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8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Serum sPD-1 and sTIM-3 as T-cell exhaustion biomarkers in systemic lu… Urinary T Cell Biomarker for Prediction in Lupus Nephritis · PMID 42551186 | Lupus | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source T-cell exhaustion marked by soluble PD-1 (sPD-1) and soluble TIM-3 (sTIM-3) has been implicated in systemic lupus eryth… | Human immunology 2026-08-13 15:00:01 | Source |
| Voclosporin for the treatment of lupus nephritis flares in patients w… Belimumab · PMID 42584031 | Lupus | Ralentissement de la progression | Publication | PubMed | Voir la publication source Lupus nephritis (LN) is a frequent and severe manifestation of systemic lupus erythematosus (SLE) associated with progr… | Journal of nephrology 2026-08-13 15:00:00 | Source |
| Effectiveness and safety of glucocorticoids bridging rituximab in neu… oral Prednisone 5mg · PMID 39923413 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Anti-CD20 monoclonal antibody rituximab have been widely used to prevent relapses in patients with neuromyelitis optica… | Multiple sclerosis and related disorders 2026-08-13 14:59:58 | Source |
| Maternal Thyroid Dysfunction During Pregnancy and Childhood Autism or… Blood sample · PMID 42590824 | Lupus · Sclérose en plaques · Lupus · Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Overt maternal hypothyroidism during pregnancy has been associated with cognitive impairment in offspring, but less is… | Autism research : official journal of the Internationa… 2026-08-13 14:59:58 | Source |
| Peripheral Blood Neutrophil-Monocyte-to-Lymphocyte Ratio and Long-Ter… Blood sample · PMID 42588399 | Lupus · Sclérose en plaques · Lupus · Sclérose en plaques | Ralentissement de la progression · Immunomodulation · Traitement symptomatique… | Publication | PubMed | Voir la publication source Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome with substantial variability in clinical progr… | Healthcare (Basel, Switzerland) 2026-08-13 14:59:58 | Source |
| Real-World Effectiveness of Tezepelumab Across T2 and Non-T2 Severe A… oral Prednisone 5mg · PMID 42342535 | Lupus | À vérifier | Publication | PubMed | Voir la publication source To evaluate real-world effectiveness of tezepelumab in severe asthma, by type-2 (T2) status and prior biologic exposure… | Archivos de bronconeumologia 2026-08-13 14:59:58 | Source |
| Dynamics of in vivo immune remodeling in Ph all patients receiving fr… Blinatumomab · PMID 42581034 | Lupus · Myasthénie · Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Blood cancer journal 2026-08-13 14:59:55 | Source |
| Fatal Neuroinvasive Astrovirus VA1 Encephalitis in a Child With High-… Blinatumomab · PMID 42590950 | Lupus · Myasthénie · Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Pediatric blood & cancer 2026-08-13 14:59:55 | Source |
| The Role of Emotions in Health Literacy and Patient Education: Trends… Educational materials · PMID 42588392 | Lupus | Thérapie génique | Publication | PubMed | Voir la publication source Health literacy and patient education play a key role in supporting informed decision-making, treatment adherence, and… | Healthcare (Basel, Switzerland) 2026-08-13 14:59:55 | Source |
| Using the Collective Impact Model to Organize Evidence-Based Programs… Educational materials · PMID 42588305 | Lupus | Ralentissement de la progression | Publication | PubMed | Voir la publication source Individuals with intellectual and/or developmental disabilities (IDDs) experience persistent health inequities, exacerb… | Healthcare (Basel, Switzerland) 2026-08-13 14:59:55 | Source |
| Achievement of real-world adapted DORIS remission targets among patie… standard therapy · PMID 42583764 | Lupus | À vérifier | Publication | PubMed | Voir la publication source IntroductionRemission is a key treatment goal associated with improved patient outcomes in systemic lupus erythematosus… | Lupus 2026-08-13 14:59:53 | Source |
| Peptide-Based Nanocomplexes Enable Transferrin-Mediated Uptake and p5… standard therapy · PMID 42589514 | Lupus | À vérifier | Publication | PubMed | Voir la publication source Glioblastoma (GB), the most prevalent and aggressive brain tumor, remains one of the most lethal challenges in modern o… | International journal of molecular sciences 2026-08-13 14:59:53 | Source |
| Case Report: Telitacicept in the treatment of refractory juvenile idi… Telitacicept · PMID 42582370 | Lupus · Myasthénie · Lupus · Myasthénie | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Refractory juvenile idiopathic arthritis (JIA) remains difficult to manage, particularly in patients with persistent di… | Frontiers in pediatrics 2026-08-13 14:59:52 | Source |
| Efficacy and safety of BAFF/APRIL-pathway inhibitors versus placebo i… Telitacicept · PMID 42587279 | Lupus · Myasthénie · Lupus · Myasthénie | À vérifier | Publication | PubMed | Voir la publication source B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) drive the galactose-deficient IgA1 (Gd-IgA1… | BMC nephrology 2026-08-13 14:59:52 | Source |
| Comparative Protective Effects of Anakinra and Tocilizumab in Experim… Tocilizumab · PMID 42589680 | Cancer · Épilepsie · Lupus | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Ocular ischemic syndrome (OIS) is a vision-threatening disorder characterized by retinal ischemia, oxidative stress, an… | International journal of molecular sciences 2026-08-13 14:59:51 | Source |
| Correction: Zhao et al. Artesunate Inhibits Metastatic Potential in C… Artesunate · PMID 42587837 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source To better reflect the first two authors' contributions in the original article [...]. | Cells 2026-08-13 14:59:49 | Source |
| Integrated Bioinformatics Analysis Identifies FCER1G, IL1R2, and BST1… Artesunate · PMID 42590911 | Lupus | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Sepsis remains difficult to diagnose since blood culture has low sensitivity and current biomarkers lack sufficient spe… | Journal of clinical laboratory analysis 2026-08-13 14:59:49 | Source |
| Unable to walk or eat without assistance in pregnancy-Wilson's diseas… Pregnancy and Medically Assisted Conception in Rare Diseases · PMID 42527939 | Lupus | Traitement symptomatique | Publication | PubMed | Voir la publication source Wilson's disease, an autosomal recessive disorder, affects body copper metabolism. It can be fatal if left untreated as… | Journal of medical case reports 2026-08-13 14:59:46 | Source |
| Iron overload cardiomyopathy. MRI, Venipuncture · PMID 42566087 | Lupus | Remyélinisation indirecte / réparation · Neuroprotection · Thérapie génique | Publication | PubMed | Voir la publication source Iron overload cardiomyopathy (IOC) remains an important cause of morbidity and mortality in patients with hereditary ha… | Heart failure reviews 2026-08-13 14:59:44 | Source |
| Secondary polycythemia as a rare cause of ischemic stroke: A case rep… MRI, Venipuncture · PMID 42491235 | Hypertension artérielle | Traitement symptomatique | Publication | PubMed | Voir la publication source Polycythemia is a known but underrecognized risk factor for ischemic stroke, particularly in the setting of chronic hyp… | Radiology case reports 2026-08-13 14:59:44 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||