | NPJ Parkinson's disease 2026-08-13 14:22:51 | Source |
| Mesenchymal stem cell secretome attenuates disease-associated microgl… Saline Intranasal Delivery · PMID 42342036 | Maladie de Parkinson | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Therapeutic options for traumatic brain injury (TBI) remain limited, in part due to injury-induced activation of microg… | Neurochemistry international 2026-08-13 14:22:51 | Source |
| Phase IIb Study of Intranasal Glutathione in Parkinson's Disease. Intranasal glutathione - (in)GSH · PMID 28436395 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Reduced glutathione (GSH) is an endogenously synthesized tripeptide depleted early in the course of Parkinson's disease… | Journal of Parkinson's disease 2026-08-13 14:22:51 | Source |
| Smell and the sinuses. Saline Intranasal Delivery · PMID 42219147 | Maladie de Parkinson | Remyélinisation indirecte / réparation · Immunomodulation | Publication | PubMed | Voir la publication source Olfactory dysfunction is a common and clinically significant manifestation of inflammatory sinonasal disease. To summar… | Annals of allergy, asthma & immunology : official publ… 2026-08-13 14:22:51 | Source |
| Amelioration of Cisplatin Nephrotoxicity by Fe-Pt Coordination Exchan… deferiprone · PMID 42581566 | Maladie de Parkinson · Sclérose latérale amyotrophique · Sclérose lat… | Immunomodulation | Publication | PubMed | Voir la publication source Ferroptosis is an iron-dependent form of regulated cell death that has emerged as one of the mechanisms underlying cisp… | Advanced healthcare materials 2026-08-13 14:22:50 | Source |
| Precision Medicine in Transfusion-Dependent and Non-Transfusion-Depen… deferiprone · PMID 42572810 | Maladie de Parkinson · Sclérose latérale amyotrophique · Sclérose lat… | Thérapie génique | Publication | PubMed | Voir la publication source β-thalassemia comprises a clinically heterogeneous group of disorders in which anemia severity, transfusion exposure, i… | Hemoglobin 2026-08-13 14:22:50 | Source |
| Orthobiologic injections for hip osteoarthritis: A systematic review… Autologous Bone Marrow Aspirate (BMA) and Bone Marrow Aspirate Concentrate (BMAC) · PMID 41450… | Maladie de Parkinson | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source The incidence of hip osteoarthritis (OA) is increasing with the aging population, leading to interest in intra-articula… | Orthopedic reviews 2026-08-13 14:22:48 | Source |
| Surgical Applications for Bone Marrow Aspirate Concentrate. Autologous Bone Marrow Aspirate (BMA) and Bone Marrow Aspirate Concentrate (BMAC) · PMID 39428… | Maladie de Parkinson | Ralentissement de la progression · Immunomodulation · Traitement symptomatique… | Publication | PubMed | Voir la publication source Bone marrow aspirate concentrate (BMAC) is an autologous orthobiologic agent that may be of benefit in specific surgica… | Arthroscopy : the journal of arthroscopic & related su… 2026-08-13 14:22:48 | Source |
| A Multiscale Spatiotemporal Causal Mapping Algorithm for Revealing Ne… Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve · PMID 42487269 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Transcutaneous auricular vagus nerve stimulation (taVNS) has shown promise in enhancing cognitive and emotional functio… | Human brain mapping 2026-08-13 14:22:47 | Source |
| Context-Dependent Modulation of Epithelial Barrier Integrity and Inte… Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve · PMID 42511455 | Maladie de Parkinson | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Inflammatory bowel disease, including ulcerative colitis (UC) and Crohn's disease (CD), is associated with reduced vagu… | International journal of molecular sciences 2026-08-13 14:22:47 | Source |
| Exploring brain-gut interaction mechanisms in Transcutaneous auricula… Sham Transcutaneous Electrical Stimulation of Vagus Nerve · PMID 42487113 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source The gut microbiota is intricately implicated in the pathogenesis of Major Depressive Disorder (MDD), with the vagus ner… | BMC psychiatry 2026-08-13 14:22:47 | Source |
| A Novel Motion-Management Workflow Using Abdominal Compression and Ex… Abdominal compression · PMID 42561494 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Respiratory motion presents a significant challenge in liver radiotherapy. Abdominal compression (AC) and exhale breath… | Clinical oncology (Royal College of Radiologists (Grea… 2026-08-13 14:22:45 | Source |
| Compression therapy for the prevention of taxane-induced peripheral n… sham compression · PMID 41255081 | Cancer | À vérifier | Publication | PubMed | Voir la publication source This systematic review and meta-analysis evaluated whether compression therapy prevents chemotherapy-induced peripheral… | Expert review of anticancer therapy 2026-08-13 14:22:45 | Source |
| Giant Ovarian Mucinous Tumor Managed by Transvaginal Drainage of Tumo… Abdominal compression · PMID 42544222 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Laparoscopic surgery is widely preferred for benign ovarian tumors because it is associated with less postoperative pai… | Cureus 2026-08-13 14:22:45 | Source |
| Muscle contraction force conforms to muscle oxygenation during consta… sham compression · PMID 35971738 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source What is the central question of this study? In electrically stimulated skeletal muscle, force production is downregulat… | Experimental physiology 2026-08-13 14:22:45 | Source |
| Oral Albuterol for the Treatment of Rate-Dependent QT Prolongation an… Midodrine · PMID 42559783 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source We describe a case of rate-related QTc prolongation and related polymorphic ventricular tachycardia (VT) managed using… | JACC. Case reports 2026-08-13 14:22:44 | Source |
| The Role of Nitric Oxide in Chronic Liver Disease: A Review. Midodrine · PMID 42559000 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Nitric oxide (NO) is a crucial regulator of hepatic and systemic vascular tone. Abnormal distribution of NO in various… | Journal of clinical and translational hepatology 2026-08-13 14:22:44 | Source |
| Betulin Alleviates 5-Fluorouracil-Induced Intestinal Mucositis in Mic… 5-Fluorouracil (5-FU) · PMID 42588111 | Maladie de Parkinson | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Chemotherapy-induced intestinal mucositis (CIM) is a common gastrointestinal complication of anticancer therapy, and 5-… | Nutrients 2026-08-13 14:22:43 | Source |
| Resveratrol Modulates Phosphatidylcholine Metabolism-Related Enzymes… 5-Fluorouracil (5-FU) · PMID 42589348 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Colorectal cancer (CRC) remains a major cause of cancer-related mortality worldwide, largely due to the emergence of ch… | International journal of molecular sciences 2026-08-13 14:22:43 | Source |
| Leucovorin Levoleucovorin Rescue After High-dose Methotrexate in Cent… Levoleucovorin · PMID 42527076 | Maladie de Parkinson | Thérapie génique | Publication | PubMed | Voir la publication source Leucovorin is the standard folinic acid rescue agent after high-dose methotrexate, whereas levoleucovorin is the pharma… | Anticancer research 2026-08-13 14:22:42 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||