Vue transversale globale
Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
Filtrer toute la vue
Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
· 41 visibles sur cette page
dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Field-ridge structured bioactive Zn-based scaffold promotes bone rege… Mesenchymal stem cells · PMID 42598026 | Sclérose en plaques | Thérapie cellulaire | Publication | PubMed | Voir la publication source Large bone defects often exhibit impaired healing due to the absence of a favorable osteoinductive microenvironment at… | Bioactive materials 2026-08-16 13:05:27 | Source |
| Key contributors to cell-free layer formation: An experimental invest… Suspension media · PMID 40846133 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source The formation of the cell-free layer (CFL) near vessel walls plays a critical role in microcirculatory function, influe… | Microvascular research 2026-08-16 13:05:27 | Source |
| Discriminative analysis of regional evolution of iron and myelin/calc… Gray Matter Demyelination in Primary Progressive MS at 7T · PMID 29537720 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Combined R2* and quantitative susceptibility (QS) has been previously used in cross-sectional multiple sclerosis (MS) s… | Journal of magnetic resonance imaging : JMRI 2026-08-16 13:05:26 | Source |
| Progressive iron accumulation across multiple sclerosis phenotypes re… Gray Matter Demyelination in Primary Progressive MS at 7T · PMID 28301067 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source To create an automated framework for localized analysis of deep gray matter (DGM) iron accumulation and demyelination u… | Journal of magnetic resonance imaging : JMRI 2026-08-16 13:05:26 | Source |
| Brain activity changes following neuroproprioceptive "facilitation, i… Effect of the Vojta Therapy in Patients Multiple Sclerosis · PMID 32935954 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Imaging methods bring new possibilities for describing the brain plasticity processes that underly the improvement of c… | European journal of physical and rehabilitation medici… 2026-08-16 13:05:24 | Source |
| Evaluation of compatibility of domperidone with selected excipients u… Domperidone · PMID 42557860 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source This study aims systematic evaluation of potential drug excipient interactions and by using a multi technique analytica… | Drug development and industrial pharmacy 2026-08-16 13:05:24 | Source |
| Reflex Locomotion Therapy for Balance, Gait, and Fatigue Rehabilitati… Effect of the Vojta Therapy in Patients Multiple Sclerosis · PMID 35160020 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source This study evaluates the effects of a rehabilitation program based on reflex locomotion therapy (RLT) on balance, gait,… | Journal of clinical medicine 2026-08-16 13:05:24 | Source |
| Serum angiogenesis-hypoxia biomarkers in relapsing-remitting multiple… Domperidone · PMID 42431138 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Studies have demonstrated that the hypoxia-angiogenic axis is dysregulated in progressive multiple sclerosis (MS), with… | Multiple sclerosis and related disorders 2026-08-16 13:05:24 | Source |
| The association of upper limb sensorimotor capacity, everyday inpatie… Effect of the Vojta Therapy in Patients Multiple Sclerosis · PMID 40045323 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Quantifying and monitoring the sensorimotor state of persons with neurological disease by means of wearables in everyda… | Journal of neuroengineering and rehabilitation 2026-08-16 13:05:24 | Source |
| [Practice of obstetric medicine in neurological disorders: towards ev… Domperidone · PMID 42572290 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Obstetric medicine is a specialized field providing medical care to women with internal diseases who wish to conceive o… | Rinsho shinkeigaku = Clinical neurology 2026-08-16 13:05:24 | Source |
| Effect of topical vaginal estrogen after radiotherapy for cervical ca… vaginal estriol · PMID 42468465 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source To evaluate the effect of topical vaginal estriol on vaginal epithelial maturation, quality of life, and sexual functio… | International journal of gynecological cancer : offici… 2026-08-16 13:05:22 | Source |
| Effects of Erbium:YAG laser combined with vaginal estriol therapy in… vaginal estriol · PMID 42276807 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Genitourinary syndrome of menopause (GSM) is a chronic, oestrogen-deficient condition that is frequently underdiagnosed… | BMJ open 2026-08-16 13:05:22 | Source |
| Vaginal Estriol Tablet Therapy for Rectovaginal Fistula after Low Rec… vaginal estriol · PMID 42535226 | Sclérose en plaques | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source Rectovaginal fistula (RVF) remains a challenging complication after low rectal surgery, lacking a standardized, effecti… | Journal of the anus, rectum and colon 2026-08-16 13:05:22 | Source |
| The lymphocyte phenotype in patients with primary fibromyalgia. Cytotron · PMID 9055389 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source The aim of this study was to examine the lymphocyte phenotype in fibromyalgia (FB) patients. Nineteen patients [18 fema… | Upsala journal of medical sciences 2026-08-16 13:05:21 | Source |
| Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset… olesoxime (TRO19622) · PMID 34536405 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Spinal muscular atrophy is a rare, autosomal recessive, neuromuscular disease caused by biallelic loss of the survival… | The Lancet. Neurology 2026-08-16 13:05:13 | Source |
| Risdiplam in Patients Previously Treated with Other Therapies for Spi… olesoxime (TRO19622) · PMID 36780114 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier for the treatment of patients with spinal muscular a… | Neurology and therapy 2026-08-16 13:05:13 | Source |
| Assessment of Opicinumab in Acute Optic Neuritis Using Multifocal Vis… BIIB033 · PMID 30267385 | Sclérose en plaques | Remyélinisation | Publication | PubMed | Voir la publication source Multifocal visual evoked potential (MF-VEP) assesses a wider visual field than full-field VEP (FF-VEP) and potentially… | CNS drugs 2026-08-16 13:05:12 | Source |
| Dysregulation of Immune Regulatory Mediators and Reduced Antitetanus… TT Vaccine · PMID 42425069 | Sclérose en plaques | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Infection with Plasmodium falciparum or Plasmodium vivax during pregnancy can result in adverse outcomes for both mothe… | The American journal of tropical medicine and hygiene 2026-08-16 13:05:09 | Source |
| Impact of dosing interval on immunogenicity following a heterologous… TT Vaccine · PMID 42556475 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Typhoid conjugate vaccines (TCVs) are essential for controlling endemic typhoid fever in low- and middle-income countri… | The Journal of infection 2026-08-16 13:05:09 | Source |
| The MYBL2-GTSE1 axis promotes laryngeal squamous cell carcinoma progr… OCR · PMID 41866755 | Sclérose en plaques | Remyélinisation indirecte / réparation · Ralentissement de la progression · Thé… | Publication | PubMed | Voir la publication source Laryngeal squamous cell carcinoma (LSCC) is a common head and neck malignancy with poor prognosis. The role of MYBL2, a… | Cancer biology & therapy 2026-08-16 13:05:08 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||