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Périmètre
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Comparative efficacy of percutaneous vertebroplasty combined with min… Control Group · PMID 42480043 | Myasthénie · Sclérose en plaques | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source The study aimed to assess the comparative efficacy of percutaneous vertebroplasty (PVP) combined with minimally invasiv… | The Libyan journal of medicine 2026-08-16 12:59:39 | Source |
| Unveiling the skin-protective material basis of Coreopsis tinctoria N… Control Group · PMID 42508546 | Myasthénie · Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Coreopsis tinctoria Nutt. (commonly known as Kunlun snow chrysanthemum) is a traditional medicinal and edible plant dis… | Journal of ethnopharmacology 2026-08-16 12:59:39 | Source |
| Brain iron deposition mediates cognitive impairment in COPD: A possib… MRI · PMID 42464739 | Épilepsie · Migraine · Myopathies · Sclérose en plaques · Sclérose la… | Immunomodulation | Publication | PubMed | Voir la publication source Cognitive impairment is a relatively prevalent comorbidity in chronic obstructive pulmonary disease (COPD), yet its neu… | Pulmonology 2026-08-16 12:59:38 | Source |
| Extraperitoneal Single-Port Robotic-Assisted Radical Cystectomy with… MRI · PMID 42397987 | Cancer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Radical cystectomy (RC) is the standard therapy for muscle-invasive bladder cancer (MIBC) and refractory high-risk non-… | International braz j urol : official journal of the Br… 2026-08-16 12:59:38 | Source |
| New pulse sequence for improving cardiac black-blood and PSIR MRI qua… MRI · PMID 42502572 | Épilepsie · Migraine · Myopathies · Sclérose en plaques · Sclérose la… | À vérifier | Publication | PubMed | Voir la publication source Most conventional cardiac MRI scans, which rely on electrocardiogram (ECG)-triggered segmented acquisition for k-space… | Magnetic resonance letters 2026-08-16 12:59:38 | Source |
| From options to decisions: an innovative model for treatment sequenci… Ambulation Study in Multiple Sclerosis · PMID 42339705 | Sclérose en plaques | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source With the expanding range of disease-modifying therapies (DMTs) for relapsing-remitting multiple sclerosis (RRMS), clini… | Journal of medical economics 2026-08-16 12:59:37 | Source |
| Therapeutic potential of astrocyte transdifferentiated neurons. Ambulation Study in Multiple Sclerosis · PMID 41467429 | Maladie d’Alzheimer · Maladie de Parkinson | Remyélinisation indirecte / réparation · Neuroprotection · Thérapie cellulaire… | Publication | PubMed | Voir la publication source The permanent functional deficits resulting from the inability of adult mammalian central nervous system neurons to reg… | Neural regeneration research 2026-08-16 12:59:37 | Source |
| Construction and characterization of novel -derived triple and quadru… Bacille Calmette-Guerin vaccine · PMID 42012295 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Tuberculosis (TB) is a deadly disease that claims the lives of over a million people each year worldwide. The Bacille C… | Infection and immunity 2026-08-16 12:59:36 | Source |
| Feasibility and efficacy of a physical activity intervention for mana… Aerobic Exercise in Persons With Multiple Sclerosis With Restless Legs Syndrome · PMID 33618120 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source This pilot randomized controlled trial examined the feasibility and efficacy of a physical activity behavior change int… | Multiple sclerosis and related disorders 2026-08-16 12:59:35 | Source |
| Fingolimod induces cytotoxic stress and apoptosis-like cell death in… Fingolimod · PMID 42269275 | Sclérose en plaques · Cancer | Remyélinisation indirecte / réparation · Ralentissement de la progression · Imm… | Publication | PubMed | Voir la publication source Over the last several years, sphingolipids have been shown to regulate numerous cellular processes, including cell adhe… | Biochemical and biophysical research communications 2026-08-16 12:59:32 | Source |
| Investigating FTY720-NF immunomodulation of key lipid, gene, and prot… Fingolimod · PMID 42161013 | Sclérose en plaques | Remyélinisation indirecte / réparation · Immunomodulation | Publication | PubMed | Voir la publication source Oronasal fistula (ONF) formation following cleft palate repair remains a significant clinical challenge, often driven b… | Biomaterials advances 2026-08-16 12:59:32 | Source |
| Discovery of Fosigotifator, a Potent eIF2B Activator with Desired Pro… Fosigotifator · PMID 42153306 | Sclérose latérale amyotrophique | Ralentissement de la progression | Publication | PubMed | Voir la publication source The integrated stress response (ISR) is a highly conserved cellular pathway triggered by a variety of insults, reducing… | Journal of medicinal chemistry 2026-08-13 15:07:32 | Source |
| Safety and efficacy of guanabenz in early-childhood onset vanishing w… Fosigotifator · PMID 42586097 | Sclérose latérale amyotrophique | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Vanishing white matter is a neurodegenerative disease with onset mostly in children aged 1-6 years that causes early de… | The Lancet. Neurology 2026-08-13 15:07:32 | Source |
| Role of Airwave Oscillometry in Patients with Combined Fibrosis-Emphy… standard pulmonary function testing · PMID 42072785 | Sclérose latérale amyotrophique | Ralentissement de la progression | Publication | PubMed | Voir la publication source Emphysema is frequently observed in patients with fibrosing interstitial lung diseases (f-ILDs), leading to the clinica… | Diagnostics (Basel, Switzerland) 2026-08-13 15:07:31 | Source |
| Role of Polysomnography in Tracheostomy Decannulation in Neuromuscula… standard pulmonary function testing · PMID 41573483 | Sclérose latérale amyotrophique | Thérapie génique | Publication | PubMed | Voir la publication source Tracheostomy decannulation in patients with neuromuscular disease presents significant challenges due to impaired airwa… | Cureus 2026-08-13 15:07:31 | Source |
| Unsupervised home spirometry versus supervised clinic spirometry: ana… remote pulmonary function testing · PMID 42557061 | Sclérose latérale amyotrophique | Ralentissement de la progression | Publication | PubMed | Voir la publication source Lung function measurement is central to assessing disease severity and monitoring progression in bronchiectasis. Althou… | Thorax 2026-08-13 15:07:30 | Source |
| Wearable Sensor System for Diver Vital Sign Monitoring. remote pulmonary function testing · PMID 42560209 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Military divers operate at the limits of human physiology, where inadequate oxygen delivery to the brain-caused by hypo… | Military medicine 2026-08-13 15:07:30 | Source |
| Evolution of Ivermectin Resistance in the Nematode Model : Critical I… Monepantel · PMID 42038536 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source The emergence and spread of anthelmintic resistance represent a major challenge for treating parasitic nematodes, threa… | Evolutionary applications 2026-08-13 15:07:29 | Source |
| Repurposing monepantel in oncology: A conceptual mini-review of propo… Monepantel · PMID 42176570 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Monepantel (MPL), an amino‑acetonitrile derivative (AAD) anthelmintic, is widely used for the treatment of nematode inf… | Biomedicine & pharmacotherapy = Biomedecine & pharmaco… 2026-08-13 15:07:29 | Source |
| Frequency and Early Predictors of Cognitive Deterioration in Amyotrop… ALS-CarE — A Programme for Amyotrophic Lateral Sclerosis Care in Europe · PMID 39891470 | Sclérose latérale amyotrophique | Ralentissement de la progression | Publication | PubMed | Voir la publication source The objective is to evaluate cognitive and behavioral progression and identify early predictors of these changes in a c… | Annals of neurology 2026-08-13 15:07:27 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||