Vue transversale de la maladie
Myopathies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
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dans le périmètre Myopathies
Niveau clinique
Études et traitements 421
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Transcutaneous Spinal Stimulation (TSS) NCT05429736 · Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spa… | Myopathies | Traitement symptomatique | Non applicable | ACTIVE_NOT_RECRUITING | For many people with spinal cord injury (SCI), the goal of walking is a hi… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:33 | Détail |
| AZD0530 Difumarate NCT04307953 · STOPFOP — Saracatinib Trial TO Prevent FOP | Myopathies | À vérifier | Phase 2 | ACTIVE_NOT_RECRUITING | This is a phase 2 study, designed as a European multicentre 6-month double… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| CABA-201 following preconditioning with fludarabine and cyclophospham… NCT06154252 · RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-… | Myopathies | Immunomodulation | Phase 2/3 | RECRUITING | RESET-Myositis: Open-Label Study to Evaluate the Safety and Efficacy of CA… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Clinical evaluation NCT07792421 · NAP SAPS CSI — Pain Phenotype and Response to Corticosteroid Injection in Patien… | Myopathies | Traitement symptomatique | À vérifier | NOT_YET_RECRUITING | The goal of this prospective cohort study is to investigate whether pain p… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Clinical evaluation NCT07792434 · The NAP SAPS — Nociplastic Pain in Patients Diagnosed With Subacromial Pain Synd… | Myopathies | Traitement symptomatique | À vérifier | NOT_YET_RECRUITING | The goal of this prospective cohort study is to investigate whether pain p… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Effectiveness of Brief Mindfulness-Based Interventions for Painful Te… NCT06582134 · NCT06582134 | Myopathies | Traitement symptomatique · Thérapie génique | Non applicable | COMPLETED | The goal of this clinical trial is to learn if brief mindfulness-based int… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| End-expiratory Transpulmonary Pressure-guided vs Electrical Impedance… NCT06697717 · End-expiratory Transpulmonary Pressure-guided vs Electrical Impedance Tomography… | Myopathies | À vérifier | Non applicable | COMPLETED | This study aims to adopt a randomized crossover design to compare the effe… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| GRASP-01-002 — Defining Endpoints in Becker Muscular Dystrophy NCT05257473 · NCT05257473 | Myopathies | À vérifier | À vérifier | ACTIVE_NOT_RECRUITING | This is a 24-month, observational study of 50 participants with Becker mus… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| INIT ART — Comparison of Integrated Neuromuscular Inhibition Techniqu… NCT07395154 · NCT07395154 | Myopathies | Ralentissement de la progression · Traitement symptomatique | Non applicable | COMPLETED | The goal of this clinical trial is to determine whether two manual therapy… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Monoplace Hyperbaric Chamber (Class III medical device). NCT06082518 · PCS-HBOT — Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments | Myopathies | Traitement symptomatique | Non applicable | ACTIVE_NOT_RECRUITING | Over 500 million people have been infected with COVID-19, and to date, mor… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Piloting a Novel Peer Support Pain Self-Management Intervention (Proj… NCT04229134 · NCT04229134 | Myopathies | Traitement symptomatique · Thérapie génique | Non applicable | COMPLETED | The proposed study will test the feasibility and acceptability of an 8-wee… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Pulsed Electromagnetic Field Therapy NCT07802938 · Pulsed Electromagnetic Field Therapy Added to ESWT for Lateral Epicondylitis | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized, sham-controlled, assessor-blinded clinical trial will eva… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Resamirigene bilparvovec NCT03199469 · ASPIRO — A Study of AT132 in Young Children With X-Linked Myotubular Myopathy (X… | Myopathies | Traitement symptomatique · Thérapie génique | Phase 2/3 | ACTIVE_NOT_RECRUITING | X-linked myotubular myopathy (XLMTM) is a rare and serious condition prese… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| SFL-0821 for injection NCT07798609 · A Trial to Assess Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and… | Myopathies | À vérifier | Phase 1/2 | NOT_YET_RECRUITING | The purpose of this study is to evaluate the safety, tolerability, and pre… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Triamcinolone injection to the shoulder, elbow, wrist, or hand NCT05292339 · Ketorolac in Upper Extremity Tendinopathy and Arthropathy | Myopathies | Immunomodulation · Traitement symptomatique | Phase 4 | RECRUITING | Osteoarthritis (OA) and inflammatory conditions of the tendons and joints… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| UX016 NCT07511556 · First-in-human Study of UX016 in GNEM | Myopathies | À vérifier | Phase 1/2 | RECRUITING | The goal of this study is to assess the safety and dose of UX016 and its i… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Whole body vibration therapy NCT07286435 · The Effect of Whole-Body Vibration Therapy Following Botulinum Toxin A Injection… | Myopathies | Traitement symptomatique | Non applicable | RECRUITING | The purpose of this clinical study is to evaluate the effect of Whole Body… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| zeleciment basivarsen (DYNE-101) NCT07486934 · Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Partic… | Myopathies | À vérifier | Phase 3 | RECRUITING | The purpose of the study is to assess the efficacy, safety, and tolerabili… À vérifier | ClinicalTrials.gov 2026-09-03 16:31:32 | Détail |
