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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Value of Annual MRI Monitoring in Patients With Multiple Sclerosis Tr… Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS) · PMID 425259… | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Current guidelines recommend annual MRI scans during treatment with disease-modifying therapies, including ocrelizumab,… | Neurology 2026-08-16 13:02:22 | Source |
| An Evaluation of the Long-term Impact of Gadolinium-based Contrast Ag… Gadoteridol · PMID 41378765 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Previous studies in rodents have investigated the potential effects of gadolinium-based contrast agents (GBCAs) on the… | Investigative radiology 2026-08-16 13:02:21 | Source |
| Dynamic Susceptibility Contrast MRI Using Gadopiclenol for Evaluation… Gadoteridol · PMID 41672714 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source DSC MRI is widely used to assess relative cerebral blood volume (rCBV) in brain tumors using gadolinium-based contrast… | AJNR. American journal of neuroradiology 2026-08-16 13:02:21 | Source |
| Gadolinium-Enhanced Portable Ultra-Low-Field MRI for Evaluating Vario… Gadoteridol · PMID 41720517 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Portable ultra-low-field (pULF) MRI scanners, operating at magnetic fields below 100 mT, are broadening MRI accessibili… | AJNR. American journal of neuroradiology 2026-08-16 13:02:21 | Source |
| Kidney transplantation in sub-Sahara African countries: challenges an… Methylprednisolone · PMID 42315970 | Cancer · Lupus · Myopathies · Maladie de Parkinson · Sclérose en plaq… | Thérapie génique | Publication | PubMed | Voir la publication source This report presents the outcomes, challenges, and lessons learned from the first 17 cases of kidney transplantation (K… | Renal failure 2026-08-16 13:02:06 | Source |
| Wt1 facilitates visceral beige fat formation to combat abdominal obes… Methylprednisolone · PMID 42125880 | Cancer · Lupus · Myopathies · Maladie de Parkinson · Sclérose en plaq… | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Visceral fat has weaker beige adipogenesis than subcutaneous fat with unclear mechanisms. The Wilms tumour gene (Wt1),… | Adipocyte 2026-08-16 13:02:06 | Source |
| Clinical manifestations and management of Androctonus bicolor envenom… Antihistamine · PMID 42264194 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source The black fat tailed scorpion (Androctonus bicolor) is one of the most venomous native scorpion species in Israel. Its… | Toxicon : official journal of the International Societ… 2026-08-16 13:02:05 | Source |
| Higher satisfaction and adherence with glatiramer acetate 40 mg/mL TI… Copaxone-Teva · PMID 31132664 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Patients who perceive their medication to be ineffective or inconvenient are less likely to be adherent to treatment, w… | Multiple sclerosis and related disorders 2026-08-16 13:02:05 | Source |
| Repurposing loratadine to reverse colistin resistance in through targ… Antihistamine · PMID 41678146 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source The emergence of multidrug-resistant poses a significant challenge to clinical treatment and public health. Strategies… | Emerging microbes & infections 2026-08-16 13:02:05 | Source |
| Targeting oxidative stress, inflammation, and apoptosis: The protecti… Antihistamine · PMID 42061022 | Sclérose en plaques | Remyélinisation indirecte / réparation · Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Vancomycin (VCM), a glycopeptide antibiotic frequently employed against methicillin-resistant Staphylococcus aureus (MR… | Tissue & cell 2026-08-16 13:02:05 | Source |
| Electroacupuncture for essential hypertension: Mechanistic insights,… Sham · PMID 42298753 | Hypertension artérielle | Immunomodulation | Publication | PubMed | Voir la publication source Essential hypertension (EH) remains a leading modifiable risk factor for cardiovascular morbidity and mortality worldwi… | Clinical and experimental hypertension (New York, N.Y.… 2026-08-16 13:01:56 | Source |
| Evaluating mucosal and systemic immunity in an observational cohort o… EMST · PMID 42323156 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Acute respiratory infections, including SARS-CoV-2, remain a leading cause of childhood morbidity and mortality in low-… | International journal of infectious diseases : IJID :… 2026-08-16 13:01:56 | Source |
| Mailuo Shutong pills alleviate limb swelling in femoral fracture rats… Sham · PMID 42476204 | Migraine · Sclérose en plaques | Remyélinisation indirecte / réparation · Immunomodulation · Traitement symptoma… | Publication | PubMed | Voir la publication source Mailuo Shutong Pill (MLSTP) is a well-established formula developed by National Grand Master of Traditional Chinese Med… | Journal of ethnopharmacology 2026-08-16 13:01:56 | Source |
| Protective effects of polysaccharide on oxidative stress and liver in… Sham · PMID 42159294 | Migraine · Sclérose en plaques | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Oxidative stress-induced liver injury can progress to severe hepatic conditions. Polysaccharides are promising therapeu… | Redox report : communications in free radical research 2026-08-16 13:01:56 | Source |
| Effects of Respiratory Muscle Training on Respiratory Function and Fa… Inspiratory Muscle Training in Individuals With Multiple Sclerosis · PMID 41512727 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source To evaluate the effects of respiratory muscle training (RMT) on respiratory function and fatigue in individuals with mu… | Multiple sclerosis and related disorders 2026-08-16 13:01:55 | Source |
| Modelling post-traumatic stress disorder-major depressive disorder co… paroxetine · PMID 41920162 | Migraine · Sclérose en plaques · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Post-traumatic stress disorder comorbid with major depressive disorder (PTSD + MDD) is a multifactorial condition with… | European journal of psychotraumatology 2026-08-16 13:01:54 | Source |
| Psychopharmacological treatment of patients with heart failure: A nar… paroxetine · PMID 42259462 | Migraine · Sclérose en plaques · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Heart failure (HF) commonly coexists with psychiatric disorders, particularly depression and anxiety, which significant… | Current problems in cardiology 2026-08-16 13:01:54 | Source |
| Redox modulation contributes to the antidepressant-like and neuroprot… paroxetine · PMID 41697767 | Maladie d’Alzheimer | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Alzheimer's disease (AD) is characterized by cognitive impairment and neuropsychiatric disturbances, including depressi… | Redox report : communications in free radical research 2026-08-16 13:01:54 | Source |
| ELISA-based validation of differentially expressed Fibrinogen, S100A9… blood sample to analyse AMH level on the serum · PMID 42034305 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Polycystic ovary syndrome (PCOS) remains difficult to diagnose reliably, especially when clinical decisions rely heavil… | Steroids 2026-08-16 13:01:50 | Source |
| Hepatic Safety of Adjunctive High-Dose Melatonin in Participants Rece… Ocrelizumab 300 mg · PMID 41706381 | Sclérose en plaques | Neuroprotection · Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Based on melatonin's neuroprotective effects in pre-clinical multiple sclerosis models, the MELATOMS-1 study was design… | CNS drugs 2026-08-16 13:01:48 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||