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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Prevention of Sleep Apnoea After General Anaesthesia Using a Thermopl… dexamethasone · PMID 42590144 | Cancer · Migraine | Thérapie génique | Publication | PubMed | Voir la publication source Sleep apnoea is associated with increased postoperative morbidity and worsens after surgery under general anaesthesia.… | Journal of clinical medicine 2026-08-13 14:46:42 | Source |
| Short-term quantitative ultrasonographic assessment of masseter muscl… Botulinum toxin type A · PMID 42579291 | Migraine · Myopathies · Myopathies · Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source To evaluate short-term clinical and ultrasonographic changes in the masseter muscle following botulinum toxin type A (B… | Cranio : the journal of craniomandibular practice 2026-08-13 14:46:38 | Source |
| The STIIM UP Protocol: Exploratory Evaluation of the Potential of Com… Botulinum toxin type A · PMID 42590155 | Migraine · Myopathies · Myopathies · Migraine | À vérifier | Publication | PubMed | Voir la publication source Cervical integument aging is a complex, multifactorial process characterized by thinning dermis, loss of elasticity, an… | Journal of clinical medicine 2026-08-13 14:46:37 | Source |
| Digoxin Dosing Errors, Drug Interactions and Off-Label Risks: Insight… Digoxin · PMID 42590087 | Épilepsie · Sclérose latérale amyotrophique · Sclérose latérale amyot… | À vérifier | Publication | PubMed | Voir la publication source : Digoxin, a positive inotropic agent with a narrow therapeutic window, is used in heart failure but carries toxicity r… | Journal of clinical medicine 2026-08-13 14:31:11 | Source |
| Sub-Saharan African Prostate Cancer Patient-Derived Cell Lines and Hi… Digoxin · PMID 42588668 | Cancer | À vérifier | Publication | PubMed | Voir la publication source : Prostate cancer (PC) exhibits marked disparities in incidence and mortality across ethnicities, with men of Sub-Sahar… | Cancers 2026-08-13 14:31:11 | Source |
| Anti-Inflammatory and Antioxidant Strategies in Epilepsy: From Molecu… Effects of Antiepileptic Drugs on Brain Excitability · PMID 42589265 | Épilepsie | Remyélinisation indirecte / réparation · Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Epilepsy is a multifactorial disorder, yet routine management still focuses on neuronal excitation and insufficient inh… | International journal of molecular sciences 2026-08-13 14:31:09 | Source |
| Cannabidiol attenuates seizure progression and recognition memory def… Effects of Antiepileptic Drugs on Brain Excitability · PMID 42532179 | Épilepsie | Neuroprotection · Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Epilepsy is a neurological disorder characterized by excessive neuronal firing, frequently originating in the hippocamp… | Neuropharmacology 2026-08-13 14:31:09 | Source |
| A Diagnostic Dilemma in a Breast Cancer Patient on Tamoxifen: Perihep… 18F-FDG · PMID 42591077 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Breast cancer metastasis to the liver carries a poor prognosis, and the identification of hypermetabolic hepatic or per… | International medical case reports journal 2026-08-13 14:31:08 | Source |
| Development and Validation of a Novel Geriatric Risk Score for Progno… 18F-FDG · PMID 42590970 | Cancer · Épilepsie · Épilepsie | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Outcomes in older patients with Hodgkin lymphoma (HL) are compromised by the interplay of patient frailty and disease a… | American journal of hematology 2026-08-13 14:31:08 | Source |
| Distinct Modulation of High- and Low-Frequency Activity by Midazolam… Allopregnanolone · PMID 42589596 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Adverse effects of benzodiazepines are largely mediated by GABA receptors containing α1-subunits. Recent efforts to rep… | International journal of molecular sciences 2026-08-13 14:31:07 | Source |
| Behavioral and Contextual Patterns Derived From Ecological Momentary… ActivPAL · PMID 42579880 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Physical activity, sedentary behavior, sleep, and eating behavior are recognized as key contributors to physical and me… | JMIR formative research 2026-08-13 14:31:02 | Source |
| Patterns of ADL and IADL independence across MMSE score ranges in Alz… Living With Frontotemporal Dementia · PMID 42567789 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Domain-level ADL and IADL independence across MMSE score ranges has been less well described in Alzheimer's disease (AD… | International psychogeriatrics 2026-08-13 14:31:02 | Source |
| Social engagement and brain structure-informed cognitive domain traje… Living With Frontotemporal Dementia · PMID 42583866 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Cognitive decline may emerge in specific domains before overt dementia, yet domain-specific cognitive benefits of socia… | Alzheimer's & dementia : the journal of the Alzheimer'… 2026-08-13 14:31:02 | Source |
| Can All Oxygen Molecules Accumulate in One Corner of the Room? Treati… Lighting Intervention Therapy · PMID 42590888 | Maladie d’Alzheimer | Thérapie génique | Publication | PubMed | Voir la publication source Narcissistic personality disorder (NPD) and pathological narcissism (PN) urgently need empirically supported treatment… | Clinical psychology & psychotherapy 2026-08-13 14:30:52 | Source |
| Real-Time Sign Language Interpretation via Customized Sign Language G… Lighting Intervention Therapy · PMID 42590660 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source A sign language interpretation system aims to translate sign gestures into spoken or written language in real time, ena… | Sensors (Basel, Switzerland) 2026-08-13 14:30:52 | Source |
| Uncovering Modifiable Contributors to Depressive Symptoms During Anti… escitalopram · PMID 42568808 | Maladie d’Alzheimer · Sclérose latérale amyotrophique · Sclérose laté… | Traitement symptomatique | Publication | PubMed | Voir la publication source Depressive symptoms in primary care often arise from a complex interplay of hormonal, biological, metabolic, psychosoci… | Clinical case reports 2026-08-13 14:30:50 | Source |
| Intelligibility of Emotional Speech in Chinese Older Adults: Effects… Hearing aids · PMID 42584965 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source The intelligibility of speech with emotional prosody may decline with aging and hearing loss. In Mandarin Chinese, both… | Journal of speech, language, and hearing research : JS… 2026-08-13 14:30:48 | Source |
| [Effects of bone conduction device on speech recognition in noise and… Hearing aids · PMID 42576633 | Maladie d’Alzheimer | Traitement symptomatique | Publication | PubMed | Voir la publication source To evaluate listening effort（LE） and listening-related fatigue（LRF） in patients with single-sided deafness（SSD）, and to… | Lin chuang er bi yan hou tou jing wai ke za zhi = Jour… 2026-08-13 14:30:48 | Source |
| Acute Pain Management in Children: A Systematic Review and GRADE-Base… Ibuprofen · PMID 42589904 | Maladie d’Alzheimer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source : Acute pain in children is frequently under-recognized and undertreated despite validated assessment tools and effecti… | Journal of clinical medicine 2026-08-13 14:30:47 | Source |
| Polyphenol-Loaded Liposomal Nanocarriers from : A Promising Nutraceut… Ibuprofen · PMID 42588507 | Maladie d’Alzheimer | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source L. aerial parts are a rich source of polyphenols with recognized antioxidant and anti-inflammatory properties; however,… | Molecules (Basel, Switzerland) 2026-08-13 14:30:47 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||