| Sham whole body vibration therapy Étude non communiquée | Myopathies | Traitement symptomatique | Non applicable | Actif | The purpose of this clinical study is to evaluate the effect of Whole Body… À vérifier | ClinicalTrials.gov 2026-09-02 | Détail |
| Shoulder orthosis Étude non communiquée | Myopathies · Sclérose latérale amyotrophique | Traitement symptomatique | Non applicable | Terminé | The goal of this clinical trial is to investigate the effect of a muscle-m… À vérifier | ClinicalTrials.gov 2026-09-02 | Détail |
Découverte scientifique
Recherches et trouvailles 0
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune trouvaille ne correspond aux filtres. | |||||||
Bibliographie
Publications 585
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Blunt Tibial Injury Is Associated With Primary Amputation for Lower E… Primary major amputation · PMID 42107181 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Single-center civilian series report up to a 20% primary amputation rate following lower-extremity vascular trauma (LEV… | The Journal of surgical research 2026-08-16 13:24:05 | Source |
| Contemporary Outcomes of Staged Versus Primary Major Amputation for S… Primary major amputation · PMID 42349641 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Lower extremity amputation is a necessary, life-saving intervention for patients with severe foot infection. Previous s… | Annals of vascular surgery 2026-08-16 13:24:04 | Source |
| Dengzhanxixin injection for acute ischemic stroke after reperfusion t… Revascularization · PMID 42518968 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Revascularization for acute ischemic stroke (AIS) can salvage at-risk brain tissue, but reperfusion injury may reduce t… | IBRO neuroscience reports 2026-08-16 13:24:04 | Source |
| Host-state biomarkers and clinical factors for stratification and opt… Revascularization · PMID 42571258 | Myopathies | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Chronic limb-threatening ischemia (CLTI) is a severe manifestation of peripheral arterial disease associated with high… | Regenerative therapy 2026-08-16 13:24:04 | Source |
| Long-term safety and effectiveness of hybrid coronary revascularizati… Revascularization · PMID 41675882 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Hybrid coronary revascularization (HCR), a combination of percutaneous coronary intervention and coronary artery bypass… | Annals of medicine and surgery (2012) 2026-08-16 13:24:04 | Source |
| Re: "Contemporary Outcomes of Staged Versus Primary Major Amputation… Primary major amputation · PMID 42401234 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Annals of vascular surgery 2026-08-16 13:24:04 | Source |
| Feasibility and Effectiveness of the WHO Caregiver Skills Training Pr… COVID-19 Pandemic and Parents of Disabled Children · PMID 42525203 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Parent-mediated interventions are a core component of services for children with autism and other neurodevelopmental co… | Journal of autism and developmental disorders 2026-08-16 13:23:58 | Source |
| Biomechanics of manual wheeled propulsion in children and adolescents… Manual muscular test · PMID 42034074 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Manual wheelchair use supports independence and participation for children with neuromuscular disorders; however, pedia… | Clinical biomechanics (Bristol, Avon) 2026-08-16 13:23:57 | Source |
| A robotic perturbation trainer for transverse-plane gait perturbation… test of walk · PMID 42502775 | Myopathies | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source This study describes the development and implementation of a robotic perturbation-based training methodology for childr… | MethodsX 2026-08-16 13:23:56 | Source |
| Nigral biochemical and structural alterations following subacute expo… test of walk · PMID 42502326 | Myopathies | Remyélinisation indirecte / réparation · Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source The substantia nigra is the critical part of the midbrain responsible for movement-related functions. Nigral alteration… | Toxicology reports 2026-08-16 13:23:56 | Source |
| A qualitative exploration of self-compassion for caregivers of childr… Awareness Levels of Caregivers of Disabled Children · PMID 40906039 | Myopathies | Ralentissement de la progression | Publication | PubMed | Voir la publication source Caregivers of children with physical disabilities face unique stressors and experience high levels of anxiety, depressi… | Rehabilitation psychology 2026-08-16 13:23:55 | Source |
| Downbeat nystagmus: a practical approach based on a clinical case. baclofen · PMID 42594882 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Spontaneous downbeat nystagmus (DBN) is the most common form of acquired nystagmus, characterized by a slow upward ocul… | Arquivos de neuro-psiquiatria 2026-08-16 13:23:43 | Source |
