Vue transversale globale
Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
Filtrer toute la vue
Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
· 41 visibles sur cette page
dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Beyond Middle Meningeal Artery: Paradoxical Predominance Sign Predict… Middle Meningeal Artery embolization · PMID 42586762 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Middle meningeal artery embolization (MMAE) is an emerging treatment for chronic subdural hematoma (CSDH). However, hem… | AJNR. American journal of neuroradiology 2026-08-13 14:47:31 | Source |
| Innovations in conservative and surgical therapy for Ménière's diseas… Rimegepant · PMID 42582108 | Migraine | Neuroprotection · Traitement symptomatique | Publication | PubMed | Voir la publication source Ménière's disease (MD) is an inner ear disorder of poorly understood etiology, and its management remains symptomatic.… | Frontiers in neurology 2026-08-13 14:47:19 | Source |
| Effectiveness and Safety of Herbal Decoctions for Functional Dyspepsi… Acupuncture · PMID 42588407 | Migraine | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source : Functional dyspepsia (FD) is frequently treated in Korean Medicine (KM) clinics in South Korea. With the recent inclu… | Healthcare (Basel, Switzerland) 2026-08-13 14:47:16 | Source |
| Intravaginal Formulation Strategies for Vaginal Disorders: Optimizing… Acupuncture · PMID 42588524 | Migraine | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Recurrent vaginal disorders remain a significant clinical challenge despite available antimicrobial and hormonal therap… | Molecules (Basel, Switzerland) 2026-08-13 14:47:16 | Source |
| Botulinum Neurotoxin Treatment of Camptocormia- A Critical Review and… OnabotulinumtoxinA · PMID 42569510 | Maladie de Parkinson · Myopathies | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Camptocormia is a disabling postural disorder characterized by involuntary forward flexion of the thoracolumbar spine t… | Tremor and other hyperkinetic movements (New York, N.Y… 2026-08-13 14:47:13 | Source |
| Health-Related Quality of Life Following Botulinum Toxin for Retrogra… OnabotulinumtoxinA · PMID 42572920 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Retrograde cricopharyngeus dysfunction (R-CPD) is a form of cricopharyngeal achalasia in which the inability to burp le… | The Laryngoscope 2026-08-13 14:47:13 | Source |
| Painful neuromas exhibit axonal phenotypic shift via nociceptive and… Calcitonin Gene-Related Peptide · PMID 42582843 | Migraine | Neuroprotection · Traitement symptomatique | Publication | PubMed | Voir la publication source Neuropathic pain encompasses a spectrum of conditions that significantly impact quality of life. In case of nerve injur… | PNAS nexus 2026-08-13 14:47:07 | Source |
| Papilledema is not the point: intracranial pressure dysregulation as… Calcitonin Gene-Related Peptide · PMID 42582597 | Hypertension artérielle · Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Accumulating evidence challenges the traditional distinction between migraine and idiopathic intracranial hypertension… | Brain communications 2026-08-13 14:47:07 | Source |
| Beyond GLP-1: Amylin-Based Pharmacotherapy and the Search for Better-… Amylin · PMID 42586227 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Amylin-based pharmacotherapy has re-emerged as a promising strategy for the treatment of obesity and metabolic disease… | Pharmacological research 2026-08-13 14:47:01 | Source |
| Digestive Hormones and Their Impact on Bariatric and Pharmacologic We… Amylin · PMID 42584007 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Obesity is a growing global health challenge associated with major cardiometabolic complications. While bariatric surge… | Endocrine reviews 2026-08-13 14:47:01 | Source |
| The Liver-Heart Axis in Rheumatoid Arthritis: Associations of Liver F… Endothelin-1 · PMID 42589498 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Liver involvement is frequent in rheumatoid arthritis (RA) and may progress from steatosis to fibrosis, cirrhosis, or h… | International journal of molecular sciences 2026-08-13 14:47:00 | Source |
| Antiseizure medication use in pregnancy and the risk of poor fetal gr… topiramate · PMID 42586099 | Migraine | Thérapie génique | Publication | PubMed | Voir la publication source Poor fetal growth is a major cause of perinatal morbidity and mortality and predisposes individuals to chronic diseases… | The Lancet. Neurology 2026-08-13 14:46:52 | Source |
| EMG-guided Onabotulinum Toxin A for provoked vestibulodynia: addressi… Onabotulinum toxin A · PMID 42575277 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | American journal of obstetrics and gynecology 2026-08-13 14:46:52 | Source |
| Systemic Medications as Triggers of Acute Angle-Closure Glaucoma: A N… topiramate · PMID 42589938 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Acute angle-closure glaucoma (AACG) is an emergency requiring rapid intervention to prevent irreversible optic nerve da… | Journal of clinical medicine 2026-08-13 14:46:52 | Source |
| In-Ear Transcranial Alternating Current Stimulation: Auditory Percept… DC Stimulator (Transcranial Direct Current Stimulator) · PMID 42573546 | Migraine | Thérapie génique | Publication | PubMed | Voir la publication source Noninvasive transcranial alternating current stimulation (tACS) of the cochlea might be a promising new therapeutic opt… | Neuromodulation : journal of the International Neuromo… 2026-08-13 14:46:48 | Source |
| Remotely Supervised Home-Based tDCS in Treatment-Resistant Depression… DC Stimulator (Transcranial Direct Current Stimulator) · PMID 42580014 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Remotely supervised home-based transcranial direct current stimulation (HB-tDCS) may expand access to neuromodulation f… | Psychiatry research 2026-08-13 14:46:48 | Source |
| Ultrasound-Guided Greater Occipital Nerve Pulsed Radiofrequency for C… Greater occipital nerve radiofrequency · PMID 42574205 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Managing chronic headache in older adults is complicated by multimorbidity and polypharmacy. This study evaluated 6-mon… | Annals of Indian Academy of Neurology 2026-08-13 14:46:46 | Source |
| Phosphodiesterase Type 5 Inhibitors as Chemical Hazards in Honey and… Sildenafil · PMID 42588529 | Migraine · Myopathies · Myopathies · Migraine | À vérifier | Publication | PubMed | Voir la publication source The processing of bee products has recently become more frequent due to the rapidly growing market and demand for healt… | Molecules (Basel, Switzerland) 2026-08-13 14:46:43 | Source |
| Sildenafil Positivity and Chronic Cardiac Pathology in Men Who Died o… Sildenafil · PMID 42587637 | Migraine · Myopathies · Myopathies · Migraine | À vérifier | Publication | PubMed | Voir la publication source Erectile dysfunction and cardiovascular disease share common pathophysiological mechanisms, yet little is known about t… | Diagnostics (Basel, Switzerland) 2026-08-13 14:46:43 | Source |
| How Common Is Hypercortisolism in Patients With Type 2 Diabetes? Risk… dexamethasone · PMID 42591054 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Hypercortisolism is an underdiagnosed contributor to metabolic dysfunction in people with Type 2 diabetes (T2D). Althou… | Diabetes, obesity & metabolism 2026-08-13 14:46:42 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||