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8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Prognostic communication in amyotrophic lateral sclerosis: findings f… ALS-CarE — A Programme for Amyotrophic Lateral Sclerosis Care in Europe · PMID 39073531 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron disease with a highly variable prognosis. Among the propose… | Neurological sciences : official journal of the Italia… 2026-08-13 15:07:27 | Source |
| Docking Analysis of Drugs Used in the Treatment of Alzheimer's Diseas… Memantine · PMID 42589213 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Molecular docking in silico techniques were used to assess the interactions between several drugs used in the treatment… | International journal of molecular sciences 2026-08-13 15:07:26 | Source |
| Otophylloside T alleviates depression-like behaviors by directly targ… Celecoxib · PMID 42585681 | Sclérose latérale amyotrophique | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Depression is closely linked to inflammation, driving interest in novel antidepressant targets. However, the inconsiste… | Phytomedicine : international journal of phytotherapy… 2026-08-13 15:07:23 | Source |
| PGE2-mediated NK cell reprogramming drives acquired immunotherapy res… Celecoxib · PMID 42586608 | Sclérose latérale amyotrophique | Thérapie génique | Publication | PubMed | Voir la publication source Acquired resistance limits the durability of programmed cell death protein-1 (PD-1) blockade in lung adenocarcinoma, ye… | Journal for immunotherapy of cancer 2026-08-13 15:07:23 | Source |
| Concomitant Antiseizure Medications' Influence on Valproic Acid and L… levetiracetam · PMID 42590959 | Épilepsie · Sclérose latérale amyotrophique · Épilepsie · Sclérose la… | À vérifier | Publication | PubMed | Voir la publication source Valproic acid (VPA) and levetiracetam (LEV) are among the most widely used anti-seizure medications (ASMs) in pediatric… | Pediatrics international : official journal of the Jap… 2026-08-13 15:07:22 | Source |
| The Feasibility and Acceptability of Sharing Video Recordings of Amyo… Determining Feasibility and Acceptability of Sharing Video Recordings With Patients With ALS a… | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Multidisciplinary clinics (MDCs) provide benefits to patients with amyotrophic lateral sclerosis (ALS) and their caregi… | JMIR formative research 2026-08-13 15:07:21 | Source |
| A randomized placebo-controlled phase 3 study of mesenchymal stem cel… MSC-NTF cells transplantation (IT) · PMID 34890069 | Sclérose latérale amyotrophique | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative illness with great unmet patient need. We aimed to eva… | Muscle & nerve 2026-08-13 15:07:20 | Source |
| MSC-NTF (NurOwn®) exosomes: a novel therapeutic modality in the mouse… MSC-NTF cells transplantation (IM) · PMID 33468250 | Sclérose latérale amyotrophique | Immunomodulation · Traitement symptomatique · Thérapie cellulaire | Publication | PubMed | Voir la publication source One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). AR… | Stem cell research & therapy 2026-08-13 15:07:20 | Source |
| Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neuro… MSC-NTF cells transplantation (IM) · PMID 26751635 | Sclérose latérale amyotrophique | Ralentissement de la progression · Thérapie cellulaire | Publication | PubMed | Voir la publication source Preclinical studies have shown that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrop… | JAMA neurology 2026-08-13 15:07:20 | Source |
| Various detailed characteristics of a new enhanced neurotrophic facto… MSC-NTF cells transplantation (IT) · PMID 35436472 | Sclérose latérale amyotrophique | Thérapie cellulaire | Publication | PubMed | Voir la publication source Because MSC-NTF has a higher ability to secrete neurotrophic factors, it may have a greater potential than ordinary MSC… | Experimental cell research 2026-08-13 15:07:20 | Source |
| Comprehensive cell type decomposition of circulating cell-free DNA wi… Involvement of Lymphocyte Type B in Amyotrophic Lateral Sclerosis (ALS) · PMID 33976150 | Sclérose latérale amyotrophique | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Circulating cell-free DNA (cfDNA) in the bloodstream originates from dying cells and is a promising noninvasive biomark… | Nature communications 2026-08-13 15:07:19 | Source |
| [IgM kappa lymphoma with antisulfatide antibodies revealed by cervica… Involvement of Lymphocyte Type B in Amyotrophic Lateral Sclerosis (ALS) · PMID 9775155 | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source It is well known that polyneuropathy is associated with monoclonal IgM kappa. We report the case of a 79-year-old man w… | La Revue de medecine interne 2026-08-13 15:07:19 | Source |
| Brain games? 3K3A-APC Protein · PMID 37972193 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Whistleblowers and former lab members suggest a star neuroscientist routinely manipulated data, compromising a planned… | Science (New York, N.Y.) 2026-08-13 15:07:18 | Source |
| Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect M… 3K3A-APC Protein · PMID 38279255 | Sclérose latérale amyotrophique | Immunomodulation | Publication | PubMed | Voir la publication source Endothelial protein C receptor (EPCR) is a receptor for the natural anti-coagulant activated protein C (aPC). It mediat… | International journal of molecular sciences 2026-08-13 15:07:18 | Source |
| Lessons from a systematic review of family-based studies in ALS. Amyotrophic Lateral Sclerosis (ALS) Families Project · PMID 42584174 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source ALS is genetically heterogeneous, with many causal genes identified through family-based gene-discovery studies. To eva… | Amyotrophic lateral sclerosis & frontotemporal degener… 2026-08-13 15:07:16 | Source |
| In vivo mapping of striatal neurodegeneration in Huntington's disease… Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Relat… | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Huntington's disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor d… | eLife 2026-08-13 15:07:12 | Source |
| RFC1 Repeat Expansions in Chronic Idiopathic Axonal Polyneuropathy: P… Mac2ALS — Expression Profile Study of Macrophages From Patients Affected by ALS or Other Relat… | Sclérose latérale amyotrophique | Neuroprotection · Traitement symptomatique | Publication | PubMed | Voir la publication source Chronic idiopathic axonal polyneuropathy (CIAP) accounts for approximately 20%-30% of adult-onset axonal polyneuropathi… | Journal of the peripheral nervous system : JPNS 2026-08-13 15:07:12 | Source |
| Intraocular inflammation and presumed retinal vasculitis following in… Pegcetacoplan (APL-2) · PMID 42577845 | Sclérose latérale amyotrophique | Immunomodulation | Publication | PubMed | Voir la publication source We report a case of presumed retinal vasculitis and precipitous complete vision loss following a single intravitreal in… | Digital journal of ophthalmology : DJO 2026-08-13 15:07:08 | Source |
| Pegcetacoplan as a targeted C3 inhibitor in C3 glomerulopathy and imm… Pegcetacoplan (APL-2) · PMID 42583599 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Annals of medicine and surgery (2012) 2026-08-13 15:07:08 | Source |
| Cutaneous alpha-synuclein deposition informs autonomic function in in… skin biopsy · PMID 42587236 | Sclérose latérale amyotrophique | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Multiple system atrophy is a progressive neurodegenerative disorder characterized by autonomic failure, parkinsonism, a… | Clinical autonomic research : official journal of the… 2026-08-13 15:07:06 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||