| Nipocalimab and other FcRn blockers in neuromuscular disorders. Nipocalimab · PMID 42398839 | Myopathies | Immunomodulation | Publication | PubMed | Voir la publication source Neonatal Fc receptor (FcRn) inhibition represents a novel and targeted therapeutic approach for autoimmune neuromuscula… | Pharmacology & therapeutics 2026-08-16 13:23:02 | Source |
| Prednisolone modulates CD8⁺ and regulatory T-cell activity to dampen… Prednisolone · PMID 41807927 | Myopathies | Ralentissement de la progression | Publication | PubMed | Voir la publication source Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced melanoma, yet their efficacy is limited… | Oncoimmunology 2026-08-16 13:22:09 | Source |
| Shared genetics of IgA nephropathy and cardiometabolic diseases revea… Prednisolone · PMID 42535737 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Immunoglobulin A nephropathy (IgAN), the most common primary glomerular disease and a leading cause of end-stage kidney… | Renal failure 2026-08-16 13:22:09 | Source |
| Biological Response of ZX50 Mg Alloy: The Role of Surface Microstruct… Study of Families With Twins or Siblings Discordant for Rheumatic Disorders · PMID 42573495 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source The surface mechanical attrition treatment (SMAT) and subsequent controlled annealing were performed on a ZX50 (Mg5Zn0.… | ACS biomaterials science & engineering 2026-08-16 13:21:48 | Source |
| How much is sexual minority stress confounded with familial causes? A… Study of Families With Twins or Siblings Discordant for Rheumatic Disorders · PMID 42572393 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Compared with heterosexual persons, non-heterosexual persons have worse mental health. Sexual Minority Stress Theory (S… | Psychological medicine 2026-08-16 13:21:48 | Source |
| Vulnerability to bullying victimization: an investigation of genetic… Study of Families With Twins or Siblings Discordant for Rheumatic Disorders · PMID 41910150 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Bullying victimization is associated with serious short- and long-term consequences, including mental health problems.… | European journal of psychotraumatology 2026-08-16 13:21:48 | Source |
| Antibody levels and immune memory in children with kaposiform hemangi… Sirolimus · PMID 42154819 | Myopathies | Immunomodulation | Publication | PubMed | Voir la publication source This study evaluated the safety, immunogenicity, and post-vaccination immune responses of timely, sequential catch-up v… | Human vaccines & immunotherapeutics 2026-08-16 13:21:43 | Source |
| Efficacy and safety of TPO-RA combined with sirolimus in the treatmen… Sirolimus · PMID 41844533 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Relapsed immune thrombocytopenia (ITP) poses challenges in treatment. Thrombopoietin receptor agonists (TPO-RAs) are re… | Hematology (Amsterdam, Netherlands) 2026-08-16 13:21:43 | Source |
Exploration — prudence
Pistes exploratoires 6
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| N-PPG N-PPG — modulation métabolique cérébrale | Myopathies | Remyélinisation indirecte / réparation · Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation métabolique et mitohormèse N-PPG est étudié dans Maladie de Huntington et documente plusieurs axes biologiques pouvant être pertinents pour Myopat… | Rapprochement Biomedical Watch · Maladie de Huntington | Détail |
| Vecteur Ple389 (ADORA2A) MiniPromoter Ple389 — ciblage striatal | Myopathies | Thérapie génique | Hypothèse exploratoire | Rapprochement automatique non validé | Expression génique ciblée dans les neurones striataux Vecteur Ple389 (ADORA2A) est étudié dans Maladie de Huntington et documente plusieurs axes biologiques pouvant être per… | Rapprochement Biomedical Watch · Maladie de Huntington | Détail |
| α-Amyrin α-Amyrin — protection mitochondriale | Myopathies | Remyélinisation indirecte / réparation · Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Protection mitochondriale et modulation de la pathologie Tau α-Amyrin est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pour Myopa… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Myopathies | Neuroprotection · Immunomodulation | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation immunométabolique de la microglie 4-octyl itaconate et dérivés est étudié dans Sclérose latérale amyotrophique et documente plusieurs axes biologiques po… | Rapprochement Biomedical Watch · Sclérose latérale amy… | Détail |
| Thonningianin A Thonningianin A — neuroprotection anti-amyloïde | Myopathies | Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Modulation du stress oxydatif et des protéines associées à Alzheimer Thonningianin A est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pou… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |
| Vutiglabridin Vutiglabridin — autophagie et PON2 | Myopathies | Neuroprotection | Hypothèse exploratoire | Rapprochement automatique non validé | Activation de PON2 et stimulation de l’autophagie Vutiglabridin est étudié dans Maladie d’Alzheimer et documente plusieurs axes biologiques pouvant être pertinents pour… | Rapprochement Biomedical Watch · Maladie d’Alzheimer | Détail |